Guo M.-H.,Kunming Medical University |
Wu W.-J.,Kunming Medical University |
Fan L.,2KIZ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases |
Peng M.-S.,2KIZ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases |
And 26 more authors.
Journal of Human Genetics | Year: 2014
Severe acne presents sexual dimorphism in its incidence in Chinese population. It is more prevalent in males. To assess the possible Y chromosomal contribution to severe acne risk in Han Chinese males, we analyzed 2041 Y chromosomal SNPs (Y-SNPs) in 725 severe acne cases and 651 controls retrieved from our recent genome-wide association study data. After data filtering, we assigned 585 cases and 494 controls into 12 Y chromosomal haplogroups based on 307 high-confidence Y-SNPs. No statistically significant difference in the distribution of Y chromosomal haplogroup frequencies was observed between the case and control groups. Our results showed a lack of association between the incidence of severe acne and the different Y chromosomal haplogroup in the Han Chinese population. © 2014 The Japan Society of Human Genetics All rights reserved.