Dartmouth College, commonly referred to as Dartmouth , is a private Ivy League research university located in Hanover, New Hampshire, United States. It consists of a liberal arts college, the Geisel School of Medicine, the Thayer School of Engineering, and the Tuck School of Business, as well as 19 graduate programs in the arts and science. Incorporated as the "Trustees of Dartmouth College," it is one of the nine Colonial Colleges founded before the American Revolution. With an undergraduate enrollment of 4,276 and a total student enrollment of 6,342 , Dartmouth is the smallest university in the Ivy League.Dartmouth College was established in 1769 by Eleazar Wheelock, a Congregational minister. After a long period of financial and political struggles, Dartmouth emerged in the early 20th century from relative obscurity.Dartmouth's somewhat-isolated rural 269-acre campus is in the Upper Valley region of New Hampshire. Participation in athletics and the school's Greek system is strong. Dartmouth's 34 varsity sports teams compete in the Ivy League conference of the NCAA Division I. Students are well known for preserving a variety of strong campus traditions. Wikipedia.
Dartmouth College | Date: 2015-04-01
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TCR-deficient T cells are designed to express a functional non-TCR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TCR-deficient T cells, populations thereof, or compositions comprising the same.
Dartmouth College | Date: 2015-10-21
A method for guiding resection of local tissue from a patient includes generating at least one image of the patient, automatically determining a plurality of surgical guidance cues indicating three-dimensional spatial properties associated with the local tissue, and generating a visualization of the surgical guidance cues relative to the surface. A system for generating surgical guidance cues for resection of a local tissue from a patient includes a location module for processing at least one image of the patient to determine three-dimensional spatial properties of the local tissue, and a surgical cue generator for generating the surgical guidance cues based upon the three-dimensional spatial properties. A patient-specific locator form for guiding resection of local tissue from a patient includes a locator form surface matching surface of the patient, and a plurality of features indicating a plurality of surgical guidance cues, respectively.
Io Therapeutics, Inc. and Dartmouth College | Date: 2015-06-05
The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.
Dartmouth College | Date: 2015-11-19
Methods for decreasing proliferation and preventing or treating a neuroendocrine cancer using an N-methyl D-aspartate-associated (NMDA) glutamate receptor antagonists or binding agent, such as an antibody, antibody fragment or peptide aptamer specific for a NMDA glutamate receptor, are disclosed.
Dartmouth College | Date: 2015-08-27
Bicyclic compounds for decreasing the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection are provided.