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Yang Z.,University of Illinois at Urbana - Champaign | Yang Z.,Dali University | Sweedler J.V.,University of Illinois at Urbana - Champaign
Analytical and Bioanalytical Chemistry | Year: 2014

Early diagnosis is the key to the effective treatment of cancer. The detection of cancer biomarkers plays a critical role not only in cancer early diagnosis, but also in classification and staging tumor progression, or assessment prognosis and treatment response. Currently, various molecular diagnostic techniques have been developed for cancer biomarker studies, with many of the more effective approaches requiring a separation step before detection. Capillary electrophoresis (CE) can perform rapid and efficient separation with small samples, which is well-suited for analysis of both small- and macro- molecule biomarkers in complex samples. CE has different separation modes and can couple to different detectors into a variety of platforms, such as conducting studies on DNA/ RNA point mutation, protein misexpression, and metabolite abnormality. Similarly, microchip capillary electrophoresis (MCE) appears as a very important biomarker screening platform with the merits of high throughput, integration, and miniaturization, which makes it a promising clinical tool. By hyphenated different detectors, or integrated with immunoassay, PCR/LDR and related technologies, MCE can be constructed into diverse platforms used in genomics, proteomics, and metabolomics study for biomarkers discovery. The multiplex biomarker screening approach via CE- or MCE-based platforms is becoming a trend. This paper focuses on studies of cancer biomarkers via CE/MCE platforms, based on the studies published over the past 3 years. Some recent CE applications in the field of cancer study, such as cancer theranostics, are introduced. © 2014 Springer-Verlag Berlin Heidelberg.


Zhang D.-Q.,Dali University | Zhou N.,Chongqing Three Gorges University
Biochemical Systematics and Ecology | Year: 2013

Taxus wallichiana var. mairei is an endangered conifer with important medicinal value in southern China. Nuclear SSR markers were employed to assess genetic diversity and structure of 13 geographically disjunct populations. The present study revealed a moderate genetic diversity (HE=0.538) and low genetic differentiation (FST=0.159). And most populations encountered in severe inbreeding and bottleneck effect. No significant genetic structure was detected by IBD and Structure analysis, which was supported by AMOVA analysis. The present results could be ascribed to an earlier period of more pronounced gene flow when the species had a more continuous distribution. However, the 13 studied populations were divided into four clusters based on the UPGMA dendrogram; these clusters were almost congruent with their geographical distributions. Vital areas such as southern mountains of Sichuan basin, Nanling Mts. and the margin of this yew's distribution range had a high priority for conservation. © 2013 Elsevier Ltd.


Kaya S.,Dali University
Türkiye parazitolojii dergisi / Türkiye Parazitoloji Derneǧi = Acta parasitologica Turcica / Turkish Society for Parasitology | Year: 2011

Myiasis is a cause of urogenital parasitosis. In this study, a 29 year-old male patient who was admitted to our hospital with urinary discharge of worms has been presented. Larvae were examined parasitologically and urogenital myiasis caused by Psychoda albipennis larvae was diagnosed. No other pathological findings were detected in the patient and the symptoms resolved spontaneously within a few days. Despite the fact that urinary myiasis is very rare in humans, it should be considered in patients with urinary complaints. Apparently, a quick recovery without treatment is possible in most cases.


Gu W.,Dali University
Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases | Year: 2012

To carry out clinical diagnosis and treatment of Fasciola gigantica infection during an outbreak in Yunnan Province. Data on epidemiology, diagnosis and treatment were collected from 27 patients. A questionnaire survey to the patients and partial villagers was carried out including history of raw food-eating and pet-raising. Animal feces were collected and examined by precipitation method and eggs incubation method. Cattle from two patients families were dissected to find Fasciola infection. Serum samples from patients, family members, and villagers were detected. Possible intermediate snails were collected from the vicinity of streams and ponds in 15 villages where patients lived. The earliest onset of symptoms among the patients was on March 10, 2011 and the last case was on January 10, 2012. The clinical manifestations were mainly fever with unknown reason, decreasing hemoglobin, increasing eosinophils, and hepatosplenomegaly. No parasite eggs were found in feces. Antibodies against F. gigantica were positive by ELISA in 23 patients. Fasciola eggs were then found in 4 patients' feces on February 16, 2012. F. gigantica eggs and adults were found in the hepatobiliary system of dissected cattle. Triclabendazole [10 mg/(kg x d) x2 d] was administered orally for the patients and the clinical symptoms eased. Snails including Physa acuta, Radix swinhoei and Galba pervia were collected and cercariae were found in only one snail. An outbreak of F. gigantica infection has been confirmed and the diagnosed cases effectively treated with triclabendazole.


Feng J.,Dali University | Zhu Y.,Yunnan Agricultural University
Biodiversity and Conservation | Year: 2010

With a wide range of habitats and exploding development of international trade, China is facing escalating risk of the plant invasion. Research on the risk assessment of alien invasive plants may help us manage the invasive with priority, and is imperatively needed in China. However, until now, few studies have been conducted for the risk of alien invasive plants and its spatial patterns in China, especially with a regard to ecosystem conservation and biodiversity protection. In this paper, we assessed the risk of invasive plants and its spatial patterns. We focused on the following basic questions: Which alien invasive plants are the most noxious, and which of them are mild? How are the spatial patterns of alien invasive plants at different risk ranks? In the present study, the risk of 100 major alien invasive plants in China was assessed based on a revised risk assessment system and an extensive consult with literatures. The results indicated that there were 18 species of rank 1st, 29 of rank 2nd, 33 of rank 3rd and 20 of rank 4th. Although, there was high richness of alien invasive plants in South China, most of them were of low risk. By contrast, low richness of alien invasive plants was observed in North China and the regions in high altitude, but most of the invasive were of high risk. Compared with previous studies, our study appears to have delivered credible results and may play an early warning function, and also further our understanding of the risk of invasive plants and its spatial patterns in China, though we acknowledged that the risk assessment may have some potential weakness, and appealed timely and further investigations in future. © 2010 Springer Science+Business Media B.V.


Liu H.,Dali University
Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases | Year: 2011

To observe the therapeutic efficacy of compound dihydroartemisinin-piperaquine for treatment of uncomplicated falciparum malaria in Myanmar. From 2007 to 2008, patients aged 6 to 60 years with uncomplicated P. falciparum infection and parasite density 500 to 200 000 parasites/microl were enrolled following an informed consent. A three-day course of total 8 tablets compound dihydroartemisinin-piperaquine was administered to an adult (each tablet containing 40 mg of dihydroartemisinin and 320 mg of piperaquine phosphate), dosage for children was based on ages (details in the treatment regimen) . The indices including fever subsiding time, parasite clearance time, asexual parasite clearance time and adverse clinical responses were observed and collected on days 7, 14, 21, and 28 after treatment. A total of 134 patients completed the treatment. The mean fever subsiding time and mean asexual parasite clearance time were (25.5 +/- 2.8) h and (39.5 +/- 7.8) h respectively. Asexual parasite clearance rate was 100% on day 7. Four cases recrudesced on day 28 and 16 cases had slight adverse clinical responses such as uncomfortable gastrointestinal tract, headache, nausea, vomit and diarrhea, which disappeared as soon as drug withdrawal. The compound dihydroartemisinin/piperaquine shows a sound efficacy in treating uncomplicated falciparum malaria


Mootnick A.R.,Gibbon Conservation Center | Fan P.,Dali University
American Journal of Primatology | Year: 2011

Crested gibbons (Nomascus) are in the rarest genus of the family Hylobatidae, with the Hainan gibbon (Nomascus hainanus) being the rarest primate in the world. In the past, the number of species in this genus has been at the center of much controversy, in part, because their color changes during immaturity as well as other factors, such as physical similarities in genitalia, creating difficulties in accurately determining the sex of individuals. Furthermore, owing to their rarity, illusiveness, and the rough terrain that comprises their native habitat, Nomascus is one of the least studied Hylobatidae. This article represents the most comprehensive dissemination of visual characteristics of the genus Nomascus to assist in the accurate identification of captive and wild crested gibbons. Through differences in pelage color, skeletal anatomy, dentition, vocalizations, behavior, distribution, and genetic studies, we are able to determine more accurately whether or not a subspecies should be elevated to species level. From the current data, there are six species and one subspecies in the genus Nomascus. However, reports of a recently identified light-cheeked gibbon (Nomascus sp.) in northeast Cambodia, Central Vietnam, and South Lao PDR, will add additional taxa to this genus. © 2010 Wiley-Liss, Inc.


Fan P.,Dali University
Acta Theriologica Sinica | Year: 2012

This paper reviews the taxonomy and conservation status of gibbons (Hylobatidae) and provides basic and comprehensive data for future conservation and research of gibbons in China. Based on the latest taxonomy of gibbons, 4 genera and 17 species are recognized.Of these, 6 species in 3 genera(Nomascus concolor, N.nasutus, N.hainanus, N.leucogenys, Hoolock leuconedys, Hylobates lar) are distributed in China.Gibbons once were widely distributed in China, but are now restricted in Yunnan, Guangxi and Hainan because of habitat loss and degradation, and hunting. Conservation of gibbons in China is an urgent problem.H.lar and N.leucogenys might have disappeared from China; the populations of N.nasutus, N.hainanus are less than 30 individuals; the populations of H.leuconedys is less than 200 individuals; and as for the largest population, N.concolor has 1 000-1 300 individuals.Law enforcement, conservation awareness education, promotion of popular science, and long-term conservation oriented research will help to conserve China's last surviving gibbons.


Fan P.F.,Dali University
Dong wu xue yan jiu = Zoological research / "Dong wu xue yan jiu" bian ji wei yuan hui bian ji | Year: 2010

We studied the sonogram and timing of duets of three groups of Central Yunnan western black crested gibbons (Nomascus concolor jingdongensis) in Dazhaizi, Mt. Wuliang. The study was based on a 13-month field observation period, from March 2003 to March 2004. A Sony TC-D5 Pro2 recorder, Sony C-76 directed microphone, and Sony tape were used to record the duet bouts in March 2007 and March 2008. Signal/RTS 4.0 was used to analyze the sonogram of the duet. We first presented sonograms of all kinds of sound units in the duets made by western black crested gibbons. The adult male could produce boom, aa notes and modulated figures. Adult females produced great call or abortive great call. The two adult females in each group usually produced great calls synchronously. After the great call, males always immediately produced a modulated figure to coordinate with the female. The interval between the modulated figure and great call was 2.7 s. On average, groups sang on 53% of days monitored, and sang 1.09 duet bouts per singing day. 91.5% of the duets were produced between half an hour before and three hours after the sunrise. The average duration of the duets was 12.9 min, and females produced 4.6 great calls during one duet bout. The intervals between two successive great calls were generally 115 s. There was no significant difference in the duration and frequency of the duet bouts, but there was significant difference in the number of the great calls and intervals between great calls among groups.


Wen X.,Dali University | Yang Q.,Dali University | Yan Z.,Dali University | Deng Q.,Dali University
Microchemical Journal | Year: 2011

In this work, a new method based on dispersive liquid-liquid microextraction (DLLME) preconcentration using tetrachloromethane (CCl4) as extraction solvent was proposed for the spectrophotometric determination of cadmium and copper in water and food samples. The influence factors relevant to DLLME, such as type and volume of extractant and disperser solvent, concentration of chelating reagents, pH, salt effect, were optimized. Under the optimal conditions, the limits of detection for cadmium and copper were 0.01ng/L and 0.5μg/L, with enhancement factors (EFs) of 3458 and 10, respectively. The tremendous contrast of EFs could come from the different maximum absorption wavelength caused by the different extraction acidity compared with some conventional works and the enhancement effect of acetone used as dilution solvent during the spectrophotometric determination. The proposed method was applied to the determination of water and food samples with satisfactory analytical results. The proposed method was simple, rapid, cost-efficient and sensitive, especially for the detection of cadmium. © 2010 Elsevier B.V.

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