Hanover, NH, United States
Hanover, NH, United States

Dartmouth College, commonly referred to as Dartmouth , is a private Ivy League research university located in Hanover, New Hampshire, United States. It consists of a liberal arts college, the Geisel School of Medicine, the Thayer School of Engineering, and the Tuck School of Business, as well as 19 graduate programs in the arts and science. Incorporated as the "Trustees of Dartmouth College," it is one of the nine Colonial Colleges founded before the American Revolution. With an undergraduate enrollment of 4,276 and a total student enrollment of 6,342 , Dartmouth is the smallest university in the Ivy League.Dartmouth College was established in 1769 by Eleazar Wheelock, a Congregational minister. After a long period of financial and political struggles, Dartmouth emerged in the early 20th century from relative obscurity.Dartmouth's somewhat-isolated rural 269-acre campus is in the Upper Valley region of New Hampshire. Participation in athletics and the school's Greek system is strong. Dartmouth's 34 varsity sports teams compete in the Ivy League conference of the NCAA Division I. Students are well known for preserving a variety of strong campus traditions. Wikipedia.


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A magnetic catheter has a flexible tube having a lumen communicating with a balloon, the balloon located near a distal end of the tube; and a nonuniform magnetic portion located near, but proximal to, the balloon. The tube is adapted to insertion into bodily orifices like a male urethra, the lumen extending from balloon to proximal end and configured such that injection of fluid into the first lumen can inflate the balloon. The nonuniform magnetic portion has a sequence of magnetically permeable objects, or a sequence of permanent magnets, to provide magnetic field gradients to the prostate, or in alternative embodiment the pancreas. The catheter is used to treat the organ by applying a nonuniform magnetic field to the organ while magnetic nanoparticles are injected into the patient where they concentrate in the nonuniform magnetic field. An AC magnetic field is applied to the magnetic nanoparticles to heat the organ.


Provided herein are photochromic organic compounds of Formula I or Formula II, which are useful as molecular switches capable of being triggered via a cis/trans isomerization process. Methods of using the molecular switch compounds to form photopharmaceutical compounds that may be used to provide selective spatiotemporal activation of pharmaceutical agents are also disclosed.


Patent
Io Therapeutics, Inc. and Dartmouth College | Date: 2016-11-02

The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.


A magnetic nanoparticle imaging system has driving coils driven at multiple frequencies, the driving coils positioned to provide magnetic fields and field gradients to an imaging zone, and a static bias field magnet positioned to provide a static magnetic field and/or field gradient to the imaging zone. Magnetic sensors are positioned to sense magnetic fields from the imaging zone, and a signal processor processes signals from the sensors to find at least signal magnitude and phase at harmonics and/or intermodulation products of the multiple frequencies. In embodiments, the signal processing apparatus also determines signal magnitudes and phase of at least second and third harmonics of the first frequency, and maps location of nanoparticles in the imaging zone based upon the magnitudes of harmonics and magnitudes of the intermodulation products.


Patent
Dartmouth College | Date: 2016-12-02

A surgical guidance system has two cameras to provide stereo image stream of a surgical field; and a stereo viewer. The system has a 3D surface extraction module that generates a first 3D model of the surgical field from the stereo image streams; a registration module for co-registering annotating data with the first 3D model; and a stereo image enhancer for graphically overlaying at least part of the annotating data onto the stereo image stream to form an enhanced stereo image stream for display, where the enhanced stereo stream enhances a surgeons perception of the surgical field. The registration module has an alignment refiner to adjust registration of the annotating data with the 3D model based upon matching of features within the 3D model and features within the annotating data; and in an embodiment, a deformation modeler to deform the annotating data based upon a determined tissue deformation.


Patent
Vib Vzw, Ghent University, The United States Of America and Dartmouth College | Date: 2017-02-01

The present invention relates to single domain antibodies that are directed against respiratory syncytial virus (RSV). More specifically, it relates to single domain antibodies that bind to the prefusion form of the fusion (F) protein of RSV. The invention relates further to the use of these single domain antibodies for prevention and/or treatment of RSV infections, and to pharmaceutical compositions comprising these single domain antibodies.


The present invention relates to a novel regulatory T cell protein. This protein, designated PD-L3 OR VISTA resembles members of the PD-L1 family, identified a novel and structurally-distinct, Ig-superfamily inhibitory ligand, whose extracellular domain bears homology to the B7 family ligand PD-L1. This molecule is designated as PD-L3 OR VISTA or V-domain Immunoglobulin Suppressor of T cell Activation (VISTA). Expression of VISTA is primarily within the hematopoietic compartment and is highly regulated on myeloid APCs and T cells. Therapeutic intervention of the VISTA inhibitory pathway represents a novel approach to modulate T cell-mediated immunity for the treatment of a wide variety of cancers, e.g., ovarian, bladder cancer and melanomas. Also, VISTA proteins, especially multimeric VISTA proteins and antibodies may be used to suppress T cell immunity in autoimmune disease, allergy, infection and inflammatory conditions, e.g. multiple sclerosis and artritic conditions such as RA.


A magnetic nanoparticle imaging system has driving coils driven at multiple frequencies, the driving coils positioned to provide magnetic fields and field gradients to an imaging zone, and a static bias field magnet positioned to provide a static magnetic field and/or field gradient to the imaging zone. Magnetic sensors are positioned to sense magnetic fields from the imaging zone, and a signal processor processes signals from the sensors to find at least signal magnitude and phase at harmonics and/or intermodulation products of the multiple frequencies. In embodiments, the signal processing apparatus also determines signal magnitudes and phase of at least second and third harmonics of the first frequency, and maps location of nanoparticles in the imaging zone based upon the magnitudes of harmonics and magnitudes of the intermodulation products.


Su X.,Dartmouth College | Aprahamian I.,Dartmouth College
Chemical Society Reviews | Year: 2014

The hydrazone functional group has been extensively studied and used in the context of supramolecular chemistry. Its pervasiveness and versatility can be attributed to its ease of synthesis, modularity, and most importantly unique structural properties, which enable its integration in different applications. This review provides an overview of the utilization of hydrazones in three supramolecular chemistry related areas: molecular switches, metallo-assemblies and sensors. These topics were chosen because they highlight the diversity of hydrazones, and emphasize their uniqueness vis-à-vis the imine functional group. Discussion entails (i) chemical and light activated switching of hydrazones, and how this can be used in controlling the properties of self-assembled systems, (ii) the use of hydrazones in the formation of dynamic and stimuli responsive metallogrids, and (iii) the use of hydrazones in detecting metal cations (Zn2+, Cu2+, Hg2+, etc.), anions (F-, CN-, P2O7 4-, etc.) and neutral molecules (amines, water, Cys, etc.). © The Royal Society of Chemistry.


Grant
Agency: NSF | Branch: Cooperative Agreement | Program: | Phase: RESEARCH INFRASTRUCTURE IMPROV | Award Amount: 6.00M | Year: 2016

Non-Technical Description
This Research Infrastructure Improvement Track-2 Focused EPSCoR Collaboration (RII Track-2 FEC) proposal is a collaboration between four institutions in New Hampshire, Montana, Nevada, and Rhode Island, namely Dartmouth College, Montana State University, the University of Nevada Reno, and Brown University. The project will develop a greater understanding of attention, which is important to society in multiple ways, including the promotion of worker productivity, driver safety, and vigilance of military and security personnel. The ultimate goal of the project is to develop a unified model of attention that applies across multiple domains, from single cells to large brain circuits. The project will assemble the world?s largest consortium of scientists focused on creating a unified understanding of attention, including seven neurophysiologists, five cognitive neuroscientists, one modeler, and one neurologist. Other goals of the project are to develop lasting collaborations and promote future grant proposals, build research and industrial pipelines for neuroscience trainees, foster the professional development of junior faculty, and extend educational opportunities to traditionally disadvantaged groups, including Native Americans and low socio-economic status students.

Technical Description
The project will investigate the neural basis of attention at micro- and macroscopic scales, using a diverse array of brain imaging methods, including functional magnetic resonance imaging (fMRI), electroencephalography (EEG), and electrocardiography (EcoG), in humans and monkeys. The research will be divided into four themes: 1) Neurophysiological effects of attention on multi-unit patterns and rates of neural firing, 2) The relationship of attention to working memory, 3) Large-scale cortical dynamics of attention, and 4) Tying data together via micro- and macro-circuit models of attention. Three female junior faculty participants will lead a yearly conference for female and under-represented minority (URM) graduate students, post-docs and junior faculty to foster mentoring and career development. The project will also include outreach to middle and high schools, including the development of a Massive Open Online Course (MOOC) targeting K-12 science teachers.

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