Mulder H.A.,Animal Breeding and Genomics Center |
Calus M.P.L.,Animal Breeding and Genomics Center |
Druet T.,University of Liege |
Schrooten C.,Crv Inc.
Journal of Dairy Science | Year: 2012
Genomic selection using 50,000 single nucleotide polymorphism (50k SNP) chips has been implemented in many dairy cattle breeding programs. Cheap, low-density chips make genotyping of a larger number of animals cost effective. A commonly proposed strategy is to impute low-density genotypes up to 50,000 genotypes before predicting direct genomic values (DGV). The objectives of this study were to investigate the accuracy of imputation for animals genotyped with a low-density chip and to investigate the effect of imputation on reliability of DGV. Low-density chips contained 384, 3,000, or 6,000 SNP. The SNP were selected based either on the highest minor allele frequency in a bin or the middle SNP in a bin, and DAGPHASE, CHROMIBD, and multivariate BLUP were used for imputation. Genotypes of 9,378 animals were used, from which approximately 2,350 animals had deregressed proofs. Bayesian stochastic search variable selection was used for estimating SNP effects of the 50k chip. Imputation accuracies and imputation error rates were poor for low-density chips with 384 SNP. Imputation accuracies were higher with 3,000 and 6,000 SNP. Performance of DAGPHASE and CHROMIBD was very similar and much better than that of multivariate BLUP for both imputation accuracy and reliability of DGV. With 3,000 SNP and using CHROMIBD or DAGPHASE for imputation, 84 to 90% of the increase in DGV reliability using the 50k chip, compared with a pedigree index, was obtained. With multivariate BLUP, the increase in reliability was only 40%. With 384 SNP, the reliability of DGV was lower than for a pedigree index, whereas with 6,000 SNP, about 93% of the increase in reliability of DGV based on the 50k chip was obtained when using DAGPHASE for imputation. Using genotype probabilities to predict gene content increased imputation accuracy and the reliability of DGV and is therefore recommended for applications of imputation for genomic prediction. A deterministic equation was derived to predict accuracy of DGV based on imputation accuracy, which fitted closely with the observed relationship. The deterministic equation can be used to evaluate the effect of differences in imputation accuracy on accuracy and reliability of DGV. © 2012 American Dairy Science Association.
News Article | June 29, 2015
The round was led by CRV with participation from Caffeinated Capital, Crunchfund, Data Collective, Founder Collective and Freestyle Capital, Brennan O’Donnell, Ilya Sukhar, Othman Laraki, and Joshua Reeves. In conjunction with the funding, Max Gazor, partner at CRV, joined Airtable’s board. The company, which has raised $10.6m in total funding, intends to use the funds to grow operations. It is hiring. Led by CEO Howie Liu and newly named vice president of growth Francis Larkin, Airtable is a flexible organizational tool allows users to organize and collaborate on everything. In addition to its grid-based desktop web interface, the company offers a mobile app that formats table rows, add and remove rows and columns, attach files, and share tables. All changes are instantly synced to all the devices.
News Article | August 30, 2015
BY JIMITOTA ONOYUME PORT HARCOURT – Vanguard newspaper Columnist, Donu Kogbara has been abducted in Port Harcourt by unknown gunmen. The state Police Public relations officer, DSP Ahmed Muhammad confirmed the ugly development, saying police was on the trail of the kidnappers. Dornu Kogbara who maintains a column in the Vanguard was whisked away in the early hours of Sunday by unknown gunmen at her Nkpogu residence in a CRV jeep. It could not be confirmed if the kidnappers has established contact with the family for ransom at press time, Meantime, the Rivers state government has condemned the abduction. Governor Nyesom Wike who spoke through his media aide, Mr Opunabo Nko-Tariah expressed strong hope that she will be released unhurt. He said the government was making effort to ensure every resident in the state enjoyed adequate security. “Although the government is not seized of the issue, no responsible government will brook such acts of criminality. On thus premise , the kidnap is roundly condemned and we believe that by God’s grace, she will come out alive. The government is working assiduously to ensure a crime free state and that is why he has stopped at noting to provide the necessary tools including the donation of 64 security fitted vans to the Police. By God’s grace , she will be released in good health”, he assured.
News Article | April 16, 2015
Making robots sure isn’t cheap. Consider Rethink Robotics, a Boston-based maker of bots meant to work alongside humans in manufacturing and similar industrial jobs: Since its founding in 2008, Rethink has raised a whopping $113.5 million in venture investment. The last bit of that cash, $13.4 million, was announced today by the company, featuring Boston’s Wellington Management Company as a new investor. Rethink said the financing represents the final piece of its Series D investment round. The new money comes as Rethink has attempted to expand its nascent market with a new product, Sawyer, a one-armed robot that specializes in precise jobs such as testing circuit boards. Rethink’s original product, the two-armed Baxter, was aimed at a wide variety of research and industrial uses. But Rethink has at times struggled to build a market for the next-generation robot, and the company had to lay off about 20 people in 2013 as it streamlined to focus on its best customers. Rethink was founded by Rodney Brooks, a robotics pioneer who also co-founded Roomba maker iRobot. Its other investors include GE Ventures, Goldman Sachs, CRV, Highland Capital Partners, and Amazon founder Jeff Bezos’s personal investment company.
News Article | November 3, 2015
Short videos, looping videos and GIFs are some of the hottest types of user-generated content on the web today, and have everyone from Instagram to Twitter and even Facebook and Google getting involved in offering support and tools for creators. Today, a new app called SPUN wants to capitalize on this growing trend by allowing users to mash up videos from their phone along with topical pop culture videos and then personalize their creations using the app’s own library of animations, cutouts, special effects and text. The idea for SPUN comes from serial entrepreneurs Andy Miller and Avi Dabir who have known each other for a decade and have worked in the past at m-Qube (mobile payments, sold to VeriSign), Quattro Wireless (sold to Apple; Miller was CEO) and, most recently, gesture control startup Leap Motion, where Miller was COO. Explains Dabir, both he and Miller are passionate about mobile and have seen the organic growth in content creation, where people take moments from pop culture – like movies or TV, sports or even politics – and then turn them into short clips or GIFs which are then shared out on social media. But the process for doing that today can still be fairly cumbersome, he says. “People are downloading a screenshot or taking a video from somewhere then putting it into After Effects or Photoshop, putting it together, then uploading it to Instagram,” says Dabir. “People are already doing this, so let’s make it easier for them to express themselves more visually through video and through creativity. [That’s how] we got to SPUN.” The app itself, live now for iOS, is really simple to use – even if you’re not used to working with video. To create your own mashup in SPUN, you first select video from your Camera Roll or SPUN’s community, or you can film using your camera. Once a video is selected, you can trim it, add other videos along with it, then decorate those videos with text, animation, and cutouts. There’s also a way to cut out people’s heads from videos and swap in others in a goofy (but thankfully, not photorealistic) way. And for those who prefer content consumption over creation, or those who are just looking for idea, the app’s feeds include featured and new videos which you can tap to “respin” – meaning, make a mashup of your own using their video as the source material. The process for making a video is roughly a minute or two, and you’ll get better the more you use the app, we’re told. And it’s still quicker than using pro-level editing tools like many do today. When your creation is finished, you can share the resulting 6-second max video back to the community as well as to a number of social channels, like Vine, Instagram, Twitter, Facebook, SMS or your can save it to your Camera Roll. While the sort of silly nature of the app immediately appeals to a younger demographic, Dabir believes SPUN could have broader appeal – especially as some of its users are mashing up videos from sports figures or politics, instead of just internet memes. The app has been in private testing before today’s public debut, and now has a catalog of thousands of clips available for use. Eventually, the startup would like to partner with brands to introduce more content to its community. In the meantime, however, SPUN has a number of content partners on board, including Shaquille O’Neal, “It’s Always Sunny in Philadelphia” writers, NBC comedy writers, political satirists, and popular Instagramers. SPUN is a free download on iOS, and plans to launch on Android next year. The startup is backed by $2 million in seed funding from CRV and Highland Capital, along with angel investors David Kenny (CEO of Weather Companies), Tony Kahn (Owner of Jacksonville Jaguars and Fulham FC Soccer Club) and Mark Mastrov (Founder of 24 Hour Fitness/co-owner Sacramento Kings).