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Thombre V.,Datta Meghe Institute of Medical Sciences
The International journal of periodontics & restorative dentistry | Year: 2013

Gingival recession remains an important problem in dental esthetics. Various surgical techniques have been proposed for treating multiple gingival recessions. The objective of this study was to evaluate and compare the effectiveness of a coronally positioned flap (CPF) with or without acellular dermal matrix allograft (ADMA) in the treatment of multiple marginal tissue recession. Twenty patients with a mean age of 31.6 years presented with 43 buccal/labial multiple recession defects (Miller Class I/II). Ten patients each were randomly assigned to one of two treatment groups: group 1 (ADMA) or group 2 (CPF). The clinical parameters gingival recession (GR), probing pocket depth (PD), clinical attachment level (CAL), and width of the keratinized gingiva (KG) were recorded before surgery and 6 month postsurgery. The mean baseline recession defect was 3.0 mm for group 1 and 2.8 mm for group 2. After 6 months, both treatments resulted in significant root coverage (P < .01), reaching an average of 2.7 mm (90%) in group 1 and 1.8 mm (66%) in group 2. The difference in recession reduction between treatments was statistically significant. There were no statistically significant differences between the treatments in PD and KG. CAL gain (3.0 mm) was significantly higher in group 1 compared with group 2 (2.0 mm). The results of this study demonstrate that ADMA with a CPF is an effective procedure for the treatment of multiple gingival recessions.

Taksande A.,Datta Meghe Institute of Medical Sciences | Prabhu S.,BJ Wadia Hospital | Venkatesh S.,BJ Wadia Hospital
Cardiovascular and Hematological Agents in Medicinal Chemistry | Year: 2012

Beta-Thalassaemia Major is a genetic blood disorder caused by the reduced synthesis of beta globin chain. The consequences of the resulting chronic anaemia are also common and include growth retardation, bone marrow expansion, extramedular hematopoiesis, splenomegaly, increased intestinal iron absorption, susceptibility to infections, and hypercoagulability. Transfusional iron overload can affect heart function by directly damaging tissue through iron deposition or via iron-mediated effects at other sites. Cardiac dysfunction is common in patients with thalassaemia and is the leading cause of mortality. The main cardiac abnormalities reported in patients with thalassaemia major (TM) and iron overload are left ventricular systolic and diastolic dysfunction, pulmonary hypertension, valvulopathies, arrhythmias and pericarditis. These cardiac abnormalities are a consequence of the general co-morbid conditions in thalassaemia but are closely related to concomitant endocrine deficiencies, hypercoagulability state and inflammatory milieu. Iron's toxicity within cells arises from its capacity to catalyse the production of reactive oxygen species that cause lipid peroxidation and organelle damage, which lead ultimately to cell death and fibrosis. With the introduction of new technologies such as cardiac magnetic resonance T2*, the early detection of cardiac iron overload and associated cardiac dysfunction is now possible, allowing time for reversal through iron chelation therapy. © 2012 Bentham Science Publishers.

Bhoyar P.S.,Datta Meghe Institute of Medical Sciences
Journal of investigative and clinical dentistry | Year: 2012

The aim of the present study was to determine the changes in masseter muscle thickness due to the state of complete edentulism and the effect of complete denture rehabilitation on the masseter muscle. Real-time ultrasonography of the masseter muscle at relaxed and contracted states was carried out for twelve patients (six dentulous and six completely edentulous). Edentulous patients were scanned at the time of denture insertion and at the end of 3 months' follow up. The mean masseter muscle thickness of the edentulous patients was significantly increased after the 3-month follow-up than the thickness at the time of denture insertion, but was significantly lower than that of the dentulous patients of the same age group. Within the limitations of this study, it can be concluded that change occurs in the masseter muscle thickness after rehabilitation with complete dentures in the form of increased muscle thickness. However, the thickness of the muscle remains smaller than that of dentate individuals. © 2011 Blackwell Publishing Asia Pty Ltd.

Totade S.,Datta Meghe Institute of Medical Sciences
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2016

In stomach mucus and bicarbonate stimulated by the local generation of prostaglandin which protect the gastric mucosa. A localised loss of gastric mucosa as well as duodenal mucosa leads to formation of peptic ulcer. Solanum nigrum linn also known as sunbery or wonder berry(Makoy) belongs to the family Solanacea, distributed as weed through dry place of India. The whole plant is used for medicinal purposes It has been claimed to have antiulcer and anti-inflammatory activity and useful for treatment of ulcer, flatulence and Hepatomegaly. Solanum nigrum linn has been documented and screened for antiulcer activity. To evaluate the gastric anti-ulcer activity of hydro alcoholic extract of leaf of Solanum nigrum in albino rates. Antiulcer activity of Solanum nigrum was studied in ethanol induced gastric ulcers in albino rates. Solanum nigrum was administered in the dose of 50,100 and 200mg/kg orally 30 min. prior to ulcer induction. The antiulcer activity was assessed by determining and comparing the ulcer index in test drug group with that of the vehicle control group. Ranitidine was used as a reference drug. The ulcer index in the Solanum nigrum treated animals was found to be significant less when compared to the vehicle control animals. Ranitidine produced a significant gastric ulcer protection. The antiulcer activity of solanum nigrum was less than that of Ranitidine. It can be concluded that solanum nigrum possesses significant antiulcer property which could be either due to cytoprotection action or by strengthening of gastric mucosa and thus enhancing mucosal defence. © 2010 RJPBCS.

Mittal R.,Datta Meghe Institute of Medical Sciences | Chowdhary D.S.,Mahatma Gandhi of Medical College and Hospital MGMCH
Journal of Clinical and Diagnostic Research | Year: 2010

Aim :To determine the normal standards of liver and spleen by ultrasonography in the Rajasthani population. Materials And Methods Two hundred subjects (100 males and 100 females) from Rajasthan were evaluated. The dimensions of the organs were measured 3 times and the mean values were recorded. The subjects were divided into 5 groups according to their ages (11-70 yrs.). Results The average longitudinal diameter of the right lobe of the liver was 12.99±0.76 cm (males) and 12.66±1.07 cm (females) and of the left lobe was 9.28±0.81 cm (males) and 9.17±1.03 cm (females). The average length of the spleen was 9.40±0.91 cm (males) and 9.34±0.95 cm (females). The average width of the spleen in males as well as in females was 3.45±0.59 cm. Conclusion: The normal values of the dimensions of the liver and spleen are important parameters during a sonographical examination. This study provides valuable data from the Rajasthani population. So, this study will be of importance in the daily practice in radiology clinics.

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