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Debrecen, Hungary

The hemorheological parameters, such as whole blood viscosity, plasma viscosity, hematocrit, fibrinogen concentration as well as the micro-rheological properties of red blood cells (red blood cell deformability and aggregation) play an important role in tissue perfusion. The alternating hemorheological parameters, which are also inter-related, have important effects in determining hemodynamical properties, as well. The altered hemorheological status has a direct effect on endothelial function by changing shear force profile on the endothelial wall, and impairment of red blood cell deformability and aggregation (presence of rigid red blood cell, and enhanced red blood cell aggregation) slows down microcirculation with disturbing capillary perfusion. In experimental surgery vascular clamping and release cause ischemia-reperfusion, which affect red blood cells in many ways: changes pH level, leads to free-radical release, changes osmolarity and lactate and NO concentrations as well as it causes mechanical trauma. Understanding of these pathophysiological processes and determining the extent of reversible-irreversible changes may help to delineate underlying causes in tissue perfusion and microcirculation better, and develop prophylactic and therapeutic possibilities. The challenges of experimental surgery also include the questions of comparability in different measurement methods, and understanding of interspecies-differences of experimental/laboratory animal models in order to increase the relevance of results in terms of applicability for the original, clinical question. Source

MicroRNAs are a class of small non-coding RNAs regulating gene expression at posttranscriptional level. Their target genes include numerous regulators of cell cycle, cell proliferation as well as apoptosis. Therefore, they are implicated in the initiation and progression of cancer, tissue invasion and metastasis formation as well. MicroRNA profiles supply much information about both the origin and the differentiation state of tumours. MicroRNAs also have a key role during haemopoiesis. An altered expression level of those have often been observed in different types of leukemia. There are successful attempts to apply microRNAs in the diagnosis and prognosis of acute lymphoblastic leukemia and acute myeloid leukemia. Measurement of the expression levels may help to predict the success of treatment with different kinds of chemotherapeutic drugs. MicroRNAs are also regarded as promising therapeutic targets, and can contribute to a more personalized therapeutic approach in haemato-oncologic patients. Source

The subject of the invention is a perorally applicable preparation of vegetable origin, resistant to pepsin and trypsin, based on histaminase, optionally for the use as an agent for improving digestion, reducing appetite or reducing body weight. The preparation of the invention is a pressed juicewhich is optionally in lyophilized formobtained from seedlings of pea (

The present invention relates to a process for the isolation of the components of seed of

In a portable electronic device, a method of authenticating a document associated with a geographical location is disclosed. A document is provided in the form of digital data, and a hash value is generated from the digital data of said document. Raw GPS data are received from at least one GPS satellite, and then digitally signed by a first private key of the portable electronic device. From the raw GPS data, exact GPS coordinates are calculated. A request for an authentic location stamp is sent to a certification unit, the request containing at least the hash value of the document, the raw GPS data and the exact GPS coordinates, wherein said request is digitally signed by a private key of the portable electronic device. In response to said location stamp request, a nonce value from the certification unit is received, said nonce value being digitally signed by a private key of the certification unit. A certification request is then sent to the certification unit, said request containing at least the hash value of the document, the raw GPS data, the exact GPS coordinates and the nonce value, wherein the certification request is digitally signed with said private key of the portable electronic device. In response to said certification request, a certified location stamp containing said certification request and a piece of time information is received, said location stamp being digitally signed by a private key of the certification unit. The certified location stamp is verified by using the corresponding public key of the certification unit, and if it is determined that the certified location stamp is signed by the certification unit, the certified location stamp will be assigned to the document.

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