Halifax, Canada

Dalhousie University

www.dal.ca/
Halifax, Canada

Dalhousie University is a public research university in Nova Scotia, Canada, with three campuses in Halifax, and a fourth in Bible Hill. Dalhousie offers more than 4,000 courses and 180 degree programs in twelve undergraduate, graduate, and professional faculties. The university is a member of the U15, a group of research-intensive universities in Canada.Dalhousie was established as a nonsectarian college in 1818 by the Lieutenant Governor of Nova Scotia, George Ramsay, 9th Earl of Dalhousie, after whom the university was named. The college did not hold its first class until 1838, until then operating sporadically due to financial difficulties. It reopened for a third time in 1863 following a reorganization which brought a change of name to "The Governors of Dalhousie College and University". The university formally changed its name to "Dalhousie University" in 1997 through provincial legislation, the same legislation which had merged the institution with the Technical University of Nova Scotia.The Dalhousie library system currently operates the largest library in Atlantic Canada, as well as holds the largest collection of agricultural resource material in the region. The university operates a total of fourteen residences. There are currently two student unions that represent student interests at the university, the Dalhousie Student Union, and the Dalhousie Association for Graduate Students. Dalhousie's varsity teams, the Tigers, compete in the Atlantic University Sport conference of Canadian Interuniversity Sport. Dalhousie’s Faculty of Agriculture varsity teams are the Dalhousie Rams, and compete in the ACAA and CCAA.Dalhousie is a coeducational university with more than 18,000 students and over 110,000 alumni. Notable alumni include government officials, academics, business leaders and 89 Rhodes Scholars. The university ranked 244th in the 2013 QS World University Rankings, 251-275th in the 2012-2013 Times Higher Education World University Rankings, and 201–300th in the 2012 Academic Ranking of World Universities. Dalhousie is a centre for marine research, and is host to the headquarters of the Ocean Tracking Network. Wikipedia.

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Methods and compositions are provided for the treatment of familial exudative vitreoretinopathy (FEVR) and retinopathy of prematurity (ROP) through the administration of a therapeutically effective amount of a Sphingosine-1-phosphate receptor type 2 (S1PR2) inhibitor.


Patent
Dalhousie University | Date: 2015-06-25

Among other things, in general, methods of increasing transfer efficiency in a power link are described, as well as power links implementing such methods. Methods of dynamic charging are also described. Applications of such methods and power links include the charging of portable electronic devices as well as implantable medical devices.


Patent
Massachusetts Institute of Technology and Dalhousie University | Date: 2016-08-09

Amblyopia is a prevalent form of visual impairment that generally arises during infancy and early childhood when inputs to the visual cortex form the two eyes are poorly balanced. Disclosed herein are methods involving retinal inactivation of at least one retina to treat visual impairment in the form of amblyopia or other conditions.


Methods are provided for the treatment of Parkinsons disease (PD) in patients bearing mutations in the LRRK2 gene. A therapeutically effective amount of piperazine derivative compounds are employed to inhibit the biological activity of ArfGAP1, inhibition that counteracts the deleterious effects of mutations in, or increased expression of, the LRRK2 protein.


Patent
Dalhousie University | Date: 2017-05-03

Among other things, in general, methods of increasing transfer efficiency in a power link are described, as well as power links implementing such methods. Methods of dynamic charging are also described. Applications of such methods and power links include the charging of portable electronic devices as well as implantable medical devices.


Patent
Dalhousie University | Date: 2017-05-24

Embodiments generally relate to cancer treatment with radiation sources. The present technology discloses techniques that can enable an automatic generation of radiotherapy trajectories using anatomical data of a patient. It can improve conformal dose distributions and target volume coverage by considering a radiation risk decided by an organs-at-risk (OAR)s relative location to the target volume and the radiation source.


Patent
Dalhousie University | Date: 2016-10-28

The present invention provides a method for removing a tattoo in a region of skin the method comprises administering to a least a portion of the tattoo, and a composition comprising an effective amount of a bisphosphonate and at least one pharmaceutically acceptable excipient to at least cause fading of the tattoo in said region.


Methods and compositions are provided for the treatment of familial exudative vitreoretinopathy (FEVR) and retinopathy of prematurity (ROP) through the administration of a therapeutically effective amount of a Sphingosine-1-phosphate receptor type 2 (S1PR2) inhibitor.


Sawynok J.,Dalhousie University
Neuroscience | Year: 2016

The main focus for the development of adenosine targets as analgesics to date has been A1Rs due to its antinociceptive profile in various preclinical pain models. The usefulness of systemic A1R agonists may be limited by other effects (cardiovascular, motor), but enhanced selectivity for pain might occur with partial agonists, potent and highly selective agonists, or allosteric modulators. A2AR agonists exhibit some peripheral pronociceptive effects, but also act on immune cells to suppress inflammation and on spinal glia to suppress pain signaling and may be useful for inflammatory and neuropathic pain. A2BR agonists exhibit peripheral proinflammatory effects on immune cells, but also spinal antinociceptive effects similar to A2AR agonists. A3Rs are now demonstrated to produce antinociception in several preclinical neuropathic pain models, with mechanistic actions on glial cells, and may be useful for neuropathic pain. Endogenous adenosine levels can be augmented by inhibition of metabolism (via adenosine kinase) or increased generation (via nucleotidases), and these approaches have implications for pain. Endogenous adenosine contributes to antinociception by several pharmacological agents, herbal remedies, acupuncture, transcutaneous electrical nerve stimulation, exercise, joint mobilization, and water immersion via spinal and/or peripheral effects, such that this system appears to constitute a major pain regulatory system. Finally, caffeine inhibits A1-, A2A- and A3Rs with similar potency, and dietary caffeine intake will need attention in trials of: (a) agonists and/or modulators acting at these receptors, (b) some pharmacological and herbal analgesics, and (c) manipulations that enhance endogenous adenosine levels, all of which are inhibited by caffeine and/or A1R antagonists in preclinical studies. All adenosine receptors have effects on spinal glial cells in regulating nociception, and gender differences in the involvement of such cells in chronic neuropathic pain indicate gender may also need attention in preclinical and human trials evaluating the efficacy of adenosine-based analgesics. © 2015 IBRO


Obrovac M.N.,Dalhousie University | Chevrier V.L.,3M
Chemical Reviews | Year: 2014

Most studies set out to make materials that improve on the specific capacity of graphite, usually without regard to average voltage, volumetric capacity, or the many other properties listed above that are more applicable to implementation in practical cells. One difficulty in choosing proper metrics for anodes stems from basic electrochemistry: it is not possible to calculate the energy of a single electrode. To provide motivation for using alloy anode materials and a framework for comparison, key performance metrics need to be defined. It is well-known that the volumetric and specific capacities of the active elements are far greater than that of graphite. Because all alloys expand considerably during lithiation, this volume must be accommodated somewhere within a battery. To make more informative performance comparisons, it is necessary to use a cell model, preferably one that is most representative of alloy materials application.

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