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Maske D.S.,D G Ruparel College | Maske D.S.,Mithibai College | Joshi M.,Mithibai College | Choudhary R.,Mithibai College | Gadkari D.B.,Mithibai College
AIP Conference Proceedings | Year: 2013

The furnace of the Vertical Directional Solidification (VDS) technique is specially designed to produce increase in temperature with the height and easy control on the temperature gradient. The technique was used for bulk growths of six ingots (12 mm diameter) of InSbBi. The source materials were filled with argon in the quartz ampoules at the pressure 200 torr. The ampoules were synthesized for 50 hr at temperature 850°C. These growths were carried out with the various temperature gradients (12°C/cm to 22°C/cm) at the solid-liquid interface, to study its effect on the detachment of the ingot from the ampoule wall. As grown ingots were partially detached or totally detached. © 2013 American Institute of Physics.

Rele R.V.,D G Ruparel College | Sawant S.A.,D G Ruparel College
Der Pharma Chemica | Year: 2012

A simple , rapid, sensitive and precise UV spectrophtometric method have been developed for the estimation of oxolamine citrate from bulk drug and pharmaceutical formulation. In this method oxolamine citrate showed maximum absorbance at about 237 nm in methanol. Beer's law was followed in the concentration range of 1 to 14 μg/ ml. Regression equation was found to be y = 0.066 x -0.0008 and coefficient of correlation was 0.9990. The proposed method is accurate, sensitive, reproducible and useful for the estimation of oxolamine citrate from bulk drug and pharmaceutical formulation.

Parab S.,D G Ruparel College | Indap M.,D G Ruparel College
Asian Journal of Microbiology, Biotechnology and Environmental Sciences | Year: 2010

The aim of the present study was to evaluate the antioxidant and anticlastogenic effect of carotenoids extracted from shells of marine crab, Scylla serrata. Shells were first extracted with methanol (CM) and carotenoids were further isolated in petroleum ether soluble part (CPE) of CM extract. Carotenoid concentrate (CPE) was analyzed qualitatively and quantitatively by thin layer chromatography and spectrophotometric analysis respectively. CPE showed the presence of carotenoids- astaxanthin, canthaxanthin, astaxanthin esters, zeaxanthin and b-carotene. Both CM and CPE were examined for its protective effect against the clastogenicity induced by cyclophosphamide (CTX) using micronucleus assay in CHO cell line. The CM extract was non-cytotoxic to CHO cells even at high concentration and significantly reduced the number of micronuclei induced by CTX. Anticlastogenic effect of CM was also investigated by measuring chromosomal aberrations in Allium cepa root tip cells for three different treatments, pre-, post- and simultaneous treatment. The extract was most effective during post-treatment since there was inhibition of chromosomal aberrations up to 60.9% at highest concentration. CM also inhibited in vitro nitric oxide formation and lipid peroxidation to 91.1% and 78.1% respectively at the highest concentration of 1000μg/mL. Thus the protective effect of extract may be attributed to its potent radical scavenging activity. © Global Science Publications.

Pai N.R.,D G Ruparel College | Patil S.S.,D G Ruparel College
Research Journal of Pharmacy and Technology | Year: 2013

A simple, rapid and sensitive RP-HPLC method developed for quantitative determination of an angina pectoris drug i.e. 2,3,4-Trimetazidine Dihydrochloride and its three related substances using C18 150 X 4.6, 5um column and mobile phase consisting of aqueous buffer and Methanol. This method was validated as per ICH guideline for parameters including specificity, precision, linearity, accuracy, limit of detection and limit of quantization. The method was found to be stability -indicating and useful for analysis of drug's related substances. © RJPT.

Pai N.R.,D G Ruparel College | Vishwasrao S.,D G Ruparel College | Dubahshi D.,D G Ruparel College
Der Pharma Chemica | Year: 2012

This study aimed at evaluating the Sedative activity of structurally diverse derivatives of lead compound 8-chloro-11-(4-fluorophenyl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b] pyridin-11-ol; synthesized via straightforward and efficient synthetic process. The structures of the compounds were characterized by spectral data (IR and 1HNMR). The work was extended to study the potential role of the novel derivatives as anti-Parkinson agents.

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