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Chen J.-X.,The National Institute of Parasitic Diseases | Chen J.-X.,Collaborating Center for Malaria | Chen M.-X.,The National Institute of Parasitic Diseases | Chen M.-X.,Collaborating Center for Malaria | And 17 more authors.
PLoS ONE | Year: 2013

Fascioliasis is a common parasitic disease in livestock in China. However, human fascioliasis is rarely reported in the country. Here we describe an outbreak of human fascioliasis in Yunnan province. We reviewed the complete clinical records of 29 patients and performed an epidemiological investigation on the general human population and animals in the outbreak locality. Our findings support an outbreak due to Fasciola gigantica with a peak in late November, 2011. The most common symptoms were remittent fever, epigastric tenderness, and hepatalgia. Eosinophilia and tunnel-like lesions in ultrasound imaging in the liver were also commonly seen. Significant improvement of patients' condition was achieved by administration of triclabendazole®. Fasciola spp. were discovered in local cattle (28.6%) and goats (26.0%). Molecular evidence showed a coexistence of F. gigantica and F. hepatica. However, all eggs seen in humans were confirmed to be F. gigantica. Herb (Houttuynia cordata) was most likely the source of infections. Our findings indicate that human fascioliasis is a neglected disease in China. The distribution of triclabendazole®, the only efficacious drug against human fascioliasis, should be promoted. © 2013 Chen et al.

Yang H.,Dali Institute of Schistosomiasis Control | Zuo J.-M.,Nanjian County Station of Schistosomiasis | Yang M.-X.,Nanjian County Station of Schistosomiasis | Bi W.-Z.,Nanjian County Station of Schistosomiasis
Chinese Journal of Schistosomiasis Control | Year: 2012

The snail control efffect of niclosamide by soil mixing and spraying method were compared, and the results showed that the effects of the two methods were similar. Though there was difficulties in getting soil and mixing durg with soil, and the cost was high, the effect of soil mixing method in some special environment such as stone ditches and terraces.

Chen F.,Dali Institute of Schistosomiasis Control | Chen S.-R.,Dali Institute of Schistosomiasis Control | Li K.-R.,Dali Institute of Schistosomiasis Control | Ii T.-H.,Dali Institute of Schistosomiasis Control | And 2 more authors.
Chinese Journal of Schistosomiasis Control | Year: 2011

Objective: To investigate the potential cause of an outbreak of eosinophilic meningitis in Dali City in March, 2011. Methods: A retrospective investigation was performed among 18 consumers who had meal together. The clinical documents of inpatients were analyzed and the diagnoses were checked. The outpatients were investigated through a case survey. Pomacea snails on sale were examined for the infection status of Angiostrongylus cantonensis. Results: Of 18 persons, 16 consumed Pomacea snail food and 9 were infected with an infection rate of 56.3%. The two persons who did not consumed snail food were not infected. Serum samples of seven patients were examined for antibody to Angiostrongyius cantonensis in peripheral blood and 3 were proved positive (42.9%). The snails consumed by the patients came from the market, and the surveillance data showed that the infection rate of Angiostrongyius cantonensis of Pomacea snails was 7.3%. Conclusion: According to the epidemiological survey, clinical manifestations, and laboratory examinations, the outbreak of eosinophilic meningitis is due to the consumption of Pomacea snails infected with Angiostrongyius cantonensis.

Chen S.-R.,Dali Institute of Schistosomiasis Control | Li B.-G.,Heqing Station of Schistosomiasis Control | Li W.-B.,Heqing Station of Schistosomiasis Control | Luo J.-J.,Dali Institute of Schistosomiasis Control | And 14 more authors.
Chinese Journal of Schistosomiasis Control | Year: 2012

Objective: To evaluate the effect of comprehensive control and management of schistosomiasis at plateaus regions in Yunnan Province. Methods: Xiaolian and Kangfu villages at plateaus regions where schistosomiasis was endemic were selected as study areas from 2006 to 2011, the schistosomiasis comprehensive control measures were conducted, and these measures included the health education, chemotherapy, stool and water management, grazing forbidden, Oncomelania snail control, etc. combined with the infrastructure of farmland water conservancy, agricultural comprehensive development, adjustment of industry structure, returning farmland to forest, ditch hardening, and aquaculture. Results: At Xiaolian Village, no schistosomiasis patient and livestock were found from 2008; and at Kangfu Village, no schistosomiasis patient was detected from 2006 and no schistosomiasis domestic animal was found from 2008. In 2011, the snail area, percent of frames with living snails, the number of snails, average concentration of living snails, and the highest concentration of living snails descended by 69.99%, 81.86%, 88.86%, 89.71%, 57.95% at Xiaolian Village, and descended by 27.65%, 1.11%, 94.71%, 92.16%, 88.00% at Kangfu Village, respectively, compared with those in 2006. The ratios of infected snail area to snail area were 68.91% in 2006 and 69.13% in 2007 at Xiaolian Village, and 61.73% in 2006 and 43.24% in 2007 at Kangfu Village. There were no infected snails from 2008 in the two villages. Conclusion: The comprehensive control and management measures can effectively control the schistosomiasis prevalence at plateaus regions.

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