Curso de Farmacia

Brazil

Curso de Farmacia

Brazil
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de Almeida V.P.,State University of Ponta Grossa | Hirt A.A.,Curso de Farmacia | Raeski P.A.,State University of Ponta Grossa | Mika B.E.,State University of Ponta Grossa | And 6 more authors.
Brazilian Journal of Pharmacognosy | Year: 2017

Mikania belongs to the Asteraceae family and includes a wide range of promising pharmacological activities. Several species of Mikania, which is popularly known in Brazil as “guaco”, occur in Southern Brazil and their external morphology is similar. The aim of this study was to investigate the morpho-anatomical characteristics of the leaf and stem of Mikania campanulata, Mikania cordifolia, Mikania glomerata, Mikania hastato-cordata, Mikania microptera and Mikania sessilifolia as a means of providing additional support for differentiating these taxa. The leaves and stems were investigated by employing scanning electron microscopy and light microscopy techniques. The morphological features of Mikania spp. leaves make it possible to differentiate between the species; nevertheless, when the plants were fragmented or pulverized the anatomical features of the leaves and stems supplied additional helpful data in this regard. The main anatomical characteristics were presence of hypodermis and lens shaped epidermal cells, set of trichomes; midrib, petiole and stem shape and vascular pattern; sclerenchymatous ring in the cortex, sclerenchymatous cells and secretory ducts in the pith. © 2016 Sociedade Brasileira de Farmacognosia.


Albano M.N.,Curso de Farmacia | Da Silveira M.R.,Curso de Farmacia | Danielski L.G.,Curso de Farmacia | Danielski L.G.,Laboratorio Of Fisiopatologia Clinica E Experimental Laficexp | And 5 more authors.
Journal of Ethnopharmacology | Year: 2013

Ethnopharmacological relevance Casearia sylvestris Sw. is widely used in popular medicine to treat inflammatory conditions. Aim of the study To investigate the anti-inflammatory and antioxidant properties of hydroalcoholic crude extract (HCE) taken from Casearia sylvestris Sw. (Salicaceae). Methods and results The effect of the HCE from this plant (3-300 mg/kg) on the reduction of inflammatory response to carrageenan was investigated in pleurisy in rats (intrapleural, 2% in 0.2 mL) or paw edema in mice (intraplantar, 300 μg/20 μL, right hind paw). The plant anti-inflammatory action was assessed by its capability in inhibiting cell migration, enzymatic activity of myeloperoxidase (MPO) and production of nitrite/nitrate or edema. The in vitro antioxidant activity of this extract against lipid peroxidation and damage to proteins was assessed as possible pathways to contribute as anti-inflammatory mechanisms. Carrageenan-induced hind paw edema (739.3±11.9 μm) was reduced by HCE (30 mg/kg: 462.8±28.38 μm) to similar extents as dexametasone (365.1±16.7). In pleurisy, treatment of the animals with HCE (100 mg/kg: 0.010±0.001 mU/mg of protein) also reduced MPO activity augmented by carrageenan (0.020±0.001 mU/mg of protein) as well as leukocytes migration (carrageenan: 17.8890±2.3900 leukocytes/mL, HCE 100 mg/kg: 7.0880±9631 leukocytes/mL). Significant effects were also observed in animals treated with different doses of HCE in biochemical tests for oxidative stress analysis. Conclusion The anti-inflammatory and antioxidant effects of HCE from Casearia sylvestris Sw. suggests a potential therapeutic benefit of this plant in treatment of inflammatory conditions. © 2013 Elsevier Ireland Ltd.


Cutaneous aging is related to the action of free radicals, which appear in greater quantity as a consequence of senescence, so that natural defenses cannot eliminate them. The aim of this study was to develop a non-ionic emulsion containing an aqueous extract of the inner bark of Lafoensia pacari A. St.-Hil. and assess its physicochemical stability, as well as its antioxidant activity. The aqueous extract was prepared under reflux with a 1:25 ratio of bark:distilled water (w/v). The total polyphenol content was determined by the Folin-Ciocalteau method, with tannic acid as standard. BHT, ascorbic acid and the aqueous extract were incorporated into the non-ionic emulsion, each of them at a concentration of 1%, the first two being used as reference substances. Antioxidant activity was analyzed by the phosphomolybdenum method, each emulsion being first diluted in water to 400 μg/mL. The addition of aqueous extract of L. pacari did not significantly affect the stability of the cream over the period of analysis. The content of polyphenols showed that hot aqueous extraction was not an efficient method, resulting in a tannic acid equivalent (TAE) of 1.0328 mg/ mL in the crude extract. Proportional to the polyphenol concentration, the antioxidant activity was also low, not exceeding 5.0% of the activity of the ascorbic acid.


Araujo L.,Curso de Farmacia | Curty S.,Curso de Farmacia | Moreira A.,Curso de Farmacia | Rossi A.,Curso de Farmacia | And 5 more authors.
Journal of Young Pharmacists | Year: 2016

Introduction: Cancer is a range of multifactorial diseases which have in common uncontrolled increase in the number of cells invading various tissues and organs. One of its leading etiological agents is sun exposure, and therefore the use of sunscreens plays an important role in cancer prevention. Objective: In this context, the aim of this study was to verify whether the selected naturally-derived raw materials (Oli-ola dry extract, Hibiscus dry extract, Raspberry ketones, Leucoanthocyanidins isolated from grapes and Resveratrol) present adequate photoprotective properties for the development of an innovative broad-spectrum sunscreen. Methods: The determination of sunscreen activity was made in vitro, and the following parameters were obtained: Sun Protection Factor (SPF), UVA Protection Factor (UVAPF), Critical Wavelength and Boots Star Rating. Results: Innovative products showed varied results (maximum SPF=46; maximum UVAPF=22), being that all of them showed to be promising for both parameters. However, the greatest protection was shown in the UVB region. Conclusion: Thus, the Oli-Ola, Hibiscus, Leucoanthocyanidins, Raspberry Ketones and Resveratrol species, grouped in a cosmetic base lotion, showed potential for the development of innovative sunscreen products. Additionally, the SPF should be confirmed in vivo.


Chorilli M.,São Paulo State University | Prestes P.S.,Curso de Farmacia | Rigon R.B.,Curso de Farmacia | Leonardi G.R.,Curso de Farmacia | And 3 more authors.
Colloids and Surfaces B: Biointerfaces | Year: 2011

Carrier systems for lipophilic drugs, such as the liquid crystalline systems (LCS) have been extensively studied to improve effect and selectivity. Retinyl palmitate (RP) is widely used in pharmaceutical and cosmetics products to improve the skin elasticity. The aim of this study was the development, characterization and the in vivo effectiveness of RP in non-ionic LCS structures. LCS containing polyether functional siloxane as oil phase, silicon glycol copolymer as surfactant and water in the ratio 30:10:60, with and without RP were studied. The results of the polarized light microscopy, small-angle X-ray scattering and rheology analysis indicated the presence of typical LCS structures with lamellar arrangement. Regardless of the presence of RP, the rheological studies showed the pseudo plastic behavior of the systems. However, highest hysteresis area was verified when comparing the system in the presence and in the absence of RP. Stability study SAXS monitored, carried out up to 30 days in various storage temperature conditions (25 ± 2 °C, 37 ± 2 °C and 5 ± 2 °C) demonstrated the great structural stability of the LCS systems. The in vivo effectiveness analysis suggests that the RP-loaded LCS provided a significant reduction of the orbicular wrinkles in human volunteers (P = 0.048). © 2011 Elsevier B.V.


Lucca P.S.R.,Curso de Farmacia | Nobrega L.H.P.,Curso de Farmacia | Alves L.F.A.,West Parana State University | Cruz-Silva C.T.A.,West Parana State University | Pacheco F.P.,West Parana State University
Revista Brasileira de Plantas Medicinais | Year: 2015

The use of natural substances for pest control in agriculture is, economically, a viable option and has benefits for both the humanbeing and the environment, due to its low persistence and toxicity. Thus, this trial aimed on determining the insecticidal potential of the extracts and essential oils of fennel (Foeniculum vulgare Mill.), anise (Pimpinella anisum L.) and clove (Caryophillus aromaticus L.) to control Brevicoryne brassicae L. in kale (Brassica oleracea var. acephala DC.). The treatments were: fennel, anise, cloves extracts at 10%; fennel, anise, cloves oils at 1% and control with distilled water. The mortality tests were carried out with aphids in laboratory, with three replications, after 1, 12, 24, 48 and 72 hours. During laboratory trials , it was found out that fennel oil at 1% showed the best rate of mortality on aphid nymphs (70% at 72 h), followed by clove extract at 10% with 37% mortality. Tests in pots were only carried out only with cloves extracts at 10% and fennel oil at 1% treatment, in which such efficiency was alsoindicated on aphid nymphs. © 2015, Instituto de Biociencias. All rights reserved.


Voncik Cordova K.R.,State University of the Central West | Santa H.S.D.,Curso de Engineering de Alimentos | Santa O.R.D.,Tecnologia de Alimentos | Perez E.,Curso de Farmacia | Waszczynskyj N.,Federal University of Paraná
Boletim Centro de Pesquisa de Processamento de Alimentos | Year: 2012

The aim of this study was to evaluate the antioxidant capacity, phenolic compounds and beta-glucans from cereal bars with Agaricus brasiliensis. The cereal bars were prepared by mixing design for simplex-centroid for three variables: oats, sesame and fermented wheat with A. brasiliensis. The content of β-glucan varied from 1.30 to 3.82 g.100 g-1, phenolic compounds ranged from 67.45 to 81.96 mg GAE.100 g-1 and showed antioxidant capacity in the range of 29.47 to 40.17 mg TECA.100 g-1. The addition of mycelium of Agaricus brasiliensis in food can make them healthier due to its nutritional properties and bioactive compounds of this micro-organism.


De Santana F.J.M.,Curso de Farmacia | De Santana F.J.M.,University of Sao Paulo | Jabor V.A.P.,University of Sao Paulo | Cesarino E.J.,University of Sao Paulo | And 2 more authors.
Journal of Separation Science | Year: 2010

A selective and reproducible off-line solid-phase microextraction procedure was developed for the simultaneous enantioselective determination of mirtazapine (MRT), demethylmirtazapine and 8-hydroxymirtazapine in human urine. CE was used for optimization of the extraction procedure whereas LC-MS was used for method validation and application. The influence of important factors in the solid-phase microextraction efficiency is discussed, such as the fiber coatings, extraction time, pH, ionic strength, temperature and desorption time. Before extraction, human urine samples were submitted to enzymatic hydrolysis at 37°C for 16 h. Then, the enzyme was precipitated with trichloroacetic acid and the pH was adjusted to 8 with 1 mol/L pH 11 phosphate buffer solution. In the extraction, the analytes were transferred from the aqueous solution to the polydimethylsiloxane-divinylbenzene fiber coating and then desorbed in methanol. The mean recoveries were 5.4, 1.7 and 1.0% for MRT, demethylmirtazapine and 8-hydroxymirtazapine enantiomers, respectively. The method was linear over the concentration range of 62-1250 ng/mL. The within-day and between-day assay precision and accuracy were lower than 15%. The method was successfully employed in a preliminary cumulative urinary excretion study after administration of racemic MRT to a healthy volunteer. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.


Serafini M.R.,Curso de Farmacia | Santos R.C.,Curso de Farmacia | Guimaraes A.G.,Curso de Farmacia | Dos Santos J.P.A.,Curso de Farmacia | And 7 more authors.
Journal of Medicinal Food | Year: 2011

Herbal drugs have been used since ancient times to treat a wide range of diseases. Morinda citrifolia Linn (popularly known as "Noni") has been used in folk medicine by Polynesians for over 2,000 years. It is reported to have a broad range of therapeutic effects, including effects against headache, fever, arthritis, gingivitis, respiratory disorders, infections, tuberculosis, and diabetes. The aim of this study was to investigate the antioxidant, anti-inflammatory, antinociceptive, and antibacterial properties of the aqueous extract from M. citrifolia leaves (AEMC). Antioxidant activity was observed against lipid peroxidation, nitric oxide, and hydroxyl radicals. The antinociceptive effect of AEMC was observed in the acetic acid-induced writhing test at the higher dose. Moreover, AEMC significantly reduced the leukocyte migration in doses of 200 and 400mg/kg and showed mild antibacterial activity. Together, the results suggest that properties of M. citrifolia leaf extract should be explored further in order to achieve newer tools for managing painful and inflammation conditions, including those related to oxidant states. © 2011 Mary Ann Liebert, Inc.


Mourao F.,Paranaense University | Umeo S.H.,Curso de Farmacia | Berteli M.B.D.,Paranaense University | Lourenco E.L.,Curso de Farmacia | And 4 more authors.
Food and Agricultural Immunology | Year: 2011

Agaricus blazei Murrill ss. Heinemann (Agaricus brasiliensis Wasser et al.; Agaricus subrufescens Peck) has raised interest in the scientific community due to its therapeutic properties. Although there are numerous studies about this fungus a few of them study the anti-inflammatory activity and the relationship with basidiocarp development phases. Thus, the objective of this study was to evaluate the effect of A. blazei extracts of closed and opened basidiocarp on the cell migration of rats submitted to an inflammatory challenge. The basidiocarp extracts were administered by gavage at 55 or 110 mg/kg. The inflammatory challenge was performed by administering phlogistic agent (carrageenan 2%) in an air-pouch induced in the animal subcutaneous tissue. It was concluded that the extracts affect leukocyte mobilisation regulation; closed basidiocarp extract in doses of 55 and 110 mg/kg and opened basidiocarp extract in 110 mg/kg modulate the anti-inflammatory response. © 2011 Copyright Taylor and Francis Group, LLC.

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