Port Talbot, United Kingdom
Port Talbot, United Kingdom

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Williams C.F.,Cultech | Walton G.E.,University of Reading | Jiang L.,Cultech | Plummer S.,Cultech | And 2 more authors.
Annual Review of Food Science and Technology | Year: 2015

The human gut is a complex ecosystem occupied by a diverse microbial community. Modulation of this microbiota impacts health and disease. The definitive way to investigate the impact of dietary intervention on the gut microbiota is a human trial. However, human trials are expensive and can be difficult to control; thus, initial screening is desirable. Utilization of a range of in vitro and in vivo models means that useful information can be gathered prior to the necessity for human intervention. This review discusses the benefits and limitations of these approaches. Copyright ©2015 by Annual Reviews. All rights reserved.


PubMed | Cultech
Type: | Journal: Annual review of food science and technology | Year: 2015

The human gut is a complex ecosystem occupied by a diverse microbial community. Modulation of this microbiota impacts health and disease. The definitive way to investigate the impact of dietary intervention on the gut microbiota is a human trial. However, human trials are expensive and can be difficult to control; thus, initial screening is desirable. Utilization of a range of in vitro and in vivo models means that useful information can be gathered prior to the necessity for human intervention. This review discusses the benefits and limitations of these approaches.

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