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Busan, South Korea

Cha J.-Y.,Daesun Distilling Co. | Park C.-K.,Korea Ginseng Corporation | Cho Y.-S.,Dong - A University
Food Science and Biotechnology | Year: 2010

Effect of chicory root extract (CRE) on the triglyceride metabolism in orotic acid (OA)-fed rats was investigated. Liver weights and hepatic triglyceride concentrations were markedly increased by OA-feeding rats. These results were attributed to the significant increase in the activity of hepatic phosphatidate phosphohydrolase (PAP), diacylglycerol acyltransferase (DGAT), and rate-limiting enzymes for triglyceride synthesis. Supplementation of CRE to OA did significantly reduced the hepatic triglyceride concentrations and DGAT activity without affecting PAP activity. Furthermore, OA treatment was significantly decreased plasma triglyceride (TG) and increased hepatic TG concentrations and reduced microsomal triglyceride transfer protein (MTP) activity without diminishing MTP mRNA expression in rats. However, hepatic TG concentration was significantly decreased and MTP activity was also reduced without diminishing MTP mRNA expression in rats fed simultaneous with OA and CRE diet. The hepatocytes in the OA-feeding rats contained numerous largely fat droplets, but CRE feeding prevented the OA-induced fat accumulation. Present study demonstrates that CRE reduces the liver TG accumulation by reduced DGAT and MTP activities without diminishing MTP mRNA expression by OA administration. © KoSFoST and Springer 2010. Source


Cha J.-Y.,Daesun Distilling Co. | Lee B.-J.,Marine Bioprocess Co. | Je J.-Y.,Chonnam National University | Kang Y.-M.,Marine Bioprocess Co. | And 2 more authors.
Fisheries and Aquatic Science | Year: 2011

The sea tangle, Laminaria japonica has long been used in Korea as a folk remedy to promote health. Gamma-amino butyric acid-enriched (5.56% of dry weight) sea tangle was obtained by fermentation with Lactobacillus brevis BJ-20 (FLJ). A suppressive effect of FLJ on carbon tetrachloride-induced hepatotoxicity has been shown previously. Alcohol administration to Sprague-Dawley rats leads to hepatotoxicity, as demonstrated by heightened levels of hepatic marker enzymes as well as increases in both the number and volume of lipid droplets as fatty liver progresses. However, FLJ attenuated alcohol-induced hepatotoxicity and the accumulation of lipid droplets following ethanol administration. Additionally, FLJ increased the activities and transcript levels of major alcohol-metabolizing enzymes, such as alcohol dehydrogenase and aldehyde dehydrogenase, and reduced blood concentrations of alcohol and acetaldehyde. These data suggest that FLJ protects against alcohol-induced hepatotoxicity and that FLJ could be used as an ingredient in functional foods to ameliorate the effects of excessive alcohol consumption. © The Korean Society of Fisheries and Aquatic Science. Source


Cha J.-Y.,Daesun Distilling Co. | Ahn H.-Y.,Dong - A University | Cho Y.-S.,Dong - A University | Je J.-Y.,Chonnam National University
Food and Chemical Toxicology | Year: 2013

This study was to investigate the protective effect of cordycepin-enriched Cordyceps militaris against alcohol-induced hepatotoxicity in Sprague-Dawley rats. Alcohol-feeding rats were fed diets with Paecilomyces japonica as CPJ group, C. militaris as CCM group, cordycepin-enriched C. militaris as CCMα group at the 3% (w/w) level and silymarin at the 0.1% (w/w) level for 4. weeks. Alcohol administration resulted in a significant increase in the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (γ-GTP), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) and the levels of blood alcohol and acetaldehyde in serum. However, CCMα group markedly prevented from alcohol-induced elevation of these parameters in serum. CCMα group showed the increased both hepatic activities of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH). Unlike the action of alcohol treatment on alcoholic fatty liver, CCMα group was also attenuated lipid droplet accumulation in the hepatocytes. Present study was also confirmed the beneficial roles of silymarin (hepatoprotective agent) against alcohol-induced liver injury in rats. Therefore, cordycepin-enriched C. militaris can be a promising candidate to prevent from alcohol-induced hepatotoxicity. © 2013 Elsevier Ltd. Source


Cha J.-Y.,Daesun Distilling Co. | Kim Y.-S.,National Academy of Agricultural Science | Moon H.-I.,Dong - A University | Cho Y.-S.,Dong - A University
International Journal of Food Sciences and Nutrition | Year: 2012

The purpose of this study was to investigate the protective effect of Bacillus subtilis fermented silkworm powder (BFSP) and Aspergillus kawachii fermented silkworms powder (AFSP) on alcohol-induced hepatotoxicity in Sprague-Dawley rats. Alcohol-feeding rats were fed with diets containing silkworm powder (SP) or both BFSP and AFSP at the 5% (w/w) levels for 4 weeks. Alcohol administration resulted in a significant increase in the activities of liver marker enzymes, aspartate aminotransferase (AST), γ-glutamyl transpeptidase (γ-GTP) and lactate dehydrogenase (LDH). Administration of BFSP markedly prevented alcohol-induced elevation of serum AST, γ-GTP and LDH activities, and the levels of blood alcohol and acetaldehyde. Interestingly, in comparison with both SP and AFSP, BFSP administration drastically increased both hepatic alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities, suggesting that BFSP was more effective in the reduction of blood alcohol and acetaldehyde. BFSP administration showed the highest induction of hepatic ADH expression in alcohol-feeding rats. Also, alcohol treatment resulted in increasing lipid peroxidative index (thiobarbituric acid-reactive substances) and decreasing antioxidant status (reduced glutathione) in the liver. Thus, these results suggest that BFSP treatment improved the antioxidant status of alcoholic rats by decreasing the levels of lipid peroxidative index and by increasing the levels of antioxidant status in the liver and serum. Specially, the concentrations of serum total cholesterol, free fatty acid and hepatic triglyceride were increased, but these parameters were significantly influenced by the BFSP in the alcohol treatment. Unlike the action of alcohol treatment on fatty liver, BFSP administration attenuated lipid droplet accumulation in hepatocytes. A high level of ADH was also observed in AFSP administered rats; on the other hand, a significant change in ALDH was not observed. Therefore, the SP can be a promising candidate in the prevention alcohol-induced hepatotoxicity and oxidative stress. © 2011 Informa UK, Ltd. Source


Kang Y.M.,Marine Bioprocess Co. | Lee B.-J.,Marine Bioprocess Co. | Kim J.I.,Dong - A University | Nam B.-H.,Marine Bio Industry Development Center | And 6 more authors.
Food and Chemical Toxicology | Year: 2012

A randomized, double-blind, and placebo-controlled clinical study was performed to evaluate the antioxidant effects of fermented sea tangle (FST) on healthy volunteers with high levels of γ-glutamyltransferse (γ-GT). Forty-eight participants were divided into a placebo group and an FST group that received FST (1.5. g/day) for 4. weeks. Serum γ-GT, malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities were determined before and after the trial. Administering FST significantly decreased serum levels of γ-GT and MDA. Additionally, SOD and CAT activities were significantly augmented compared to those in the placebo group after 4. weeks, but no significant alteration was observed in GPx activity compared to that in the placebo group. Our findings indicate that FST enhanced the antioxidant defense system in a healthy population and may be useful as a functional food ingredient. © 2011 Elsevier Ltd. Source

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