Kobayashi D.,Tohoku University |
Kusama M.,Tohoku University |
Onda M.,Daiichi Fine Chemical Co. |
Nakahata N.,Tohoku University
Journal of Pharmacological Sciences | Year: 2011
It has been reported that pantothenic acid (vitamin B5) and panthenol, an alcohol derivative of pantothenic acid, have beneficial moisturizing effects on the skin. However, few studies have investigated the mechanism of action of pantothenic acid on skin tissues. We tried to clarify the role of pantothenic acid on skin function by using keratinocytes and fibroblasts. The depletion of pantothenic acid from the culture medium suppressed keratinocyte proliferation and promoted differentiation. Moreover, pantothenic acid depletion decreased the synthesis of keratinocyte growth factor and procollagen 4a2 in fibroblasts. These results suggest that pantothenic acid is essential for maintaining keratinocyte proliferation and differentiation. © The Japanese Pharmacological Society.
Kuroyanagi J.-I.,Daiichi Sankyo |
Kanai K.,Daiichi Sankyo |
Sugimoto Y.,Daiichi Sankyo |
Fujisawa T.,Daiichi Sankyo |
And 4 more authors.
Bioorganic and Medicinal Chemistry | Year: 2010
Preparations and in vitro antifungal activities of triazolopyridines, imidazopyridines, and a pyrazolopyridine were reported. Among those scaffolds, triazolopyridine was found to be the specific inhibitor of the synthesis of β-1,6-glucan, an essential component of the fungal cell wall, and to show potent antifungal activities against several Candida species. © 2010 Elsevier Ltd. All rights reserved.
Daiichi Fine Chemical Co. | Date: 2012-08-21
Chemicals, namely, chemical additives for use in the manufacture of skin care and hair products; chemicals, namely, pyridoxine phosphate; chemical reagents other than for medical or veterinary purposes. Soaps and detergents; perfumery, fragrances and incenses, all other than perfumes used as cosmetics or toiletries; cosmetics and non-medicated toiletries; dentifrices. Pharmaceutical, veterinary and sanitary preparations, namely, antibiotics, pharmaceutical preparations for the treatment of infectious diseases, allergy medications, veterinary vaccines, flea powders, hand-sanitizing preparations, disinfectants for medical instruments; reagents for medical purposes.
Kyowa Pharma Chemical Co. and Daiichi Fine Chemical Co. | Date: 2012-10-02
Dietary ingredients, namely, active chemical ingredients for use in the manufacture of dietary supplements or nutritional supplements.
Daiichi Fine Chemical Co. | Date: 2010-09-06
A pantethine phosphate ester represented by the following formula (1) or formula (2) exhibits superior tyrosinase inhibitory effect and melanin production inhibitory effect.