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Seoul, South Korea

Mok C.H.,Konkuk University | Lee J.H.,CTC Bio Inc. | Kim B.G.,Konkuk University
Animal Feed Science and Technology | Year: 2013

The objective of the present study was to determine the effects of phytase and β-mannanase on apparent ileal and total tract digestibilities of energy and nutrients in diets containing 10% palm kernel expellers fed to pigs. A basal diet was mainly based on maize, soybean meal, and palm kernel expellers without inorganic P. Four experimental diets were prepared in a 2. ×. 2 factorial treatment arrangement with 2 concentrations of supplemental phytase at 0 or 1000. U/kg and 2 concentrations of supplemental β-mannanase at 0 or 1600. U/kg. Eight pigs with an initial body weight of 70.9. kg (SD. =11.9) were fitted with ileal T-cannulas and were fed experimental diets in a replicated 4. ×. 4 Latin square design with 4 dietary treatments and 4 periods. In each period, faeces were collected on d 7 and ileal digesta samples were collected on d 8 and 9. Supplemental phytase increased the coefficient of ileal apparent digestibilities (CIAD) and the coefficient of total tract apparent digestibilities (CTTAD) of P by 0.161 and 0.191, respectively (P. <. 0.01). Supplemental β-mannanase increased CIAD of dry matter, organic matter and energy by 0.035-0.038 (P. <. 0.05), and CTTAD of energy by 0.019 (P. <. 0.05). However, no interaction between phytase and β-mannanase was observed in the digestibility of nutrients. Phytase increased CIAD of aspartic acid, glutamic acid, and serine, by 0.021-0.029 (P. <. 0.05), and β-mannanase increased CIAD of leucine and phenylalanine by 0.018 and 0.019, respectively (P. <. 0.05). In conclusion, phytase and β-mannanase improved P and organic nutrient digestibilities, respectively, and to a lesser extent, the 2 enzymes improved amino acid digestibility. © 2013 Elsevier B.V.


Kong C.,Purdue University | Lee J.H.,CTC Bio Inc. | Adeola O.,Purdue University
Canadian Journal of Animal Science | Year: 2011

Kong, C., Lee, J. H. and Adeola, O. 2011. Supplementation of β-mannanase to starter and grower diets for broilers. Can. J. Anim. Sci. 91: 389-397. Two experiments were conducted to investigate the efficacy of β-mannanase on ileal nutrient digestibility, total tract utilization of dry matter (DM), N, energy, and apparent metabolizable energy (AME, exp. 1), and growth performance (exp. 2) of birds fed practical corn-soybean meal (SBM)-based diets. In each experiment, 192 male broilers were assigned to four diets arranged in a 2×2 factorial of energy level [corn-SBM-based diet that met or exceeded NRC nutrient requirements (AE) or low energy (LE) diet containing 100 kcal of ME kg-1 less than the AE diet] and enzyme supplementation (with or without β-mannanase) for 21 d. Supplementing the diet with β-mannanase increased the birds' apparent ileal DM digestibility of the experimental diets (P<0.05), whereas there was no effect of energy level. Neither β-mannanase supplementation nor energy level had any effect on apparent ileal digestibility of any of the amino acids. The interaction between enzyme and energy levels was not significant for any criteria measured in the excreta except for DM (P<0.05). Addition of b-mannanase improved (PB0.01) the apparent total tract utilization of DM and energy in the broilers, and there was the same trend (P=0.06) for N utilization. Supplementing the diet with β-mannanase also improved the AME and AMEn of diets by 4.6 and 5.0%, respectively. For all growth performance responses in exp. 2, the interaction between enzyme and energy levels was not significant. During the starter period (day 2 to 22 post-hatch), β-mannanase supplementation significantly (P<0.05) increased the body weight (BW) gain of birds. During the grower period (day 22 to 44 post-hatch) and for the overall period there was no significant difference in BW gain or feed intake of birds regardless of energy level and β-mannanase supplementation. There were no dietary effects on feed efficiency of birds during the starter and the grower periods, whereas the birds fed AE diets had higher feed efficiency (P<0.01) than the birds fed LE diets. The results indicate that supplementing with β-mannanase may improve gain and energy utilization of broilers, whereas it may not affect ileal amino acid digestibility.


The present disclosure relates to a film formulation for oral administration, containing tadalafil free base and a method of preparing the same, and a film may be provided with maximized dispersion stability of tadalafil free base in the film by the addition of a dispersion stabilizing agent in small amounts without unique fragrance or favor that may appear when other dispersion stabilizing agents known in the art are used, and an extremely low likelihood that a reagglomeration phenomenon of tadalafil free base particles will occur, and an amount of bubbles generated may be significantly reduced during a production process.


Patent
CTC Bio Inc. and Gwangju Agricultural Technology Center | Date: 2012-01-10

The present invention relates to an eco-friendly probiotic composition, and more particularly, to a probiotic composition for livestock production, comprising a lactic acid bacteria culture medium and an organic acid, wherein the organic acid is contained in an amount of 0.002 to 0.1 parts by weight relative to 1 parts by weight of the lactic acid bacteria culture medium. The present invention also relates to a method for preparing the composition. The eco-friendly probiotic composition of the present invention does not contain antibiotics and may exhibit complex effect of sterilization and virucidal effectiveness.


The present invention provides a method for producing a film which contains a tasteless donepezil-free base, has an appropriate size and thickness, has flexibility for providing stability when handled so as to not easily tear, and has a uniformly dispersed donepezil-free base. In addition, the present invention provides a film containing the donepezil-free base produced through the method.

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