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Govindapuram, India

Satya Deepti S.,D. No 30 195 2 | Nandini L.,D. No 30 195 2
Research Journal of Pharmaceutical, Biological and Chemical Sciences

Helminth infections during pregnancy may be associated with adverse outcomes, including maternal anemia, low birth weight, and perinatal mortality. Deworming during pregnancy has therefore been strongly advocated, but its benefits have not been rigorously evaluated. In SBMCH, Chennai, 500 pregnant women were recruited to a randomized, double-blind, placebo-controlled trial investigating albendazole and mebendazole in a 2×2 factorial design. Hematinics and sulphadoxine-pyrimethamine for presumptive treatment of malaria were provided routinely. Maternal and perinatal outcomes were recorded. Analyses were by intention to treat. At enrollment, 68% of women had helminths, 45% had hookworm, 18% had Trichuris trichiura infection; 40% were anemic (hemoglobin level, < 11 g/dL). At delivery, 35% were anaemic; there was no overall effect of albendazole (odds ratio [OR], 0.95; 95% confidence interval [CI], 0.79-1.15) or Mebendazole (OR, 1.00; 95% CI, 0.83-1.21) on maternal anemia, but there was a suggestion of benefit of albendazole among women with moderate to heavy hookworm (OR, 0.45; 95% CI, 0.21-0.98; P =.15 for interaction). There was no effect of either anthelminthic treatment on mean birth weight (difference in mean associated with albendazole: -0.00 kg; 95% CI, -0.05 to 0.04 kg; difference in mean associated with praziquantel: -0.01 kg; 95% CI, -0.05 to 0.04 kg) or on proportion of low birth weight. Anthelminthic use during pregnancy showed no effect on perinatal mortality or congenital anomalies. In our study area, where helminth prevalence was high but infection intensity was low, there was no overall effect of anthelminthic use during pregnancy on maternal anemia, birth weight, perinatal mortality, or congenital anomalies. The possible benefit of albendazole against anemia in pregnant women with heavy hookworm infection warrants further investigation. Source

Surala S.D.,D. No 30 195 2 | Saraswathi K.,D. No 30 195 2 | Maram S.,D. No 30 195 2
Research Journal of Pharmaceutical, Biological and Chemical Sciences

Psychological adjustment is a significant part of Puerperium without which motherhood may become a disconcerting period in the mother, baby and the family's life. Our present study also throws more light to this fact. A Simple descriptive study was conducted in a Tertiary Care Hospital in South India to assess the incidence of early psychological manifestations and risk factors in normal puerpera with no known previous psychiatric disorders or conspicuous triggers of the same. It is found in our study that psychological manifestations are a fairly common and sizeable problem as significant numbers of puerperal women were suffering from psychological manifestations. Diagnosing any psychological manifestations, as early as 3 to 5 days post partum enables prompt and timely support and counselling to these needy women. Therefore, obstetricians who are the first contact health care personnel to the puerpera should be aware of the problem which will help notice small signs and thus help in early diagnosis and early intervention which will ultimately help better mother and child health. Source

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