Daejeon Health science College

Daejeon, South Korea

Daejeon Health science College

Daejeon, South Korea
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Shin H.K.,Korea Research Institute of Chemical Technology | Shin H.K.,Ewha Womans University | Kim J.,Yonsei University | Lee E.J.,Daejeon Health Science College | Kim S.H.,Korea Research Institute of Chemical Technology
Phytotherapy Research | Year: 2010

Oral squamous cell carcinomas (OSCCs) are characterized by a marked propensity for local invasion, so the identification of agents inhibiting the onset and progression of OSCC has recently gained interest. Here, we found that curcumin inhibited cell proliferation and motility with decreased activities of matrix metalloproteinase (MMP)-2/9 and decreased mRNA expressions of urokinase-type plasminogen activator (uPA) and its receptor uPAR in the highly invasive human YD-10B OSCC cells. Western blot analysis showed that curcumin inhibited the activation of MAP kinases (especially ERK) and NF-κB, which are involved in the transcriptional regulation of proteolytic enzymes. In conclusion, curcumin is one of the strong phytochemicals with antimotility activity of OSCC; the inhibitory effect of curcumin on the motility of YD-10B cells could result from its potential to inhibit the activation of ERK/MAP kinase and NF-κB that consequently down-regulate the mRNA expressions and activities of proteolytic enzymes such as uPA and MMP-2/9. Copyright © 2009 John Wiley & Sons, Ltd.


Choi H.J.,Daejeon Health science College | Song J.H.,Wonkwang University | Kwon D.H.,Korea Research Institute of Bioscience and Biotechnology
Phytotherapy Research | Year: 2012

Our previous report showed that quercetin 3-rhamnoside (Q3R) possessed antiviral activity against influenza A/WS/33 virus in vitro. The present study evaluated the effect of Q3R on influenza A/WS/33 virus infected mice. Mice orally treated with Q3R (6.25mg/kg per dose) at 2 h before and once daily for 6 days after influenza virus infection showed significant decreases in weight loss, and decreased mortality. Lung virus titers of mice killed at 6 days after infection were about 2000 times lower than that of the placebo-treated control mice and about two times lower than that for the oseltamivir-treated mice. Furthermore, histological evaluation showed that administration of Q3R delayed the development and progression of pulmonary lesions. Therefore, Q3R could be an attractive lead for the development of antiviral agents against influenza virus. Copyright © 2011 John Wiley & Sons, Ltd.


Nguyen T.D.,Chungnam National University | Nguyen T.D.,Vietnam Academy of Science and Technology | Lee K.J.,Chungnam National University | Lee M.H.,Daejeon Health science College | Lee G.H.,Chungnam National University
Microchemical Journal | Year: 2010

A rapid, specific and sensitive multiresidue method based on dispersive solid phase extraction sample preparation and gas chromatography with the mass spectrometric detection for the analysis of 234 pesticides in Korean herbs (Acanthopanax senticosus, Morus alba L., Hovenia dulcis) has been developed. Method recoveries were found to be between 62 and 119% with relative standard deviation lower than 21% for all compounds in the concentration range of 0.05 to 0.400 mg kg- 1. Limits of quantification of most compounds are below 0.050 mg kg- 1. The data demonstrate that this method was successfully used for analysis of 234 pesticides in Korean herbs. © 2009 Elsevier B.V. All rights reserved.


Nguyen T.D.,Chungnam National University | Nguyen T.D.,Vietnam Academy of Science and Technology | Lee M.H.,Daejeon Health science College | Lee G.H.,Chungnam National University
Microchemical Journal | Year: 2010

A multi-residue method using liquid-liquid extraction (LLE) followed by centrifugation, freezing and dispersive solid phase extraction (dispersive SPE) as clean up steps and gas chromatography with mass spectrometric detection has been developed for the determination of trace levels of 95 pesticides in soybean oil. LLE has been optimized to extract these pesticide residues from soybean oil by studying the effect of different partitions between (i) acetonitrile (MeCN) saturated with petroleum ether and a soybean oil solution dissolved in petroleum ether saturated with MeCN, (ii) partition between MeCN and a soybean oil solution dissolved in petroleum ether saturated with MeCN, (iii) partition between MeCN and a soybean oil solution dissolved in petroleum ether, (iv) partition between MeCN saturated with n-hexane and a soybean oil solution dissolved in n-hexane saturated with MeCN, (v) partition between MeCN and a soybean oil solution, (vi) partition between MeCN and a soybean oil solution dissolved in n-hexane and (vii) partition between MeCN and a soybean oil solution dissolved in mixture of acetone and n-hexane (3:2) to the highest recovery yield of pesticides and the lowest co-extract fat residue in the final extract. Experiments were carried out in order to study the efficiency of using centrifugation and freezing steps as well as the used of primary secondary amine (PSA), florisil, graphite carbon black (GCB) and C18 for dispersive SPE on clean up stages to minimize the co-extract fat. The recoveries obtained ranged from 80 to 114% and the relative standard deviation (RSDs) from 2 to 14% for spiking levels of 0.040, 0.080 and 0.160 mg kg- 1. The limits of quantification (LOQs) of almost all compounds were below the maximum residue limits (MRLs) established by the Korean legislations for soybean oil. © 2009 Elsevier B.V. All rights reserved.


Lee K.-J.,Daejeon University | An J.H.,Konkuk University | Chun J.-R.,Daejeon Health science College | Chung K.-H.,Seoul National University of Science and Technology | And 4 more authors.
Journal of Biomedical Nanotechnology | Year: 2013

In this study, the anti-tumor activity of mitoxantrone loaded on magnetic nanoparticles (MTMP) was examined using DU145 prostate cancer cells. Composite nanoparticles with an average size of 20 nm were prepared using a chemical co-precipitation technique. The MTMP nanoparticles were cytotoxic to DU145 cells and inhibited cell proliferation. The expression levels of apoptosis related proteins in DU145 cells, including PARP and caspase 3, were increased after MTMP treatment. In this study, the therapeutic potential of MTMP in targeted-therapy against prostate cancer was demonstrated and MTMP was more effective when coupled to drug delivery vehicle than pure mitoxantrone. Copyright © 2013 American Scientific Publishers All rights reserved.


Song J.,Wonkwang University | Shim J.,Korea Nazarene University | Choi H.,Daejeon Health science College
Virology Journal | Year: 2011

Background: On the base of our previous study we were observed relevant studies on the hypothesis that the antiviral activity of quercetin 7-rhamnoside (Q7R), a flavonoid, won't relate ability of its antioxidant. Methods. We were investigated the effects of Q7R on the cytopathic effects (CPE) by CPE reduction assay. Production of DNA fragment and reactive oxygen species (ROS) induced by PEDV infection were studied using DNA fragmentation assay and flow cytometry. Results: In the course of this study it was discovered that Q7R is an extremely potent compound against PEDV. The addition of Q7R to PEDV-infected Vero cells directly reduced the formation of a visible cytopathic effect (CPE). Also, Q7R did not induce DNA fragmentation. Furthermore, ROS increased the infection of PEDV, which was strongly decreased by N-acetyl-L-cysteins (NAC). However, the increased ROS was not decreased by Q7R. Antiviral activity of antioxidants such as NAC, pyrrolidine dithiocarbamate (PDTC), and the vitamin E derivative, trolox, were hardly noticed. Conclusions: We concluded that the inhibition of PEDV production by Q7R is not simply due to a general action as an antioxidants and is highly specific, as several other antioxidants (NAC, PDTC, trolox) are inactive against PEDV infection. © 2011 Song et al; licensee BioMed Central Ltd.


Chun J.R.,Daejeon Health Science College
International Journal of Applied Engineering Research | Year: 2014

Recently, mobile-healthcare service becomes hot issue in the healthcare industry. Therefore, it is very meaningful to study about mobile-healthcare service and also its success factors. This research aims to analyze the weight of various factors affecting the successful implementation of mobile-healthcare service. To get the significant factors, exploratory factor analysis (EFA) was carried out. After carrying out the EFA, we conducted the analytic hierarchy process (AHP) to measure the weight of each critical success factor (CSF) and also its variables. As the result of EFA, 4 major factors, i.e. governmental legal support, level of ICT-infrastructure (mobile devices and application), user education, and profit/growth of mobilehealthcare service organization, were constructed. These factors are the CSF for the successful implementation of mobile-healthcare system. AHP analysis showed the weight list of CSF according to their significance. The results of this paper could be useful references for the policy making process of the mobile-healthcare system in Korea. © Research India Publications.


Choi H.J.,Daejeon Health science College
Journal of medicinal food | Year: 2010

Human rhinoviruses (HRVs), members of the Picornaviridae family, are composed of over 100 different virus serotypes. Until now there is no recorded clinically effective antiviral chemotherapeutic agent for treatment of diseases caused by HRVs. Our previous study of raoulic acid tested against serotype human rhinoviruses showed anti-HRV2 (species A) and -3 (species B) activities. In this study, raoulic acid was found to possess broad-spectrum antiviral activity against six HRVs with a 50% inhibition concentration of less than 9.5 microg/mL through inhibition of the cellular absorption of the HRV particles. Furthermore, the effect of raoulic acid on resistance of HRV5 exhibited to pleconaril was more pronounced than the effect on HRV1b, -6, -14, -15, and -40. However, ribavirin did possess weak antiviral activity against HRVs. Collectively, the results demonstrate that raoulic acid is a novel therapeutic candidate for two different groups of human rhinovirus.


Lee Y.R.,Daejeon Health science College
Journal of the Korean Society of Food Science and Nutrition | Year: 2016

This study investigated the nutritional components and antioxidant activity of dry bitter melon (Momordica charantia L.). The moisture, crude protein, crude fat, crude ash, carbohydrate, and ascorbic acid contents of dry bitter melon were 6.10%, 3.31%, 1.08%, 2.31%, 87.20%, and 908.84 mg/100 g, respectively. Potassium was the most abundant mineral, followed by Mg, P, Na, Ca, Zn, Cu, and Mn, which means dry bitter melon was an alkali material. Regarding amino acid contents, dry bitter melon was rich in arginine, urea, asparagine, γ-aminobutyric acid, and alanine. Total polyphenol and total flavonoid contents of dry bitter melon extract were 36.08 mg gallic acid equivalents/extract g and 15.66 mg tannic acid equivalents/extract g, respectively. The IC50 value for 2,2-diphenyl- 1-picrylhydrazyl radical scavenging activity was 9.81 mg/mL for dry bitter melon ethanol extracts. © 2016, Korean Society of Food Science and Nutrition. All rights reserved.


Lee H.,Daejeon Health science College
Proceedings - 6th International Conference on Computer Sciences and Convergence Information Technology, ICCIT 2011 | Year: 2011

In order to satisfy the performance improvement of computing speed, many researchers have been studying in areas of both processor and memory system architectures. In the area of memory system, the linear skewing scheme has been known as a suitable one for the single instrution multiple data stream (SIMD) architecture. The scheme maps the data element located at coordinates (i, j) in an M x N data array to memory modules (ai + bj)%m, where a and b are constants and can access data elements within a block, a row, or a column subarray simultaneously without conflicts if the number of memory modules is a prime number greater than the number of data elements of within the subarray. Although these functionalities of the linear skewing scheme, it needs more memory cells than M x N data array an application uses. In this paper, a memory system is proposed to make sufficient use of unused memory cells as a local memory system for processing elements in SIMD architecture. © 2011 AICIT.

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