Curso de Farmacia


Curso de Farmacia

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Chorilli M.,São Paulo State University | Prestes P.S.,Curso de Farmacia | Rigon R.B.,Curso de Farmacia | Leonardi G.R.,Curso de Farmacia | And 3 more authors.
Colloids and Surfaces B: Biointerfaces | Year: 2011

Carrier systems for lipophilic drugs, such as the liquid crystalline systems (LCS) have been extensively studied to improve effect and selectivity. Retinyl palmitate (RP) is widely used in pharmaceutical and cosmetics products to improve the skin elasticity. The aim of this study was the development, characterization and the in vivo effectiveness of RP in non-ionic LCS structures. LCS containing polyether functional siloxane as oil phase, silicon glycol copolymer as surfactant and water in the ratio 30:10:60, with and without RP were studied. The results of the polarized light microscopy, small-angle X-ray scattering and rheology analysis indicated the presence of typical LCS structures with lamellar arrangement. Regardless of the presence of RP, the rheological studies showed the pseudo plastic behavior of the systems. However, highest hysteresis area was verified when comparing the system in the presence and in the absence of RP. Stability study SAXS monitored, carried out up to 30 days in various storage temperature conditions (25 ± 2 °C, 37 ± 2 °C and 5 ± 2 °C) demonstrated the great structural stability of the LCS systems. The in vivo effectiveness analysis suggests that the RP-loaded LCS provided a significant reduction of the orbicular wrinkles in human volunteers (P = 0.048). © 2011 Elsevier B.V.

Lucca P.S.R.,Curso de Farmacia | Nobrega L.H.P.,Curso de Farmacia | Alves L.F.A.,West Parana State University | Cruz-Silva C.T.A.,West Parana State University | Pacheco F.P.,West Parana State University
Revista Brasileira de Plantas Medicinais | Year: 2015

The use of natural substances for pest control in agriculture is, economically, a viable option and has benefits for both the humanbeing and the environment, due to its low persistence and toxicity. Thus, this trial aimed on determining the insecticidal potential of the extracts and essential oils of fennel (Foeniculum vulgare Mill.), anise (Pimpinella anisum L.) and clove (Caryophillus aromaticus L.) to control Brevicoryne brassicae L. in kale (Brassica oleracea var. acephala DC.). The treatments were: fennel, anise, cloves extracts at 10%; fennel, anise, cloves oils at 1% and control with distilled water. The mortality tests were carried out with aphids in laboratory, with three replications, after 1, 12, 24, 48 and 72 hours. During laboratory trials , it was found out that fennel oil at 1% showed the best rate of mortality on aphid nymphs (70% at 72 h), followed by clove extract at 10% with 37% mortality. Tests in pots were only carried out only with cloves extracts at 10% and fennel oil at 1% treatment, in which such efficiency was alsoindicated on aphid nymphs. © 2015, Instituto de Biociencias. All rights reserved.

Voncik Cordova K.R.,State University of the Central West | Santa H.S.D.,Curso de Engineering de Alimentos | Santa O.R.D.,Tecnologia de Alimentos | Perez E.,Curso de Farmacia | Waszczynskyj N.,Federal University of Paraná
Boletim Centro de Pesquisa de Processamento de Alimentos | Year: 2012

The aim of this study was to evaluate the antioxidant capacity, phenolic compounds and beta-glucans from cereal bars with Agaricus brasiliensis. The cereal bars were prepared by mixing design for simplex-centroid for three variables: oats, sesame and fermented wheat with A. brasiliensis. The content of β-glucan varied from 1.30 to 3.82 g.100 g-1, phenolic compounds ranged from 67.45 to 81.96 mg GAE.100 g-1 and showed antioxidant capacity in the range of 29.47 to 40.17 mg TECA.100 g-1. The addition of mycelium of Agaricus brasiliensis in food can make them healthier due to its nutritional properties and bioactive compounds of this micro-organism.

De Santana F.J.M.,Curso de Farmacia | De Santana F.J.M.,University of Sao Paulo | Jabor V.A.P.,University of Sao Paulo | Cesarino E.J.,University of Sao Paulo | And 2 more authors.
Journal of Separation Science | Year: 2010

A selective and reproducible off-line solid-phase microextraction procedure was developed for the simultaneous enantioselective determination of mirtazapine (MRT), demethylmirtazapine and 8-hydroxymirtazapine in human urine. CE was used for optimization of the extraction procedure whereas LC-MS was used for method validation and application. The influence of important factors in the solid-phase microextraction efficiency is discussed, such as the fiber coatings, extraction time, pH, ionic strength, temperature and desorption time. Before extraction, human urine samples were submitted to enzymatic hydrolysis at 37°C for 16 h. Then, the enzyme was precipitated with trichloroacetic acid and the pH was adjusted to 8 with 1 mol/L pH 11 phosphate buffer solution. In the extraction, the analytes were transferred from the aqueous solution to the polydimethylsiloxane-divinylbenzene fiber coating and then desorbed in methanol. The mean recoveries were 5.4, 1.7 and 1.0% for MRT, demethylmirtazapine and 8-hydroxymirtazapine enantiomers, respectively. The method was linear over the concentration range of 62-1250 ng/mL. The within-day and between-day assay precision and accuracy were lower than 15%. The method was successfully employed in a preliminary cumulative urinary excretion study after administration of racemic MRT to a healthy volunteer. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

Serafini M.R.,Curso de Farmacia | Santos R.C.,Curso de Farmacia | Guimaraes A.G.,Curso de Farmacia | Dos Santos J.P.A.,Curso de Farmacia | And 7 more authors.
Journal of Medicinal Food | Year: 2011

Herbal drugs have been used since ancient times to treat a wide range of diseases. Morinda citrifolia Linn (popularly known as "Noni") has been used in folk medicine by Polynesians for over 2,000 years. It is reported to have a broad range of therapeutic effects, including effects against headache, fever, arthritis, gingivitis, respiratory disorders, infections, tuberculosis, and diabetes. The aim of this study was to investigate the antioxidant, anti-inflammatory, antinociceptive, and antibacterial properties of the aqueous extract from M. citrifolia leaves (AEMC). Antioxidant activity was observed against lipid peroxidation, nitric oxide, and hydroxyl radicals. The antinociceptive effect of AEMC was observed in the acetic acid-induced writhing test at the higher dose. Moreover, AEMC significantly reduced the leukocyte migration in doses of 200 and 400mg/kg and showed mild antibacterial activity. Together, the results suggest that properties of M. citrifolia leaf extract should be explored further in order to achieve newer tools for managing painful and inflammation conditions, including those related to oxidant states. © 2011 Mary Ann Liebert, Inc.

Mourao F.,Paranaense University | Umeo S.H.,Curso de Farmacia | Berteli M.B.D.,Paranaense University | Lourenco E.L.,Curso de Farmacia | And 4 more authors.
Food and Agricultural Immunology | Year: 2011

Agaricus blazei Murrill ss. Heinemann (Agaricus brasiliensis Wasser et al.; Agaricus subrufescens Peck) has raised interest in the scientific community due to its therapeutic properties. Although there are numerous studies about this fungus a few of them study the anti-inflammatory activity and the relationship with basidiocarp development phases. Thus, the objective of this study was to evaluate the effect of A. blazei extracts of closed and opened basidiocarp on the cell migration of rats submitted to an inflammatory challenge. The basidiocarp extracts were administered by gavage at 55 or 110 mg/kg. The inflammatory challenge was performed by administering phlogistic agent (carrageenan 2%) in an air-pouch induced in the animal subcutaneous tissue. It was concluded that the extracts affect leukocyte mobilisation regulation; closed basidiocarp extract in doses of 55 and 110 mg/kg and opened basidiocarp extract in 110 mg/kg modulate the anti-inflammatory response. © 2011 Copyright Taylor and Francis Group, LLC.

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