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News Article | October 29, 2016
Site: www.prlog.org

The CSL Group, a Konica Minolta supplier based in Leicester, have just announced the opening of their newly refurbished showroom and demonstration facility.


Wen Y.,CSL Group | Han L.,CSL Group | Han L.,Sanofi S.A. | Palladino G.,CSL Group | And 5 more authors.
Vaccine | Year: 2015

Influenza vaccines are the primary intervention for reducing the substantial health burden from pandemic and seasonal influenza. Hemagglutinin (HA) is the most important influenza vaccine antigen. Subunit and split influenza vaccines are formulated, released for clinical use, and tested for stability based on an in vitro potency assay, single-radial immunodiffusion (SRID), which selectively detects HA that is immunologically active (capable of eliciting neutralizing or hemagglutination inhibiting antibodies in an immunized subject). The time consuming generation of strain-specific sheep antisera and calibrated antigen standards for SRID can delay vaccine release. The limitation in generating SRID reagents was evident during the early days of the 2009 pandemic, prompting efforts to develop more practical, alternative, quantitative assays for immunologically active HA. Here we demonstrate that, under native conditions, trypsin selectively digests HA produced from egg or mammalian cell in monovalent vaccines that is altered by stress conditions such as reduced pH, elevated temperature, or deamidation, leaving native, pre-fusion HA, intact. Subsequent reverse-phase high pressure liquid chromatography (RP-HPLC) can separate trypsin-resistant HA from the digested HA. Integration of the resulting RP-HPLC peak yields HA quantities that match well the values obtained by SRID. Therefore, trypsin digestion, to pre-select immunologically active HA, followed by quantification by RP-HPLC is a promising alternative in vitro potency assay for influenza vaccines. © 2015 Elsevier Ltd.


News Article | November 16, 2016
Site: www.prnewswire.com

MONTREAL, Nov. 16, 2016 /PRNewswire/ - The CSL Group is pleased to announce that CSL President and CEO, Rod Jones was selected as co-Personality of the Year by the Women's International Shipping and Trading Association (WISTA) during the organization's annual conference last week....

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