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Ḩawallī, Kuwait

Abdullgaffar B.,Dubai Hospital | Kamal M.O.,Cytology Unit | Hasoub A.,Dubai Hospital
Diagnostic Cytopathology | Year: 2010

The aim of this study was to compare the frequency of abnormal cervical cytology in women with infertility problems with that of fertile women by using ThinPrep liquid-based Pap Tests™. A retrospective case-control study for over 2 years was conducted. The cases included all women with infertility problems who had Pap tests during their infertility treatment period. The cases were further subdivided into primary and secondary infertility groups. The control group included all women without infertility problems who had routine Pap tests in the same period. The age and demographic features were adjusted and matched for both groups. Statistical analysis included chi-square test and Fischer exact test. The infertility group (n = 490) showed significantly (P < 0.05) more abnormal cervical squamous epithelial abnormalities (48 positive cases, 9.8%) than the controls (n = 7,150, 216 positive cases, 3%). Women with secondary infertility had more epithelial abnormalities and more high-grade lesions than women with primary infertility. Women with infertility had statistically significant higher frequency of squamous intraepithelial lesions than women without infertility problems of similar age and demographic background. The data suggest that women with infertility might benefit from more frequent cervical cytology screening. Diagn. Cytopathol. 2010;38:791-794. © 2009 Wiley-Liss, Inc.

Das D.K.,Kuwait University | Muqim A.A.,Mubarak Al Kabeer Hospital | Sheikh Z.A.,Cytology Unit | Al-Kandari M.,Histopathology Unit | Junaid T.A.,Kuwait University
Acta Cytologica | Year: 2010

Background: Sarcoidosis is a multisystem granulomatous disorder of unknown etiology. The fine needle aspiration cytologic features are noncaseating granulomas, lymphocytes and multinucleated giant cells (MGCs) with or without asteroid bodies. Case: A 41-year-old man, an ex-smoker, presented to the Pulmonary Division of Mubarak Al-Kabeer Hospital, Safat, Kuwait, with chief complaints of dyspnea, wheezing and persistent cough of 6 weeks' duration. The imaging findings revealed air-space disease involving the right and left lower lobes and widened mediastinum with bilateral hilar and subcarinal lymphadenopathy. Such possibilities as tuberculosis, sarcoidosis and lymphoma were considered based on clinical and imaging findings. The patient underwent transbronchial needle aspiration of the enlarged paratracheal and subcarinal lymph nodes and transbronchial biopsy. Smears from the subcarinal lymph node and paraffin sections of the transbronchial biopsy revealed noncaseating epithelioid granulomas. Smears from the lymph node in addition showed asteroid bodies in epithelioid histiocytes and MGCs. Both the cytologic and histopathologic diagnoses were sarcoidosis. Conclusion: This case report highlights the presence of asteroid bodies in epithelioid histiocytes for the first time in a case of sarcoidosis. © The International Academy of Cytology.

Zappacosta R.,University of Chieti Pescara | Zappacosta R.,Surgical Pathology Unit | Gatta D.M.P.,University of Chieti Pescara | Marinucci P.,University of Chieti Pescara | And 4 more authors.
Expert Review of Molecular Diagnostics | Year: 2015

Objective: Colposcopy is widely used to triage women with mild cervical abnormalities. However, this approach is associated with low specificity and predictive value. The efficacy of E6/E7 mRNA test for this purpose has been demonstrated, but studies estimating its cost-effectiveness are still lacking. Given the limited healthcare financial resources, such an evaluation is a priority. Methods: We analyzed the clinical history of 432 women referred to colposcopy and colposcopy-directed biopsy for persisting ASCUS and LSIL, and compared three alternative triage protocols: immediate colposcopy; reflex HPV DNA testing and HPV DNA plus mRNA tests in sequence. Results: Molecular tests in sequence significantly reduce colposcopy referral, cost for assessed women, and cost for CIN2 detected. On the other hand, incremental cost-effectiveness ratio of this protocol was the highest. Conclusion: Our preliminary data, providing an estimation of the economic burden deriving from the introduction of E6/E7 mRNA test in the triage algorithm of patients with mild cervical abnormalities, may be useful for future healthcare policy. © 2015 Informa UK, Ltd.

Das D.K.,Kuwait University | Das D.K.,Cytology Unit
Geriatrics and Gerontology International | Year: 2015

Aim: Tuberculosis and carcinomatosis are the two most frequent causes of pleural effusion and exudative ascites, and both are characterized by lymphocyte-rich effusion. We attempted to discover if there is any significant difference in the age and sex distribution between patients presenting with these two conditions. Methods: A total of 161 serous effusion samples from 127 patients (89 with pleural effusion and 38 with ascites) having follow-up biopsy and histopathological examination were included in the present study. Three groups - malignancy (47 patients), tuberculosis (47) and non-tuberculous benign lesions (26) as per histopathological diagnoses - were compared in respect to age and sex distribution. Results: A total of 29 (61.7%) patients with malignancy were aged ≥50years as compared with three (6.4%) tuberculosis patients with serous effusions (P=0.00000). A similar trend was observed in the ≥60years age group (18 or 38.3% malignancy vs none with tuberculosis, P=0.00000). A total of 36 (76.6%) tuberculous effusion patients were aged less than 40years as opposed to eight (17.0%) patients with malignant effusions (P=0.00000). There was also s significant difference between tuberculous and non-tuberculous benign lesions in the ≥50years age group (6.4% vs 69.2%, P=0.00000), but no significant difference between malignancy and non-tuberculous benign lesions (P=0.61385). There were 31 female (66.0%) patients with malignancy, which was significantly higher than that of patients with tuberculosis (16, [34%], P=0.00365) and non-specific inflammation/benign lesions (23.1%, P=0.00059). However, the difference between tuberculosis and non-tuberculous benign lesions was not significant (P=0.42756). Conclusion: Whereas malignancy in serous effusions is found in older and middle-aged people, tuberculous effusion is a disease of younger people. © 2015 Japan Geriatrics Society.

Das D.K.,Kuwait University | Das D.K.,Cytology Unit | Muqim A.T.,Mubarak Al Kabeer Hospital | Haji B.I.,Cytology Unit | And 2 more authors.
Journal of Cytology | Year: 2011

Small cell lung carcinoma represents a group of highly malignant tumors giving rise to early and widespread metastasis at the time of diagnosis. However, the pancreas is a relatively infrequent site of metastasis by this neoplasm, and there are only occasional reports on its fine needle aspiration (FNA) cytology diagnosis. A 66-year-old man presented with extensive mediastinal lymphadenopathy and a mass in the pancreatic tail. Ultrasound-guided FNA smears from the pancreatic mass contained small, round tumor cells with extensive nuclear molding. The cytodiagnosis was metastatic small cell carcinoma. Immunocytochemical staining showed that a variable number of neoplastic cell were positive for cytokeratin, chromogranin A, neurone-specific enolase and synaptophysin but negative for leukocyte common antigen. The trans-bronchial needle aspiration was non-diagnostic, but biopsy was suspicious of a small cell carcinoma. This case represents a rare metastatic lesion in the pancreas from small cell lung carcinoma, diagnosed by FNA cytology.

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