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Saint Paul, MN, United States
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Conrads P.A.,U.S. Geological Survey | Roehl E.A.,Data Sciences International
Geological Society Special Publication | Year: 2017

Natural-resource managers and stakeholders face difficult challenges when managing interactions between natural and societal systems. Potential changes in climate could alter interactions between environmental and societal systems and adversely affect the availability of water resources in many coastal communities. The availability of freshwater in coastal streams can be threatened by saltwater intrusion. Even though the collective interests and computer skills of the community of managers, scientists and other stakeholders are quite varied, there is an overarching need for equal access by all to the scientific knowledge needed to make the best possible decisions. This paper describes a decision support system, PRISM-2, developed to evaluate salinity intrusion due to potential climate change along the South Carolina coast in southeastern USA. The decision support system is disseminated as a spreadsheet application and integrates the output of global circulation models, watershed models and salinity intrusion models with real-time databases for simulation, graphical user interfaces, and streaming displays of results. The results from PRISM-2 showed that a 31-cm and 62-cm increase in sea level reduced the daily availability of freshwater supply to a coastal municipal intake by 4% and 12% of the time, respectively. Future climate change projections by a global circulation model showed a seasonal change in salinity intrusion events from the summer to the fall for the majority of events. © 2017 The Author(s).

Grady N.W.,Data Sciences International
Proceedings - 2016 IEEE International Conference on Big Data, Big Data 2016 | Year: 2016

Cross-Industry Standard process model (CRISP-DM) was developed in the late 90s by a consortium of industry participants to facilitate the end-to-end data mining process for Knowledge Discovery in Databases (KDD). While there have been efforts to better integrate with management and software development practices, there are no extensions to handle the new activities involved in using big data technologies. Data Science Edge (DSE) is an enhanced process model to accommodate big data technologies and data science activities. In recognition of the changes, the author promotes the use of a new term, Knowledge Discovery in Data Science (KDDS) as a call for the community to develop a new industry standard data science process model. © 2016 IEEE.

Sarazan R.D.,Data Sciences International | Kroehle J.P.,Data Sciences International | Main B.W.,Data Sciences International
Journal of Pharmacological and Toxicological Methods | Year: 2012

Increasing or decreasing cardiac contractility is an undesirable property of drugs being developed for noncardiovascular indications. The International Conference on Harmonization (ICH) Topic S7A and S7B guidelines only require the assessment of heart rate, blood pressure and the electrocardiogram in nonclinical in vivo safety pharmacology studies. Assessment of drug effects on contractility is only suggested as an optional follow-up study. However, these nonclinical safety assessment studies can detect these effects if properly designed and conducted using appropriate instrumentation. Left ventricular dP/dt is the first derivative of left ventricular pressure, which is computed by software algorithms by using calculus. Its peak value, dP/dtmax, is a common, robust and sensitive indicator of changes in cardiac contractility if experimental parameters such as preload, afterload and heart rate are well controlled. In order to ensure accuracy and avoid errors in the measurement of contractility in experimental animals, the frequency response of the pressure sensing system and the sample rate of the data acquisition system must be optimized for the signal. For dogs, nonhuman primates, and normotensive rats, all important information in a left ventricular pressure signal can be captured with a system with a frequency response of 100Hz. Although systems with much higher frequency response can be used to measure left ventricular pressure, the output of these devices must be filtered to allow no frequencies to be acquired that are higher than one-half the sample rate of the acquisition system. Stated conversely, the sample rate of the acquisition system must be at least 2× the highest frequency contained in the signal. Failure to follow these principals can lead to incorrect results due to measurement artifacts from high frequency noise, which could be present but not detectable by the investigator. This manuscript has been written for biologists who do not have advanced knowledge of physics and/or engineering and is therefore less technical and more simplified than what would be found in the engineering literature. © 2012 Elsevier Inc.

Sarazan R.D.,Data Sciences International
Journal of Pharmacological and Toxicological Methods | Year: 2014

In the early days of in vivo nonclinical pressure measurement, most laboratories were required to have considerable technical/engineering expertise to configure and maintain pressure transducers, amplifiers, tape recorders, chart recorders, etc. Graduate students and postdoctoral fellows typically had some training in the requirements and limitations of the technology they used and were closely engaged in the collection and evaluation of data from their own experiments. More recently, pressure sensing telemetry and data acquisition/analysis systems are provided by vendors as turnkey systems, often resulting in a situation where users are less familiar with the technicalities of their operation. Also, investigators are now more likely to be absent and rely on technical staff for the collection of raw in vivo pressure data from their experiments than in the past. Depending on the goals of an experiment, an investigator may require the measurement of a variety of different pressure parameters, over varying periods of time. A basic understanding of the requirements and limitations that can affect the accuracy and precision of these parameters is important to ensure that the results and conclusions from an experiment are reliable. Factors to consider include the possibility of hydrostatic pressure effects from blood inside the vasculature of the animal, depending on the location of the sensor, as well as from fluid inside a fluid-filled catheter system; long-term stability (lack of drift) of a sensor over time, which can affect the interpretation of absolute pressure changes over a prolonged experiment; frequency response of the sensor and associated electronics; and the phase shift that occurs depending on location of the sensor in the vasculature or because of a fluid-filled catheter system. Each of these factors is discussed, and the particular requirements of frequency response as applied to the measurement of cardiac left ventricular pressure are emphasized. When these factors are understood, a pressure sensing and measurement system can be selected that is optimized for the experimental model being studied, thus eliminating errors or inaccurate results. © 2014 Published by Elsevier Inc.

Fritsche P.,Data Sciences International
2016 Pan Pacific Microelectronics Symposium, Pan Pacific 2016 | Year: 2016

Data Sciences International's (DSI) customers were experiencing an unacceptably high failure rate on one of our small (1.1 cc) implantable RF transmitters. With the help of Foresite, Inc., contamination on the circuit was identified to be one of the primary causes for the poor performance and reliability. Extensive research was conducted and no viable industry standard circuit washing system existed to meet the specific needs (small circuit size [< 0.4 in2], lower production volumes [∼50,000 circuits per year], thoroughly drying circuits and continuous flow [non-batch processing]). To fill this need, a new washing technology was developed. © 2016 SMTA.

Data Sciences International | Date: 2013-06-21

Inhalation measurement systems and methods enable, during inhalant exposure, substantially real-time respiratory measurements of a test subject using techniques that obtain measurements of respiration directly from that test subject, instead of from inhalation chamber parameter measurements. Direct test subject respiratory measurements may be, by way of example only, impedance measurements. These respiratory measurements taken directly from the test subject may be transmitted, wirelessly for example, for processing during the course of the test to a processing system to determine a cumulative volume of inhalant inspired by the test subject. From that, a cumulative amount of inhalant (or dose) inspired by the test subject may be determined during the course of the inhalation compound test. In addition, a calibration procedure may be performed before the inhalant exposure to provide correlation needed to translate chest and/or abdominal wall expansion measurements, made during the test, into lung volume measurements.

Data Sciences International | Date: 2011-04-15

A medical device is disclosed for implantation on an epicardial surface of the heart. The device has a transmural member providing optimal electrode locations for various therapies. The hemodynamically optimal therapy is guided by sensed left ventricular pressure and electrical activity. The device may be used alone or with a companion implanted cardiac rhythm management device.

Data Sciences International | Date: 2014-06-10

Telemetry Devices for Medical and Veterinary Applications; Medical Apparatus and Instruments; Implant Devices for Veterinary Purposes, Namely, Telemetry Devices for Collection, Transmission, and Processing of Physiological Data Collected from Animals; Electrocardiographs for Veterinary Purposes; Medical Devices and Apparatus, Namely, Surgical Implants; Medical and Surgical Implants Made of Artificial Materials; Medical Instruments to Measure Blood Pressure, Cardiac Output and Other Physiological and Cardiovascular Parameters.

Data Sciences International | Date: 2014-06-10

Computer Software and Computerized Analyzers for Collection and Processing of Physiological Data Collected from Animals and Instructional/User Manuals Sold Therewith as a Unit; Computer Programs for Acquisition, Analysis and Processing of Physiological Data in the Field of Medical Care for Animals and for Clinical Diagnosis and Research Purposes; Computer Software for Providing Notifications and Reports About Animal Vital Signs, Health and Condition; Transmitters, Receivers and Electronic Relay Stations for Sensing, Collecting, Transmitting, and Analyzing Physiological Data Collected from Animals, and Instructional/User Manuals Sold Therewith as a Unit; Signal Conditioners, Acquisition Interface Unit, Thermal Writer, Amplifiers, Output Box, Cable Kits, Probes, Transducers, Sensors, Electrodes and Accessories for the Acquisition, Recording, Storage and Display of Data, and Instructional/User Manuals Sold Therewith as a Unit; Computer Hardware and Software for Use in the Acquisition and Analysis of Physiological Data; Computer Software for Circulatory System, Cardiovascular System, Digestive System, Endocrine System, Immune System, Integumentary System, Lymphatic System, Muscular System, Nervous System, Reproductive System, Respiratory System, Skeletal System and Urinary System Analysis of Animals; Computer Software and Computerized Preclinical Laboratory Analyzers for Collection and Processing of Physiological Data Collected from Animals; Transmitters and Receivers for Animal Telemetry; Laboratory Equipment, Namely, Brain Activity Monitors, Blood Pressure Sensors, Force Transducers, Temperature Probes, Flow Meters, Pneumotachs, Respiratory Chambers, Dimension Gauges and Headstages for the Clinical Care of Animals; Prerecorded Video Tapes, CDs, and DVDs Featuring Instruction on and Information About Physiological Data, Animal Vital Signs, and Telemetry; Digital Materials, Namely, Downloadable Audio Files and Downloadable Video Files Featuring Instruction on and Information About Physiological Data, Animal Vital Signs, and Telemetry; Electronic Devices for Animal Locating and Tracking Programmed to Use Global Positioning Systems (GPS) and Cellular Communications.

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