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Egan L.,Discipline of Pharmacology and Therapeutics | D'Inca R.,University of Padua | Jess T.,Statens Serum Institute | Pellino G.,The Second University of Naples | And 7 more authors.
Journal of Crohn's and Colitis | Year: 2014

Patients with inflammatory bowel diseases (IBD) have an excess risk of certain gastrointestinal cancers. Much work has focused on colon cancer in IBD patients, but comparatively less is known about other more rare cancers. The European Crohn's and Colitis Organization established a pathogenesis workshop to review what is known about these cancers and formulate proposals for future studies to address the most important knowledge gaps. This article reviews the current state of knowledge about small bowel adenocarcinoma, ileo-anal pouch and rectal cuff cancer, and anal/perianal fistula cancers in IBD patients. © 2013 European Crohn's and Colitis Organisation.


Patel H.R.H.,University of Tromsø | Santos P.B.,Hospital CUF Descobertas | de Oliveira M.C.,Centro Hospitalar Do Porto Hospital Of San Antonio | Muller S.,Akershus University Hospital | Muller S.,University of Oslo
World Journal of Urology | Year: 2016

Background: Totally intracorporeal robotic-assisted radical cystectomy (RARC) has perceived difficulties compared to open radical cystectomy (ORC). As the technique is increasingly adopted around the world, the benefits of RARC with intra- or extracorporeal urinary diversion or ORC for the patients are still unclear. In this article, we consider the current evidence for this issue. Methods: We assessed two questions through using expert opinion and the medical literature: (A) Is RARC better than ORC for removing the cancer surgery and outcome? (B) Is RARC better than ORC for the urinary diversion? Outcomes: (A) RARC is better than ORC for shorter length of stay, blood loss and complication rates. (B) Intracorporeal orthotopic neobladder may have a significant physiological and surgical benefit to the patient recovery. Conclusions: RARC with total intracorporeal reconstruction has potential benefits to the patient. We recommend that all surgeons document patient-related outcome measures, urodynamics and enhanced recovery protocols for cystectomy patients to help us understand the real improvements within bladder cancer surgery and reconstruction. © 2015, Springer-Verlag Berlin Heidelberg.


PubMed | Karolinska Institutet, Regional Health Service Lazio Region, Libra Foundation, University of Plymouth and 212 more.
Type: | Journal: Clinical and translational allergy | Year: 2017

The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA-disseminated and implemented in over 70 countries globally-is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (


PubMed | Karolinska Institutet, University of Versailles, University of Coimbra, Medical University of Graz and 33 more.
Type: | Journal: Allergy | Year: 2017

The use of Apps running on smartphones and tablets profoundly affects medicine. The MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) App (Allergy Diary) assesses allergic rhinitis symptoms, disease control and impact on patients lives. It is freely available in 20 countries (iOS and Android platforms).To assess in a pilot study whether (i) Allergy Diary users were able to properly provide baseline characteristics (ii) simple phenotypic characteristics based upon data captured by the Allergy Diary could be identified and (iii) information gathered by this study could suggest novel research questions.The Allergy Diary users were classified into 6 groups according to the baseline data that they entered into the App: (1) asymptomatic; (2) nasal symptoms excluding rhinorrhea; (3) rhinorrhea; (4) rhinorrhea plus 1-2 nasal/ocular symptoms; (5) rhinorrhea plus 3 nasal /ocular symptoms and (6) rhinorrhea plus all nasal/ocular symptoms.By June 1, 2016, 3,260 users had registered with the Allergy Diary and 2,710 had completed the baseline questionnaire. Troublesome symptoms were found mainly in the users with the most symptoms. Around 50% of users with troublesome rhinitis and/or ocular symptoms suffered work impairment. Sleep was impaired by troublesome symptoms and nasal obstruction.This is the first App (iOS and Android) to have tested for allergic rhinitis and conjunctivitis. A simple questionnaire administered by cell phones enables the identification of phenotypic differences between a priori defined rhinitis groups. The results suggest novel concepts and research questions in allergic rhinitis that may not be identified using classical methods. This article is protected by copyright. All rights reserved.

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