Cyclotron Research Center

South Korea

Cyclotron Research Center

South Korea

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Galanaud D.,University Pierre and Marie Curie | Perlbarg V.,University Pierre and Marie Curie | Gupta R.,Massachusetts General Hospital | Stevens R.D.,Johns Hopkins University | And 18 more authors.
Anesthesiology | Year: 2012

BACKGROUND:: Existing methods to predict recovery after severe traumatic brain injury lack accuracy. The aim of this study is to determine the prognostic value of quantitative diffusion tensor imaging (DTI). METHODS:: In a multicenter study, the authors prospectively enrolled 105 patients who remained comatose at least 7 days after traumatic brain injury. Patients underwent brain magnetic resonance imaging, including DTI in 20 preselected white matter tracts. Patients were evaluated at 1 yr with a modified Glasgow Outcome Scale. A composite DTI score was constructed for outcome prognostication on this training database and then validated on an independent database (n = 38). DTI score was compared with the International Mission for Prognosis and Analysis of Clinical Trials Score. RESULTS:: Using the DTI score for prediction of unfavorable outcome on the training database, the area under the receiver operating characteristic curve was 0.84 (95% CI: 0.75-0.91). The DTI score had a sensitivity of 64% and a specificity of 95% for the prediction of unfavorable outcome. On the validation-independent database, the area under the receiver operating characteristic curve was 0.80 (95% CI: 0.54-0.94). On the training database, reclassification methods showed significant improvement of classification accuracy (P < 0.05) compared with the International Mission for Prognosis and Analysis of Clinical Trials score. Similar results were observed on the validation database. CONCLUSIONS:: White matter assessment with quantitative DTI increases the accuracy of long-term outcome prediction compared with the available clinical/radiographic prognostic score. © 2012, the American Society of Anesthesiologists, Inc.


Sohn M.-H.,Research Institute of Clinical Medicine | Sohn M.-H.,Cyclotron Research Center | Lim S.T.,Research Institute of Clinical Medicine | Lim S.T.,Cyclotron Research Center | And 6 more authors.
Clinical Nuclear Medicine | Year: 2010

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. However, RMS rarely affects adults. A 68-year-old woman was admitted for evaluation of a huge mass in the left lower leg. A biopsy confirmed RMS. Tc-99m MDP bone scintigraphy was obtained to evaluate bone metastases, and diffusely increased uptake was noted in the huge soft tissue mass of the left lower extremity with linear increased uptake along the left tibia and fibula corresponding to the bony destructive lesion on the radiograph. This case presents extraosseous uptake of Tc-99m MDP by a giant RMS with bone invasion of the left lower extremity in an elderly woman. © 2010 by Lippincott Williams & Wilkins.


PubMed | Cyclotron Research Center and University of Liège
Type: Journal Article | Journal: Cerebral cortex (New York, N.Y. : 1991) | Year: 2016

Genetic variability related to the catechol-O-methyltransferase (COMT) gene (Val(158)Met) has received increasing attention as a possible modulator of executive functioning and its neural correlates. However, this attention has generally centered on the prefrontal cortices because of the well-known direct impact of COMT enzyme on these cerebral regions. In this study, we were interested in the modulating effect of COMT genotype on anterior and posterior brain areas underlying interference resolution during a Stroop task. More specifically, we were interested in the functional connectivity between the right inferior frontal operculum (IFop), an area frequently associated with inhibitory efficiency, and posterior brain regions involved in reading/naming processes (the 2 main non-executive determinants of the Stroop effect). The Stroop task was administered during functional magnetic resonance imaging scanning to 3 groups of 15 young adults divided according to their COMT Val(158)Met genotype [Val/Val (VV), Val/Met (VM), and Met/Met (MM)]. Results indicate greater activity in the right IFop and the left middle temporal gyrus in homozygous VV individuals than in Met allele carriers. In addition, the VV group exhibited stronger positive functional connectivity between these 2 brain regions and stronger negative connectivity between the right IFop and left lingual gyrus. These results confirm the impact of COMT genotype on frontal functions. They also strongly suggest that differences in frontal activity influence posterior brain regions related to a non-executive component of the task. Particularly, changes in functional connectivity between anterior and posterior brain areas might correspond to compensatory processes for performing the task efficiently when the available dopamine level is low.


Jeong H.-S.,Chonbuk National University | Jeong H.-S.,Biomedical Research Institute | Jeong H.-S.,Cyclotron Research Center | Jeong H.-S.,Institute for Medical science | And 29 more authors.
Journal of Liposome Research | Year: 2013

The imaging of sentinel lymph nodes (SLN) has been researched for its role in assessing cancer progression and postsurgical lymphedema. Indocyanine green (ICG) is a near-infrared (NIR) optical dye that has been approved by the Food and Drug Administration. It is known that liposome-encapsulated ICG (LP-ICG) has improved stability and fluorescence signal compared with ICG. We designed mannosylated liposome-encapsulated ICG (M-LP-ICG) as an optical contrast agent for SLN. M-LP-ICG has a higher UV absorbance spectrum and fluorescence intensity than LP-ICG. The stability of M-LP-ICG measured in 50° fetal bovine serum solution by a dialysis method was better than that of LP-ICG. M-LP-ICG demonstrated a high uptake in RAW 264.7 macrophage cell because the density of mannose is high. There were differences between M-LP-ICG and glucosylated liposome-encapsulated ICG (G-LP-ICG), which are geometrical isomers. The result of an inhibition study of M-LP-ICG showed a statistically significant decrease in uptake in RAW 264.7 cells after either co-treatment or pre-treatment with d-(+)-mannose as an inhibitor. Results from an in vitro experiment demonstrated that M-LP-ICG was specifically taken up by macrophage cells through the mannose receptor on its surface. The time-series images acquired from a normal mouse model after subcutaneous injection showed that the signal from M-LP-ICG in SLN and other organs appeared early and disappeared quickly in comparison with signals from LP-ICG. Not only the sentinel but also the draining lymph nodes were observed partly in M-LP-ICG. M-LP-ICG appears to increase the specificity of uptake and retention in macrophages, making it a good candidate contrast agent for an optic imaging system for SLN and the lymphatic system. © 2013 Informa Healthcare USA, Inc. All rights reserved.


Boutaayamou M.,University of Liège | Boutaayamou M.,INTELSIG Laboratory | Bruls O.,University of Liège | Denoel V.,University of Liège | And 6 more authors.
2015 International Conference on 3D Imaging, IC3D 2015 - Proceedings | Year: 2015

We describe a new gait segmentation method based on the continuous wavelet transform to identify stride-by-stride gait cycles from measurements of foot-mounted three-dimensional (3D) accelerometers. The detection of such gait cycles is indeed a crucial step for an accurate extraction of relevant gait events such as heel strike, toe strike, heel-off, and toe-off. We demonstrate the ability of this segmentation method, used in conjunction with a validated extraction algorithm, to calculate the following gait (duration) parameters for each gait cycle during the gait of a healthy young subject and of an elderly subject with Parkinson's disease (PD) in OFF and ON states: durations of (1) loading response, (2) mid-stance, (3) push-off, (4) stance, (5) swing, (6) stride, (7) step, and (8) double support phases. The experimental results show that the proposed method can extract relevant refined gait parameters to quantify subtle gait disturbances in subjects with PD. © 2015 IEEE.


Henrottin J.,Cyclotron Research Center | Zervosen A.,Cyclotron Research Center | Lemaire C.,Cyclotron Research Center | Sapunaric F.,University of Liège | And 6 more authors.
ACS Medicinal Chemistry Letters | Year: 2015

Indoleamine 2,3-dioxygenase (hIDO) is an enzyme that catalyzes the oxidative cleavage of the indole ring of l-tryptophan through the kynurenine pathway, thereby exerting immunosuppressive properties in inflammatory and tumoral tissues. The syntheses of 1-(2-fluoroethyl)-tryptophan (1-FETrp) and 1-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methyl)-tryptophan, two N1-fluoroalkylated tryptophan derivatives, are described here. In vitro enzymatic assays with these two new potential substrates of hIDO show that 1-FETrp is a good and specific substrate of hIDO. Therefore, its radioactive isotopomer, 1-[18F]FETrp, should be a molecule of choice to visualize tumoral and inflammatory tissues and/or to validate new potential inhibitors. © 2015 American Chemical Society.


Javanainen A.,University of Jyväskylä | Trzaska W.H.,University of Jyväskylä | Trzaska W.H.,Helsinki Institute of Physics | Harboe-Sorensen R.,European Space Agency | And 3 more authors.
IEEE Transactions on Nuclear Science | Year: 2010

Semi-empirical fitting based on classical Bohr theory has been applied to the experimental LET data in silicon of the RADEF heavy ion cocktail species. The parameterized LET descriptions to be used in the European Component Irradiation Facilities are introduced and compared with the commonly used estimations from SRIM-code. Also, a new user interface, ECIF Cocktail Calculator, based on this work, has been published under the RADEF webpages at http://www.jyu.fi/accelerator/radef/ECIFCalc. © 2010 IEEE.


Landsness E.,University of Liège | Landsness E.,University of Wisconsin - Madison | Bruno M.-A.,University of Liège | Noirhomme Q.,University of Liège | And 8 more authors.
Brain | Year: 2011

The existence of normal sleep in patients in a vegetative state is still a matter of debate. Previous electrophysiological sleep studies in patients with disorders of consciousness did not differentiate patients in a vegetative state from patients in a minimally conscious state. Using high-density electroencephalographic sleep recordings, 11 patients with disorders of consciousness (six in a minimally conscious state, five in a vegetative state) were studied to correlate the electrophysiological changes associated with sleep to behavioural changes in vigilance (sustained eye closure and muscle inactivity). All minimally conscious patients showed clear electroencephalographic changes associated with decreases in behavioural vigilance. In the five minimally conscious patients showing sustained behavioural sleep periods, we identified several electrophysiological characteristics typical of normal sleep. In particular, all minimally conscious patients showed an alternating non-rapid eye movement/rapid eye movement sleep pattern and a homoeostatic decline of electroencephalographic slow wave activity through the night. In contrast, for most patients in a vegetative state, while preserved behavioural sleep was observed, the electroencephalographic patterns remained virtually unchanged during periods with the eyes closed compared to periods of behavioural wakefulness (eyes open and muscle activity). No slow wave sleep or rapid eye movement sleep stages could be identified and no homoeostatic regulation of sleep-related slow wave activity was observed over the night-time period. In conclusion, we observed behavioural, but no electrophysiological, sleep wake patterns in patients in a vegetative state, while there were near-to-normal patterns of sleep in patients in a minimally conscious state. These results shed light on the relationship between sleep electrophysiology and the level of consciousness in severely brain-damaged patients. We suggest that the study of sleep and homoeostatic regulation of slow wave activity may provide a complementary tool for the assessment of brain function in minimally conscious state and vegetative state patients. © 2011 The Author.


Seelaar H.,Erasmus University Rotterdam | Papma J.M.,Erasmus University Rotterdam | Garraux G.,Cyclotron Research Center | Garraux G.,University of Liège | And 7 more authors.
Neurology | Year: 2011

Objective: Frontotemporal lobar degeneration (FTLD) is a clinically, genetically, and pathologically heterogeneous disorder. The aim of this study was to compare clinical features and perfusion patterns on SPECT of patients with familial FTLD-TAR DNA binding protein 43 kDa (TDP) and MAPT mutations. Methods: Patients were included if they had MAPT or GRN mutations, positive family history with pathologically proven FTLD in the patient or first-degree relative, or were part of FTD-MND families. All patients and 10 age- and gender-matched controls underwent measurement of brain perfusion using 99mTc-HMPAO SPECT. We used SPM8 to perform image processing and oxelbased group analyses (p < 0.001). Gender and age were included as nuisance variables in the design matrices. Results: Of the 29 patients with familial FTLD, 19 had familial FTLD-TDP (GRN mutations in 6), and 10 had MAPT mutations. At clinical presentation, familial FTLD-TDP patients were older at onset (p = 0.030) and had more memory deficits (p < 0.011), whereas patients with MAPT had more naming deficits (p = 0.001) and obsessive-compulsive behavior (p = 0.001). The betweengroups SPECT analyses revealed significantly less perfusion in the right frontal lobe, precuneus, cuneus, and inferior parietal lobule in familial FTLD-TDP, whereas significantly less perfusion was found in the left temporal and inferior frontal gyri in MAPT. Post hoc analysis of familial FTLD-TDP with unknown genetic defect vs MAPT revealed less perfusion in the right frontal and parietal lobe. Conclusion: Familial FTLD-TDP shows relatively more posterior hypoperfusion, including the precuneus and inferior parietal lobule, possibly related to significant memory impairment. Patients with MAPT were characterized by impaired perfusion of the temporal regions and naming deficits. © 2011 by AAN Enterprises Inc.

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