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Rome, Italy

This study presents a consecutive series of patients who underwent total knee arthroplasty (TKA) after prior distal femoral fracture without hardware removal. The purpose of this study was to determine the effectiveness of computer-assisted TKA in patients with posttraumatic arthritis, specifically those with retained hardware after prior distal femoral fracture. The study group included a consecutive series of 16 patients who had developed posttraumatic knee arthritis after a distal femoral fracture with retention of hardware (group A). Patients in the study group were matched with patients who had undergone a computer-assisted TKA using the same implant and software (group B). The indication for TKA in all group B patients was atraumatic arthritis, and surgery was performed during the same period as that in the study group. Patients were matched for age, sex, preoperative range of motion, preoperative severity of arthritis, type and grade of deformity, and implant features. No statistically significant differences existed between the 2 study groups in terms of operative time, duration of hospital stay, or intra- and postoperative complications. At last follow-up, no statistically significant differences existed in Knee Society Scores and Western Ontario and McMaster Universities Arthritis Index scores. Implant alignment and radiological parameters were similar in both groups. This study demonstrated that posttraumatic knee arthritis after prior distal femoral fracture can be safely managed using a computer-assisted TKA without hardware removal. Comparison between the study group and a matched group with atraumatic arthritis showed similar postoperative results and complication rates. Copyright 2012, SLACK Incorporated. Source


Vaienti L.,University of Milan | Merle M.,Institute Europeen Of La Main | Battiston B.,CTO Hospital | Villani F.,University of Milan | Gazzola R.,University of Milan
Journal of Hand Surgery: European Volume | Year: 2013

The purpose of this study was to evaluate the effectiveness and middle-term durability of the results achieved with perineural fat grafting of painful neuromas of the upper limb. We retrospectively analysed eight patients, affected by eight neuromas, treated by neuroma excision and fat grafting around the proximal nerve stump. Clinical parameters, the disabilities of the arm shoulder and hand score, and the visual analogue scale were recorded at 2, 6 and 12 months after surgery.A reduction of 23.2% was observed in the mean disabilities of the arm shoulder and hand scores at 12 months. The spontaneous baseline visual analogue scale score showed a mean improvement of 22% at 12 months, although not this was not statistically significant.Perineural fat grafting is a quick and useful procedure and could represent a useful primary operation in the treatment of pain syndromes of neuropatic origin. © The Author(s) 2012. Source


Piga M.,University of Cagliari | Peltz M.T.,G. Brotzu General Hospital | Montaldo C.,CTO Hospital | Perra D.,University of Cagliari | And 4 more authors.
Autoimmunity Reviews | Year: 2015

To evaluate the long-term progression of cerebral MRI abnormalities in patients with longstanding SLE, 30 patients (age 53.5. ±. 11.3) underwent brain MRI at baseline (b-MRI) and after 19.4. ±. 3.7. years of follow-up (fu-MRI). Two neuroradiologists visually analyzed the MRIs comparing: 1) white matter hyperintensities (WMHIs), 2) cerebral volume, and 3) parenchymal defects; these outcomes were also built in a modified MRI scoring system (mMSS) to estimate the cumulative parenchymal damage. The independent risk factors for accrual of MRI brain damage, as well as the association between MRI abnormalities and the development of new neuropsychiatric (NP) manifestations classified according to the 1999 ACR case definition were also analyzed. Twenty-three patients (76.7%) showed worsening of mMSS; 19 (63.3%) had increased number and volume of WMHIs, 8 (26.7%) had significant cerebral volume loss, and 6 (20%) showed new ischemic parenchymal lesions. Only 6 patients had normal MRI. Antimalarial agents (p = 0.006; OR 0.08) were protective against worsening of WMHIs. High cumulative dose of corticosteroids (p = 0.026; OR 8.8) and dyslipidemia (p = 0.044; OR 10.1) were associated with increased mMSS and cerebral volume loss, respectively. Higher mMSS score at baseline was independently associated with worsening of WMHIs (p = 0.001; OR 5.7) and development of new NP events (p = 0.019; OR 2.0); higher load of deep WMHIs at b-MRI (p = 0.018; OR 2.0) was independently associated with stroke risk. This study shows that MRI brain damage in SLE patients progresses independently from NP involvement as effect of potentially modifiable risk factors and it is associated with increased risk of new NP events. © 2015 Elsevier B.V. Source


Manzotti A.,CTO Hospital | Chemello C.,Clinica Ortopedica | Pullen C.,Royal Melbourne Hospital | Cerveri P.,Polytechnic of Milan | Confalonieri N.,CTO Hospital
Knee Surgery, Sports Traumatology, Arthroscopy | Year: 2013

Purpose: Despite good overall clinical results, unicompartmental knee replacements (UKR) are not without their problems and failures have been reported. The most common causes of UKR failure are component loosening, poor patient selection, poor surgical technique, polyethylene wear and progression of arthritis in other compartments. The purpose of this study is to present a series of atraumatic fractures of metallic components in a UKR treated in a single orthopaedic centre. Method: Since 1999, 121 failed unicompartmental knee arthroplasties have been referred to our centre. In six of these, atraumatic breakage of a metal component in the cemented UKR was seen and included in this study. Pre-operative alignment, BMI and implant longevity were documented. The femoral implant failed in 4 patients and the tibial implant in a further 2. Results: All the femoral implant fractures occurred within 3 years of UKR surgery (mean: 22.2 months, SD: 10.6 months). Tibial implant breakage occurred at a mean of 8.5 years (SD: 2.4 months) following UKR. All patients were treated with conversion to a navigated total knee replacement. A primary total knee arthroplasty was used in all cases with one patient requiring a tibial component incorporating a wedge and stem following breakage of the original UKR tibial implant. Conclusion: Fracture of the metallic components is a potential cause of failure of unicompartmental knee arthroplasty. In our experience, the incidence of this complication was 4.9 % of all UKR failures. Patients with a BMI greater than 30 and a progressive deterioration in limb alignment were at greater risk. Level of evidence: IV. © 2012 Springer-Verlag. Source


Manzotti A.,CTO Hospital | Cerveri P.,Polytechnic of Milan | Pullen C.,Royal Melbourne Hospital | Confalonieri N.,CTO Hospital
International Orthopaedics | Year: 2014

Purpose: The aim of this study was to retrospectively compare the results of two matched-paired groups of patients who had undergone a medial unicompartmental knee arthroplasty (UKA) performed using either a conventional or a non-image-guided navigation technique specifically designed for unicompartmental prosthesis implantation. Methods: Thirty-one patients with isolated medial-compartment knee arthritis who underwent an isolated navigated UKA were included in the study (group A) and matched with patients who had undergone a conventional medial UKA (group B). The same inclusion criteria were used for both groups. At a minimum of six months, all patients were clinically assessed using the Knee Society Score (KSS) and the Western Ontario and McMaster Osteoarthritis Index (WOMAC) index. Radiographically, the frontal-femoral- component angle, the frontal-tibial-component angle, the hip-knee-ankle angle and the sagittal orientation of components (slopes) were evaluated. Complications related to the implantation technique, length of hospital stay and surgical time were compared. Results: At the latest follow-up, no statistically significant differences were seen in the KSS, function scores and WOMAC index between groups. Patients in group B had a statistically significant shorter mean surgical time. Tibial coronal and sagittal alignments were statistically better in the navigated group, with five cases of outliers in the conventional alignment technique group. Postoperative mechanical axis was statistically better aligned in the navigated group, with two cases of overcorrection from varus to valgus in group B. No differences in length of hospital stay or complications related to implantation technique were seen between groups. Conclusion: This study shows that a specifically designed UKA-dedicated navigation system results in better implant alignment in UKA surgery. Whether this improved alignment results in better clinical results in the long term has yet to be proven. © 2013 Springer-Verlag Berlin Heidelberg. Source

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