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Amagasaki, Japan

Tanaka K.-I.,Kumamoto University | Tanaka Y.,Kumamoto University | Suzuki T.,Daiso Company Ltd | Mizushima T.,Kumamoto University
British Journal of Nutrition | Year: 2011

β-(1,3)-d-Glucan with β-(1,6) branches has been reported to have various pharmacological activities, such as anti-tumour and anti-infection activities, which result from its immunomodulating effects. Gastric lesions result from an imbalance between aggressive and defensive factors. In the present study, we examined the effect of β-(1,3)-d-glucan with β-(1,6) branches isolated from Aureobasidium pullulans on the gastric ulcerogenic response in mice. Oral administration of β-glucan ameliorated gastric lesions induced by ethanol (EtOH) or HCl. This administration of β-glucan also suppressed EtOH-induced inflammatory responses, such as infiltration of neutrophils and expression of pro-inflammatory cytokines, chemokines and cell adhesion molecules (CAM) at the gastric mucosa. Of the various defensive factors, the levels of heat shock protein (HSP) 70 and mucin but not PGE2 were increased by the administration of β-glucan. β-Glucan-dependent induction of the expression of HSP70 and mucin proteins and suppression of the expression of pro-inflammatory cytokines, chemokines and CAM were also observed in cultured cells in vitro. The results of the present study suggest that β-glucan protects the gastric mucosa from the formation of irritant-induced lesions by increasing the levels of defensive factors, such as HSP70 and mucin. © 2011 The Authors.

Inoue S.,Kansai University | Inoue S.,Daiso Company Ltd | Tamezawa H.,Kansai University | Aota H.,Kansai University | And 4 more authors.
Macromolecules | Year: 2011

The addition fragmentation chain transfer in allyl polymerization at the elevated temperatures was reported. The reinitiation efficiencies of monomeric allyl radical at different temperatures were estimated by the dead-end polymerizations of allyl benzoate (ABz) at 80, 105, and 130° C. The enhanced reinitiation could bias the well-known degradative monomer chain transfer characteristic of allyl polymerization toward the chain transfer in common vinyl polymerization at an elevated temperature. The direct contribution of cumyloxy radical to initiation reaction was not observed in the polymerization of ABz with dicumyl peroxide (DCPO) as a typical peroxide initiator at elevated temperatures but the methyl radical initiation preceded by β-scission of cumyloxy radical occurred predominantly. The occurrence of addition fragmentation chain transfer could be enhanced at elevated temperatures and at a lower monomer concentration.

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