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Il'ina M.V.,Mendeleev University of Chemical Technology | Timofeeva A.V.,Moscow State University | Ivanova V.T.,Ivanovskii Research Institute of Virology | Burtseva E.I.,Ivanovskii Research Institute of Virology | And 3 more authors.
Applied Biochemistry and Microbiology | Year: 2012

A modern nanomaterial made of Taunit multiwalled carbon nanotubes (MWCNTs) was used for the first time to adsorb and desorb gramicidin S and teicoplanin A2 polypeptide antibiotics. Taunit was found to absorb efficiently antibiotics under particular conditions when MWCNTs were taken in excess at 20°C for 18 h. The desorption efficiency depended on the eluent content and the structure of antibiotics. The teicoplanin A2 antibiotic was eluted with a higher yield because of its higher polarity compared to gramicidin S (86% against 65% of the total Taunit-bound antibiotic). © 2012 Pleiades Publishing, Ltd.

Golovchenko V.,Moscow State University | Bogdanova O.Y.,Ivanovskii Research Institute of Virology | Stepanov A.L.,Moscow State University | Zvyagintsev D.G.,Moscow State University
Eurasian Soil Science | Year: 2014

In a model experiment, the abundance of microorganisms was monitored for half a year in native and mechanically comminuted samples of live and dead sphagnum using the method of luminescent microscopy. The effect of the mechanical comminution was more pronounced for live sphagnum than for its waste. Mechanical comminution of live sphagnum stimulated a 2- to 4-fold increase in the total microbial biomass and a twofold increase in the emission of CO2 owing to the active development of fungi and bacteria. The abundance of microorganisms and the intensity of the CO2 flow increased with the degree of sphagnum comminution. As a result of the mechanical treatment of live sphagnum, its destruction occurred, which is indicated by the significant decrease in the C : N ratio. © 2014, Pleiades Publishing, Ltd.

Sangadzhieva A.D.,Moscow State University | Bakaeva Z.V.,Russian National Research Medical University | Samonina G.E.,Moscow State University | Mezentseva M.V.,Ivanovskii Research Institute of Virology | And 2 more authors.
Moscow University Biological Sciences Bulletin | Year: 2014

We have studied the effects of glyprolines PGP and N-acetyl-PGP on cytokine gene expression during stress and acetate-induced ulceration. Levels of RNA in mononuclear cells in circulating blood were evaluated using reverse transcription polymerase chain reaction. Intranasal administration of PGP (3.7 μmol/kg) has had a significant protective effect against stress-induced (59.4%) and acetate-induced (78.5%) ulceration in rats. N-acetyl-PGP has not changed the area of stress-induced damage, but it tended to inhibit the development of acetate ulcers. We found that stress-induced damage of gastric mucosa is accompanied by an increase in TNFα transcription and a decrease in IL-4 transcription. The development of acetate ulcers is accompanied by a decrease in expression of a number of cytokines: IFNα, IFNγ, IL-2, IL-4, IL-6, IL-12, and TNFα. The protective effect of PGP is accompanied by an increase in expression of IL-6. When N-acetyl-PGP is administered, an increase in the expression of Th-1 and Th-2 cytokines have been observed: IFNα, IFNγ, and IL-4. © 2014, Allerton Press, Inc.

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