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Carver, MA, United States

Zhu M.,U.S. National Institute on Aging | Hu J.,U.S. National Institute on Aging | Perez E.,U.S. National Institute on Aging | Phillips D.,U.S. National Institute on Aging | And 4 more authors.
Journals of Gerontology - Series A Biological Sciences and Medical Sciences | Year: 2011

The effects of long-term cranberry consumption on age-related changes in endocrine pancreas are not fully understood. Here we treated male Fischer 344 rats with either 2% whole cranberry powder supplemented or normal rodent chow from 6 to 22 month old. Both groups displayed an age-related decline in basal plasma insulin concentrations, but this age-related decline was delayed by cranberry. Cranberry supplementation led to increased β-cell glucose responsiveness during the oral glucose tolerance test. Portal insulin concentration was 7.6-fold higher in rats fed cranberry, coupled with improved β-cell function. However, insulin resistance values were similar in both groups. Total β-cell mass and expression of pancreatic and duodenal homeobox 1 and insulin within islets were significantly enhanced in rats fed cranberry relative to controls. Furthermore, cranberry increased insulin release of an insulin-producing β-cell line, revealing its insulinotropic effect. These findings suggest that cranberry is of particular benefit to β-cell function in normal aging rats. © 2011 The Author. Source

Zou S.,U.S. National Institute on Aging | Carey J.R.,University of California at Davis | Liedo P.,Colegio de Mexico | Ingram D.K.,Pennington Biomedical Research Center | And 2 more authors.
Journals of Gerontology - Series A Biological Sciences and Medical Sciences | Year: 2010

Botanicals have numerous health benefits. Here, we used the Mexican fruit fly to screen 14 compounds and botanicals for their prolongevity effects and found an oregano and cranberry mixture (OC) improved survival. We then evaluated prolongevity effects of OC within the context of diet composition. Individual flies were fed 0%, 1%, or 2% OC in one of the three diets containing sugar and yeast extract (SY) at a ratio of 3:1, 9:1, or 24:1. We found that prolongevity effects of OC depended upon dose, gender, and diet composition. The greatest increase in longevity was observed in females fed the SY24:1 diet with 2% OC compared to the non-supplemented diet. OC did not reduce egg laying and, hence, did not compromise fecundity under any dietary condition tested here. This study reveals the prolongevity effects of OC and supports the emerging view that benefits of botanicals on aging depend on diet composition and gender. Source

Decas Cranberry Products Inc. | Date: 2010-06-28

Fruit juices, namely, Spiced Cranberry and Cherry juice.

Decas Cranberry Products Inc. | Date: 2010-06-29

Nutritional supplements. Dried fruits. Fruit juices.

Decas Cranberry Products Inc. | Date: 2010-09-21

Dried fruits.

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