Curasan AG

Frankfurt am Main, Germany

Curasan AG

Frankfurt am Main, Germany
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Lopez-Heredia M.A.,University of Marburg | Barnewitz D.,Veterinary Clinic | Genzel A.,Veterinary Clinic | Stiller M.,University of Marburg | And 5 more authors.
Key Engineering Materials | Year: 2015

Calcium phosphates (CaPs) are synthetic bone grafting materials. CaPs are an alternative to overcome the drawbacks present with autologous bone grafting and/or xenograft materials. Among the CaPs, tricalcium phosphate (TCP) stands out as a good candidate due to its physicochemical properties. The clinical performance of β-TCP has already been proven and established. Nevertheless, the format in which TCP is delivered is also important in terms of clinical handling. This work assessed the in vivo performance of TCP-based bone grafting materials with different formats. Materials studied were a TCP paste (TCP-P), a TCP foam (TCP-F) and TCP granules (TCP-G). A sheep scapula model was used to evaluate the osteogenic performance of these bone grafting materials. All materials performed well in terms of bone regenerative capacity and material resorption. However, TCP-P and TCP-F displayed a more pronounced initial material resorption and also exhibited better handling properties compared to TCP-G. TCP-based materials with improved handling properties, such as TCP-P and TCP-F, which at the same time possess the advantageous properties of β-TCP are suitable bone substitute materials for grafting and reconstruction of bone defects in numerous clinical applications. © (2015) Trans Tech Publications, Switzerland.


News Article | November 1, 2016
Site: www.PR.com

Global Dental Bone Graft Market, By Product Type (Synthetic Bone Grafts (Ceramics, Tricalcium Phosphate, Hydroxyapatite, Others), Xenograft, Allograft, Demineralized Bone Allograft, Repair Membranes (Bio-reabsorbable, Non Bio-reabsorbable), By Procedure Type (Ridge Augmentation, Socket Preservation, Periodontal Defect Regeneration, Implant Bone Regeneration, Sinus Lift), By Material Form, By Geography – Trends and Forecast to 2022 Dallas, TX, November 01, 2016 --( The market is segmented on the basis of product type, procedure type, material type, and geography. Request for sample pages: http://databridgemarketresearch.com/reports/global-dental-bone-graft-market-trends-forecast-2022/ On the basis of product type the Dental Bone Graft market is segmented into synthetic bone grafts, xenograft, allograft, demineralized allograft and repair membranes. synthetic grafts market is further segmented into ceramics, tricalcium phosphate, hydroxyapatite and others. The repair membrane segment is further sub-divided into bio-reabsorbable, non bio-reabsorbable membranes. Based on procedure the market is segmented into ridge augmentation, socket preservation, periodontal defect regeneration, implant bone regeneration and sinus lift. On the basis of material type the global dental bone graft substitute market is segmented into putty, Injectable and granules. Based on geography the market is segmented into geographical regions such as North America, Europe, Asia-Pacific, South America and rest of the world. The report of this market shares countries such as U.S. Canada, Mexico, Germany, France, U.K., Belgium, Switzerland, Belgium, Turkey, Japan, China, Singapore, Brazil, India, Russia, South Africa. Read more: http://databridgemarketresearch.com/reports/global-dental-bone-graft-market-trends-forecast-2022/ The major players operating in this market are Institut Straumann AG, Genoss, Curasan AG, Geistlich, Olympus Terumo Biomaterials Corp, Kerr Corporation, DENTSPLY Sirona International, Sunstar Americas, Inc., Zimmer Biomet, NovaBone, Medtronic, Cortex Dental Implants Industries Ltd., BioHorizons IPH, Inc., ACE Surgical Supply Company, Inc., RTI Surgical, Inc., Graftys, Collagen Matrix, Inc., LifeNet Health, and Dentium. About Data Bridge Market Research: Data Bridge set forth itself as an unconventional and neoteric Market research and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best market opportunities and foster efficient information for your business to thrive in the market. Data Bridge endeavors to provide appropriate solutions to the complex business challenges and initiates an effortless decision-making process. Dallas, TX, November 01, 2016 --( PR.com )-- The market for Dental Bone Graft Market has accounted for USD 433.4 million by 2015, growing at 10.3% during the forecast years to 2022.The market is segmented on the basis of product type, procedure type, material type, and geography.Request for sample pages: http://databridgemarketresearch.com/reports/global-dental-bone-graft-market-trends-forecast-2022/On the basis of product type the Dental Bone Graft market is segmented into synthetic bone grafts, xenograft, allograft, demineralized allograft and repair membranes. synthetic grafts market is further segmented into ceramics, tricalcium phosphate, hydroxyapatite and others. The repair membrane segment is further sub-divided into bio-reabsorbable, non bio-reabsorbable membranes.Based on procedure the market is segmented into ridge augmentation, socket preservation, periodontal defect regeneration, implant bone regeneration and sinus lift.On the basis of material type the global dental bone graft substitute market is segmented into putty, Injectable and granules.Based on geography the market is segmented into geographical regions such as North America, Europe, Asia-Pacific, South America and rest of the world. The report of this market shares countries such as U.S. Canada, Mexico, Germany, France, U.K., Belgium, Switzerland, Belgium, Turkey, Japan, China, Singapore, Brazil, India, Russia, South Africa.Read more: http://databridgemarketresearch.com/reports/global-dental-bone-graft-market-trends-forecast-2022/The major players operating in this market are Institut Straumann AG, Genoss, Curasan AG, Geistlich, Olympus Terumo Biomaterials Corp, Kerr Corporation, DENTSPLY Sirona International, Sunstar Americas, Inc., Zimmer Biomet, NovaBone, Medtronic, Cortex Dental Implants Industries Ltd., BioHorizons IPH, Inc., ACE Surgical Supply Company, Inc., RTI Surgical, Inc., Graftys, Collagen Matrix, Inc., LifeNet Health, and Dentium.About Data Bridge Market Research:Data Bridge set forth itself as an unconventional and neoteric Market research and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best market opportunities and foster efficient information for your business to thrive in the market. Data Bridge endeavors to provide appropriate solutions to the complex business challenges and initiates an effortless decision-making process. Click here to view the list of recent Press Releases from Data Bridge Market Research


Ghanaati S.,Johannes Gutenberg University Mainz | Ghanaati S.,Goethe University Frankfurt | Barbeck M.,Johannes Gutenberg University Mainz | Orth C.,Johannes Gutenberg University Mainz | And 8 more authors.
Acta Biomaterialia | Year: 2010

In this study the tissue reaction to five different β-tricalcium phosphate (β-TCP)-based bone substitute materials differing only in size, shape and porosity was analyzed over 60 days, at 3, 10, 15, 30 and 60 days after implantation. Using the subcutaneous implantation model in Wistar rats both the inflammatory response within the implantation bed and the resulting vascularization of the biomaterials were qualitatively and quantitatively assessed by means of standard and special histological staining methods. The data from this study showed that all investigated β-TCP bone substitutes induced the formation of multinucleated giant cells. Changes in size, shape and porosity influenced the integration of the biomaterials within the implantation bed and the formation of tartrate-resistant acid phosphatase (TRAP)-positive and TRAP-negative multinucleated giant cells, as well as the rate of vascularization. While a high porosity generally allowed cell and fiber in-growth within the center of the bone substitute, a lower porosity resulted in a mosaic-like integration of the materials, with the granules serving as place holders. The number of multinucleated giant cells located in the implantation bed positively correlated with the vascularization rate. These data emphasize that all biomaterials investigated were capable of inducing the formation of TRAP-positive multinucleated giant cells as a sign of biomaterial stability. Furthermore, these cells directly influenced vascularization by secretion of vascular endothelial growth factor (VEGF), as well as other chemokines. Based on these findings, the role of multinucleated giant cells in the foreign body reaction to biomaterials might need to be reconsidered. This study demonstrates that variations in the physical properties of a bone substitute material clearly influence the (extent of the) inflammatory reaction and its consequences. © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.


Lange T.,University of Hamburg | Schilling A.F.,University of Hamburg | Schilling A.F.,TU Munich | Peters F.,Curasan AG | And 3 more authors.
Biomaterials | Year: 2011

Cellular responses to particulate calcium phosphate ceramics can lead to inflammatory reactions under certain conditions that depend on particle composition, size and morphology. In this context, the potential influence of varying sizes of particulate beta-tricalciumphosphate (beta-TCP) on the induction of inflammation and cytotoxicity remains to be determined. The present work investigates the effects of beta-TCP particles of five different sizes (1, 3, 13, 32 and 40 μm) on human peripheral blood mononuclear cells (PBMC) in vitro concerning the release of TNF-alpha, IL-1beta and IL-8 after six and 18 h of incubation (ELISA) as well as intracellular TNF-alpha, IFN-gamma, IL-1alpha, IL-1beta and IL-8 levels within distinct PBMC subpopulations after 12 h (FACS). Potential cytotoxic effects were determined by assaying lactate dehydrogenase (LDH) and morphological analyses (electron microscopy). Beta-TCP 1 μm did not induce any cytokine after 6 h but slightly increases TNF-alpha, IL-1beta and IL-8 release after 18 h. Larger particles (32 and 40 μm) consistently caused higher levels of cytokine release by increasing the fraction of cytokine producing monocytes. They also caused higher levels of LDH release as did smaller, phagocytosable particles. These data suggest a less inflammatory and cytotoxic profile of beta-TCP devices with a smaller primary particle size when compared to larger particles. © 2011 Elsevier Ltd.


Zheng H.,PharmaLegacy Laboratories | Bai Y.,PharmaLegacy Laboratories | Shih M.-S.,PharmaLegacy Laboratories | Hoffmann C.,Curasan AG | And 3 more authors.
Journal of Biomedical Materials Research - Part B Applied Biomaterials | Year: 2014

In this study, we tested the performance and biocompatibility of a composite of β-tricalcium phosphate (β-TCP) to collagen as a bone void filler (Cerasorb® Ortho Foam) in a rabbit distal femoral condyle model. β-TCP is a completely resorbable synthetic calcium phosphate and the addition of a collagen matrix couples the osteoconductive effects of the two components. Furthermore, the malleable properties of the implant material during surgical applications for shape control will be enhanced. A critical size defect of 6 mm in diameter and 10 mm in depth was drilled into each distal femur of the rabbits. One hole was filled with the test substance and the other was left empty for control. After 1, 3, and 6 months the animals were killed and the degree of bone healing analyzed. In total, 18 animals were investigated. When the β-TCP composite was used, histological, histomorphometric, and biomechanical evaluations revealed significantly better bone healing in terms of quantity and quality of the newly formed bone. Moreover, no signs of inflammation were observed in the animals and no allergic or foreign body reaction was noted. This suggests high biocompatibility and osteoconductivity of the investigated material to a bone void in an immune responsive species. Copyright © 2013 Wiley Periodicals, Inc.


Krause M.,University of Hamburg | Oheim R.,University of Hamburg | Catala-Lehnen P.,University of Hamburg | Pestka J.M.,University of Hamburg | And 5 more authors.
Journal of Biomaterials Applications | Year: 2014

Purpose: Adequate filling of bone defects still poses a challenge in every day clinical work. As many bone defects are irregularly shaped the need for appropriate scaffolds reaching the complete defect surface are great. The purpose of this pre-clinical pilot study was to investigate the handling, biocompatibility, biodegradation and osteoconductivity of a new pasty bone substitute (pure phase β-TCP, hyaluronic acid, methylcellulose) in bone tissue. Methods: In an unilateral tibial defect model the peri-implant and bone tissue response to the new pasty bone substitute was tested in New Zealand white rabbits for up to 24 weeks compared to empty controls. Analysis included HR-pQCT scans, histomorphometric evaluation and quantification of vascularization of un-decalcified histological slices. Results: After 1 week the experimental group presented significantly higher new bone volume fraction (p=0.021) primarily consisting of immature bone matrix and higher vessel density compared to controls (p=0.013). After 4 weeks bone formation was not significantly different to controls but was distributed more evenly throughout the defect. Bone matrix was now mineralized and trabeculae were thicker than in controls (p=0.002) indicating faster intramedullary bone maturation. Controls presented extensive periosteal bone formation, major fibrous tissue influx and high vascularization. After 12 and 24 weeks there was no new bone detectable. There were no severe signs of inflammation at all time points. Conclusion: The substitute showed an early induction of bone formation. It promoted accelerated intramedullary bone repair and maturation and prevented periosteal bone formation indicating its potential use for reconstructive surgery of bone defects. © 2013 The Author(s).


Ghanaati S.,Johannes Gutenberg University Mainz | Ghanaati S.,Goethe University Frankfurt | Barbeck M.,Johannes Gutenberg University Mainz | Hilbig U.,Johannes Gutenberg University Mainz | And 5 more authors.
Acta Biomaterialia | Year: 2011

In this study, the in vivo tissue reaction to a new triphasic and injectable paste-like bone-substitute material composed of beta-tricalcium phosphate (β-TCP), methylcellulose and hyaluronic acid was analyzed. Using a subcutaneous implantation model, the interaction of these materials and the peri-implant tissue reaction were tested in Wistar rats for up to 60 days by means of established histological methods, including histomorphometrical analysis. The study focused on tissue integration, classification of the cellular inflammatory response and the degradation of the material. Groups composed of animals injected only with β-TCP granules, sham-operated animals and animals injected with saline were used as controls. After implantation, the triphasic bone-substitute material was present as a bulk-like structure with an inner and outer core. Over a period of 60 days, the material underwent continuous degradation from the periphery towards the core. The implantation bed of the β-TCP granule control group was invaded by phagocytes and formed a poorly vascularized connective tissue soon after implantation. This inflammatory response continued throughout the study period and filled the implantation bed. Significantly, the combination of the three biocompatible materials into one injectable paste-like bone-substitute material enabled modification of the tissue reaction to the implant and resulted in a longer in vivo lifetime than that of β-TCP granules alone. In addition, this combination increased the vascularization of the implantation bed, which is essential for successful tissue regeneration. © 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.


Hoenig E.,TU Hamburg - Harburg | Leicht U.,Ludwig Maximilians University of Munich | Winkler T.,TU Hamburg - Harburg | Mielke G.,TU Hamburg - Harburg | And 5 more authors.
Tissue Engineering - Part A | Year: 2013

The implantation of osteochondral constructs-tissue-engineered (TE) cartilage on a bone substitute carrier-is a promising method to treat defects in articular cartilage. Currently, however, the TE cartilage's mechanical properties are clearly inferior to those of native cartilage. Their improvement has been the subject of various studies, mainly focusing on growth factors and physical loading during cultivation. With the approach of osteochondral constructs another aspect arises: the permeability of the carrier materials. The purpose of this study was to investigate whether and how the permeability of the subchondral bone influences the properties of native cartilage and whether the bone substitute carrier's permeability influences the TE cartilage of osteochondral constructs accordingly. Consequently, the influence of the subchondral bone's permeability on native cartilage was determined: Native porcine cartilage-bone cylinders were cultivated for 2 weeks in a bioreactor under mechanical loading with and without restricted permeability of the bone. For the TE cartilage these two permeability conditions were investigated using permeable and impermeable tricalciumphosphate carriers under equivalent cultivation conditions. All specimens were evaluated mechanically, biochemically, and histologically. The restriction of the bone's permeability significantly decreased the Young's modulus of native cartilage in vitro. No biochemical differences were found. This finding was confirmed for TE cartilage: While the biochemical parameters were not affected, a permeable carrier improved the cell morphology and mechanical properties in comparison to an impermeable one. In conclusion, the carrier permeability was identified as a determining factor for the mechanical properties of TE cartilage of osteochondral constructs. © 2013, Mary Ann Liebert, Inc.


Chai F.,University of Lille Nord de France | Chai F.,Lille 2 University of Health and Law | Abdelkarim M.,University of Lille Nord de France | Abdelkarim M.,Lille 2 University of Health and Law | And 15 more authors.
Journal of Biomedical Materials Research - Part B Applied Biomaterials | Year: 2014

The progress in bone cancer surgery and multimodal treatment concept achieve only modest improvement in the overall survival, due to failure in clearing out residual cancer cells at the surgical margin and extreme side-effects of adjuvant postoperative treatments. Our study aims to propose a new method based on cyclodextrin polymer (polyCD) functionalized hydroxyapatite (HA) for achieving a high local drug concentration with a sustained release profile and a better control of residual malignant cells via local drug delivery and promotion of the reconstruction of bone defects. PolyCD, a versatile carrier for therapeutic molecules, can be incorporated into HA (bone regeneration scaffold) through thermal treatment. The parameters of polyCD treatment on the macroporous HA (porosity 65%) were characterized via thermogravimetric analysis. Good cytocompatibility of polyCD functionalized bioceramics was demonstrated on osteoblast cells by cell vitality assay. An antibiotic (gentamicin) and an anticancer agent (cisplatin) were respectively loaded on polyCD functionalized bioceramics for drug release test. The results show that polyCD functionalization leads to significantly improved drug loading quantity (30% more concerning gentamicin and twice more for cisplatin) and drug release duration (7 days longer concerning gentamicin and 3 days longer for cisplatin). Conclusively, this study offers a safe and reliable drug delivery system for bioceramic matrices, which can load anticancer agents (or/and antibiotics) to reduce local recurrence (or/and infection). © 2014 Wiley Periodicals, Inc.


Patent
Curasan Ag | Date: 2012-05-31

The invention relates to a biologically degradable composite material and to a process for the preparation thereof. The biologically degradable composite material according to the invention is preferably a bone reconstruction material which can be used in the field of regenerative medicine, especially as a temporary bone defect filler for bone regeneration.

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