DeBartolo Family Personalized Medicine Institute

Sun City Center, FL, United States

DeBartolo Family Personalized Medicine Institute

Sun City Center, FL, United States
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SOUTH PLAINFIELD, N.J., May 17, 2017 (GLOBE NEWSWIRE) -- Advanced Molecular Diagnostics company, Admera Health, (www.admerahealth.com) announced today the appointment of Howard McLeod, PharmD to its advisory board. Dr. McLeod brings more than 18 years of experience to Admera Health and is an internationally recognized expert on pharmacogenomics and the role that genetic differences have in individual responses to cancer therapy. Dr. McLeod has a long list of accolades. He is the Medical Director of the DeBartolo Family Personalized Medicine Institute at the Moffitt Cancer Center, chairs multiple committees on cancer care, the National Human Genome Research Institute (NHGRI), the eMERGE Network’s External Scientific Panel, and a recent member of the FDA committee on Clinical Pharmacology and the NIH Human Genome Advisory Council. In addition, Dr. McLeod has published over 500 peer reviewed papers on pharmacogenomics, applied therapeutics, and clinical pharmacology. “Howard McLeod is an outstanding addition to our advisory board,” stated Guanghui Hu, PhD, CEO and President of Admera Health. “His expertise and level of experience in pharmacogenomics will contribute to further our mission of providing innovative, personalized solutions. We are especially looking forward to him providing guidance as we move our pharmacogenomics expertise further into supportive care for cancer patients.” Admera Health offers the most comprehensive pharmacogenomics testing services available, its PGxOne™ Plus test interrogates 50 genes with coverage of ~200 genetic variants and provides recommendation on over 300 drugs. Admera Health is a CLIA-certified and CAP-accredited advanced molecular diagnostics company focused on personalized medicine, non-invasive cancer testing, digital health, and providing research use only services. Research and development efforts are dedicated to developing cutting-edge diagnostics that span the continuum of care. Utilizing next generation technology platforms and advanced bioinformatics, Admera Health seeks to redefine disease screening, diagnosis, treatment, monitoring, and management through its innovative, personalized solutions. It is Admera’s mission to deliver transformative, valuable solutions for patients, physicians, and clinical researchers. Admera health is committed to improving the health and well-being of the global community through the direct delivery of personalized, medically actionable results.


SOUTH PLAINFIELD, N.J., May 17, 2017 (GLOBE NEWSWIRE) -- Advanced Molecular Diagnostics company, Admera Health, (www.admerahealth.com) announced today the appointment of Howard McLeod, PharmD to its advisory board. Dr. McLeod brings more than 18 years of experience to Admera Health and is an internationally recognized expert on pharmacogenomics and the role that genetic differences have in individual responses to cancer therapy. Dr. McLeod has a long list of accolades. He is the Medical Director of the DeBartolo Family Personalized Medicine Institute at the Moffitt Cancer Center, chairs multiple committees on cancer care, the National Human Genome Research Institute (NHGRI), the eMERGE Network’s External Scientific Panel, and a recent member of the FDA committee on Clinical Pharmacology and the NIH Human Genome Advisory Council. In addition, Dr. McLeod has published over 500 peer reviewed papers on pharmacogenomics, applied therapeutics, and clinical pharmacology. “Howard McLeod is an outstanding addition to our advisory board,” stated Guanghui Hu, PhD, CEO and President of Admera Health. “His expertise and level of experience in pharmacogenomics will contribute to further our mission of providing innovative, personalized solutions. We are especially looking forward to him providing guidance as we move our pharmacogenomics expertise further into supportive care for cancer patients.” Admera Health offers the most comprehensive pharmacogenomics testing services available, its PGxOne™ Plus test interrogates 50 genes with coverage of ~200 genetic variants and provides recommendation on over 300 drugs. Admera Health is a CLIA-certified and CAP-accredited advanced molecular diagnostics company focused on personalized medicine, non-invasive cancer testing, digital health, and providing research use only services. Research and development efforts are dedicated to developing cutting-edge diagnostics that span the continuum of care. Utilizing next generation technology platforms and advanced bioinformatics, Admera Health seeks to redefine disease screening, diagnosis, treatment, monitoring, and management through its innovative, personalized solutions. It is Admera’s mission to deliver transformative, valuable solutions for patients, physicians, and clinical researchers. Admera health is committed to improving the health and well-being of the global community through the direct delivery of personalized, medically actionable results.


SOUTH PLAINFIELD, N.J., May 17, 2017 (GLOBE NEWSWIRE) -- Advanced Molecular Diagnostics company, Admera Health, (www.admerahealth.com) announced today the appointment of Howard McLeod, PharmD to its advisory board. Dr. McLeod brings more than 18 years of experience to Admera Health and is an internationally recognized expert on pharmacogenomics and the role that genetic differences have in individual responses to cancer therapy. Dr. McLeod has a long list of accolades. He is the Medical Director of the DeBartolo Family Personalized Medicine Institute at the Moffitt Cancer Center, chairs multiple committees on cancer care, the National Human Genome Research Institute (NHGRI), the eMERGE Network’s External Scientific Panel, and a recent member of the FDA committee on Clinical Pharmacology and the NIH Human Genome Advisory Council. In addition, Dr. McLeod has published over 500 peer reviewed papers on pharmacogenomics, applied therapeutics, and clinical pharmacology. “Howard McLeod is an outstanding addition to our advisory board,” stated Guanghui Hu, PhD, CEO and President of Admera Health. “His expertise and level of experience in pharmacogenomics will contribute to further our mission of providing innovative, personalized solutions. We are especially looking forward to him providing guidance as we move our pharmacogenomics expertise further into supportive care for cancer patients.” Admera Health offers the most comprehensive pharmacogenomics testing services available, its PGxOne™ Plus test interrogates 50 genes with coverage of ~200 genetic variants and provides recommendation on over 300 drugs. Admera Health is a CLIA-certified and CAP-accredited advanced molecular diagnostics company focused on personalized medicine, non-invasive cancer testing, digital health, and providing research use only services. Research and development efforts are dedicated to developing cutting-edge diagnostics that span the continuum of care. Utilizing next generation technology platforms and advanced bioinformatics, Admera Health seeks to redefine disease screening, diagnosis, treatment, monitoring, and management through its innovative, personalized solutions. It is Admera’s mission to deliver transformative, valuable solutions for patients, physicians, and clinical researchers. Admera health is committed to improving the health and well-being of the global community through the direct delivery of personalized, medically actionable results.


SOUTH PLAINFIELD, N.J., May 17, 2017 (GLOBE NEWSWIRE) -- Advanced Molecular Diagnostics company, Admera Health, (www.admerahealth.com) announced today the appointment of Howard McLeod, PharmD to its advisory board. Dr. McLeod brings more than 18 years of experience to Admera Health and is an internationally recognized expert on pharmacogenomics and the role that genetic differences have in individual responses to cancer therapy. Dr. McLeod has a long list of accolades. He is the Medical Director of the DeBartolo Family Personalized Medicine Institute at the Moffitt Cancer Center, chairs multiple committees on cancer care, the National Human Genome Research Institute (NHGRI), the eMERGE Network’s External Scientific Panel, and a recent member of the FDA committee on Clinical Pharmacology and the NIH Human Genome Advisory Council. In addition, Dr. McLeod has published over 500 peer reviewed papers on pharmacogenomics, applied therapeutics, and clinical pharmacology. “Howard McLeod is an outstanding addition to our advisory board,” stated Guanghui Hu, PhD, CEO and President of Admera Health. “His expertise and level of experience in pharmacogenomics will contribute to further our mission of providing innovative, personalized solutions. We are especially looking forward to him providing guidance as we move our pharmacogenomics expertise further into supportive care for cancer patients.” Admera Health offers the most comprehensive pharmacogenomics testing services available, its PGxOne™ Plus test interrogates 50 genes with coverage of ~200 genetic variants and provides recommendation on over 300 drugs. Admera Health is a CLIA-certified and CAP-accredited advanced molecular diagnostics company focused on personalized medicine, non-invasive cancer testing, digital health, and providing research use only services. Research and development efforts are dedicated to developing cutting-edge diagnostics that span the continuum of care. Utilizing next generation technology platforms and advanced bioinformatics, Admera Health seeks to redefine disease screening, diagnosis, treatment, monitoring, and management through its innovative, personalized solutions. It is Admera’s mission to deliver transformative, valuable solutions for patients, physicians, and clinical researchers. Admera health is committed to improving the health and well-being of the global community through the direct delivery of personalized, medically actionable results.


Abernethy A.,Duke University | Abrahams E.,Personalized Medicine Coalition | Barker A.,Arizona State University | Buetow K.,Arizona State University | And 11 more authors.
Clinical Cancer Research | Year: 2014

An ever-expanding understanding of the molecular basis of the more than 200 unique diseases collectively called cancer, combined with efforts to apply these insights to clinical care, is forming the foundation of an era of personalized medicine that promises to improve cancer treatment. At the same time, these extraordinary opportunities are occurring in an environment of intense pressure to contain rising healthcare costs. This environment presents a challenge to oncology research and clinical care, because both are becoming progressively more complex and expensive, and because the current tools to measure the cost and value of advances in care (e.g., comparative effectiveness research, cost-effectiveness analysis, and health technology assessments) are not optimized for an ecosystem moving toward personalized, patient-centered care. Reconciling this tension will be essential to maintaining progress in a cost-constrained environment, especially because emerging innovations in science (e.g., increasing identification of molecular biomarkers) and in clinical process (implementation of a learning healthcare system) hold potential to dramatically improve patient care, and may ultimately help address the burden of rising costs. For example, the rapid pace of innovation taking place within oncology calls for increased capability to integrate clinical research and care to enable continuous learning, so that lessons learned from each patient treated can inform clinical decision making for the next patient. Recognizing the need to define the policies required for sustained innovation in cancer research and care in an era of cost containment, the stakeholder community must engage in an ongoing dialogue and identify areas for collaboration. This article reflects and seeks to amplify the ongoing robust discussion and diverse perspectives brought to this issue by multiple stakeholders within the cancer community, and to consider how to frame the research and regulatory policies necessary to sustain progress against cancer in an environment of constrained resources. © 2014 AACR.


Hertz D.L.,University of Michigan | McLeod H.L.,Personalized Medicine Institute | McLeod H.L.,DeBartolo Family Personalized Medicine Institute
Clinical Cancer Research | Year: 2014

The patient (germline) genome can influence the pharmacokinetics and pharmacodynamics of cancer therapy. The field of pharmacogenetics (PGx) has primarily focused on genetic predictors of pharmacokinetics, largely ignoring pharmacodynamics, using a candidate approach to assess single-nucleotide polymorphisms (SNP) with known relevance to drug pharmacokinetics such as enzymes and transporters. A more comprehensive approach, the genome-wide association study, circumvents candidate selection but suffers because of the necessity for substantial statistical correction. Pharmacogene panels, which interrogate hundreds to thousands of SNPs in genes with known relevance to drug pharmacokinetics or pharmacodynamics, represent an attractive compromise between these approaches. Panels with defined or customizable SNP lists have been used to discover SNPs that predict pharmacokinetics or pharmacodynamics of cancer drugs, most of which await successful replication. PGx discovery, particularly for SNPs that influence drug pharmacodynamics, is limited by weaknesses in both genetic and phenotypic data. Selection of candidate SNPs for inclusion on pharmacogene panels is difficult because of limited understanding of biology and pharmacology. Phenotypes used in analyses have primarily been complex toxicities that are known to be multifactorial. A more measured approach, in which sensitive phenotypes are used in place of complex clinical outcomes, will improve the success rate of pharmacodynamics SNP discovery and ultimately enable identification of pharmacodynamics SNPs with meaningful effects on treatment outcomes. © 2014 American Association for Cancer Research.


Shain K.H.,H. Lee Moffitt Cancer Center and Research Institute | Dalton W.S.,H. Lee Moffitt Cancer Center and Research Institute | Dalton W.S.,DeBartolo Family Personalized Medicine Institute | Tao J.,University of South Florida
Oncogene | Year: 2015

B-cell tumorigenesis results from a host of known and unknown genetic anomalies, including non-random translocations of genes that normally function as determinants of cell proliferation or cell survival to regions juxtaposed to active immunoglobulin heavy chain enhancer elements, chromosomal aneuploidy, somatic mutations that further affect oncogenic signaling and loss of heterozygosity of tumor-suppressor genes. However, it is critical to recognize that even in the setting of a genetic disease, the B-cell/plasma cell tumor microenvironment (TME) contributes significantly to malignant transformation and pathogenesis. Over a decade ago, we proposed the concept of cell adhesion-mediated drug resistance to delineate a form of TME-mediated drug resistance that protects hematopoietic tumor cells from the initial effect of diverse therapies. In the interim, it has been increasingly appreciated that TME also contributes to tumor initiation and progression through sustained growth/proliferation, self-renewal capacity, immune evasion, migration and invasion as well as resistance to cell death in a host of B-cell malignancies, including mantle cell lymphoma, diffuse large B-cell lymphoma, Waldenstroms macroglobulinemia, chronic lymphocytic leukemia and multiple myeloma. Within this review, we propose that TME and the tumor co-evolve as a consequence of bidirectional signaling networks. As such, TME represents an important target and should be considered integral to tumor progression and drug response. © 2015 Macmillan Publishers Limited.


Hertz D.L.,University of Michigan | McLeod H.L.,DeBartolo Family Personalized Medicine Institute
Clinical Pharmacology and Therapeutics | Year: 2016

Tumor genome analysis is transforming cancer treatment by enabling identification of specific oncogenic drivers and selection of effective targeted agents. Meanwhile, patient genome analysis is being employed across therapeutic areas to inform selection of appropriate drugs and doses for treatment safety. Integration of patient genome analysis concurrent with preemptive tumor genetic testing will enable oncologists to make informed treatment decisions to select the right dose of the right drug for each patient and their tumor. © 2015 ASCPT.


He Y.,University of South Florida | McLeod H.L.,DeBartolo Family Personalized Medicine Institute
Medicine (United Kingdom) | Year: 2016

Pharmacokinetics is the science that describes (using the ADME approach) the absorption of a drug from its site of administration, its distribution throughout the body, its metabolism or conjugation, and its excretion from the body. Pharmacokinetics can be thought of as what the body does to the drug. This article describes the basic principles and outlines how an understanding of pharmacokinetics can support rational prescribing. © 2016 Elsevier Ltd. All rights reserved.


PubMed | University of Michigan and DeBartolo Family Personalized Medicine Institute
Type: Journal Article | Journal: Clinical pharmacology and therapeutics | Year: 2016

Tumor genome analysis is transforming cancer treatment by enabling identification of specific oncogenic drivers and selection of effective targeted agents. Meanwhile, patient genome analysis is being employed across therapeutic areas to inform selection of appropriate drugs and doses for treatment safety. Integration of patient genome analysis concurrent with preemptive tumor genetic testing will enable oncologists to make informed treatment decisions to select the right dose of the right drug for each patient and their tumor.

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