CST Inc.

San Mateo, CA, United States
San Mateo, CA, United States
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Hitosugi T.,Emory University | Zhou L.,University of Chicago | Fan J.,Emory University | Elf S.,Emory University | And 22 more authors.
Nature Communications | Year: 2013

How oncogenic signalling coordinates glycolysis and anabolic biosynthesis in cancer cells remains unclear. We recently reported that the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) regulates anabolic biosynthesis by controlling intracellular levels of its substrate 3-phosphoglycerate and product 2-phosphoglycerate. Here we report a novel mechanism in which Y26 phosphorylation enhances PGAM1 activation through release of inhibitory E19 that blocks the active site, stabilising cofactor 2,3-bisphosphoglycerate binding and H11 phosphorylation. We also report the crystal structure of H11-phosphorylated PGAM1 and find that phospho-H11 activates PGAM1 at least in part by promoting substrate 3-phosphoglycerate binding. Moreover, Y26 phosphorylation of PGAM1 is common in human cancer cells and contributes to regulation of 3-phosphoglycerate and 2-phosphoglycerate levels, promoting cancer cell proliferation and tumour growth. As PGAM1 is a negative transcriptional target of TP53, and is therefore commonly upregulated in human cancers, these findings suggest that Y26 phosphorylation represents an additional acute mechanism underlying phosphoglycerate mutase 1 upregulation. © 2013 Macmillan Publishers Limited. All rights reserved.


Shalaev M.I.,State University of New York at Buffalo | Sun J.,State University of New York at Buffalo | Tsukernik A.,University of Toronto | Pandey A.,CST Inc. | And 2 more authors.
Nano Letters | Year: 2015

Metasurfaces are two-dimensional structures enabling complete control on light amplitude, phase, and polarization. Unlike plasmonic metasurfaces, silicon structures facilitate high transmission, low losses, and compatibility with existing semiconductor technologies. We experimentally demonstrate two examples of high-efficiency polarization-sensitive dielectric metasurfaces with 2π phase control in transmission mode (45% transmission efficiency for the vortex converter and 36% transmission efficiency for the beam steering device) at telecommunication wavelengths. Silicon metasurfaces are poised to enable a versatile platform for the realization of all-optical circuitry on a chip. © 2015 American Chemical Society.


PubMed | University of Toronto, Moscow State University, CST Inc. and State University of New York at Buffalo
Type: Journal Article | Journal: Nano letters | Year: 2015

Metasurfaces are two-dimensional structures enabling complete control on light amplitude, phase, and polarization. Unlike plasmonic metasurfaces, silicon structures facilitate high transmission, low losses, and compatibility with existing semiconductor technologies. We experimentally demonstrate two examples of high-efficiency polarization-sensitive dielectric metasurfaces with 2 phase control in transmission mode (45% transmission efficiency for the vortex converter and 36% transmission efficiency for the beam steering device) at telecommunication wavelengths. Silicon metasurfaces are poised to enable a versatile platform for the realization of all-optical circuitry on a chip.


Krier A.,Lancaster University | Yin M.,Lancaster University | Marshall A.R.J.,Lancaster University | Kesaria M.,Lancaster University | And 6 more authors.
Infrared Physics and Technology | Year: 2015

We demonstrate the first low bandgap thermophotovoltaic (TPV) arrays capable of operating with heat sources at temperatures as low as 345°C, which is the lowest ever reported. The individual array elements are based on narrow band gap InAs/InAs0.61Sb0.13P0.26 photodiode structures. External power conversion efficiency was measured to be ∼3% from a single element at room temperature, using a black body at 950°C. Both 25-element and 65-element arrays were fabricated and exhibited a TPV response at different source temperatures in the range 345-950°C suitable for electricity generation from waste heat and other applications. © 2015 Published by Elsevier B.V.

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