Daana Pharmaceutical Company

Tabrīz, Iran

Daana Pharmaceutical Company

Tabrīz, Iran
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Moogooee M.,Tabriz University of Medical Sciences | Ramezanzadeh H.,Daana Pharmaceutical Company | Jasoori S.,Daana Pharmaceutical Company | Omidi Y.,Tabriz University of Medical Sciences | Davaran S.,Tabriz University of Medical Sciences
Journal of Pharmaceutical Sciences | Year: 2011

In this paper, we report the synthesis and characterization of a novel cross-linked N-isopropylacrylamide-acrylic acid-hydroxyethyl methacrylate [P (NIPASM-AA-HEM)] hydrogel nanoparticles (NPs) containing amoxicillin. The aim of present study was to investigate whether these hydrogel NPs have the potential to be used in antibiotic delivery to stomach for treatment of Helicobacter pylori. Amoxicillin-loaded hydrogel NPs were prepared using cross-linked P (NIPASM-AA-HEM) as mucoadhesive polymer for the potential use of treating gastric and duodenal ulcers. Aiming at predicting the in vivo behavior of the amoxicillin-loaded NPs, the physicochemical properties in terms of entrapment efficiency (EE%), mean diameter, and morphology of NPs was evaluated. The dependence of the EE% of the drug on the organic to aqueous phase ratio was also studied. The profile of amoxicillin release from P (NIPASM-AA-HEM) NPs system was studied under various conditions. In all these experiments, amoxicillin release in the free form was studied by ultraviolet (UV) spectrophotometric analysis. Experimental results showed that at pH 7.4, drug release rises when polymer concentration in the formulation increases; in human plasma on the contrary, drug release is reduced as concentration of the polymer in the formulation rises. In vitro amoxicillin release rate was also higher in pH 1 than that in pH 7.4. About 88.5% of amoxicillin entrapped in the NPs was released in 4 h in the pH 1.0 medium, whereas in phosphate buffer at pH 7.4 no more than 45% was released after 4 h incubation at 37°C. Amoxicillin concentration in rat's gastric tissue was determined. The results of in vivo studies showed that the hydrogel NPs enhance drug concentration at topical site than powder amoxicillin. Thus, amoxicillin-loaded hydrogel NPs may provide therapeutic concentration at a much lower dose that may reduce the adverse effects of amoxicillin in high doses. © 2010 Wiley-Liss, Inc. and the American Pharmacists Association.


Basmenji S.,Daana Pharmaceutical Company | Valizadeh H.,Tabriz University of Medical Sciences | Zakeri-Milani P.,Tabriz University of Medical Sciences
Arzneimittel-Forschung/Drug Research | Year: 2011

The aim of this study was the comparison of in vitro dissolution and in vivo bioavailability of two different brands of diclofenac sodium (CAS 15307-86-5) enteric coated tablets in healthy male Iranian volunteers in a single-dose, randomized, open-label, single blind study, which was conducted according to a crossover design in healthy volunteers. A washout interval of two weeks was selected between administrations to each subject in this study. Serial venous blood samples over 10 h after each administration to measure diclofenac sodiumconcentration in serumwere obtained, and placed into tubes containing sodium heparin. Then the plasma was separated and kept frozen at -20 °C for subsequent analysis with a modified HPLC method with UV detection. In addition, the in vitro dissolution study was performed on the brands. For the test and reference formulation, mean C max values were 2257.3 (ng/ml) and 2156 (ng/ml), respectively. The mean AUC 0 t and AUC 0 ∞ were 5726.1 (ng • h/ml) and 5917.8 (ng • h/ml) for the test and 5689.9 (ng • h/ml) and 5967.4 (ng • h/ml) for the reference formulation, respectively. Results show that the 90%confidence intervals for the ratio of test and reference products in C max (101.4-114.9%), AUCt 0 (96.3-109.1%) and AUC 0 ∞ (94.7-107.3%) were all within the 80-125% interval proposed by the FDA and EMA. Both formulations released > 80% of drug within 30 min in buffer pH= 6.8 medium. Therefore the diclofenac sodium enteric coated tablets of the test and reference formulations are bioequivalent in terms of rate and extent of absorption. © ECV • Editio Cantor Verlag.


An ultra-preconcentration technique composed of solid-phase extraction (SPE) and dispersive liquid-liquid microextraction (DLLME) coupled with gas chromatography-flame photometric detection (GC-FPD) was used for determination of thirteen organophosphorus pesticides (OPPs) including phorate, diazinon, disolfotane, methyl parathion, sumithion, chlorpyrifos, malathion, fenthion, profenphose, ethion, phosalone, azinphose-methyl and co-ral in aqueous samples. The analytes were collected from large volumes of aqueous solutions (100mL) into 100mg of a SPE C 18 sorbent. The effective variables of SPE including type and volume of elution solvent, volume and flow rate of sample solution, and salt concentration were investigated and optimized. Acetone was selected as eluent in SPE and disperser solvent in DLLME and chlorobenzene was used as extraction solvent. Under the optimal conditions, the enrichment factors were between 15,160 and 21,000 and extraction recoveries were 75.8-105.0%. The linear range was 1-10,000ngL -1 and limits of detection (LODs) were between 0.2 and 1.5ngL -1. The relative standard deviations (RSDs) for 50ngL -1 of OPPs in water with and without an internal standard, were in the range of 1.4-7.9% (n=5) and 4.0-11.6%, respectively. The relative recoveries of OPPs from well and farm water sat spiking levels of 25 and 250ngL -1 were 88-109%. © 2011 Elsevier B.V.


Aghazadeh M.,Islamic Azad University | Badali M.,Islamic Azad University | Badali M.,Daana Pharmaceutical Co. | Baradarani M.M.,Urmia University
Chimica Oggi/Chemistry Today | Year: 2016

Reaction of 5-bromo-3-(1-methylpyrrolidine)ylidene-3H-indole with methyl iodide or acetic anhydride, followed in each case by base, leads to the formation of 3-keto indoles. The reaction of this ylidene-3H-indole with acidic methylene compounds such as 1-phenylbutane-1,3-dione and malononitrile led to the formation of azepine and carbazole containing systems.


Shamsipur M.,Razi University | Fattahi N.,Razi University | Fattahi N.,Kermanshah University of Medical Sciences | Assadi Y.,Daana Pharmaceutical Company | And 2 more authors.
Talanta | Year: 2014

A solid phase extraction (SPE) coupled with dispersive liquid-liquid microextraction based on the solidification of floating organic drop (DLLME-SFO) method, using diethyldithiphosphate (DDTP) as a proper chelating agent, has been developed as an ultra preconcentration technique for the determination of inorganic arsenic in water samples prior to graphite furnace atomic absorption spectrometry (GFAAS). Variables affecting the performance of both steps were thoroughly investigated. Under optimized conditions, 100 mL of As(ΙΙΙ) solution was first concentrated using a solid phase sorbent. The extract was collected in 2.0 mL of acetone and 60.0 μL of 1-undecanol was added into the collecting solvent. The mixture was then injected rapidly into 5.0 mL of pure water for further DLLME-SFO. Total inorganic As(III, V) was extracted similarly after reduction of As(V) to As(III) with potassium iodide and sodium thiosulfate and As(V) concentration was calculated by difference. A mixture of Pd(NO3)2 and Mg(NO 3)2 was used as a chemical modifier in GFAAS. The analytical characteristics of the method were determined. The calibration graph was linear in the rage of 10-100 ng L-1 with detection limit of 2.5 ng L-1. Repeatability (intra-day) and reproducibility (inter-day) of method based on seven replicate measurements of 80 ng L-1 of As(ΙΙΙ) were 6.8% and 7.5%, respectively. The method was successfully applied to speciation of As(III), As(V) and determination of the total amount of As in water samples and in a certified reference material (NIST RSM 1643e). © 2014 Elsevier B.V.


Jamali M.R.,Payame Noor University | Assadi Y.,Daana Pharmaceutical Company | Rahnama Kozani R.,Payame Noor University
Journal of Chemistry | Year: 2013

A simple, rapid, and powerful microextraction technique was used for determination of palladium (II) ion in water samples using dispersive liquid-liquid microextraction (DLLME) followed by graphite furnace atomic absorption spectrometry (GF AAS). The different variables affecting the complexation and extraction conditions such as extraction and disperser solvent type, extraction time, pH, and concentration of chelating agent were optimized. Under the optimum conditions, the calibration graph was linear in the ranges of 0.05-1 μg L -1 with detection limit of 0.02 μg L -1. The precision (RSD ) for ten replicate determination at 0.2 μg L -1 of palladium was better than 3.5 and the enrichment factor 166.5 was obtained from only 5.0 mL of sample. Under the presence of foreign ions, no significant interference was observed. Finally, accuracy and application of the method were estimated by using test samples of natural waters spiked with different amounts of palladium. © 2013 Mohammad Reza Jamali et al.


Salehpour P.,DAANA Pharmaceutical Company | Yegani R.,Sahand University of Technology | Hajmohammadi R.,Sahand University of Technology | Hajmohammadi R.,DAANA Pharmaceutical Company
Organic Process Research and Development | Year: 2012

Cephalosporin G (Ceph-G) is one of the most important components for producing β-lactam antibiotics. It is also a starting material for the synthesis of cephalosporin antibiotics. Ceph-G was produced from penicillin G potassium (Pen-G.K.) during multiple steps consisting of conversion of Pen-G.K. to penicillin G sulfoxide followed by dehydration and ring expansion to produce Ceph-G. In this work, the amount of all starting materials and stoichiometric ratios were balanced, and the optimum values were determined. In addition, the process was optimized to evaluate the parameters affecting the scale-up of our test apparatus from laboratory to pilot scale. Difficulties for the industrial production of Ceph-G have been considered, and the production cost has been considerably decreased. In this research, Ceph-G with high purity more than 98% and high yield more than 94% was obtained. © 2012 American Chemical Society.


Majidi M.R.,University of Tabriz | Asadpour-Zeynali K.,University of Tabriz | Hafezi B.,University of Tabriz | Hafezi B.,Daana Pharmaceutical Co.
Analytical Methods | Year: 2011

A copper hexacyanoferrate nanostructure was prepared on the surface of a disposable pencil graphite electrode. The copper hexacyanoferrate nanostructures showed a pair of symmetric voltammetric peaks at 0.67 V/SCE. An electrochemical comparative characterization between copper hexacyanoferrate nano and bulk structures was presented. The transfer coefficient (α) and apparent charge rate constant (Ks) were evaluated for each of copper hexacyanoferrate nano and bulk structures. The resulting electrode exhibits an excellent electrocatalytic activity for the oxidation of ceftriaxone sodium. Cyclic voltammetry and chronoamperometry were employed to characterize the response to ceftriaxone sodium that changes linearly in the concentration range from 2 to 72 μM, with a detection limit of 0.54 μM (at a signal to noise ratio of 3). Typical features of the sensor include low cost, simple preparation, fast response, good stability, selectivity, and reproducibility. It was applied to the determination of ceftriaxone sodium in pharmaceutical samples. All results obtained were compared to the recommended procedure by British Pharmacopeia. © 2011 The Royal Society of Chemistry.


Farajzadeh M.A.,University of Tabriz | Goushjuii L.,University of Tabriz | Bashour Y.,Daana Pharmaceutical Company
Journal of Separation Science | Year: 2010

A simple, rapid and efficient sample preparation technique, dispersive liquid-liquid microextraction, coupled with gas chromatography-flame ionization detection has been developed to determine N-methylpyrrolidine in cefepime. The effect of various experimental factors on the preparation procedure, such as the nature and volume of extraction and disperser solvents, extraction time, the nature of buffer and its pH, and salt effect, was investigated, optimized and the following results were obtained: extraction solvent, chloroform; dispersive solvent and solvent for dissolving cefepime, a mixture of methanol/water (88:12, v/v); salting out agent, NaCl; and buffer, carbonate/bicarbonate (C=0.5 M, pH=12). The optimized conditions were applied to the real sample (cefepime) for the extraction and determination of N-methylpyrrolidine. The calibration graph is linear from 0.02 to 850 mg/L with the square of correlation coefficient 0.999. LOD and LOQ are 6.4 and 21.2 μg/L in solution, respectively, and 0.2 (2× 10 -5) and 0.6 (6× 10 -5) μg/g (%, w/w) in cefepime powder, respectively, using sample size 50 mg. Repeatability of the method is good and RSD% for six repeated experiments (C=170 mg/L) is 6.35%. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


A solid phase extraction (SPE) coupled with dispersive liquid-liquid microextraction based on the solidification of floating organic drop (DLLME-SFO) method, using diethyldithiphosphate (DDTP) as a proper chelating agent, has been developed as an ultra preconcentration technique for the determination of inorganic arsenic in water samples prior to graphite furnace atomic absorption spectrometry (GFAAS). Variables affecting the performance of both steps were thoroughly investigated. Under optimized conditions, 100mL of As() solution was first concentrated using a solid phase sorbent. The extract was collected in 2.0 mL of acetone and 60.0 L of 1-undecanol was added into the collecting solvent. The mixture was then injected rapidly into 5.0 mL of pure water for further DLLME-SFO. Total inorganic As(III, V) was extracted similarly after reduction of As(V) to As(III) with potassium iodide and sodium thiosulfate and As(V) concentration was calculated by difference. A mixture of Pd(NO3)2 and Mg(NO3)2 was used as a chemical modifier in GFAAS. The analytical characteristics of the method were determined. The calibration graph was linear in the rage of 10-100 ng L(-1) with detection limit of 2.5 ng L(-1). Repeatability (intra-day) and reproducibility (inter-day) of method based on seven replicate measurements of 80 ng L(-1) of As() were 6.8% and 7.5%, respectively. The method was successfully applied to speciation of As(III), As(V) and determination of the total amount of As in water samples and in a certified reference material (NIST RSM 1643e).

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