Central Hospital of Dalian

Dalian, China

Central Hospital of Dalian

Dalian, China
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PubMed | Central Hospital of Dalian
Type: Journal Article | Journal: Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis | Year: 2016

The Sprague-Dawley rat strain is a common used model for esophageal carcinoma disease study. We sequenced this rat strain mitochondrial genome for the first time. Its mitogenome was 16,312bp and coding 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes. A total of 96 SNPs were examined when compared to reference BN sequence.


Sun Y.,Dalian Medical University | Ying H.,Dalian Medical University | Seetohul R.M.,Dalian Medical University | Xuemei W.,Central Hospital of Dalian | And 4 more authors.
Behavioural Brain Research | Year: 2012

Objective: To study crave-related cerebral regions induced by game figure cues in online game addicts. fMRI brain imaging was done when the subjects were shown picture cues of the WoW (World of Warcraft, Version: 4.1.014250) game. Methods: 10 male addicts of WoW were selected as addicts' group, and 10 other healthy male non-addicts who were matched by age, were used as non-game addicts' group. All volunteers participated in fMRI paradigms. WoW associated cue pictures and neutral pictures were shown. We examined functional cerebral regions activated by the pictures with 3.0. T Philips MRI. The imaging signals' database was analyzed by SPM5. The correlation between game craving scores and different image results were assessed. Results: When the game addicts watch the pictures, some brain areas show increased signal activity namely: dorsolateral prefrontal cortex, bilateral temporal cortex, cerebellum, right inferior parietal lobule, right cuneus, right hippocampus, parahippocampal gyrus, left caudate nucleus. But in these same brain regions we did not observe remarkable activities in the control group. Differential image signal densities of the addict group were subtracted from the health control group, results of which were expressed in the bilateral dorsolateral prefrontal cortex, anterior cingulate cortex, inferior parietal lobe and inferior temporal gyrus, cerebellum, right insular and the right angular gyrus. The increased imaging signal densities were significant and positively correlated with the craving scale scores in the bilateral prefrontal cortex, anterior cingulate cortex and right inferior parietal lobe. Conclusions: Craving of online game addicts was successfully induced by game cue pictures. Crave related brain areas are: dorsolateral prefrontal cortex, anterior cingulate cortex, and right inferior parietal lobe. The brain regions are overlapped with cognitive and emotion related processing brain areas. © 2012 Elsevier B.V..


Dai S.-F.,Dalian Medical University | Long X.-F.,Dalian University | Ji L.-L.,Central Hospital of Dalian | Tian H.,Exploitation Area Hospital of Dalian | And 3 more authors.
Journal of Dalian Medical University | Year: 2012

[Objective] Discuss a new method of the myocardial infarction established in rabbits, the micro-method. [Methods] Rabbits were anaesthetized by 3% napental, 30 mg/kg. The heart was exposed by blunt dissecting the left intercostal muscles between the 3rd and 4th ribs. The left anterior descending of coronary artery was ligated, which would not only prevent the blood blow of coronary, but also make the similar condition of myocardial infarction between rabbits and single coronary artery blocked in clinic. [Results] Twenty minutes later, the ST segment of rabbit ECG was raised, and R segment was droped. Two weeks later, the ventricular wall motion was weak and stiff from M-mode ultrasound. Ischemic myocardium was shrinked and ventricular wall was subsided and the color was lighter than surrounding normal myocardial tissue. [Conclusion] By this establishment, the myocardial infarction model is simple, light trauma and high success rate.


Li-na R.,Shenyang University | Xin-hui F.,Shenyang University | Li-dong R.,Central Hospital of Dalian | Jian G.,Shenyang Pharmaceutical University | And 2 more authors.
Cardiovascular Diabetology | Year: 2012

Background: Many patients who survive a myocardial infarction (MI) remain at risk of sudden cardiac death despite revascularization and optimal medical treatment. We used the modified moving average (MMA) method to assess the utility of T-wave alternans (TWA) and heart rate turbulence (HRT) as risk markers in MI patients with or without diabetes mellitus (DM).Methods: We prospectively enrolled 248 consecutive patients: 96 with MI (post-MI patients); 77 MI with DM (post-MI + DM patients); 75 controls without cardiovascular disease (group control). Both TWA and HRT were measured on ambulatory electrocardiograms (AECGs). HRT was assessed by two parameters {box drawings light horizontal} turbulence onset (TO) and turbulence slope (TS). HRT was considered positive when both TO ≥0% and TS ≤2.5 ms/R-R interval were met. The endpoint was cardiac mortality. . Results: TWA values differed significantly between MI and controls. Post-MI + DM patients had higher TWA values than post-MI patients (58 ± 21 μV VS 52 ± 18 μV, P = 0.029). Impaired HRT--increased TO and decreased TS were observed in MI patients with or without DM. During follow-up of 578 ± 146 days, cardiac death occurred in ten patients and three of them suffered sudden cardiac death (SCD). Multivariate analysis determined that a HRT-positive outcome [HR (95% CI): 5.01, 1.33-18.85; P = 0.017], as well as the combination of abnormal TWA (≥47 μV) and positive HRT had significant association with the endpoint [HR (95% CI): 9.08, 2.21-37.2; P = 0.002)].Conclusion: This study indicates that AECGs-based TWA and HRT can predict cardiac mortality in MI patients with or without DM. Combined analysis TWA and HRT may be a convenient and useful method of identifying patients at high risk for cardiovascular death. © 2012 Li-na et al.; licensee BioMed Central Ltd.


Lv R.-F.,Central Hospital of Dalian | Xu Z.,Central Hospital of Dalian | Min N.,Central Hospital of Dalian
Chinese Journal of Interventional Imaging and Therapy | Year: 2011

Objective To observe the impact of different scanning directions on image quality of united head and cervical arteries CT angiography, in order to avoid artifacts of intracranial venous reflux and artifacts in the subclavian vein with the arm injection. Methods Totally of 200 patients who underwent united head and neck CTA were randomly divided into Group A and B (each n=100). Patients in Group A were scanned from cranial-caudal direction, while in Group B were scanned from caudal-cranial direction. The other parameters of scanning were the same. Image quality in the two groups were scored, CT value of the ascending aorta, common carotid artery, basilar artery, injection side subclavian vein and pattern noise value were recorded and statistically analyzed. Results (1) The image quality of Group A was obviously better than that of Group B (U=7.40, P < 0.001). (2) The differences of CT value of basilar artery, common carotid artery and aorta between the two groups were not statistically significant (all P > 0.05). (3) CT value of injection side subclavian vein in the two groups were significantly different (U=22.91, P < 0.001). (4) Pattern noise value of the two groups were significantly different (U=2.61, P < 0.001). Conclusion Scanning from cranial-caudal direction in united head and neck CTA can effectively avoid heavy artifacts from intracranial venous reflux and the artifacts in the subclavian vein with the arm injection, and enhance the uniform imaging quality.


Miao L.-P.,Central Hospital of Dalian | Jin X.-Y.,Central Hospital of Dalian
Journal of Dalian Medical University | Year: 2010

The pathogenesis of female stress urinary incontinence (SUI) is unclear up to now. The current study shows that as a main component of the extracellular matrix, collagen plays an important role in maintaining elasticity and tenacity of pelvic supporting structure. Changes of pelvic floor collagen are important mechanism in SUI. Matrix metalloproteinases (MMPs) can degrade collagen in pelvic floor tissue, the dysfunction of MMPs and their inhibitory family may result in increased degradation of pelvic floor tissue, and induce SUI.

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