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Patent
CSIC - Institute of Refrigeration | Date: 2017-03-01

The object of the present invention is a biomimetic and zoosemiotic aerial vehicle incorporating sensors and means to detect and frighten off animals, its main characteristic being that it is equipped with a programmable automatic pilot. An object of the present invention is also the use of this vehicle in applications such as the control of certain plagues, in addition to the inspection of environmentally protected areas.


Patent
CSIC - Institute of Refrigeration | Date: 2017-04-05

A non-magnetic insertion probe for spectroscopic measurements comprising a hollow optic rod (1), an experimental space sealer (2), a sample holder (3) provided with a sample space (3-2), and at least two optic fiber guides (3-3) that traverse the sealer (2), the rod (1) and the sample holder (3), a first or irradiating guide guiding the light towards the sample space (3-2) and a second or collecting guide guiding the light from the sample space to the exterior of the probe. The materials and design of the probe allow for spectroscopic measurements inside a cryostat.


Patent
CSIC - Institute of Refrigeration and Complutense University of Madrid | Date: 2017-03-01

The invention relates to a novel implant based on titanium, consisting of a titanium coating formed over biomaterials, applicable in bone implantology. The nanotopographical characteristics of said implants inhibit bacterial adhesion and formation of bacterial biofilm on the surface, the implants simultaneously exhibiting suitable properties for the adhesion, extension, and proliferation of the bone-forming cells. The invention also relates to a method for producing the implant by means of oblique incidence techniques and to the use thereof in bone implantology..


The invention relates to a method and a device for detecting the temporal variation of the light intensity in a matrix of photosensors, comprising a matrix of pixels, a block for the automatic adjustment of the amplification of the photocurrent, and an arbitrating and event-encoding block. Each pixel comprises a photosensor that generates a photocurrent, an adjustable gain current mirror connected to the outlet of the photosensor, a transimpedance amplifier arranged at the outlet of the current mirror, optionally at least one amplification circuit arranged at the outlet of the transimpedance amplifier, and capacitors and detectors of thresholds for determining whether the output voltage exceeds a higher threshold or drops below a lower threshold in order to generate an event in the pixel.


Patent
CSIC - Institute of Refrigeration and Embl European Molecular Biology Laboratory | Date: 2017-02-08

The invention provides an isolated multiple integration element (MIE) comprising, in the specified order: a) a homing endonuclease site (HE); b) a promoter selected from the group consisting of AOX1, FLD1, FMD1, GAP and TEF1; c) a BstBI restriction site; d) a sequence encoding a secretion signal; e) a Ncol restriction site; f) a selection marker gene; g) a Pmel restriction site; h) a DNA sequence encoding a detection and/or purification polypeptide; i) a terminator selected from the group consisting of AOX1, FLD1, FMD1, GAP and TEF1; and j) a BstXI restriction site, wherein the HE and BstXI sites are selected such that HE and BstXI result in compatible cohesive ends when cut by the homing endonuclease and the BstXI restriction enzyme, respectively, and the ligation product of HE and BstXI cohesive ends can neither be cleaved by the homing endonuclease nor the BstXI restriction enzyme.


Patent
CSIC - Institute of Refrigeration | Date: 2016-09-14

The device (100) comprises a base component (10) for supporting at least one electrode (30), a cover component (60) for at least partially covering the base component (10) and having at least one opening (65) to confine a volume of a solution and for feeding magnetic particles to the electrode (30) for electrochemical detection; and at least one magnet (50) in at least one magnet support (40) that can be moved at least in two different positions for switching on/off the magnetic field to the electrodes (30) for confining or releasing the magnetic particles.


The invention relates to a method for protecting biological material in general and thermolabile substances, particularly useful in microorganisms and viruses and any other biological material, as well as in any substance, derived or otherwise, that requires protection to extend the useful life thereof or broaden the scope of use thereof, by electrohydrodynamic or aerodynamic processing. Said processing makes it possible to extend the useful life of the product in a unique manner, since exposing the substance to be protected to a temperature is not involved. In addition, depending on the features and variables used during the coating process, encapsulation makes it possible to maintain the viability of the product against stress conditions such as temperature, relative humidity or pH among others, offering effective protection during the subsequent preparation, processing and storage thereof, and even, for example, during the passage thereof through the gastrointestinal tract in the case of probiotic microorganisms.


Patent
CSIC - Institute of Refrigeration | Date: 2016-08-03

The invention relate to graphite materials, and more specifically to the exfoliation of graphite using deep eutectic solvents, to methods related thereto, to polymeric composite materials containing graphene and the methods for the production thereof, and to graphene/metal, exfoliated graphite/metal, graphene/metal oxide and exfoliated graphite/metal oxide composite materials and the methods for the production thereof.


The present invention relates to a family of S-substituted quinazoline derivatives that are inhibitors of the enzyme phosphodiesterase 7 (PDE7), useful for the treatment or prevention of diseases mediated by said enzyme, especially inflammatory, neurodegenerative, neurological, psychiatric and/or autoimmune diseases.


Patent
CSIC - Institute of Refrigeration | Date: 2016-12-21

The invention relates to an ion sensor based on differential measurement, comprising an ISFET/REFET pair, wherein the REFET is defined by a structure formed by an ISFET covered by a micro-reservoir containing an internal reference solution. The sensor comprises: a first and a second ion-selective field effect transistor; an electrode; a substrate on the surface of which the two transistors, connection tracks and the electrode are integrated; and a structure adhered to the first ion-selective field effect transistor, creating a micro-reservoir on the gate of said first transistor, said micro-reservoir having a micro-channel connecting the micro-reservoir with the exterior, and said micro-reservoir being filled with the reference solution

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