Sarazan R.D.,Data Sciences International
Journal of Pharmacological and Toxicological Methods | Year: 2014
In the early days of in vivo nonclinical pressure measurement, most laboratories were required to have considerable technical/engineering expertise to configure and maintain pressure transducers, amplifiers, tape recorders, chart recorders, etc. Graduate students and postdoctoral fellows typically had some training in the requirements and limitations of the technology they used and were closely engaged in the collection and evaluation of data from their own experiments. More recently, pressure sensing telemetry and data acquisition/analysis systems are provided by vendors as turnkey systems, often resulting in a situation where users are less familiar with the technicalities of their operation. Also, investigators are now more likely to be absent and rely on technical staff for the collection of raw in vivo pressure data from their experiments than in the past. Depending on the goals of an experiment, an investigator may require the measurement of a variety of different pressure parameters, over varying periods of time. A basic understanding of the requirements and limitations that can affect the accuracy and precision of these parameters is important to ensure that the results and conclusions from an experiment are reliable. Factors to consider include the possibility of hydrostatic pressure effects from blood inside the vasculature of the animal, depending on the location of the sensor, as well as from fluid inside a fluid-filled catheter system; long-term stability (lack of drift) of a sensor over time, which can affect the interpretation of absolute pressure changes over a prolonged experiment; frequency response of the sensor and associated electronics; and the phase shift that occurs depending on location of the sensor in the vasculature or because of a fluid-filled catheter system. Each of these factors is discussed, and the particular requirements of frequency response as applied to the measurement of cardiac left ventricular pressure are emphasized. When these factors are understood, a pressure sensing and measurement system can be selected that is optimized for the experimental model being studied, thus eliminating errors or inaccurate results. © 2014 Published by Elsevier Inc. Source
Fritsche P.,Data Sciences International
2016 Pan Pacific Microelectronics Symposium, Pan Pacific 2016 | Year: 2016
Data Sciences International's (DSI) customers were experiencing an unacceptably high failure rate on one of our small (1.1 cc) implantable RF transmitters. With the help of Foresite, Inc., contamination on the circuit was identified to be one of the primary causes for the poor performance and reliability. Extensive research was conducted and no viable industry standard circuit washing system existed to meet the specific needs (small circuit size [< 0.4 in2], lower production volumes [∼50,000 circuits per year], thoroughly drying circuits and continuous flow [non-batch processing]). To fill this need, a new washing technology was developed. © 2016 SMTA. Source
Data Sciences International | Date: 2011-04-15
A medical device is disclosed for implantation on an epicardial surface of the heart. The device has a transmural member providing optimal electrode locations for various therapies. The hemodynamically optimal therapy is guided by sensed left ventricular pressure and electrical activity. The device may be used alone or with a companion implanted cardiac rhythm management device.
Data Sciences International | Date: 2013-06-21
Inhalation measurement systems and methods enable, during inhalant exposure, substantially real-time respiratory measurements of a test subject using techniques that obtain measurements of respiration directly from that test subject, instead of from inhalation chamber parameter measurements. Direct test subject respiratory measurements may be, by way of example only, impedance measurements. These respiratory measurements taken directly from the test subject may be transmitted, wirelessly for example, for processing during the course of the test to a processing system to determine a cumulative volume of inhalant inspired by the test subject. From that, a cumulative amount of inhalant (or dose) inspired by the test subject may be determined during the course of the inhalation compound test. In addition, a calibration procedure may be performed before the inhalant exposure to provide correlation needed to translate chest and/or abdominal wall expansion measurements, made during the test, into lung volume measurements.
Data Sciences International | Date: 2014-06-10
Computer Software and Computerized Analyzers for Collection and Processing of Physiological Data Collected from Animals and Instructional/User Manuals Sold Therewith as a Unit; Computer Programs for Acquisition, Analysis and Processing of Physiological Data in the Field of Medical Care for Animals and for Clinical Diagnosis and Research Purposes; Computer Software for Providing Notifications and Reports About Animal Vital Signs, Health and Condition; Transmitters, Receivers and Electronic Relay Stations for Sensing, Collecting, Transmitting, and Analyzing Physiological Data Collected from Animals, and Instructional/User Manuals Sold Therewith as a Unit; Signal Conditioners, Acquisition Interface Unit, Thermal Writer, Amplifiers, Output Box, Cable Kits, Probes, Transducers, Sensors, Electrodes and Accessories for the Acquisition, Recording, Storage and Display of Data, and Instructional/User Manuals Sold Therewith as a Unit; Computer Hardware and Software for Use in the Acquisition and Analysis of Physiological Data; Computer Software for Circulatory System, Cardiovascular System, Digestive System, Endocrine System, Immune System, Integumentary System, Lymphatic System, Muscular System, Nervous System, Reproductive System, Respiratory System, Skeletal System and Urinary System Analysis of Animals; Computer Software and Computerized Preclinical Laboratory Analyzers for Collection and Processing of Physiological Data Collected from Animals; Transmitters and Receivers for Animal Telemetry; Laboratory Equipment, Namely, Brain Activity Monitors, Blood Pressure Sensors, Force Transducers, Temperature Probes, Flow Meters, Pneumotachs, Respiratory Chambers, Dimension Gauges and Headstages for the Clinical Care of Animals; Prerecorded Video Tapes, CDs, and DVDs Featuring Instruction on and Information About Physiological Data, Animal Vital Signs, and Telemetry; Digital Materials, Namely, Downloadable Audio Files and Downloadable Video Files Featuring Instruction on and Information About Physiological Data, Animal Vital Signs, and Telemetry; Electronic Devices for Animal Locating and Tracking Programmed to Use Global Positioning Systems (GPS) and Cellular Communications.