Gorczyca W.,Csi Inc.
Polish Journal of Pathology | Year: 2012
A total of 97 acute promyelocytic leukemia (APL) patients with adequate flow cytometry (FC) data, bone marrow aspirates and presence of t(15;17)/PML-RARA by cytogenetics and/or FISH studies were analyzed for immunophenotypic pattern. Leukemic cells had the following phenotype: CD11b -, CD11c -, CD13 +, CD33 +, CD45 +, CD64 +/-, CD117 +, and HLA-DR -. A subset of cases showed also an expression of CD2, CD4, CD34, and CD56. Based on the immunophenotype and side scatter properties (SSC), four FC patterns were recognized. The majority of cases represented classical (hypergranular) APL and were characterized by high SSC, positive CD117, lack of CD34, heterogeneous CD13, and bright CD33 (pattern 1). Second most common type, corresponding to the hypogranular (microgranular) variant of APL differed from classical APL by low SSC and frequent co-expression of CD2 and CD34 (pattern 2). Rare cases of APL (pattern 3) showed a mixture of neoplastic cells (low SSC/CD2 +/CD13 +/CD33 +/CD34 +/CD117 +) and prominent population of benign granulocytes/maturing myeloid precursors (high SSC/CD10 +/-/CD16 +/-/ CD117 -). One case showed two APL populations, one with hypogranular and one with hypergranular characteristics (pattern 4). Apart from a well-known FC pattern of hypergranular APL, we presented less common immunophenotypic variants of APL, which helps to identify an additional group of patients who would benefit from fast confirmatory FISH and/or PCR testing for t(15;17)/PML-RARA. Source
Armario P.,Csi Inc. |
Waeber B.,University of Lausanne
Journal of Hypertension | Year: 2013
Blood pressure is poorly controlled in most European countries and the control rate is even lower in high-risk patients such as patients with chronic kidney disease, diabetic patients or previous coronary heart disease. Several factors have been associated with poor control, some of which involve the characteristic of the patients themselves, such as socioeconomic factors, or unsuitable life-styles, other factors related to hypertension or to associated comorbidity, but there are also factors directly associated with antihypertensive therapy, mainly involving adherence problems, therapeutic inertia and therapeutic strategies unsuited to difficult-to-control hypertensive patients.It is common knowledge that only 30% of hypertensive patients can be controlled using monotherapy; all the rest require a combination of two or more antihypertensive drugs, and this can be a barrier to good adherence and log-term persistence in patients who also often need to use other drugs, such as antidiabetic agents, statins or antiplatelet agents. The fixed combinations of three antihypertensive agents currently available can facilitate long-term control of these patients in clinical practice. If well tolerated, a long-term therapeutic regimen that includes a diuretic, an ACE inhibitor or an angiotensin receptor blocker, and a calcium channel blocker is the recommended optimal triple therapy. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins. Source
Degtyarev V.V.,Csi Inc.
Journal of Structural Engineering (United States) | Year: 2012
This paper presents a reliability-based evaluation of the American National Standards Institute/Steel Deck Institute (ANSI/SDI) C1.0 and Structural Engineering Institute/American Society of Civil Engineers (SEI/ASCE) 37 design provisions for composite steel decks in the construction stage. Reliability of the allowable stress design (ASD) and load and resistance factor design (LRFD) methods at the strength and deflection limit states was evaluated in terms of reliability indices employing the first-order reliability method. A large number of composite slab configurations, which cover the range of slab parameters typically used in the U.S. construction practice, were investigated. Obtained results demonstrate that the current design provisions for steel decks in the construction stage are overconservative. Modifications of the ANSI/SDI C1.0 construction load requirements are proposed. The modified load requirements result in longer maximum unshored construction spans and acceptable reliability. Safety of the deck designed according to the modified load requirements is more uniform across the typical design parameters when compared with the current design provisions. © 2012 American Society of Civil Engineers. Source
Penningroth S.M.,Csi Inc.
New solutions : a journal of environmental and occupational health policy : NS | Year: 2013
The risk of contaminating surface and groundwater as a result of shale gas extraction using high-volume horizontal hydraulic fracturing (fracking) has not been assessed using conventional risk assessment methodologies. Baseline (pre-fracking) data on relevant water quality indicators, needed for meaningful risk assessment, are largely lacking. To fill this gap, the nonprofit Community Science Institute (CSI) partners with community volunteers who perform regular sampling of more than 50 streams in the Marcellus and Utica Shale regions of upstate New York; samples are analyzed for parameters associated with HVHHF. Similar baseline data on regional groundwater comes from CSI's testing of private drinking water wells. Analytic results for groundwater (with permission) and surface water are made publicly available in an interactive, searchable database. Baseline concentrations of potential contaminants from shale gas operations are found to be low, suggesting that early community-based monitoring is an effective foundation for assessing later contamination due to fracking. Source
Csi Inc. | Date: 2014-06-27
A periodic signal parameter (PSP) indicates periodic patterns in an autocorrelated vibration waveform and potential faults in a monitored machine. The PSP is calculated based on statistical measures derived from an autocorrelation waveform and characteristics of an associated vibration waveform. The PSP provides an indication of periodicity and a generalization of potential fault, whereas characteristics of the associated waveform indicate severity. A periodic information plot (PIP) is derived from a vibration signal processed using two analysis techniques to produce two X-Y graphs of the signal data that share a common X-axis. The PIP is created by correlating the Y-values on the two graphs based on the corresponding X-value. The amplitudes of Y-values in the PIP is derived from the two source graphs by multiplication, taking a ratio, averaging, or keeping the maximum value.