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Cuza Vodă, Romania

Grigore M.,Grigore T. Popa University of Medicine and Pharmacy | Grigore M.,Medis Medical Center | Iliev G.,Cuza Voda Hospital
Medical Ultrasonography

The occurrence of a fetal tumor is rare, 50% of all fetal tumors being sacrococcygeal teratomas. Prenatal diagnosis of this condition is important for the monitoring of the affected fetuses and for establishing the mode and time of delivery. We describe two cases of fetal sacrococcygeal teratoma diagnosed by 2D- and 3D-ultrasound. Three-dimensional ultrasound proved to be useful both in the diagnosis and patient counseling. The combination of 2D- and 3D-ultrasound enables the diagnosis to be made during the first trimester of pregnancy. Source

Grigore M.,Grigore T. Popa University of Medicine and Pharmacy | Scripcaru D.,Cuza Voda Hospital
Romanian Journal of Legal Medicine

Umbilical cord entanglement occurs during early pregnancy. Typically, fetal asphyxia and demise because of umbilical cord entanglement is a unique characteristic of mono-amniotic twin pregnancies. We describe a case of a woman in late pregnancy that presented to medical consult at 36 weeks of amenorrhea because of the absence of fetal movements. The ultrasound found no fetal heartbeat and because the patient had two previous cesarean sections, another one was performed. We discovered a complex entanglement of the umbilical cord around the leg of the fetus that proved to be the cause of the fetal demise. Cord entanglement must be considered in cases of unexplained intrauterine fetal death. For all cases of intrauterine demise, it is important to look for marks of this condition around different parts of the body. © 2013 Romanian Society of Legal Medicine. Source

Grigore M.,Grtpopa University Of Medicine And Pharmacy | Iliev G.,Cuza Voda Hospital | Gafiteanu D.,Grtpopa University Of Medicine And Pharmacy | Cojocaru C.,Medis Medical Center
Medical Ultrasonography

The use of fetal ultrasound in prenatal care allows the diagnosis of the majority of abdominal wall defects with subsequent opportunities for parental counseling and optimal perinatal management. Outcome of a fetus with an abdominal wall defect is significantly affected by the presence of additional malformations or chromosomal defects. Appropriate management is dependent on the early identification of such anomalies in addition to accurate delineation of the abdominal wall defect itself. Cases with anterior wall defects are presented to illustrate the spectrum of appearances with 2D and 3D ultrasound. 2D combined with 3D ultrasound are very effective methods in the diagnosis of these anomalies and MRI should be reserved only for difficult and intricate cases. Source

Ancuta C.,Grigore T. Popa University of Medicine and Pharmacy | Ancuta E.,Cuza Voda Hospital | Zugun-Eloae F.,Grigore T. Popa University of Medicine and Pharmacy | Zugun-Eloae F.,Immunopathology and Genetics Laboratory | And 2 more authors.
Romanian Journal of Morphology and Embryology

Despite recent advances in understanding the immune mechanisms of cervical cancer (CC), relapse remains still an actual issue and recognition of new predictive biomarkers is essential. Aim: The purpose of this retrospective study was to investigate neo-angiogenesis in CC and its possible utility as prognostic biomarker. Material and Methods: Paraffin-embedded tissue samples from 61 consecutive women with CC were immunostained for CD34 and E-cadherin. Statistical analysis was performed in SPSS-12 software, p<0.05. Results: Statistically significant differences between CD34 distribution among three interest tumor regions: micro-vessels density increase from central to peripheral area (x2, p<0.05); statistically significant correlation between CD34 expression, particularly in stromal and peripheral sites, E-cadherin (Spearman n=-0.321) and lymphatic invasion (Spearman r2=0.455) (p<0.05) were reported. Overall five-year survival is clearly dependent on level and distribution of tumor angiogenesis among defined area of interest as suggested by Kaplan-Meier analysis. Conclusions: Angiogenesis is essential for guiding CC evolution and prognosis, particularly in squamous invasive types. Source

Haba D.,Grigore T. Popa University of Medicine and Pharmacy | Teslaru S.,Grigore T. Popa University of Medicine and Pharmacy | Ungureanu D.,Grigore T. Popa University of Medicine and Pharmacy | Hodorog D.,Grigore T. Popa University of Medicine and Pharmacy | And 7 more authors.
Romanian Journal of Morphology and Embryology

Background: Recent advances have suggested that periodontitis (PD), the paradigm of chronic infection in dental pathology, shares several pathogenic pathways with cardio- and cerebro-vascular disorders (CVD), based on inflammatory mediators including IL-1, IL-6, TNF-a. Aim: To assess pro-inflammatory biomarkers (C-reactive protein - CRP, IL-6) in serum and gingival crevicular fluid (GCF) in patients with PD and with transient ischemic attacks (TIAs). Materials and Methods: Prospective observational study on 143 patients classified as follows: 40 healthy subjects (group A), 50 PD patients (group B) and 53 PD-TIAs patients (group C). The predefined assessment protocol has included: current medical data, risk factors for CRP changes, periodontal status (clinical, orthopantomography, Schei Ruler technique), inflammatory biomarkers (CRP, IL-6). Results: High serum CRP and IL-6 have been reported in both TIAs and PD, while statistically significant increase in GCF CRP only in PD-TIAs (p<0.05). Moreover, both generalized and localized chronic PD may be at higher risk for CVD, since CRP level was higher in these subgroups. However, no significant differences were reported in serum IL-6 between generalized and localized PD. A score function was demonstrated, including bone loss degree, bleeding index, collection site depth, serum and GCF IL-6 and CRP, tooth loss, allowing the classification of PD based on risk for developing TIAs. Conclusions: CRP and IL-6 are commonly involved in the pathways of PD and TIAs. Interdisciplinary assessment should be promoted in order to implement the stratification of PD patients according to the risk for TIAs as suggested by the proposed algorithm. Source

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