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Debrecen, Hungary

The University of Debrecen is a university located in Debrecen, Hungary. It is the oldest continuously operating institution of higher education in Hungary . The university has a well established programme in the English language for international students, particularly in the Medical field, which first established education in English in 1986. There are nearly 4000 international students studying at the university.Until 2014 technical Academy Awards have been awarded to five former students.The university also has a Basic Medicine campus in Geochang County, South Korea. Wikipedia.

Banfalvi G.,Debrecen University
Cancer metastasis reviews | Year: 2012

Parathymic lymph nodes as potential sites of tumor progression have been neglected in humans. We have established a rat renal capsule-parathymic lymph node model to study in vivo metastasis. Epithelial liver carcinoma (HeDe) and mesenchymal mesoblastic nephroma (NeDe) cell lines have been established after inducing chemical carcinogenesis in newborn Fisher 344 inbred rats by N-nitrosodimethylamine. Implanting the exact number of tumor cells (HeDe, NeDe) under the renal capsule allowed the standardization and timing of metastatic development. Tumor cells released from the primary tumor in the peritoneal cavity were drained to the parathymic lymph nodes (PTNs) as sentinel lymph nodes. Similarly, tumor cells injected i.p. were engulfed by macrophages, drained through the transdiaphragmatic channels, and transported to the thoracal lymphatics, primarily to PTNs. Tumor cells after transdiaphragmic drainage can enter both anterior mammary and parathymic sentinel lymph nodes. The potential common origin can shed new light on the metastatic cell progression of PTNs and mammary tumors. Source

Banfalvi G.,Debrecen University
Cancer and Metastasis Reviews | Year: 2012

The ancient view regarding breast cancer as a metastasis has not been supported so far by experimental evidence. We have implanted nephroblastoma tumor cells resulting in a rat metastatic kidney capsule-parathymic lymph node (PTN) model. India ink implantation confirmed the lymphatic connection between the primary tumor of the kidney and PTNs. 18F-FDG glucose analog distribution provided further evidence that the first metastatic sites of distant tumor progression are PTNs. Tumor invasion caused disruptions in the tissue of the primary renal tumor, releasing cancer cells into the peritoneal cavity. Colloidal particles, among them bacteria and India ink, crossed transdiaphragmatic channels drained from the peritonel cavity to the thoracic lymphatics and entered not only in the parathymic lymph nodes but also in the anterior mammary lymph nodes. The kidney capsule-PTN complex is reflecting a so far unknown mechanism of tumor development and suggests a similar tumor progression directed towards mammary lymph nodes. The mammalian tumor model provides a reasonable explanation for breast cancer development viewed as a metastasis, rather than a primary tumor. © 2012 Springer Science+Business Media, LLC. Source

Bai P.,Debrecen University | Bai P.,Hungarian Academy of Sciences | Canto C.,Nestle
Cell Metabolism | Year: 2012

While originally described as DNA damage repair agents, recent data suggest a role for poly(ADP-ribose) polymerase (PARP) enzymes in metabolic regulation by influencing mitochondrial function and oxidative metabolism. Here we review how PARP activity has a major metabolic impact and the role of PARP-1 and PARP-2 in diverse metabolic complications. © 2012 Elsevier Inc. Source

Angeli I.,Debrecen University | Marinova K.P.,Joint Institute for Nuclear Research
Atomic Data and Nuclear Data Tables | Year: 2013

The present table contains experimental root-mean-square (rms) nuclear charge radii R obtained by combined analysis of two types of experimental data: (i) radii changes determined from optical and, to a lesser extent, Kα X-ray isotope shifts and (ii) absolute radii measured by muonic spectra and electronic scattering experiments. The table combines the results of two working groups, using respectively two different methods of evaluation, published in ADNDT earlier. It presents an updated set of rms charge radii for 909 isotopes of 92 elements from 1H to 96Cm together, when available, with the radii changes from optical isotope shifts. Compared with the last published tables of R-values from 2004 (799 ground states), many new data are added due to progress recently achieved by laser spectroscopy up to early 2011. The radii changes in isotopic chains for He, Li, Be, Ne, Sc, Mn, Y, Nb, Bi have been first obtained in the last years and several isotopic sequences have been recently extended to regions far off stability, (e.g., Ar, Mo, Sn, Te, Pb, Po). © 2012 Elsevier Inc. Source

OBJECTIVE: HLA-DR [shared epitope (SE)] alleles have recently been re-classified into S1, S2, S3P and S3D groups. S2 and S3P have been associated with increased risk for RA. We assessed the impact of S1, S2, S3P and S3D alleles on anti-citrullinated protein antibody (ACPA) production. Instead of comparing allele-carriers to non-carriers, we studied each allele group individually, using the X/X (non-SE) genotype as reference. METHODS: Serum and genomic DNA samples of 91 RA patients and 78 healthy controls were obtained. Various ACPAs and IgM RF were determined by ELISA. HLA-DRB1 genotyping and subtyping was performed by PCR. HLA-DRB1 alleles were re-classified as described above. Correlations between SE and ACPAs were determined. RESULTS: Not only S2 and S3P, but, to a lesser extent, S1 and S3D alleles also predisposed to anti-cyclic citrullinated peptide (CCP) production (P < 0.0001, P = 0.004, P = 0.01 and P = 0.027, respectively), with the following hierarchy of association: S2+S3P > S1+S3D > X/X. Similar associations were observed for anti-citrullinated vimentin. Anti-citrullinated fibrinogen (CF) exerted a different association pattern with the strongest correlation with S1 alleles [odds ratio (OR) 16.00; P = 0.05]. In addition, HLA-DRB1*15 alleles may represent a special predisposing effect for anti-CF antibody production. Finally, in this study, RF production was associated only with the HLA-DRB1*0401 SE allele (P = 0.04). CONCLUSIONS: Our approach of comparing individual S allele carriers with X/X genotype patients allowed us to perform unequivocal analyses and demonstrate new associations. Thus, novel subgroups of RA could be identified with potential relevance for prognosis and therapy. Source

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