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Lucknow, India

Pathak S.R.,Amity University | Malhotra V.,CSJMMU | Nath R.,CSJMMU
Central Nervous System Agents in Medicinal Chemistry | Year: 2014

A series of novel substituted quinazolin-4(3H)-one derivatives were synthesized and screened in vivo for their antihypertensive activities. Out of eighteen synthesized compounds, seven i.e. 2a, 2c, 4a, 4d, 5d, 6a & 6b compounds have shown hypotensive effect and produced bradycardia. These compounds have shown better activity than reference drug Prazosin (which acts as anti-hypertensive agent by α1 blocking action). All the compounds have shown ALD50>1000mg/kg with maximum in 2c & 4d (>1200mg/kg). © 2014 Bentham Science Publishers.


Malhotra V.,CSJMMU | Pathak S.R.,Amity University | Nath R.,CSJMMU | Mukherjee D.,CSJMMU
Bioorganic and Medicinal Chemistry Letters | Year: 2011

A series of novel substituted imidazole derivatives were synthesized and have been screened in vivo for their hypotensive and acute toxicity activities. Out of seventeen compounds eight compounds (2b, 2c, 3b, 3c, 3f, 4a, 4b and 4c) have shown good hypotensive and bradycardiac responses. Compounds 3b, 3c, 3f and 4c have shown better activity than reference drug clonidine. All the compounds have shown ALD50 >1000 mg/kg with maximum in 2e and 4c (>1200 mg/kg). © 2010 Elsevier Ltd. All rights reserved.

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