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Cuttler J.M.,Cuttler and Associates Inc. | Feinendegen L.,Brookhaven National Laboratory
Canadian Nuclear Society - 35th Annual Conference of the Canadian Nuclear Society and 38th CNS/CNA Student Conference 2015 | Year: 2015

Several studies on the effect of inhaled plutonium-dioxide particulates and the incidence of lung tumors in dogs reveal beneficial effects when the cumulative alpha-radiation dose is low. There is a threshold at an exposure level of about 100 cGy for excess tumor incidence and reduced lifespan. The observations conform to the expectations of the radiation hormesis dose-response model and contradict the predictions of the Linear No-Threshold (LNT) hypothesis. These studies suggest investigating the possibility of employing low-dose alpha-radiation, such as from 239PuO2 inhalation, as a prophylaxis against lung cancer. © Copyright 2015 by the Canadian Nuclear Society. All rights reserved.


Cuttler J.M.,Cuttler and Associates Inc. | Feinendegen L.E.,Brookhaven National Laboratory
Dose-Response | Year: 2015

Several studies on the effect of inhaled plutonium-dioxide particulates and the incidence of lung tumors in dogs reveal beneficial effects when the cumulative alpha-radiation dose is low. There is a threshold at an exposure level of about 100 cGy for excess tumor incidence and reduced lifespan. The observations conform to the expectations of the radiation hormesis dose-response model and contradict the predictions of the LNT hypothesis. These studies suggest investigating the possibility of employing low-dose alpha-radiation, such as from 239PuO2 inhalation, as a prophylaxis against lung cancer. © 2014 University of Massachusetts.


Cuttler J.M.,Cuttler and Associates Inc. | Sanders C.L.,New Hampshire Street
Dose-Response | Year: 2015

Cohen’s lung cancer mortality data, from his test of the LNT theory, do not extend to the no observed adverse effects level (NOAEL) above which inhaled radon decay products begin to induce excess lung cancer mortality. Since there is concern about the level of radon in homes, it is important to set the radon limit near the NOAEL to avoid the risk of losing a health benefit. Assuming that dogs model humans, data from a study on inhaled plutonium dioxide particulates in dogs were assessed, and the NOAEL for radon-induced lung tumors was estimated to be about 2100 Bq/m3. The US Environmental Protection Agency should consider raising its radon action level from 150 to at least 1000 Bq/m3. © The Author(s) 2015.


PubMed | MidMichigan Health, Midland Internal Medicine Associates PC, Cuttler and Associates Inc. and Dow Chemical Company
Type: Journal Article | Journal: Dose-response : a publication of International Hormesis Society | Year: 2016

Alzheimer disease (AD) primarily affects older adults. This neurodegenerative disorder is the most common cause of dementia and is a leading source of their morbidity and mortality. Patient care costs in the United States are about 200 billion dollars and will more than double by 2040. This case report describes the remarkable improvement in a patient with advanced AD in hospice who received 5 computed tomography scans of the brain, about 40 mGy each, over a period of 3 months. The mechanism appears to be radiation-induced upregulation of the patients adaptive protection systems against AD, which partially restored cognition, memory, speech, movement, and appetite.


Cuttler J.M.,Cuttler and Associates Inc.
Canadian Nuclear Society - 34th Annual Conference of the Canadian Nuclear Society and 37th CNS/CNA Student Conference 2013 | Year: 2013

Approximately 160,000 people evacuated the area around the Fukushima Dai-ichi NPP shortly after it was damage by the earthquake and tsunami. The evacuation order applied to 70,000 of them, while the other 90,000 left voluntarily and returned soon afterward. After more than two years, most of the 70,000 are still not allowed to return to their homes. The 1100 disaster-related deaths caused by the evacuation order show that this precautionary action, taken to minimize cancer risks, was not "conservative." In this paper, recent studies are reviewed on the consequences of the radioactive releases and on the benefits of many medical treatments with low doses of radiation that were carried out until the 1950s, before the radiation scare was created. Recent research has shed light on the high rate of spontaneous double-strand breaks in DNA and the adaptive protections in cells, tissues and humans that are up-regulated by low radiation. These defences prevent, repair, remove and replace damage, from all causes including external agents. Cancer mortality is reduced. The ICRP's concept of radiation risk is wrong. It should revert to its 1934 concept, which was a tolerance dose of 0.2 roentgen (r) per day based on more than 35 years of medical experience.


Cuttler J.M.,Cuttler and Associates Inc.
Canadian Nuclear Society - 31st Annual Conference of the Canadian Nuclear Society and 34th CNS/CNA Student Conference 2010 | Year: 2010

This paper discusses the recent problems with Canadian supply of molybdenum-99 for medical diagnostic scanning. It proposes an alternate method that exploits the on-power refueling capability of CANDU reactors to produce large amounts of Mo-99. An extraction and refining plant near the used fuel bay of a multi-reactor station could process one standard fuel bundle per day (after irradiation for 5 days). This method avoids using enriched uranium. The plant might cost less than 50 million dollars and be constructed within several years. The radioactive residue would be managed in conjunction with the existing methods of used fuel management.


Cuttler J.M.,Cuttler and Associates Inc.
Health Physics | Year: 2016

Although almost 120 y of medical experience and data exist on human exposure to ionizing radiation, advisory bodies and regulators claim there are still significant uncertainties about radiation health risks that require extreme precautions be taken. Decades of evidence led to recommendations in the 1920s for protecting radiologists by limiting their daily exposure. These were shown in later studies to decrease both their overall mortality and cancer mortality below those of unexposed groups. In the 1950s, without scientific evidence, the National Academy of Sciences Biological Effects of Atomic Radiation (BEAR) Committee and the NCRP recommended that the linear no-threshold (LNT) model be used to assess the risk of radiation-induced mutations in germ cells and the risk of cancer in somatic cells. This policy change was accepted by the regulators of every country without a thorough review of its basis. Because use of the LNT model has created extreme public fear of radiation, which impairs vital medical applications of low-dose radiation in diagnostics and therapy and blocks nuclear energy projects, it is time to change radiation protection policy back into line with the data. © 2016 Lippincott Williams & Wilkins.


Cuttler J.M.,Cuttler and Associates Inc.
Dose-Response | Year: 2014

Seeking a remedy for the radiation fear in Japan, the author re-examined an article on radiation hormesis. It describes the background for this fear and evidence in the first UNSCEAR report of a reduction in leukemia of the Hiroshima survivors in the low dose zone. The data are plotted and dose-response models are drawn. While UNSCEAR suggested the extra leukemia incidence is proportional to radiation dose, the data are consistent with a hormetic J-shape and a threshold at about 100 rem (1 Sv). UNSCEAR data on lifespan reduction of mammals exposed continuously to gamma rays indicate a 2 gray/year threshold. This contradicts the conceptual basis for radiation protection and risk determination established in 1956-58. In this paper, beneficial effects and thresholds for harmful effects are discussed, and the biological mechanism is explained. The key point: the rate of DNA damage (double-strand breaks) caused by background radiation is 1000 times less than the endogenous (spontaneous) rate. It is the effect of radiation on an organism's very powerful adaptive protection systems that determines the dose-response characteristic. Low radiation up-regulates the protection systems, while high radiation impairs these systems. The remedy for radiation fear is to expose and discard the politicized science. © 2014 University of Massachusetts.


Cuttler J.M.,Cuttler and Associates Inc.
Dose-Response | Year: 2012

This commentary reviews the international radiation protection policy that resulted in the evacuation of more than 90,000 residents from areas near the Fukushima Daiichi NPS and the enormous expenditures to protect them against a hypothetical risk of cancer. The basis for the precautionary measures is shown to be invalid; the radiation level chosen for evacuation is not conservative. The actions caused unnecessary fear and suffering. An appropriate level for evacuation is recommended. Radical changes to the ICRP recommendations are long overdue.


PubMed | Cuttler and Associates Inc.
Type: Journal Article | Journal: Health physics | Year: 2016

Although almost 120 y of medical experience and data exist on human exposure to ionizing radiation, advisory bodies and regulators claim there are still significant uncertainties about radiation health risks that require extreme precautions be taken. Decades of evidence led to recommendations in the 1920s for protecting radiologists by limiting their daily exposure. These were shown in later studies to decrease both their overall mortality and cancer mortality below those of unexposed groups. In the 1950s, without scientific evidence, the National Academy of Sciences Biological Effects of Atomic Radiation (BEAR) Committee and the NCRP recommended that the linear no-threshold (LNT) model be used to assess the risk of radiation-induced mutations in germ cells and the risk of cancer in somatic cells. This policy change was accepted by the regulators of every country without a thorough review of its basis. Because use of the LNT model has created extreme public fear of radiation, which impairs vital medical applications of low-dose radiation in diagnostics and therapy and blocks nuclear energy projects, it is time to change radiation protection policy back into line with the data.

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