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Patent
Cytocentrics | Date: 2015-05-21

A compact in vitro diagnostic (WD) device is used to provide in vitro model-based diagnosis and a basis for model-based therapy planning. The IVD device and an associated procedure may be used to assess the effect of drugs on the electro-physiological phenotype of cardiomyocytes or any cell of a patient. The effects may be assessed in a clinical environment. The assessed information for the patient may be combined with clinical data for the patient and provided to a database. The database may collect the assessment results and clinical patient data for a plurality of patients. The information in the database may be used to assist in therapy planning for future patients.


Grant
Agency: European Commission | Branch: H2020 | Program: ECSEL-IA | Phase: ECSEL-02-2014 | Award Amount: 48.05M | Year: 2015

The goal of the InForMed project is to establish an integrated pilot line for medical devices. The pilot line includes micro-fabrication, assembly and even the fabrication of smart catheters. The heart of this chain is the micro-fabrication and assembly facility of Philips Innovation Services, which will be qualified for small/medium-scale production of medical devices. The pilot facility will be open to other users for pilot production and product validation. It is the aim of the pilot line: to safeguard and consolidate Europes strong position in traditional medical diagnostic equipment, to enable emerging markets - especially in smart minimally invasive instruments and point-of-care diagnostic equipment - and to stimulate the development of entirely new markets, by providing an industrial micro-fabrication and assembly facility where new materials can be processed and assembled. The pilot line will be integrated in a complete innovation value chain from technology concept to high-volume production and system qualification. Protocols will be developed to ensure an efficient technology transfer between the different links in the value chain. Six challenging demonstrators products will be realized that address societal challenges in: Hospital and Heuristic Care and Home care and well-being, and demonstrate the trend towards Smart Health solutions.


Leifert A.,Institute of Inorganic Chemistry | Pan Y.,RWTH Aachen | Kinkeldey A.,RWTH Aachen | Schiefer F.,Institute of Inorganic Chemistry | And 7 more authors.
Proceedings of the National Academy of Sciences of the United States of America | Year: 2013

Understanding the mechanism of toxicity of nanomaterials remains a challenge with respect to both mechanisms involved and product regulation. Here we show toxicity of ultrasmall gold nanoparticles (AuNPs). Depending on the ligand chemistry, 1.4-nm-diameter AuNPs failed electrophysiology-based safety testing using human embryonic kidney cell line 293 cells expressing human ether-á-go-go- Related gene (hERG), a Food and Drug Administration- established drug safety test. In patch-clamp experiments, phosphine-stabilized AuNPs irreversibly blocked hERG channels, whereas thiol-stabilized AuNPs of similar size had no effect in vitro, and neither particle blocked the channel in vivo. We conclude that safety regulations may need to be reevaluated and adapted to reflect the fact that the binding modality of surface functional groups becomes a relevant parameter for the design of nanoscale bioactive compounds.


Patent
Cytocentrics | Date: 2015-02-18

An apparatus for determining preferably Biologically Relevant Measurement Variables at membranes has at least one first plate-like or film-like substrate, which is made from at least one first material and has continuous openings or pores or can be perforated, and also has a second plate-like or film-like substrate which is made from at least one second material, to which measuring elements are assigned or on which measuring elements are situated. Cells or similar structures may be at least temporarily applied or permanently cultivated on the first substrate. According to the invention, the first substrate and the second substrate are assigned to one another at least during the measuring operation for determining the corresponding measurement variables, specifically preferably on flat sides which are opposite one another. In particular, this assignment is a connection of the two substrates, preferably a joining-together.


Trademark
Cytocentrics | Date: 2016-11-18

AUTOMATED OR MANUALLY OPERATED APPARATUS, DEVICES AND EQUIPMENT FOR ANALYSIS AND/OR RESEARCH OF PROCESSES IN OR WITH BIOLOGICAL CELLS OR FOR THE ANALYSIS AND/OR RESEARCH OF CHARACTERISTICS OF BIOLOGICAL CELLS, namely, MICROFLUIDIC CHIPS FOR CONTACTING BIOLOGICAL CELLS, HOLDERS FOR CONTACTING AND HANDLING THE AFOREMENTIONED CHIPS, AND ASSAY MACHINES FOR SUPPLYING BIOLOGICAL CELLS TO THE AFOREMENTIONED CHIPS AND FOR TAKING MEASUREMENTS OF BIOLOGICAL CHARACTERISTICS OF THE CELLS. TRAINING SERVICES IN THE FIELD OF SCIENTIFIC ANALYSIS AND RESEARCH OF BIOLOGICAL CELLS; TRAINING SERVICES IN THE FIELD OF ESTIMATION OF ELECTROPHYSIOLOGICAL QUANTITIES OF BIOLOGICAL CELLS BY MEANS OF MEASURING TECHNOLOGY. SCIENTIFIC AND INDUSTRIAL RESEARCH; RESEARCH AND ANALYSIS IN THE FIELD OF BIOLOGICAL CELLS; COMPUTER SOFTWARE DEVELOPMENT, NAMELY, DEVELOPING DATA PROCESSING COMPUTER PROGRAMS; COMPUTER PROGRAMMING IN THE FIELD OF AUTOMATED ESTIMATION OF PHYSICAL STATE VARIABLES OF BIOLOGICAL CELLS BY MEANS OF MEASURING TECHNOLOGY; COMPUTER HARDWARE DEVELOPMENT, NAMELY, CUSTOMER SPECIFIC DEVELOPMENT OF APPARATUS, DEVICES AND EQUIPMENT FOR SCIENTIFIC ANALYSIS AND/OR RESEARCH OF BIOLOGICAL CELLS AND/OR FOR THE ESTIMATION OF PHYSICAL STATE VARIABLES OF BIOLOGICAL CELLS BY MEANS OF MEASURING TECHNOLOGY.


Trademark
Cytocentrics | Date: 2016-12-07

AUTOMATED OR MANUALLY OPERATED APPARATUS, DEVICES AND EQUIPMENT FOR ANALYSIS AND/OR RESEARCH OF PROCESSES IN OR WITH BIOLOGICAL CELLS OR FOR THE ANALYSIS AND/OR RESEARCH OF CHARACTERISTICS OF BIOLOGICAL CELLS, namely, MICROFLUIDIC CHIPS FOR CONTACTING BIOLOGICAL CELLS, HOLDERS FOR CONTACTING AND HANDLING THE AFOREMENTIONED CHIPS, AND ASSAY MACHINES FOR SUPPLYING BIOLOGICAL CELLS TO THE AFOREMENTIONED CHIPS AND FOR TAKING MEASUREMENTS OF BIOLOGICAL CHARACTERISTICS OF THE CELLS. TRAINING SERVICES IN THE FIELD OF SCIENTIFIC ANALYSIS AND RESEARCH OF BIOLOGICAL CELLS; TRAINING SERVICES IN THE FIELD OF ESTIMATION OF ELECTROPHYSIOLOGICAL QUANTITIES OF BIOLOGICAL CELLS BY MEANS OF MEASURING TECHNOLOGY. SCIENTIFIC AND INDUSTRIAL RESEARCH; RESEARCH AND ANALYSIS IN THE FIELD OF BIOLOGICAL CELLS; COMPUTER SOFTWARE DEVELOPMENT, NAMELY, DEVELOPING DATA PROCESSING COMPUTER PROGRAMS; COMPUTER PROGRAMMING IN THE FIELD OF AUTOMATED ESTIMATION OF PHYSICAL STATE VARIABLES OF BIOLOGICAL CELLS BY MEANS OF MEASURING TECHNOLOGY; COMPUTER HARDWARE DEVELOPMENT, NAMELY, CUSTOMER SPECIFIC DEVELOPMENT OF APPARATUS, DEVICES AND EQUIPMENT FOR SCIENTIFIC ANALYSIS AND/OR RESEARCH OF BIOLOGICAL CELLS AND/OR FOR THE ESTIMATION OF PHYSICAL STATE VARIABLES OF BIOLOGICAL CELLS BY MEANS OF MEASURING TECHNOLOGY.


Trademark
Cytocentrics | Date: 2016-09-21

AUTOMATED OR MANUALLY OPERATED APPARATUS, DEVICES AND EQUIPMENT FOR ANALYSIS AND/OR RESEARCH OF PROCESSES IN OR WITH BIOLOGICAL CELLS OR FOR THE ANALYSIS AND/OR RESEARCH OF CHARACTERISTICS OF BIOLOGICAL CELLS, namely, MICROFLUIDIC CHIPS FOR CONTACTING BIOLOGICAL CELLS, HOLDERS FOR CONTACTING AND HANDLING THE AFOREMENTIONED CHIPS, AND ASSAY MACHINES FOR SUPPLYING BIOLOGICAL CELLS TO THE AFOREMENTIONED CHIPS AND FOR TAKING MEASUREMENTS OF BIOLOGICAL CHARACTERISTICS OF THE CELLS. TRAINING SERVICES IN THE FIELD OF SCIENTIFIC ANALYSIS AND RESEARCH OF BIOLOGICAL CELLS; TRAINING SERVICES IN THE FIELD OF ESTIMATION OF ELECTROPHYSIOLOGICAL QUANTITIES OF BIOLOGICAL CELLS BY MEANS OF MEASURING TECHNOLOGY. SCIENTIFIC AND INDUSTRIAL RESEARCH; RESEARCH AND ANALYSIS IN THE FIELD OF BIOLOGICAL CELLS; COMPUTER SOFTWARE DEVELOPMENT, NAMELY, DEVELOPING DATA PROCESSING COMPUTER PROGRAMS; COMPUTER PROGRAMMING IN THE FIELD OF AUTOMATED ESTIMATION OF PHYSICAL STATE VARIABLES OF BIOLOGICAL CELLS BY MEANS OF MEASURING TECHNOLOGY; COMPUTER HARDWARE DEVELOPMENT, NAMELY, CUSTOMER SPECIFIC DEVELOPMENT OF APPARATUS, DEVICES AND EQUIPMENT FOR SCIENTIFIC ANALYSIS AND/OR RESEARCH OF BIOLOGICAL CELLS AND/OR FOR THE ESTIMATION OF PHYSICAL STATE VARIABLES OF BIOLOGICAL CELLS BY MEANS OF MEASURING TECHNOLOGY.


SAN ANTONIO--(BUSINESS WIRE)--Cytocentrics, Inc. tiene un nuevo nombre, CytoBioscience, y un nuevo logotipo. La nueva identidad corporativa entrará en vigor con efecto inmediato, ha comentado el CEO de la empresa, el Dr. James Garvin. «Estamos ampliando nuestra presencia en el campo de la biociencia», ha declarado Garvin, «y este nuevo nombre refleja el continuo crecimiento de este campo de negocio”. «CytoBioscience crea y fabrica dispositivos que representan una convergencia de biociencia, nan


SAN ANTONIO--(BUSINESS WIRE)--Cytocentrics, Inc. has a new name – CytoBioscience – and a new logo. The new corporate identity is effective immediately, said company CEO Dr. James Garvin. “We are expanding our footprint in the biosciences arena,” Garvin said, “and this new name reflects that growing area of business activity.” CytoBioscience creates and manufactures devices that represent a convergence of bioscience, nano science, microchip development, algorithms and engineering, he said. The company’s devices allow other researchers, medical institutions and pharmaceutical companies to better understand how human cells react to medicine. “This name change is a natural step for us,” Garvin said. “We are more and more involved in treatment modalities, research associated with cancer, diabetes and other diseases. Our ion channel research facility is pulling us into these areas as we help researchers and doctors look into disease causes and potential treatment options.” Garvin said the company is considering new acquisitions and other business development opportunities, and hopes to have new announcements soon. CytoBioscience was founded in Germany and moved its headquarters and manufacturing to San Antonio in 2015.

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