Zhang S.,University of North Carolina at Chapel Hill |
Zhang S.,Dalian Nationalities University |
Zhi D.,Dalian Nationalities University |
Huang L.,University of North Carolina at Chapel Hill
Journal of Drug Targeting | Year: 2012
siRNA therapeutics has developed rapidly and already there are clinical trials ongoing or planned; however, the delivery of siRNA into cells, tissues or organs remains to be a major obstacle. Lipid-based vectors hold the most promising position among non-viral vectors, as they have a similar structure to cell or organelle membranes. But when used in the form of liposomes, these vectors have shown some problems. Therefore, either the nature of lipids themselves or forms used should be improved. As a novel class of lipid like materials, lipidoids have the advantages of easy synthesis and the ability for delivering siRNA to obtain excellent silencing activity. However, the toxicities of lipidoids have not been thoroughly studied. pH responsive lipids have also gained great attention recently, though some of the amine-based lipids are not novel in terms of chemical structures. More complex self-assembly structures, such as LPD (LPH) and LCP, may provide a good solution to siRNA delivery. They have demonstrated controlled particle morphology and size and siRNA delivery activity for both in vitro and in vivo. © 2012 Informa UK, Ltd.
Xu D.,Harbin Engineering University |
Zhang H.,Dalian Maritime University |
Liu L.,Dalian Nationalities University
Neural Computation | Year: 2010
This letter presents a unified convergence analysis of the split-complex nonlinear gradient descent (SCNGD) learning algorithms for complex-valued recurrent neural networks, covering three classes of SCNGD algorithms: standard SCNGD, normalized SCNGD, and adaptive normalized SCNGD. We prove that if the activation functions are of split-complex type and some conditions are satisfied, the error function is monotonically decreasing during the training iteration process, and the gradients of the error function with respect to the real and imaginary parts of the weights converge to zero. A strong convergence result is also obtained under the assumption that the error function has only a finite number of stationary points. The simulation results are given to support the theoretical analysis. © 2010 Massachusetts Institute of Technology.
Ruan C.-J.,Dalian Nationalities University |
Teixeira Da Silva J.A.,Kagawa University
Critical Reviews in Biotechnology | Year: 2011
Breeders have long been interested in understanding the biological function and mechanism of xero-halophytes and their ability for growth in drought-stricken and salinized environments. However, the mechanisms in response to stress have been difficult to unravel because their defenses require regulatory changes to the activation of multiple genes and pathways. Metabolomics is becoming a key tool in comprehensively understanding the cellular response to abiotic stress and represents an important addition to the tools currently employed in genomics-assisted selection for plant improvement. In this review, we highlight the applications of plant metabolomics in characterizing metabolic responses to salt and drought stress, and identifying metabolic quantitative trait loci (QTLs). We also discuss the potential of metabolomics as a tool to unravel stress response mechanisms, and as a viable option for the biotechnological improvement of xero-halophytes when no other genetic information such as linkage maps and QTLs are available, by combining with germplasm-regression-combined marker-trait association identification. © 2011 Informa Healthcare USA, Inc.
Ruan C.-J.,Dalian Nationalities University |
da Silva J.A.T.,Kagawa University
Critical Reviews in Plant Sciences | Year: 2011
Since Darwin observed the reconfiguration of pollinia in orchards and referred to it as a function to reduce self-pollination, diverse floral movements have been investigated and various hypotheses have been proposed to explain their adaptive significance. However, adaptive significance of floral movement in some species has yet to be fully explained. Increasing evidence suggests that some floral movements, which have previously been considered as a mechanism to avoid self-pollination, may act as a mechanism to reduce intrafloral male-female interference. In this review, we first explore insect-induced floralmovement-such as secondary pollen presentation-that enhances the efficiency and accuracy of pollination. Secondly, we outline the active movements of different floral structures of pistil (style), stamen (filament, anther, pollen), and corolla, such as flexistyly, pollen sliding and catapulting, and anther rotation. Thirdly, we introduce movement herkogamy, which makes herkogamy decrease or increase via the movements of floral structures, especially decreased approach herkogamy via style curvature in the Malvaceae with a monadelphous column. Fourthly, we highlight the different adaptive significances in floral movements for understanding their evolution, including reduction in intrafloral male-female interference, promotion of outcrossing and/or avoidance of self-pollination, delayed autonomous selfing, and tolerance to harsh environments. In particular, we explore the possibility of three functions of one floral movement in one species, which differs from the generally recognized and conventional notion of one floral movement in one species with only one or two functional mechanisms. Finally, we provide perspectives on the challenges and opportunities for using demographic and molecular genetic approaches to (i) study the relative importance and evolutionary mechanism of different adaptive significances in one floral movement; and (ii) simultaneously investigate the floral movement and correlative traits of broader species in related or unrelated families to test how they evolved and the evolutionary relationship between their functions. © Taylor & Francis Group, LLC.
Dong B.,Dalian Nationalities University |
Cao B.,Dalian Nationalities University |
He Y.,Dalian Nationalities University |
He Y.,University of Duisburg - Essen |
And 3 more authors.
Advanced Materials | Year: 2012
A novel high excited state energy transfer pathway to overcome the phonon quenching effect in rare-earth (RE) oxide upconversion (UC) materials is reported. In Er(Tm)-Yb oxide systems, an extraordinary enhancement of UC luminescence efficiency with four orders of magnitude is realized by Mo co-doping. The RE oxides with significant UC efficiency are successfully utilized for temperature sensing and in vivo imaging. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Li B.-H.,Dalian Nationalities University |
Zhang N.,University of Manchester |
Smith R.,University of Manchester
Applied Energy | Year: 2016
An improved rate-based model of the typical CO2 capture process by aqueous MonoEthanolAmine (MEA) solution is built within Aspen Plus V8.0 software in this study. The improved model is built on the basis of an example model coming along with Aspen Plus V8.0, and thermodynamic model of ENRTL-RK is adopted. Improvements include the washing section of the absorption column is strictly modelled by a separate column, and the error on mass balance of MEA is greatly reduced. The new model is validated by the recently published pilot-scale experimental results of the absorption of CO2 by MEA solution, in which both absorption and desorption columns are equipped with the structured packing Sulzer Mellapak 250.Y™. It predicts the experimental profiles of the temperature and the concentration of CO2 in the liquid phase with an accuracy of ±4%, and obviously much better than recently reported model with an accuracy of ±8%. Important insights have been obtained on the function of washing sections on the top of both absorber and desorption column, the factors to determine the flowrates of make-up water and recycle water around the washing section of the absorber are first analyzed. © 2015 Elsevier Ltd.
News Article | March 4, 2016
Colin of Bike Radar points to the Bike Washing Machine (BWM), designed by students at Dalian Nationalities University and shown on Tuvie. The Tuvie Washing Machine gives the term ‘spin cycle’ a whole new meaning. Targeted at the time starved athlete or those wishing to cut down on their utility bills, it’s essentially a spin bike, where the front wheel has been replaced with a laundry drum. As you pedal, the drum spins and gets your clothing clean. We’re dreaming of spin class rooms filled with these, where patrons get a workout and a clean basket of clothing after their 45 minute session. Got a stubborn stain? We’re sure someone will create ‘stain intervals’ to see those gone. According to the designers, any energy in excess of what is needed for the washing machine is used to power the display or saved for later. Of course this was dreamed up years ago by Steven M. Johnson. See more pedal powered washing machines in Related Links below.
Wu S.L.,Dalian Nationalities University
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2015
We apply the time-dependent decoherence-free subspace theory to a Markovian open quantum system in order to present a proposal for a quantum-state engineering program. By quantifying the purity of the quantum state, we verify that the quantum-state engineering process designed via our method is completely unitary within any total engineering time. Even though the controls on the open quantum system are not perfect, the asymptotic purity is still robust. Owing to its ability to completely resist decoherence and the lack of restraint in terms of the total engineering time, our proposal is suitable for multitask quantum-state engineering program. Therefore, this proposal is not only useful for achieving the quantum-state engineering program experimentally, it also helps us build both a quantum simulation and quantum information equipment in reality. © 2015 American Physical Society.
Ruan C.,Dalian Nationalities University
African Journal of Biotechnology | Year: 2010
In the past 20 years, the major effort in plant breeding has changed from quantitative to molecular genetics with emphasis on quantitative trait loci (QTL) identification and marker assisted selection (MAS). However, results have been modest. This has been due to several factors including absence of tight linkage QTL, non-availability of mapping populations and lack of substantial time needed to develop such populations. To overcome these limitations and as an alternative to planned populations, molecular marker- trait associations have been identified by the combination between germplasm and the regression technique. In the present preview, we first surveyed the successful applications of germplasm-regression-combined (GRC) molecular marker-trait association identification in plants; secondly, we described how to do the GRC analysis and its differences from mapping QTL based on a linkage map reconstructed from the planned populations; thirdly, we considered the factors that affect the GRC association identification, including selections of optimal germplasm and molecular markers and testing of identification efficiency of markers associated with traits; and finally we discussed the future prospects of GRC marker-trait association analysis used in plant MAS/QTL breeding programs, especially in long-juvenile woody plants when no other genetic information such as linkage maps and Quantitative Trait Loci are available. © 2010 Academic Journals.
Agency: European Commission | Branch: FP7 | Program: MC-IIFR | Phase: FP7-PEOPLE-2010-IIF | Award Amount: 15.00K | Year: 2013
Sea buckthorn (Hippophae L.) is a woody, dioecious plant that can be grown in areas characterized by severe drought, high salinity and poor soil conditions. It has recently received considerable attention in Europe and China as a new berry crop with a very high nutritional value and unique medicinal properties, as well as a means of combating soil erosion. Methods must, however, be developed that enable fast and efficient identification of genotypes carrying genes for desirable plant architecture and fruit quality as well as resistance to the very detrimental dried-shrink disease (DSD) in order to achieve a sustainable commercial production of this crop. The objectives of this proposal are to investigate fruit quality parameters and DSD-resistance in already collected germplasm presently conserved in China and in Sweden, respectively, and then develop molecular techniques that will allow fast and accurate development of elite cultivars destined both for direct usage and as a parental material in plant breeding programs. Fruit quality traits and disease resistance will be screened in European and Chinese plant materials. SCAR and SSR markers associated with these traits will be identified using the germplasm-regression-combined marker-trait association analysis. Relationships between genotypic and environmental effects on desirable traits will be investigated using metabolomic techniques based on GC/LC-MS and 1H-NMR. Carefully selected genetic resource collections (gene banks) will be established both at Balsgard in Sweden and at Fuxin in China. A germplasm evaluation system, based on markers associated with desirable traits and results from the metabolomics analysis, will be constructed that provides fast and efficient identification and selection of elite genotypes with high fruit quality in combination with DSD-resistance. These tools will provide a platform for marker- and metabolomics-assisted breeding to develop further improved cultivars.