Time filter

Source Type

Garcia-Urdiales E.,University of Oviedo | Alfonso I.,CSIC - Institute of Advanced Chemistry of Catalonia | Gotor V.,University of Oviedo
Chemical Reviews | Year: 2011

Various developments made towards the use of biocatalysts for the desymmetrization of meso and prochiral compounds are reviewed. Studied have found that the hydrolysis of meso epoxides generally displays low enantioselectivities. Fukuyama and co-workers reported the total synthesis of Leustroducsin, a potent colonystimulating factor inducer isolated from the culture broth of Streptomyces platensis SANK 60191. Prati and co-workers have carried out the Amano PS lipasecatalyzed desymmetrization of aziridine, whose monoacetylated derivative, obtained in high yield and ee, is related to a key intermediate used in the total synthesis of the already mentioned antibiotic FR-900482. Sugai and co-workers have investigated the substrate specificity of the reduction of different triketones with the yeast strain Torulaspora delbrueckii IFO10921.

Alfonso I.,CSIC - Institute of Advanced Chemistry of Catalonia | Quesada R.,University of Burgos
Chemical Science | Year: 2013

The control of ion transport and homeostasis is a critical function of living organisms. In this perspective, an overview of different synthetic systems capable of facilitating the transmembrane transport of ions along with the biological activity exerted by these compounds is presented. Examples of both cation selective and anion selective transporters are highlighted. The potential future applications of these systems in the treatment of conditions derived from the dysregulation of natural ion transport mechanisms and the development of new antimicrobials and anticancer drugs are discussed. © 2013 The Royal Society of Chemistry.

Alfonso I.,CSIC - Institute of Advanced Chemistry of Catalonia
Current Organic Synthesis | Year: 2010

This review highlights the development of new receptors based on enantiopure trans-cyclohexane-1,2-diamine, a chiral building block presenting unique structural and conformational properties. Different architectures sharing this structural motif, which were prepared following several synthetic approaches, have been summarized from the recent literature. © 2010 Bentham Science Publishers Ltd.

Clapes P.,CSIC - Institute of Advanced Chemistry of Catalonia | Garrabou X.,CSIC - Institute of Advanced Chemistry of Catalonia
Advanced Synthesis and Catalysis | Year: 2011

Biocatalytic carbon-carbon bond formation by means of aldolases offers an exceptionally stereoselective and green tool for this strategic reaction in synthetic organic chemistry. Recent developments have shown that aldolases are particularly suitable catalysts for asymmetric framework construction and preparation of innovative molecules, which are valuable for investigations in drug discovery. Finding novel carboligases with unprecedented activities and engineering those available for improved substrate tolerance and stereoselectivity towards new synthetic challenges are fostering the advances in this field. Extensive knowledge of the precise reaction mechanism and the enzyme-substrate interactions arising from biochemical and structural studies are leading to the development of novel catalysts by rational strategies, as well as to de novo computational design of enzymes. Besides, a number of industrially-oriented processes with aldolases have been developed towards the production of drug precursors and dietary commodities. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Mannelli I.,CSIC - Institute of Advanced Chemistry of Catalonia | Marco M.-P.,CSIC - Institute of Advanced Chemistry of Catalonia
Analytical and Bioanalytical Chemistry | Year: 2010

In the last decade the use of anisotropic nanoparticles in analytical and bioanalytical applications has increased substantially. In particular, noble metal nanorods have unique optical properties that have attracted the interest of many research groups. The localized surface plasmon resonance (LSPR) generated by interaction of light at a specific wavelength with noble metal nanoparticles was found to depend on particle size and shape and on the constituting material and the surrounding dielectric solution. Because of their anisotropic shape, nanorods are characterized by two LSPR peaks: the transverse, fixed at approximately 530 nm, and the longitudinal, which is in the visible-near infra-red region of the spectrum and varies with nanorod aspect ratio. The intense surface plasmon band enables nanorods to absorb and scatter light in the visible and near infra-red regions, and fluorescence and two-photon induced luminescence are also observed. These optical properties, with the reactivity towards binding events that induce changes in the refractive index of the surrounding solution, make nanorods a useful tool for tracking binding events in different applications, for example assembly, biosensing, in-vivo targeting and imaging, and single-molecule detection by surface-enhanced Raman spectroscopy. This review presents the promising strategies proposed for functionalizing gold nanorods and their successful use in a variety of analytical and biomedical applications. © Springer-Verlag 2010.

Discover hidden collaborations