Dangore-Khasbage S.,Datta Meghe Institute of Medical Sciences
Dental and Medical Problems | Year: 2017
Oral cancer is the sixth-most common cancer globally; nevertheless, there is a wide geographical variation in its incidence all over the world. In India, it accounts for about 30% of all new cases annually and the gingival-buccal complex (alveolar ridge, gingival-buccal sulcus, buccal mucosa) forms the most common subsite for cancer of the oral cavity, in contrast to cancer of the tongue that is more common in the Western world. There is a trend towards increasing incidence and delayed presentation of oral cancer as approximately 50% of patients present at stage III or IV. Although, oral cancer is a disease of the older age groups, many patients contract it at an early age (< 40 years of age), especially in high incidence countries such as India where the lower socioeconomic strata of society plays a vital role. Despite improvement in diagnostic and management techniques, the age-standardized mortality rates in oral cancer are constant, which is attributable to a failure to detect potentially malignant lesions and early stage oral cancer which precludes successful treatment. This article describes three cases of oral squamous cell carcinoma occurring at an early age, with more emphasis on the clinical aspects of squamous cell carcinoma and measures for the prevention and early detection of oral cancer. © 2017 by Wroclaw Medical University and Polish Dental Society.
Mittal R.,Datta Meghe Institute of Medical Sciences |
Chowdhary D.S.,Mahatma Gandhi of Medical College and Hospital MGMCH
Journal of Clinical and Diagnostic Research | Year: 2010
Aim :To determine the normal standards of liver and spleen by ultrasonography in the Rajasthani population. Materials And Methods Two hundred subjects (100 males and 100 females) from Rajasthan were evaluated. The dimensions of the organs were measured 3 times and the mean values were recorded. The subjects were divided into 5 groups according to their ages (11-70 yrs.). Results The average longitudinal diameter of the right lobe of the liver was 12.99±0.76 cm (males) and 12.66±1.07 cm (females) and of the left lobe was 9.28±0.81 cm (males) and 9.17±1.03 cm (females). The average length of the spleen was 9.40±0.91 cm (males) and 9.34±0.95 cm (females). The average width of the spleen in males as well as in females was 3.45±0.59 cm. Conclusion: The normal values of the dimensions of the liver and spleen are important parameters during a sonographical examination. This study provides valuable data from the Rajasthani population. So, this study will be of importance in the daily practice in radiology clinics.
Taksande A.,Datta Meghe Institute of Medical Sciences |
Prabhu S.,BJ Wadia Hospital |
Venkatesh S.,BJ Wadia Hospital
Cardiovascular and Hematological Agents in Medicinal Chemistry | Year: 2012
Beta-Thalassaemia Major is a genetic blood disorder caused by the reduced synthesis of beta globin chain. The consequences of the resulting chronic anaemia are also common and include growth retardation, bone marrow expansion, extramedular hematopoiesis, splenomegaly, increased intestinal iron absorption, susceptibility to infections, and hypercoagulability. Transfusional iron overload can affect heart function by directly damaging tissue through iron deposition or via iron-mediated effects at other sites. Cardiac dysfunction is common in patients with thalassaemia and is the leading cause of mortality. The main cardiac abnormalities reported in patients with thalassaemia major (TM) and iron overload are left ventricular systolic and diastolic dysfunction, pulmonary hypertension, valvulopathies, arrhythmias and pericarditis. These cardiac abnormalities are a consequence of the general co-morbid conditions in thalassaemia but are closely related to concomitant endocrine deficiencies, hypercoagulability state and inflammatory milieu. Iron's toxicity within cells arises from its capacity to catalyse the production of reactive oxygen species that cause lipid peroxidation and organelle damage, which lead ultimately to cell death and fibrosis. With the introduction of new technologies such as cardiac magnetic resonance T2*, the early detection of cardiac iron overload and associated cardiac dysfunction is now possible, allowing time for reversal through iron chelation therapy. © 2012 Bentham Science Publishers.
Bhoyar P.S.,Datta Meghe Institute of Medical Sciences
Journal of investigative and clinical dentistry | Year: 2012
The aim of the present study was to determine the changes in masseter muscle thickness due to the state of complete edentulism and the effect of complete denture rehabilitation on the masseter muscle. Real-time ultrasonography of the masseter muscle at relaxed and contracted states was carried out for twelve patients (six dentulous and six completely edentulous). Edentulous patients were scanned at the time of denture insertion and at the end of 3 months' follow up. The mean masseter muscle thickness of the edentulous patients was significantly increased after the 3-month follow-up than the thickness at the time of denture insertion, but was significantly lower than that of the dentulous patients of the same age group. Within the limitations of this study, it can be concluded that change occurs in the masseter muscle thickness after rehabilitation with complete dentures in the form of increased muscle thickness. However, the thickness of the muscle remains smaller than that of dentate individuals. © 2011 Blackwell Publishing Asia Pty Ltd.
Thombre V.,Datta Meghe Institute of Medical Sciences
The International journal of periodontics & restorative dentistry | Year: 2013
Gingival recession remains an important problem in dental esthetics. Various surgical techniques have been proposed for treating multiple gingival recessions. The objective of this study was to evaluate and compare the effectiveness of a coronally positioned flap (CPF) with or without acellular dermal matrix allograft (ADMA) in the treatment of multiple marginal tissue recession. Twenty patients with a mean age of 31.6 years presented with 43 buccal/labial multiple recession defects (Miller Class I/II). Ten patients each were randomly assigned to one of two treatment groups: group 1 (ADMA) or group 2 (CPF). The clinical parameters gingival recession (GR), probing pocket depth (PD), clinical attachment level (CAL), and width of the keratinized gingiva (KG) were recorded before surgery and 6 month postsurgery. The mean baseline recession defect was 3.0 mm for group 1 and 2.8 mm for group 2. After 6 months, both treatments resulted in significant root coverage (P < .01), reaching an average of 2.7 mm (90%) in group 1 and 1.8 mm (66%) in group 2. The difference in recession reduction between treatments was statistically significant. There were no statistically significant differences between the treatments in PD and KG. CAL gain (3.0 mm) was significantly higher in group 1 compared with group 2 (2.0 mm). The results of this study demonstrate that ADMA with a CPF is an effective procedure for the treatment of multiple gingival recessions.
Totade S.,Datta Meghe Institute of Medical Sciences
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2016
In stomach mucus and bicarbonate stimulated by the local generation of prostaglandin which protect the gastric mucosa. A localised loss of gastric mucosa as well as duodenal mucosa leads to formation of peptic ulcer. Solanum nigrum linn also known as sunbery or wonder berry(Makoy) belongs to the family Solanacea, distributed as weed through dry place of India. The whole plant is used for medicinal purposes It has been claimed to have antiulcer and anti-inflammatory activity and useful for treatment of ulcer, flatulence and Hepatomegaly. Solanum nigrum linn has been documented and screened for antiulcer activity. To evaluate the gastric anti-ulcer activity of hydro alcoholic extract of leaf of Solanum nigrum in albino rates. Antiulcer activity of Solanum nigrum was studied in ethanol induced gastric ulcers in albino rates. Solanum nigrum was administered in the dose of 50,100 and 200mg/kg orally 30 min. prior to ulcer induction. The antiulcer activity was assessed by determining and comparing the ulcer index in test drug group with that of the vehicle control group. Ranitidine was used as a reference drug. The ulcer index in the Solanum nigrum treated animals was found to be significant less when compared to the vehicle control animals. Ranitidine produced a significant gastric ulcer protection. The antiulcer activity of solanum nigrum was less than that of Ranitidine. It can be concluded that solanum nigrum possesses significant antiulcer property which could be either due to cytoprotection action or by strengthening of gastric mucosa and thus enhancing mucosal defence. © 2010 RJPBCS.
Agarwal A.,Datta Meghe Institute of Medical Sciences |
Bhake A.,Datta Meghe Institute of Medical Sciences |
Kakani A.,Datta Meghe Institute of Medical Sciences
Asian Spine Journal | Year: 2011
Intramedullary spinal epidermoid cysts are benign ectopic embryological growths with reported incidence of less than 1% of intramedullary tumors. In this case we report an unusual cervical intramedullary epidermid with liquid contents. A 40-year-old patient presented with progressive weakness of all four limbs of four months duration, bowel and bladder disturbances of two days duration, pain and paresthesias in all four limbs. Magnetic resonance imaging (MRI) revealed a well defined intramedullary lesion extending from C2-C3 level with widening of the cord. The lesion was hypointense on T1W images, hyperintense on T2W and fluid attenuation and inversion recovery images with thin rim of enhancement after contrast administration. Histopathological examination of the excised specimen revealed epidermal lining and keratinous material features of an epidermoid cyst. As in present case, rarely epidermoid cyst can have clear contents, and an MRI finding can closely mimic the features of arachnoid cyst, findings not classical and is different than described in literature. © 2011 by Korean Society of Spine Surgery.
Tayde P.,Datta Meghe Institute of Medical Sciences |
Kumar S.,Datta Meghe Institute of Medical Sciences
Asian Journal of Gerontology and Geriatrics | Year: 2013
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and morbidity in older adults worldwide. It can be exacerbated by other chronic and acute health problems (myocardial infarction, angina, osteoporosis, respiratory infection, depression, diabetes, and lung cancer). Although the prevalence of COPD in the elderly is high, it is often undiagnosed and thus undertreated. Diagnosis is primarily based on physiological airflow limitation using spirometry. Controversies exist as to the range of predicted normal values in the elderly, in whom its clinical presentation may be complicated by other comorbidities. Many non-pharmacological and pharmacological interventions are available for managing COPD. However, polypharmacy may pose a challenge to the management of COPD, as it can interfere with compliance to optimal therapy. This article highlights the evaluation of COPD in the elderly and its management.
Chalak S.S.,Datta Meghe Institute of Medical Sciences
National Journal of Physiology, Pharmacy and Pharmacology | Year: 2015
Background: Auditory evoked potentials (AEP) can be used to assess the integrity of auditory pathway for early hearing loss and planning rehabilitative procedures. It is noninvasive and can be performed in uncooperative and difficult-to-test children under mild sedation. Aims and Objective: To determine the hearing threshold to assess the integrity of auditory pathway in children of suspected hearing loss and to find out the importance of AEP where other screening tests cannot be performed. Materials and Methods: This retrospective study was conducted in Acharya Vinoba Bhave Rural Hospital and Department of Physiology, Jawaharlal Nehru Medical College, Sawangi (Meghe), Wardha, Maharashtra, India. It included 80 children of suspected hearing loss in the age group of 1–12 years, referred under Sarva Shiksha Abhiyan program. Brainstem auditory responses were recorded in these children using multichannel polyrite system. Silver chloride disk electrodes were used on standard scalp locations. Results: Our results showed that 40 of 80 children were having definite mild-to-severe hearing loss. In nearly 50% children hearing loss was confirmed by AEP. In remaining 40 children, brainstem electric response audiometry showed normal responses indicating normal hearing. Of 80 suspected children, 20 were either uncooperative or not fit for any other screening tests for hearing. AEP showed that of these 20 children, 12 (15% of total), were having sensorineural loss that helped them in seeking treatment. Conclusion: Our results concluded that AEP at present is one of the most useful tools for assessment of integrity of auditory pathway and detection of early hearing loss, and it can greatly contribute in its management. It can definitely be used in screening for deafness and assessing the nature of hearing loss, particularly in patients who cannot perform in the usual audiometric procedures. It can also be used to assess the maturity of central nervous system in newborn and young children. © 2015, Mrs Deepika Charan. All right reserved.
Srivastava T.,Datta Meghe Institute of Medical Sciences |
Waghmare L.,Datta Meghe Institute of Medical Sciences
National Journal of Physiology, Pharmacy and Pharmacology | Year: 2014
Background: Tutorial embodies a major teaching learning strategy in basic sciences of medical education. Essentially tutorial should be a small class of few students in which the tutor gives individual attention each student. However; increase in student strength, and concurrent decrease in the faculty requirements by regulatory bodies in recent years; have posed immense hiccups in organizing tutorial in small groups. Aims & Objective: Objective of present study was to evaluate the feasibility of modifying traditional tutorial as Interactive Intergroup tutorial (IIT) and its efficacy to improve learning outcome. Materials and Methods: Study was conducted in Department of Physiology, Jawaharlal Nehru Medical College, Wardha, with sample population as students in first year of medical curriculum (n=150). They were sequentially subjected to traditional tutorial & Interactive Intragroup tutorial for 4 weeks. Difference in impact by the two methods was studied by pre and post - test design. Results: There was a significant difference in pre and post-test P = 0.011 and P = 0.023 (P < 0.05 was considered statistically significant) by traditional tutorial and Interactive Intragroup tutorial respectively. The difference in post test scores by both methods was found to be highly significant P = 0.00. Conclusion: The modified method can serve to be logistically straightforward to implement in a large class, particularly in subjects of basic sciences with added benefits of establishing group dynamics, interactivity, improving presentation and reasoning skills which are otherwise not a part of traditional tutorials.