Time filter

Source Type

Ma J.,Dalian Municipal Central Hospital
Zhonghua wai ke za zhi [Chinese journal of surgery]

To analyze anatomy data of popliteal veins (PV), with the purpose of selection of popliteal venous valves construction segment via venography, and to evaluate the surgical results. From February 1998 to November 2010, after analyzing the popliteal vessel anatomy data of 39 limbs and related phlebography research of 862 cases, 102 patients (69 male and 33 female patients, aged from 48 to 71 years, mean 59 years) with severe deep venous insufficiency were selected for popliteal venous valve construction procedures. Doppler ultrasound, continuous dynamic venography, and intraoperative venous pressure measurements were used to assess the hemodynamic changes pre- and postoperatively. Venous clinical severity score (VCSS) were used to evaluate long-term results of deep venous valve construction procedures. In the 102 patients, 93.7% patients had one pair of valves in popliteal vein (PV), locating in the distal 1/3 segment of PV, with gastrocnemius veins (GV) joining with PV above PV valves. Postoperative blood flow volume of the PV was significantly higher than the preoperative volume (732.3 ml/min vs. 150.2 ml/min, t = 8.979, P < 0.001). The proximal pressure was significantly lower than the distal pressure ((12 ± 3) cm H(2)O vs. (15 ± 3) cm H(2)O, 1 cm H(2)O = 0.098 kPa, t = 8.049, P < 0.001). VCSS score was significantly lower after the surgery ((34 ± 15) cm H(2)O vs. (41 ± 14) cm H(2)O, t = 59.780, P < 0.001). Pre- and postoperative hemodynamic changes and VCSS scores were statistically significant (9.3 ± 1.9 vs. 1.8 ± 1.0, t = 59.780, P < 0.001). Mean follow-up were 8.9 years with an ulcer recovery rate of 96.3%, and a 3.7% ulcer recurrent rate. Popliteal vessel anatomy study and venography research provide critical information for the PV valve construction part selection, which stayed proximal to the communications of GV and PV. Restoration of gastrocnemius pump function and satisfactory long-term efficacy are received after valve construction. Source

Chen D.,Dalian Municipal Central Hospital
Chinese Journal of Cerebrovascular Diseases

Objective: To retrospectively analyze the efficacy and safety of carotid endarterectomy (CEA) in the treatment of carotid artery stenosis in three domestic hospitals and to evaluate the risk factors affecting stroke and death within ≤ 30 days after procedure. Methods The clinical data of 494 patients with carotid artery stenosis (15 of them underwent bilateral operation, each patient was calculated as two separate cases, there were a total of 509 cases.) treated with CEA at Beijing Xuanwu Hospital of Capital Medical University, Liaocheng Brain Hospital, and Dalian Municipal Central Hospital from 2001 to 2011 were summarized retrospectively. The safety and efficacy of the procedure were observed. Univariate and multivariate logistic regression analysis was used to assess the related factors that impacted the adverse events in patients within ≤ 30 days after procedure. Results Circled digit oneIn the 509 patients, 439 with simple stenosis had vascular patency; 70 patients had been completed occlusion or near-total occlusion, seven of them failed recanalization. The success rate of surgery was 98.6%. Circled digit twoWithin 30 days after procedure, 20 cases (3.9%) had adverse outcome, including 6 died (1.2%) and 14 had stroke (2.8%). The secondary adverse outcome occurred in 120 cases (23.6%). Circled digit threeAll the 503 survival patients were followed up at 3 months after procedure, among them 494 (98.2%) were followed up for ≥ 6 months. During the follow-up period, 5 had new attack of stroke, one of them was died; 28 (5.6%) had restenosis and 6 (1.2%) had occlusion. Circled digit fourUnivariate analysis showed that the incidences of stroke and death within 30 days after procedure in patients with preoperative modified Rankin scale (mRS) ≥ 3 were significantly higher than those > 3 (17.4% vs. 2.6%; P < 0.01). Multivariate logistic regression analysis showed that smoking (OR = 2.667, 95% CI 1.048 to 6.791, P = 0.040) and mRS score ≥ 3 (OR = 8.690, 95% CI 3.279 to 23.031; P = 0.000) were the independent influencing factors that impacted postoperative primary adverse outcome within 30 days. The physician's learning curve affected the primary endpoint events within 30 days. Conclusion: In the treatment of carotid artery stenosis, CEA is safe and effective. The risk of surgery will increase in patients with smoke and severe neurological deficits before the procedure. Source

Zhang Q.,Dalian Municipal Central Hospital
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

To introduce a new surgical treatment for subglottic stenosis. Six patients with subglottic stenosis were retrospectively studied. Four cases had history of intubation or tracheostomy. Two cases were because of B cell lymphoma and Wegener granulomatosis. All cases underwent endoscope assisted coblation surgery. All of the patients were discharged from hospital with no tube in one week after surgery. In a follow-up of 3-21 months, stenosis in 2 cases of B cell lymphoma and Wegener granulomatosis recurred 3 months after operation. These 2 patients were operated by coblation again and are still followed-up by now. The endoscope assisted coblation surgery is a new minimally invasive method for treating subglottic stenosis. Further more,it can be reused to whom has a relapse. Source

Zhang Z.-Q.,Dalian Municipal Central Hospital | Meng H.,Dalian Medical University | Wang N.,Dalian Medical University | Liang L.-N.,Dalian Medical University | And 3 more authors.
Diagnostic Pathology

Background: Hepatocellular carcinoma (HCC) is regarded as one of the most common malignancies and among the leading causes of cancer death among the whole world. The most urgent needs are to find sensitive markers for early diagnosis or monitor postoperative recurrence and to give adequate treatment for HCC. MicroRNAs (miRNAs) are reported as a group of small non-coding RNAs that can function as endogenous RNA interference to regulate expression of the targeted genes. This study was conducted to detect the application of miR-143 and miR-215 in the diagnosis of HCC.Methods: A total of 340 serum samples (127 samples from controls, 118 samples from hepatitis and 95 samples from HCC patients) were collected. The levels of the two mature miRNAs (miR-143 and miR-215) were detected by probe-based stem-loop quantitative reverse-transcriptase PCR (RT-qPCR) in controls, hepatitis and HCC patients. Besides, the relationship between miR-143 and miR-215 levels and clinical and pathological factors was explored.Results: We found that the expression of serum miR-215 was distinctly increased in chronic hepatitis compared with controls (mean ± SD: 6.79 ± 0.72 vs. 3.46 ± 0.37, P < 0.001 and mean ± SD: 8.38 ± 0.87 vs. 3.46 ± 0.37, P < 0.001). In addition, we conduct ROC analyses to detect the potential application of miR-143 and miR-215 in the diagnosis of chronic hepatitis and HCC. Our results showed that miR-143 and miR-215 might be a potential biomarker for the hepatitis and HCC.Conclusions: In conclusion, the expression of miR-143 and miR-215 in serum were significantly up-regulated in patients with chronic hepatitis and HCC. Due to its reasonable sensitivity and specificity for both diseases, miR-143 and miR-215 could be as potential circulating biomarkers.Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1048932281272754. © 2014 Zhang et al.; licensee BioMed Central Ltd. Source

Haidong L.,Hands and Feet Microsurgery | Fang Y.,Dalian University | Zhihong T.,Hands and Feet Microsurgery | Changle R.,Dalian Municipal Central Hospital
International Journal of Biological Macromolecules

Microencapsulation of ethanol extract of tea was performed in this study. In order to microencapsulate, β-cyclodextrin was used as wall material. Ethanol extract of tea was used as the core material. Microcapsules in the solid form were obtained by drying the emulsions. RSM showed that optimal processing parameters were as followings: core material/wall material 1/4, β-cyclodextrin content 16%, stirring time 30. min and stirring temperature 200 °C. Pharmacological activities of β-cyclodextrin encapsulation tea extract were determined. It was found that β-cyclodextrin encapsulation tea extract could enhance BMD, BMC and bone Ca, Zn and Cu contents. In addition, β-cyclodextrin encapsulation tea extract could still reduce blood Ca contents. These results indicated that β-cyclodextrin encapsulation tea extract was useful for improving bone quality in aged animals. © 2011 Elsevier B.V. Source

Discover hidden collaborations