Hanover, NH, United States
Hanover, NH, United States

Dartmouth College, commonly referred to as Dartmouth , is a private Ivy League research university located in Hanover, New Hampshire, United States. It consists of a liberal arts college, the Geisel School of Medicine, the Thayer School of Engineering, and the Tuck School of Business, as well as 19 graduate programs in the arts and science. Incorporated as the "Trustees of Dartmouth College," it is one of the nine Colonial Colleges founded before the American Revolution. With an undergraduate enrollment of 4,276 and a total student enrollment of 6,342 , Dartmouth is the smallest university in the Ivy League.Dartmouth College was established in 1769 by Eleazar Wheelock, a Congregational minister. After a long period of financial and political struggles, Dartmouth emerged in the early 20th century from relative obscurity.Dartmouth's somewhat-isolated rural 269-acre campus is in the Upper Valley region of New Hampshire. Participation in athletics and the school's Greek system is strong. Dartmouth's 34 varsity sports teams compete in the Ivy League conference of the NCAA Division I. Students are well known for preserving a variety of strong campus traditions. Wikipedia.


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Patent
Vib Vzw, Ghent University, The United States Of America and Dartmouth College | Date: 2017-02-01

The present invention relates to single domain antibodies that are directed against respiratory syncytial virus (RSV). More specifically, it relates to single domain antibodies that bind to the prefusion form of the fusion (F) protein of RSV. The invention relates further to the use of these single domain antibodies for prevention and/or treatment of RSV infections, and to pharmaceutical compositions comprising these single domain antibodies.


An apparatus and method for medical imaging uses a first and second contrast agent, the second agent targeted to a particular tissue type. First images are obtained using the first agent, and second images using the second agent using medical imaging systems. An image processing system is adapted to process the first and second medical images by fitting parameters of a pharmacokinetic model to the first medical images, identifying a nontargeted tissue type, scaling the fitted parameters to best match the nontargeted tissue in the second medical images, executing the pharmacokinetic model to prepare a correction image, and generating corrected medical images by subtracting the correction image from the second medical images.


A system for heating tissue in a subject, has an alternating current (AC) source coupled to a coil; a magnetically permeable passive magnetic concentrator, and positioned to alter an intensity distribution of the field;. The system has a processor with a computer model of coil and concentrator, the memory with code for simulating magnetic fields and configured to generate an intensity map describing the intensity distribution of the AC magnetic field. A method of providing an alternating current (AC) magnetic field to magnetic nanoparticles includes: providing a source of alternating current coupled to a coil; positioning the coil in a vicinity of the nanoparticles; positioning a passive concentrator near the nanoparticles; and energizing the coil to generate the AC field, the field shaped by the concentrator and heats the nanoparticles. A particular embodiment simulates the magnetic field and compares the field to parameters to verify adequate heating of the nanoparticles.


A magnetic nanoparticle imaging system has driving coils driven at multiple frequencies, the driving coils positioned to provide magnetic fields and field gradients to an imaging zone, and a static bias field magnet positioned to provide a static magnetic field and/or field gradient to the imaging zone. Magnetic sensors are positioned to sense magnetic fields from the imaging zone, and a signal processor processes signals from the sensors to find at least signal magnitude and phase at harmonics and/or intermodulation products of the multiple frequencies. In embodiments, the signal processing apparatus also determines signal magnitudes and phase of at least second and third harmonics of the first frequency, and maps location of nanoparticles in the imaging zone based upon the magnitudes of harmonics and magnitudes of the intermodulation products.


A method for characterizing electrical impedance of an energy storage device includes the following steps: (a) controlling a first switching power converter to transfer electric power between a first energy storage device and a load, (b) controlling the first switching power converter to generate a sinusoidal perturbation on electric current flowing through the first energy storage device, (c) determining an alternating current (AC) component of the electric current flowing through the first energy storage device, (d) determining an AC component of voltage across the first energy storage device, and (e) determining a complex impedance of the first energy storage device based at least in part on the AC component of the electric current flowing through the first energy storage device and the AC component of the voltage across the first energy storage device.


Patent
Dartmouth College | Date: 2016-12-02

A modular battery array includes a plurality of battery modules electrically coupled in series to a high-voltage electric power bus, a low-voltage electric power bus, and a respective switching power converter electrically interfacing each of the plurality of battery modules with the low-voltage electric power bus. Each of the plurality of battery modules includes a plurality of battery cells electrically coupled in series and at least one switching power converter for balancing energy stored in the plurality of battery cells of the battery module.


Patent
Dartmouth College | Date: 2016-12-09

Disclosed herein are new face-centered cubic (f.c.c.) high-entropy alloys with compositions (in atomic %) of Fe_(a)Ni_(b)Mn_(c)Al_(d)Cr_(e)C_(f )where a is between 37-43 atomic %, b is between 8-14 atomic %, c is between 32-38 atomic %, d is 4.5-10.5 atomic %, e is between 2.5-9 atomic % and f is between 0-2 atomic %. The undoped alloy has strength of 159 MPa and 40% elongation to failure, but the doped, carbon-containing alloy having 1.1 atomic percent carbon has yield strength of 360 MPa, an ultimate tensile strength (UTS) of 1200 MPa and 50% elongation to failure at room temperature. At 700 C., the yield strength is 214 MPa with 24% elongation to failure. Thus, the present alloy may replace austenitic stainless steels in applications where better strength is needed at both room temperature and elevated temperature in an oxidation resistant alloy.


Patent
Dartmouth College and West Coast Magnetics | Date: 2017-06-14

A magnetic device having height includes a magnetic core, a first foil winding, and a second foil winding. The magnetic core includes first and second inner posts separated from each other in the height direction by a first inner gap and first and second outer elements separated from each other in the height direction by a first outer gap. The first foil winding is wound around the first inner post without extending along a height of the first inner gap and without extending along a height of the first outer gap. The second foil winding is wound around the second inner post without extending along the height of the first inner gap and without extending along the height of the first outer gap.


Patent
Dartmouth College | Date: 2016-09-30

Provided herein are vinylogous thioester compounds and methods for using the compounds.


Patent
Dartmouth College and Biologics | Date: 2017-03-22

Compositions comprising deimmunized lysostaphin and methods of using the same, e.g., to treat microbial infection in or on a subject, are provided.

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