CT Institute of Pharmaceutical science

Jalandhar, India

CT Institute of Pharmaceutical science

Jalandhar, India
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Thakur R.,P.A. College | Swami G.,CT Institute of Pharmaceutical science | Rahman M.,P.A. College
Current Drug Delivery | Year: 2014

The present investigation was carried out to formulate and optimize the bioerodable insert of Azithromycin in order to prolong the release time and improve the ocular availability in ophthalmic infections. A modified solvent casting method was used for the preparation of azithromycin insert in which hydroxyl propyl methyl cellulose (HPMC) and Eudragit RL100 were used as drug reservoir and rate controlling membrane respectively. Thereafter the, formulations were evaluated for the uniformity of thickness and weight, surface pH, folding endurance, percentage moisture loss, percentage moisture absorption, drug content, in-vitro release, kinetics studies (zero order, first order, Higuchi and Korsmeyer - Peppas model) and stability studies. The Formulation H8 (amongst the range of H1-H10), comprising of 1.5% HPMC and 3% Eudragit RL100, was found to be optimized formulation on the basis of uniformity of thickness (0.26±0.004 mm) and weight (24.9±0.27 mg), surface pH (7.1±0.063), folding endurance (18.3±0.81), percentage moisture loss (7.49±0.30%), percentage moisture absorption (5.7%), drug content (1.98 mg), in-vitro release (99%), AUC for in vitro and in vivo release is 38828.33 and 39783.33 g min/ml respectively and higher than pure drug (1190 g min/ml), (Shelf life-622 days) and further better occular tolerablity found. The formulation H8 showed a steady and controlled release of the drug over a 12 hour period with non-Fickian diffusion release mechanism, compared to a normal release period of 2-3 hours. The optimized insert showed promising results and can be used to treat a wide range of ocular infections. © 2014 Bentham Science Publishers.


Chawla A.,CT Institute of Pharmaceutical science | Kaur R.,CT Institute of Pharmaceutical science | Goyal A.,Chitkara University
Journal of Chemical and Pharmaceutical Research | Year: 2011

Benzimidazoles belonging to the fused heterocyclic system prepared from amino acids are associated with diverse pharmacological activities such as antimicrobial, antiviral, antidiabetic and anticancer activity. This review deals with the review of an efficient "green" synthesis of benzimidazole derivatives by microwave induced reactions.


Kharb R.,CT Institute of Pharmaceutical science | Kaur M.,CT Institute of Pharmaceutical science | Kumar Sharma A.,CT Institute of Pharmaceutical science
International Journal of Pharmaceutical Sciences Review and Research | Year: 2013

Emergence of resistance by bacterial and fungal stains towards existing antimicrobial agents is one of the major problem as well as motivation to synthesize a new class of antimicrobial agents possessing potent activity compared to commonly used therapy. Coumarin is the heterocyclic compound formed from benzene and pyrone ring containing oxygen and its derivatives are of wide awareness because of their diverse biological activity and clinical applications, they are remarkably effective compounds both with respect to their inhibitory activity and their favourable selectivity ratio. Coumarins are regarded as a promising class of bioactive heterocyclic compounds that exhibit a range of biological activities like anti-microbial, anti-viral, anti-diabetic, anti-cancer activity, anti-oxidant, anti-parasitic, anti-helmintic, anti-proliferative, anti-convulsant, anti-inflammatory and anti-hypertensive activities etc. The information given in this manuscript may be helpful in the further research of better antimicrobial agents having lesser microbial resistance and improved antimicrobial profile.


Kharb R.,CT Institute of Pharmaceutical science | Rana M.,CT Institute of Pharmaceutical science | Chander Sharma P.,Kurukshetra University | Shahar Yar M.,Hamdard University
Journal of Chemical and Pharmaceutical Research | Year: 2011

Today there is a highly elevated demand for synthesis and screening of nature-like biopolymers and their more stable modified derivatives like peptidomimetics because availability of huge amounts of genomic and proteomic data can contribute for research in this area. The design and synthesis of peptidomimetics are most important because of the dominant position peptide and protein-protein interactions play in molecular recognition and signaling, especially in living systems. The design of peptide mimetics can be viewed from several different perspectives and peptidomimetics can be categorized in a number of different ways. Study of the vast literature would suggest that medicinal and organic chemists, who deal with peptide mimics, utilize these methods in many different ways. This manuscript is an endeavor to discuss a variety of methodologies and strategies to develop and establish systematic tools for transformation of peptides into peptidomimetics or further into small drug-like molecules and their pharmacological activities having significance in modern drug design.


Kharb R.,CT Institute of Pharmaceutical science | Yar M.S.,Jamia Hamdard University | Sharma P.C.,Kurukshetra University
Current Medicinal Chemistry | Year: 2011

Research and development for novel substances possessing anti-infective activity have attracted considerable attention due to the escalating resistance towards conventional antibiotics. Therefore, the discovery and development of effective antimicrobial drugs with novel mechanism of action have become an insistent task for infectious diseases research programs. Triazole scaffold has been consistently rewarded as a promising versatile lead molecule with a pivotal position in modern medicinal chemistry. The literature reveals that this heterocyclic moiety has drawn attention of the chemists, pharmacologists, microbiologists and other researchers owing to its indomitable biological potential as anti-infective agents. The present communication is a cogent attempt to review the chemistry and antimicrobial activities of triazole derivatives reported in recent scientific literature. The biological profiles of these new triazole derivatives represent a fruitful matrix for further development as promising and superior anti-infective medicinal agents. © 2011 Bentham Science Publishers Ltd.


Kaur R.,CT Institute of Pharmaceutical science | Kharb R.,CT Institute of Pharmaceutical science
International Journal of Pharma and Bio Sciences | Year: 2011

The acquired immunodeficiency syndrome (AIDS) is a result of human immunodeficiency virus (HIV) infection which leads to severe suppression of immune functions. AIDS is a real threat to the health of mankind, and the search for effective therapies is still of great importance. However besides the high cost, there are adverse effects and limitations associated with chemotherapy applied. Thus herbal medicines are frequently used as an alternate therapy by individuals living with HIV. Numerous plant derived compounds have been evaluated for inhibitory effects on HIV replication, and many have been found to inhibit different steps in HIV replication cycle. The aim of this review is to list research findings for herbal medicines which are endowed with the ability to inhibit HIV.


Kharb R.,CT Institute of Pharmaceutical science | Bansal K.,CT Institute of Pharmaceutical science | Sharma A.K.,CT Institute of Pharmaceutical science
Der Pharma Chemica | Year: 2012

The worldwide problem of microbial resistance has drawn utmost attention for medicinal chemists because of failure of currently available antimicrobial therapy against microbial infections. Therefore, there is an urgent need to develop novel antimicrobial agents with different mode of actions. In the search of better antimicrobial agents, different heterocyclic compounds have been explored and out of them piperazine derivatives have shown a broad spectrum of pharmacological activities like antibacterial, antifungal, antitubercular, anticancer, antiviral, antioxidant activities etc. This communication is focused on to review antimicrobial activities of different piperazine derivatives in detail and the valuable information provided in this manuscript may help in the drug design and development of better antimicrobial agents.


Kaur J.,CT Institute of Pharmaceutical science
International Journal of Pharmaceutical Sciences Review and Research | Year: 2014

In Pharmaceutical Industry, Regulatory Affairs Department makes an interface between the regulatory authorities and pharmaceutical industry. The Regulatory Affairs department is an important part of the organizational structure of pharmaceutical companies. Internally it liaises at the inter phase of drug development, manufacturing, marketing and clinical research. Externally it is the key interface between the company and the regulatory authorities. Regulatory Affairs is involved in the development of new medicinal products from early on, by integrating regulatory principles and by preparing and submitting the relevant regulatory dossiers to health authorities. Regulatory Affairs is actively involved in every stage of development of a new medicine and in the post-marketing activities with authorized medicinal products. This professional can play a key role in guiding drug development strategy in an increasingly global environment and has an important role for submitting the newly discovered drug products approval documents to the US FDA regulatory authorities and to carry out all the practices required for obtaining the drug products approval. This article mainly focuses on the US FDA drug approval strategies. These strategies playing core job in the pharmaceutical industry. These strategies having all the guidelines which are indispensable part of the IND, NDA and ANDA drug approval applications. It plays a significant role in sequence for registration of newly exposed products and also providing the guidelines which is helpful preparing the registration documents to regulatory authorities.


Chawla A.,CT Institute of Pharmaceutical science | Sharma A.,CT Institute of Pharmaceutical science | Sharma A.K.,CT Institute of Pharmaceutical science
Der Pharma Chemica | Year: 2012

Imidazole is the heterocyclic 5-membered ring structure, out of which three are carbon and the remaining two are nitrogen, arranged at 1 and 3 positions. It is the constituent of several natural compounds like histamine, histidine, biotin, alkaloids and nucleic acid and a very important class among the medicinal compounds. Large number of imidazole derivatives have been are being developed for different therapeutic actions, therefore this article aims to review the work reported on the synthesis of imidazole derivatives using microwave reactions as a modern method for synthesis, to get better yield, economic and environment friendly reaction.


Sharma A.K.,CT Institute of Pharmaceutical science | Kharb R.,CT Institute of Pharmaceutical science | Kaur R.,CT Institute of Pharmaceutical science
International Journal of Pharma and Bio Sciences | Year: 2011

Medicinal plants have remained the major sources of drugs; in fact many of the currently available drugs were derived either directly or indirectly from them. The approach to new drugs through natural products has proved to be the single most successful strategy for the discovery of new drugs. In the past decade, research has been focused on scientific evaluation of traditional drugs of plant origin for the treatment of various diseases. Calotropis procera is small, erect and compact shrub, which is used in several traditional medicines to cure various diseases. This shrub has been known to possess analgesic, antitumor, antihelmintic, antioxidant, hepatoprotective, antidiarrhoeal, anticonvulsant, antimicrobial, oestrogenic, antinociceptive, and antimalarial activity. This review is a sincere attempt to summarize the information concerning pharmacognostical features of Calotropis procera shrubs.

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