Hanover, NH, United States

Dartmouth College

Hanover, NH, United States

Dartmouth College, commonly referred to as Dartmouth , is a private Ivy League research university located in Hanover, New Hampshire, United States. It consists of a liberal arts college, the Geisel School of Medicine, the Thayer School of Engineering, and the Tuck School of Business, as well as 19 graduate programs in the arts and science. Incorporated as the "Trustees of Dartmouth College," it is one of the nine Colonial Colleges founded before the American Revolution. With an undergraduate enrollment of 4,276 and a total student enrollment of 6,342 , Dartmouth is the smallest university in the Ivy League.Dartmouth College was established in 1769 by Eleazar Wheelock, a Congregational minister. After a long period of financial and political struggles, Dartmouth emerged in the early 20th century from relative obscurity.Dartmouth's somewhat-isolated rural 269-acre campus is in the Upper Valley region of New Hampshire. Participation in athletics and the school's Greek system is strong. Dartmouth's 34 varsity sports teams compete in the Ivy League conference of the NCAA Division I. Students are well known for preserving a variety of strong campus traditions. Wikipedia.

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A magnetic nanoparticle imaging system has driving coils driven at multiple frequencies, the driving coils positioned to provide magnetic fields and field gradients to an imaging zone, and a static bias field magnet positioned to provide a static magnetic field and/or field gradient to the imaging zone. Magnetic sensors are positioned to sense magnetic fields from the imaging zone, and a signal processor processes signals from the sensors to find at least signal magnitude and phase at harmonics and/or intermodulation products of the multiple frequencies. In embodiments, the signal processing apparatus also determines signal magnitudes and phase of at least second and third harmonics of the first frequency, and maps location of nanoparticles in the imaging zone based upon the magnitudes of harmonics and magnitudes of the intermodulation products.

Dartmouth College | Date: 2017-01-06

A system and method for identifying ictal states in a patient, the system including a plurality of sensors for sensing different non-electroencephalographic signals from the patient, and a processing unit. The processing unit has a processor and memory with instructions for classifying data from the plurality of sensors to determine probability of the patient being ictal, when the probability is high asking the patient if the patient is in an ictal state, reporting to a caregivers if the patient is ictal, and updating the classifier based upon sensor data, probability, and the response. The method includes sensing, using a plurality of non-electroencephalographic sensors, determining, using a classifier trained using a training dataset, probability of the patient being in an ictal state, and if probability is high, asking the patient if the patient is in ictal state, logging the occurrence of an ictal state, and updating the classifier.

Vib Vzw, Ghent University, The United States Of America and Dartmouth College | Date: 2017-02-01

The present invention relates to single domain antibodies that are directed against respiratory syncytial virus (RSV). More specifically, it relates to single domain antibodies that bind to the prefusion form of the fusion (F) protein of RSV. The invention relates further to the use of these single domain antibodies for prevention and/or treatment of RSV infections, and to pharmaceutical compositions comprising these single domain antibodies.

Provided herein are photochromic organic compounds of Formula I or Formula II, which are useful as molecular switches capable of being triggered via a cis/trans isomerization process. Methods of using the molecular switch compounds to form photopharmaceutical compounds that may be used to provide selective spatiotemporal activation of pharmaceutical agents are also disclosed.

Dartmouth College and Biologics | Date: 2017-03-22

Compositions comprising deimmunized lysostaphin and methods of using the same, e.g., to treat microbial infection in or on a subject, are provided.

Io Therapeutics, Inc. and Dartmouth College | Date: 2016-11-02

The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.

Dartmouth College and West Coast Magnetics | Date: 2017-06-14

A magnetic device having height includes a magnetic core, a first foil winding, and a second foil winding. The magnetic core includes first and second inner posts separated from each other in the height direction by a first inner gap and first and second outer elements separated from each other in the height direction by a first outer gap. The first foil winding is wound around the first inner post without extending along a height of the first inner gap and without extending along a height of the first outer gap. The second foil winding is wound around the second inner post without extending along the height of the first inner gap and without extending along the height of the first outer gap.

A system for heating tissue in a subject, has an alternating current (AC) source coupled to a coil; a magnetically permeable passive magnetic concentrator, and positioned to alter an intensity distribution of the field;. The system has a processor with a computer model of coil and concentrator, the memory with code for simulating magnetic fields and configured to generate an intensity map describing the intensity distribution of the AC magnetic field. A method of providing an alternating current (AC) magnetic field to magnetic nanoparticles includes: providing a source of alternating current coupled to a coil; positioning the coil in a vicinity of the nanoparticles; positioning a passive concentrator near the nanoparticles; and energizing the coil to generate the AC field, the field shaped by the concentrator and heats the nanoparticles. A particular embodiment simulates the magnetic field and compares the field to parameters to verify adequate heating of the nanoparticles.

An apparatus and method for medical imaging uses a first and second contrast agent, the second agent targeted to a particular tissue type. First images are obtained using the first agent, and second images using the second agent using medical imaging systems. An image processing system is adapted to process the first and second medical images by fitting parameters of a pharmacokinetic model to the first medical images, identifying a nontargeted tissue type, scaling the fitted parameters to best match the nontargeted tissue in the second medical images, executing the pharmacokinetic model to prepare a correction image, and generating corrected medical images by subtracting the correction image from the second medical images.

The present invention relates to a novel regulatory T cell protein. This protein, designated PD-L3 OR VISTA resembles members of the PD-L1 family, identified a novel and structurally-distinct, Ig-superfamily inhibitory ligand, whose extracellular domain bears homology to the B7 family ligand PD-L1. This molecule is designated as PD-L3 OR VISTA or V-domain Immunoglobulin Suppressor of T cell Activation (VISTA). Expression of VISTA is primarily within the hematopoietic compartment and is highly regulated on myeloid APCs and T cells. Therapeutic intervention of the VISTA inhibitory pathway represents a novel approach to modulate T cell-mediated immunity for the treatment of a wide variety of cancers, e.g., ovarian, bladder cancer and melanomas. Also, VISTA proteins, especially multimeric VISTA proteins and antibodies may be used to suppress T cell immunity in autoimmune disease, allergy, infection and inflammatory conditions, e.g. multiple sclerosis and artritic conditions such as RA.

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