Kim H.-Y.,Chungnam National University |
Kim H.-Y.,Daejeon Regional Cancer Center |
Oh Y.-S.,Chungnam National University |
Oh Y.-S.,Daejeon Regional Cancer Center |
And 11 more authors.
Leukemia Research | Year: 2013
We investigated the role of endogenous stromal cell-derived factor-1 (SDF-1; CXCL12) in the survival and proliferation of acute myeloid leukemia (AML) cells in vitro. CD34+ cells from the peripheral blood of five patients with AML, as well as five AML cell lines, produced and secreted SDF-1. Knock-down of endogenous SDF-1 expression using siRNA technology downregulated the constitutive phosphorylation of SDF-1-related signaling molecules and significantly inhibited spontaneous proliferation of the AML cell lines during a 3-day incubation in serum-free conditions. These results indicate that endogenous SDF-1 expression by AML cells plays a role in the autonomous growth of the cells. © 2013 Elsevier Ltd.
Lee J.-A.,Seoul National University |
Lee J.-A.,National Cancer Control Institute |
Kim S.-Y.,National Cancer Control Institute |
Kim Y.,Seoul National University |
And 5 more authors.
Japanese Journal of Clinical Oncology | Year: 2014
Objective: We assessed health-related quality of life in cancer survivors treated in designated cancer centers when compared with the general population in Korea. Methods: A multicenter survey was conducted from July through August 2008 using the quotasampling approach. A general population sample was drawn from the Fourth Korean National Health and Nutrition Examination Survey, second year. We compared the multivariate-adjusted least square means of cancer patients with those of the general population to examine relationships between EuroQol five-dimensional questionnaire components and cancer sites, cancer stage and time since diagnosis. The independent variables of responses to the EuroQol five-dimensional questionnaire were evaluated using logistic regression analysis. Results: Cancer patients scored significantly poorer on measures of self-care (means: stomach 1.25; lung 1.40; liver 1.27; colon 1.26; breast 1.27; cervical 1.29 vs. general 1.18), engagement in usual activities (means: stomach 1.47; lung 1.63; liver 1.45; colon 1.44; breast 1.46; cervical 1.47 vs. general 1.33) and anxiety/depression (means: stomach 1.41; lung 1.50; liver 1.41; colon 1.42; breast 1.50; cervical 1.47 vs. general 1.28). Those in the local stage scored significantly better on mobility (mean = 1.35) than the general population (mean = 1.40). Cancer patients, especially those with lung cancer, in the advanced stage and more than 5 years since diagnosis had poorer health-related quality of life than the general population. Some factors such as medical insurance and healthcare services were related to health-related quality of life among cancer patients. Conclusions: Health-related quality of life of cancer survivors with lung cancer at advanced stages, <1 year earlier and more than 5 years since diagnosis was poorer than that for the noncancer control group, and these differences were statistically significant. Cancer survivors should be continuously observed and offered support. © The Author 2013. Published by Oxford University Press. All rights reserved.
Kang J.,National Cancer Center |
Koh S.J.,Sunlin Hospital |
Yoo Y.S.,Catholic University of Korea |
Choi Y.S.,Daejeon Regional Cancer Center |
And 4 more authors.
Journal of Palliative Medicine | Year: 2010
Purpose: To describe development of the Standard Hospice & Palliative Care Education Program in Korea, a basic training program for hospice & palliative care professionals, and to report preliminary results from the 2008-2009 demonstration project at 2 sites that support its effectiveness. Method: We developed the Standard Hospice & Palliative Care Education Program, consisting of 19 modules, under the initiative and financial support of the Ministry of Health, Welfare, and Family Affairs. We adapted the train-the-trainer model and benchmarked the EPEC (Education in Palliative and End-of-life Care) course. In order to evaluate the effectiveness of the program, session evaluation, pre-post test of knowledge, and overall course evaluation were assessed by participants. Results: The demonstration program included a total of 105 participants. Overall rating by participants was 4.1 for relevance and usefulness of program contents (range, 4.1-4.2; 1=strongly disagree, 5=strongly agree) and 4.1 for the trainer's teaching skills (range, 4.0-4.2). Participants demonstrated significant improvement in their knowledge on the pre-post test for 6 of the 17 modules, and reported that they had gained confidence in their ability to perform palliative care practices (overall mean ratings, 4.0, range; 3.6-4.3; 1=very low, 5=very high). Overall evaluation of the program was very high (very satisfied or satisfied; 86%). Conclusion: Development of the Standard Hospice & Palliative Care Education Program was successful, and its preliminary effectiveness was shown by the demonstration program. Comments on our experience in Korea would be helpful to efforts in other countries, particularly those with limited resources for hospice and palliative care. © 2010, Mary Ann Liebert, Inc.