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Patent
CyberLogic, Inc. | Date: 2011-01-27

An invention is disclosed for locating a region of interest in the calcaneus. A pair of ultrasound transducers are positioned on the medial and lateral sides of the heel, respectively. The positioning is based on a size of a portion of the body of a subject upon whom the ultrasound assessment of the calcaneus is to be made. In a presently preferred embodiment, the length of the foot from the back to the head of the first metatarsal is used in conjunction with a proportionality constant and an angle, to position the pair of transducers. The positioning so obtained facilitates (i) reproducible measurements and (ii) comparisons of the results obtained in one person with another, because relatively analogous portions of the highly heterogeneous calcanei are assessed in both. In an alternative embodiment, a single transducer is positioned similarly on the heel, operating in pulse-echo mode.


Patent
CyberLogic, Inc. | Date: 2010-02-11

An invention is disclosed for locating a region of interest (ROI) in the radius. A method and apparatus are disclosed that use a pair of ultrasound transducers for ultrasound assessment of various properties of bone. The invention includes positioning the transducers on the anterior-posterior (dorsal and ventral) sides of a forearm of an individual. The positioning is based on the forearm length, and a selected percentage of this length at which the ROI is desired. In a presently preferred embodiment of the invention, the ROI is defined as the ^(rd )location. An arm is placed in an ultrasound fixture which has a first surface, a second surface with a raised portion against which the ulna styloid process is placed, and a third surface on which the elbow is placed. The distance between the raised portion of the second surface and the centerlines of the pair of ultrasound transducers is adjustable. The positioning so obtained leads to the ability to make both (i) reproducible measurements and (ii) to be able to compare the results obtained in one person with another, because relatively analogous portions of the radii are assessed in both. In an alternative embodiment of the invention, a single transducer is positioned similarly on the forearm, operating in pulse-echo mode.


Grant
Agency: National Science Foundation | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 150.00K | Year: 2013

This Small Business Innovation Research (SBIR) Phase I project has as its long range objective development of a portable and non-invasive 'ocean-ready' ultrasound device for measuring dolphin bone mineral density (BMD), as a means for assessing and monitoring dolphin and ecosystem health. At present there is no way to assess bone health in dolphins in managed or in free-ranging populations. The specific objectives of this project are (i) to determine the BMD associated with an extensive set of archived skeletal samples from stranded bottlenose dolphins across a range of geographically distinct populations and obtain a set of normative BMD curves versus age, according to gender and other individual-specific morphometric features; (ii) to determine a functional relationship between age and BMD and other individual-specific features; and (iii) to develop an ultrasound method and laboratory system capable of accurately estimating dolphin BMD. X-ray densitometry will be used to determine the BMD of the dolphin radii, and computer simulated and in vitro ultrasound measurements will be used to determine a set of ultrasound parameters. An ultrasound based-estimate of BMD will be established, and the degree to which BMD and morphometric measurements can estimate dolphin age (a key aspect of understanding dolphin/marine ecosystem health) will be established. The broader impact/commercial potential of this project is in its potential for managing and dealing with changes in the ecosystem such as through climate change and from exposure to contaminants. The proposed technology therefore has the potential for significantly expanding the ability of the scientific community to assess not only dolphin but overall marine ecosystem health. In addition, an ultrasonically determined value of BMD that could further be used to estimate dolphin age would have significant and additional commercial value worldwide. This value will be realized by marketing a commercial ultrasound product and by offering a commercial service to marine ecosystem health assessment groups. The degree to which the understanding of dolphin and ecosystem health may be positively impacted by the ultrasound technology to be developed in this project cannot be understated. As already noted, there is virtually little if anything presently known about bone properties of dolphins, how they may change over time, and how they may reflect changing climates and contaminants in the oceans. This research may also have analogous significant impacts on the health assessments of other aquatic mammals, such as sea lions and whales. In addition, the USB-based portable ultrasound technology developed in this project should also have large commercial value in the field of non-destructive testing.


Patent
CyberLogic, Inc. | Date: 2011-07-07

A method and apparatus for non-invasive and quantitative assessment of the status of a lumbar vertebral body in a living being for at least one of several quantities (e.g., bone-mineral density, bone mass, etc.) is provided. The method includes the steps of acoustically coupling first and second transducers to nearby skin on opposite sides of a torso of the living being and generating an ultrasound signal and directing the ultrasound signal from the first transducer to the second transducer through the torso. At least a portion of the ultrasound signal passes through the lumbar vertebral body and the second transducer generates an output signal responsive to receipt of the ultrasound signal. The method further includes the step of processing the output signal to obtain an estimate of the at least one quantity.


Grant
Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: SBIR | Phase: Phase II | Award Amount: 1.21M | Year: 2014

DESCRIPTION provided by applicant This Lab to Marketplace SBIR Phase I Phase II Fast Track Application has as its long term objective to establish ultrasound as a safe effective and non invasive method for assessing fracture risk an important component in clinical management of osteoporosis Osteoporosis afflicts over million people in the U S and is responsible for more than hip fractures annually Currently the primary means for assessment relies on densitometric techniques These methods subject the patient to ionizing radiation are relatively expensive and do not always provide good estimates of bone strength Ultrasound offers several potential advantages It is non ionizing and relatively inexpensive Moreover since ultrasound is a mechanical wave and interacts with bone in a fundamentally different manner than electromagnetic radiation it may ultimately be able to provide more accurate estimates of bone strength and fracture risk compared with current densitometric methods The goal of this research is to develop a new ultrasound system for bone assessment that is not only accurate but also highly reproducible The system will assess the heel bone calcaneus distal forearm employ a novel positioning device that is foot size based The technology is designed to achieve both high reproducibility as well as analogous regions of interest among different individuals to be compared This is crucial given the high degree of heterogeneity that exists in the calcaneus This research should enable the widespread detection of osteoporosis and fracture risk and will find application not only in the U S but worldwide as well The specific aims of this Lab to Marketplace Fast Track SBIR Application are to demonstrate the feasibility of a novel positioning device which in conjunction with CyberLogicandapos s NTD technology to accurately and reproducibly estimate BMD at the calcaneus This will be achieved by clinical testing in Phase I using a laboratory prototype that incorporates the patented positioning technology This will if successful be followed by fabrication of a clinical device in the first year of Phase II followed by months of extensive Phase II clinical testing which will include comparison of ultrasound data in subjects with and without fragility fractures Finally the last year of Phase II will include submission to FDA of a k application The ultimate goal of this research is to commercialize this novel heel ultrasound device and to bring it into worldwide use for a simple safe and effective instrument for bone density estimation and fracture risk assessment PUBLIC HEALTH RELEVANCE As stated by the National Osteoporosis Foundation osteoporosis is a major public health threat for an estimated million Americans or percent of the people years of age and older In the U S million individuals are estimated to already have the disease and almost million more are estimated to have low bone mass placing them at increased risk for osteoporosis While osteoporosis is often thought of as an older personandapos s disease it can strike at any age Osteoporosis is responsible for more than million fractures annually including over hip fractures and approximately vertebral fractures and wrist fractures Notwithstanding these facts osteoporosis is under recognized and under treated The proposed research should enable bone testing to be done conveniently and safely in a primary care setting This should lead to earlier detection and treatment and ultimately to reductions in the number of fractures


Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase II | Award Amount: 857.86K | Year: 2010

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Trademark
CyberLogic, Inc. | Date: 2010-07-06

Medical non-imaging ultrasound apparatus for diagnosis and management of osteoporosis and assessment of bone strength and bone fracture risk.


Patent
CyberLogic, Inc. | Date: 2015-01-13

A method and system for quantitatively evaluating bone fracture risk in a living being are provided that generate a value for an index indicative of a degree of bone fracture risk. In one embodiment, the method includes the step of acquiring values for a height H, a weight W, and a bone mineral density BMD of the living being. The method further includes the step of calculating a quantitative bone fracture risk index QI associated with the living being in accordance with the formula QI=H^()*W^()/BMD^() where , , and are constants selected based on previously obtained data indicative of bone fracture risk.


Patent
CyberLogic, Inc. | Date: 2015-01-12

An ultrasound measurement device and related method for ultrasonic measurement are provided. In one embodiment the device includes a first a first ultrasound transducer and a second ultrasound transducer spaced from the first ultrasound transducer and configured to receive a plurality of ultrasound signals transmitted from the first ultrasound transducer through a fixed object. The device further includes means for moving the first and second ultrasound transducers together relative to the object over an area of the object in a first direction, the first ultrasound transducer generating an ultrasound signal of the plurality of ultrasound signals at each of a plurality of locations within the area. In this manner, the device achieves the functionality of array transducers with transducers having fewer transducer elements.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: | Award Amount: 150.00K | Year: 2013

This Small Business Innovation Research (SBIR) Phase I project has as its long range objective development of a portable and non-invasive ocean-ready ultrasound device for measuring dolphin bone mineral density (BMD), as a means for assessing and monitoring dolphin and ecosystem health. At present there is no way to assess bone health in dolphins in managed or in free-ranging populations. The specific objectives of this project are (i) to determine the BMD associated with an extensive set of archived skeletal samples from stranded bottlenose dolphins across a range of geographically distinct populations and obtain a set of normative BMD curves versus age, according to gender and other individual-specific morphometric features; (ii) to determine a functional relationship between age and BMD and other individual-specific features; and (iii) to develop an ultrasound method and laboratory system capable of accurately estimating dolphin BMD. X-ray densitometry will be used to determine the BMD of the dolphin radii, and computer simulated and in vitro ultrasound measurements will be used to determine a set of ultrasound parameters. An ultrasound based-estimate of BMD will be established, and the degree to which BMD and morphometric measurements can estimate dolphin age (a key aspect of understanding dolphin/marine ecosystem health) will be established.


The broader impact/commercial potential of this project is in its potential for managing and dealing with changes in the ecosystem such as through climate change and from exposure to contaminants. The proposed technology therefore has the potential for significantly expanding the ability of the scientific community to assess not only dolphin but overall marine ecosystem health. In addition, an ultrasonically determined value of BMD that could further be used to estimate dolphin age would have significant and additional commercial value worldwide. This value will be realized by marketing a commercial ultrasound product and by offering a commercial service to marine ecosystem health assessment groups. The degree to which the understanding of dolphin and ecosystem health may be positively impacted by the ultrasound technology to be developed in this project cannot be understated. As already noted, there is virtually little if anything presently known about bone properties of dolphins, how they may change over time, and how they may reflect changing climates and contaminants in the oceans. This research may also have analogous significant impacts on the health assessments of other aquatic mammals, such as sea lions and whales. In addition, the USB-based portable ultrasound technology developed in this project should also have large commercial value in the field of non-destructive testing.

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