DaVinci Biosciences LLC

Costa Mesa, CA, United States

DaVinci Biosciences LLC

Costa Mesa, CA, United States
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Gonzalez R.,DaVinci Biosciences LLC | Griparic L.,DaVinci Biosciences LLC | Umana M.,DaVinci Biosciences LLC | Burgee K.,DaVinci Biosciences LLC | And 4 more authors.
Cell Transplantation | Year: 2010

There have been various forms of mesenchymal stem cell-like (MSC-like) cells isolated from umbilical cords (UCs). The isolation of umbilical cord lining stem cells (ULSCs) may be of great value for those interested in a possible treatment to several disease/disorders. Unlike umbilical cord blood cells, these cells are unique because they can be expanded to therapeutically relevant numbers and cryopreserved for several different uses. Here we efficiently isolate stem cells from a small segment of pre- and postnatal UCs, and obtain therapeutically relevant amounts of ULSCs within 3 weeks. We demonstrate their growth potential and characterize them using immunocytochemistry, flow cytometry, and RT-PCR. In addition, we differentiate ULSCs into multiple lineages. Pre- and postnatal ULSCs are morphologically similar to mesenchymal stem cells (MSCs) and easily expand to greater than 70 population doublings. They express pluripotent markers Oct4 and nanog at the protein and RNA level. Flow cytometry demonstrates that they express markers indicative of MSCs in addition to high SSEA-4 expression. ULSCs are easily differentiated into osteogenic, adipogenic, chondrogenic, cardiogenic, and neurogenic cells. Pre- and postnatal ULSCs are characteristically similar in respect to their growth, marker expression, and plasticity, demonstrating they are highly conserved throughout development. ULSCs have phenotypic and genotypic properties of MSCs. These studies demonstrate the therapeutic potential of an otherwise discarded tissue. They are a perfect HLA match for the donor and an excellent match for immediate family members; therefore, they may serve as a therapeutic cell source. Copyright © 2010 Cognizant Comm. Corp. All rights reserved.


Patent
Davinci Biosciences Llc | Date: 2010-06-02

Adult human gonadal stem cells that are capable of differentiating into cells of the mesodermal lineage and ectodermal lineage are described.


Human umbilical cord lining stem cells that are capable of differentiating into cells of the mesodermal lineage and ectodermal lineage are described, as well as methods of isolating, expanding, culturing, and cryopreserving such cells.


Patent
Davinci Biosciences Llc | Date: 2013-03-06

Adult human gonadal stem cells that are capable of differentiating into cells of the mesodermal lineage and ectodermal lineage are described.


The invention provides Natural Killer cells and improved methods for increasing Natural Killer cell viability, proliferation and cytotoxicity following cryopreservation.


Trademark
Davinci Biosciences LLC | Date: 2012-11-29

immune cells, namely, cells for medical or veterinary use; tissue cells, namely, cells for medical or veterinary use; biological tissues, namely, stem cells, progenitor cells, immune cells, tumor cells, blood-derived cells, stromal cells, connective tissue, support tissue, organ tissue, adipose and soft tissue, vascular tissue, skin and surface tissues, mucosal tissue, neural tissue, decellularized tissue, demineralized tissue, umbilical cords, placentas, bone marrow and tumor tissue for medical or veterinary use; derivatives of the aforementioned goods, namely, vaccines, proteins, peptides, cytokines, chemokines, antibodies, DNA, RNA, growth factors, cell lysate, extracellular matrix, and conditioned media for medical or veterinary use; Prophylactic and therapeutic vaccines; immune cells for medical use; pharmaceutical preparations for stimulating the immune system; pharmaceutical preparations for the treatment of immune system related diseases and conditions; Biochemicals, namely, proteases for use in human therapeutics, namely, for the treatment of infectious, auto-immune, cell-proliferative, inflammatory, metabolic, cardiovascular, respiratory, neurological, and musculoskeletal disorders and diseases.


Trademark
Davinci Biosciences LLC | Date: 2012-11-29

immune cells, namely, cells for medical or veterinary use; tissue cells, namely, cells for medical or veterinary use; biological tissues, namely, stem cells, progenitor cells, immune cells, tumor cells, blood-derived cells, stromal cells, connective tissue, support tissue, organ tissue, adipose and soft tissue, vascular tissue, skin and surface tissues, mucosal tissue, neural tissue, decellularized tissue, demineralized tissue, umbilical cords, placentas, bone marrow and tumor tissue for medical or veterinary use; derivatives of the aforementioned goods, namely, vaccines, proteins, peptides, cytokines, chemokines, antibodies, DNA, RNA, growth factors, cell lysate, extracellular matrix, and conditioned media for medical or veterinary use; Prophylactic and therapeutic vaccines; immune cells for medical use; pharmaceutical preparations for stimulating the immune system; pharmaceutical preparations for the treatment of immune system related diseases and conditions; Biochemicals, namely, proteases for use in human therapeutics, namely, for the treatment of infectious, auto-immune, cell-proliferative, inflammatory, metabolic, cardiovascular, respiratory, neurological, and musculoskeletal disorders and diseases.

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