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Wang Z.-D.,Sixth Peoples Hospital of Dalian | Zhang Q.-Q.,Sixth Peoples Hospital of Dalian | Zhang Z.-J.,Childrens Hospital of Dalian | Sun P.,Sixth Peoples Hospital of Dalian | Pu C.-W.,Sixth Peoples Hospital of Dalian
Journal of Dalian Medical University | Year: 2015

Objective: To investigate the expression and clinical significance of GPC3 and CD44v6 in hepatocellular carcinoma (HCC), and evaluating their clinical value in the process of HCC development. Methods: The GPC3 and CD44v6 expressions in HCC and the liver tissue adjacent to carcinoma of 38 cases were detected by immunohistochemistry. Results: The positive expression frequency of GPC3 and CD44v6 protein in HCC tissue (84. 2% and 84. 2%) were significantly higher than that in the liver tissue adjacent to carcinoma (0% and 0%) (P < 0.01). The GPC3 expression was correlated with the CD44v6 expression in HCC (r = 0. 502,P <0.001). Conclusion: The combination detection of GPC3 and CD44v6 would be helpful to HCC diagnosis.

Fan Z.,Third Peoples Hospital of Dalian | Jing H.,Dalian Medical University | Yao J.,Dalian Medical University | Li Y.,Liaoning Cancer Hospital and Institute | And 6 more authors.
Oxidative Medicine and Cellular Longevity | Year: 2014

Objective. In this study, we investigated the protective effect and mechanism of curcumin on a rat model of intestinal ischemia/reperfusion (I/R), which induces an acute liver lesion. Methods. Curcumin was injected into rats in the curcumin groups through left femoral vein. The same volume of vehicle (0.9% normal saline) was injected into shamand I/R groups. Blood and liver tissue were gathered for serological and histopathological determination. Results. Intestinal I/R led to severe liver injurymanifested as a significant increase in serum AST and ALT levels; all of those were reduced by treatment with curcumin. Simultaneously, the activity of SOD in liver decreased after intestinal I/R, which was increased by curcumin treatment. On the other hand, curcumin reduced MPO activity of liver tissue, as well as serumIL-6 and TNF-α levels observably.This is in parallel with the decreased level of liver intercellular cell adhesion molecule-1 (ICAM-1) and nuclear factor-κB (NF-κB) expression. Conclusion. Our findings suggest that curcumin treatment attenuates liver lesion induced by intestinal I/R, attributable to the antioxidative and anti-inflammatory effect via inhibition of the NF-κB pathway. Copyright © 2014 Zhe Fan et al.

PubMed | Jinzhou Central Hospital, Dalian Medical University and Childrens Hospital of Dalian
Type: Journal Article | Journal: Genetics and molecular research : GMR | Year: 2015

Acute ischemic stroke (AIS) has become a serious health problem in many countries because of its poor outcome and worsening epidemic trend. Early identification of genetic risk factors and physiological indicators for stroke occurrence may help to reduce the incidence of stroke. Therefore, we conducted a case-control study including 50 AIS patients and 50 healthy individuals from a Chinese population to explore the association between AIS and patient complete blood profiles and the association between AIS and the genetic polymorphism K469E in intercellular adhesion molecule-1 (ICAM-1). Compared to the control group, AIS patients showed a high percentage of mononuclear cells, low platelet count, low ratio of platelet to lymphocyte count, high frequency of the 469K allele, and low frequency of the 469E allele. White blood cell count, percentage of neutrophils, percentage of lymphatic cells, platelet distribution width, mean platelet volume, and platelet hematocrit levels showed no significant differences between the 2 groups and between different genotypes. Our results suggested an association of elevated levels of mononuclear cells and reduced platelet count with higher AIS risk. Our results also supported the hypothesis that the KK genotype at the K469E locus in ICAM-1 is a risk factor for AIS.

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