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Daegu, South Korea

Daegu Haany University is a South Korean university specialized in providing training for practitioners of Oriental medicine. The main campus is located a short distance outside Daegu in Gyeongsan City, North Gyeongsang province. Another campus, along with the university hospital, operates within Daegu. The current president is Joon-Koo Lee, who has served since 2010. Wikipedia.

Lee W.,Kyungpook National University | Ku S.-K.,Daegu Haany University | Bae J.-S.,Kyungpook National University
Vascular Pharmacology | Year: 2014

Endothelial cell protein C receptor (EPCR) can be shed from the cell surface, and this process is mediated by tumor necrosis factor-α converting enzyme (TACE), and high levels of soluble EPCR are involved in vascular inflammation. Orientin, one of the C-glycosyl flavonoids, has been known to have anxiolytic and antioxidative activities. However, the effect of orientin on lipopolysaccharide (LPS)-induced inflammatory response has not been studied. Here we investigated the barrier protective effects of orientin against pro-inflammatory responses induced by LPS and the associated signaling pathways. We found that orientin inhibited LPS-induced barrier disruption, expression of cell adhesion molecules (CAMs), and adhesion/transendothelial migration of monocytes to human endothelial cells. Orientin induced potent inhibition of phorbol-12-myristate 13-acetate (PMA) and LPS-induced EPCR shedding. Orientin also suppressed LPS-induced hyperpermeability and leukocyte migration in vivo. Furthermore, orientin suppressed the production of tumor necrosis factor-α (TNF-α) or Interleukin (IL)-6 and the activation of nuclear factor-κB (NF-κB) or extracellular regulated kinases (ERK) 1/2 by LPS. Moreover, treatment with orientin resulted in reduced LPS-induced lethal endotoxemia. These results suggest that orientin protects vascular barrier integrity by inhibiting hyperpermeability, expression of CAMs, and adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapy for vascular inflammatory diseases. © 2014 Elsevier Inc. Source

Kim H.-S.,Daegu Haany University
Public Health Nursing | Year: 2010

Until very recently, Korea was largely considered to be a homogenous, racially intolerant country that had little or no experience with large-scale immigration. However, this paradigm is in the process of changing. For the first time in the country's history, large numbers of foreigners are immigrating to work and live in Korea, and many are seeking to become Koreans. In particular, international marriage migrations, especially those of women entering the country through marriages to Korean men, have become common in South Korea. This has given rise to serious challenges within the country. Although conventional ideologies portray Korea as a country of a single race, culture, and language, the growing number of immigrants has disrupted this homogenous monoculture. Indeed, there are signs that Korea has reached a turning point, with an increasingly permanent and visible migrant population challenging the country's national identity. This article explores the statistics and trends related to international marriage migrant women in South Korea, particularly in terms of their social insecurities and health-related problems. In addition, some aspects of Korean governmental policies for the social integration and health promotion of these women are examined, and some suggestions are made for ways in which public health nursing and nursing education may be changed in response to the current trends. © 2010 Wiley Periodicals, Inc. Source

Ku S.-K.,Daegu Haany University | Bae J.-S.,Kyungpook National University
BMB Reports | Year: 2014

Enzymatic oxidation of pyrogallol was efficiently transformed to an oxidative product, purpurogallin (PPG). Here, the anticoagulant activities of PPG were examined by monitoring activated partial thromboplastin time (aPTT), prothrombin time (PT), and the activities of thrombin and activated factor X (FXa). And, the effects of PPG on expression of plasminogen activator inhibitor type 1 (PAI-1) and tissue-type plasminogen activator (t-PA) were evaluated in tumor necrosis factor (TNF)-α activated human umbilical vein endothelial cells (HUVECs). Treatment with PPG resulted in prolonged aPTT and PT and inhibition of the activities of thrombin and FXa, as well as inhibited production of thrombin and FXa in HUVECs. In addition, PPG inhibited thrombin-catalyzed fibrin polymerization and platelet aggregation. PPG also elicited anticoagulant effects in mice. In addition, treatment with PPG resulted in significant reduction of the PAI-1 to t-PA ratio. Collectively, PPG possesses antithrombotic activities and offers a basis for development of a novel anticoagulant. © 2014 by the The Korean Society for Biochemistry and Molecular Biology. Source

Lee Y.,Seoul National University | Ha I.D.,Daegu Haany University
Statistics and Computing | Year: 2010

Recently, the orthodox best linear unbiased predictor (BLUP) method was introduced for inference about random effects in Tweedie mixed models. With the use of h-likelihood, we illustrate that the standard likelihood procedures, developed for inference about fixed unknown parameters, can be used for inference about random effects. We show that the necessary standard error for the prediction interval of the random effect can be computed from the Hessian matrix of the h-likelihood. We also show numerically that the h-likelihood provides a prediction interval that maintains a more precise coverage probability than the BLUP method. © 2009 Springer Science+Business Media, LLC. Source

This study aimed to determine whether calcium gluconate exerts protective effects on osteoarthritis (OA) induced by anterior cruciate ligament (ACL) transection and partial medial meniscectomy. Calcium gluconate was administered by mouth daily for 84 days to male ACL transected and partial medial meniscectomized Sprague-Dawley rats 1 week after operation. Eighty-four days of treatment with 50 mg/kg calcium gluconate led to a lower degree of articular stiffness and cartilage damage compared to the OA control, possibly through inhibition of overexpressed cyclooxygenase (COX)-2 and related chondrocyte apoptosis. Similar favorable effects on stiffness and cartilage were detected in calcium gluconate-administered rats. Additionally, calcium gluconate increased 5-bromo-2'-deoxyuridine (BrdU) uptake based on observation of BrdU-immunoreactive cells on both the femur and tibia articular surface cartilages 84 days after intra-joint treatment with calcium gluconate. Taken together, our results demonstrate that calcium gluconate has a protective effect against OA through inhibition of COX-2 and related chondrocyte apoptosis. Source

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