News Article | April 6, 2017
Virtually all farms could significantly cut their pesticide use while still producing as much food, according to a major new study. The research also shows chemical treatments could be cut without affecting farm profits on over three-quarters of farms. The scientists said that many farmers wanted to reduce pesticide use, partly due to concerns for their own health. But farmers do not have good access to information on alternatives, the researchers said, because much of their advice comes from representatives of companies that sell both seeds and pesticides. The work presents a serious challenge to the billion-dollar pesticide industry, which has long argued its products are vital to food production, especially with the world population set to grow to nine billion people by 2050. However, this was dismissed as a “myth” in March by UN food and pollution experts, who said pesticides cause “catastrophic impacts on the environment and human health” and accused pesticide manufacturers of a “systematic denial of harms”. In a further blow, the Guardian revealed in March that Europe is poised to ban the world’s most widely used insecticides from all fields. The new research, published in the peer-reviewed journal Nature Plants, analysed the pesticide use, productivity and profitability of almost 1,000 farms of all types across France. By comparing similar farms using high or low levels of pesticides, the scientists found that 94% of farms would lose no production if they cut pesticides and two-fifths of these would actually produce more. The results were most startling for insecticides: lower levels would result in more production in 86% of farms and no farms at all would lose production. The research also indicated that 78% of farms would be equally or more profitable when using less pesticide of all types. “It is striking,” said Nicolas Munier-Jolain, at France’s National Institute for Agricultural Research, and one of the team who conducted the new study. He said the results show that pesticide reduction is possible today for most arable farmers, without losing money: “Our results are quite consistent with the UN [myth] report.” “But [the research] does not mean pesticides are useless or inefficient,” he said. The farmers using low levels of chemicals employ other methods to control pests, he said, such as rotating crops, mechanical weeding, using resistant varieties and carefully managing sowing dates and fertiliser use. “It’s a big change, but not a revolution,” he said. “If you want real reduction in pesticide use, give the farmers the information about how to replace them,” said Munier-Jolain. “This is absolutely not the case at the moment. A large proportion of advice is provided by organisations that are both selling the pesticides and collecting the crops. I am not sure the main concern of these organisations is to reduce the amount of pesticide used.” Prof Dave Goulson, at the University of Sussex, UK, said: “While we have a system where farmers are advised by agronomists, most of whom work on commission for agrochemical companies, then inevitably pesticides will be massively overused. Even the few independent agronomists struggle to get independent information and advice to pass on to farmers.” “Despite evidence that much pesticide use is unnecessary and a big European Union initiative to encourage sustainable use, farming continues to be dominated by pesticide use,” said Matt Shardlow, chief executive of Buglife. France’s deadline for a 50% cut in pesticide use was meant to be 2018 but has been postponed to 2025, with use actually rising not falling. The UK’s action plan for the sustainable use of pesticides contains no targets or timetable. “Financial advisors and doctors cannot profit from their advice to individuals and it is time that this market failure was corrected for pesticide sales as well,” Shardlow said. Graeme Taylor, a spokesman for the European Crop Protection Association (ECPA) which represents pesticide manufacturers, said: “Characterising it as an argument between using more or less is unhelpful as it ignores the reality that any genuine commitment to sustainable agriculture means giving farmers access to a variety of tools. Pesticides are not a panacea, but are one of the most important tools available to the farmer to fight pests and diseases.” He said a recent consultancy report commissioned by the ECPA indicated that French farmers would lose €2bn of grape production without access to certain pesticides. The new research showed that the type of farms most sensitive to cuts in pesticide use are potato and sugar beet farms, because they use high levels of pesticides and are highly profitable. But it showed that most arable farms could cut pesticides by over 40% without losses. The researchers wrote: “The reduction of pesticide use is one of the critical drivers to preserve the environment and human health.” “Farmers are doing their best to use fewer pesticides,” said Munier-Jolain. “Many are motivated because they are thinking about their own health.” He said that there was a perception among farmers that cutting pesticide use increases the risk of poor harvests, but that those diversifying their crops actually decreased such risks: “They sleep better than the other farmers.”
News Article | March 7, 2017
The idea that pesticides are essential to feed a fast-growing global population is a myth, according to UN food and pollution experts. A new report, being presented to the UN human rights council on Wednesday, is severely critical of the global corporations that manufacture pesticides, accusing them of the “systematic denial of harms”, “aggressive, unethical marketing tactics” and heavy lobbying of governments which has “obstructed reforms and paralysed global pesticide restrictions”. The report says pesticides have “catastrophic impacts on the environment, human health and society as a whole”, including an estimated 200,000 deaths a year from acute poisoning. Its authors said: “It is time to create a global process to transition toward safer and healthier food and agricultural production.” The world’s population is set to grow from 7 billion today to 9 billion in 2050. The pesticide industry argues that its products – a market worth about $50bn (£41bn) a year and growing – are vital in protecting crops and ensuring sufficient food supplies. “It is a myth,” said Hilal Elver, the UN’s special rapporteur on the right to food. “Using more pesticides is nothing to do with getting rid of hunger. According to the UN Food and Agriculture Organisation (FAO), we are able to feed 9 billion people today. Production is definitely increasing, but the problem is poverty, inequality and distribution.” Elver said many of the pesticides are used on commodity crops, such as palm oil and soy, not the food needed by the world’s hungry people: “The corporations are not dealing with world hunger, they are dealing with more agricultural activity on large scales.” The new report, which is co-authored by Baskut Tuncak, the UN’s special rapporteur on toxics, said: “While scientific research confirms the adverse effects of pesticides, proving a definitive link between exposure and human diseases or conditions or harm to the ecosystem presents a considerable challenge. This challenge has been exacerbated by a systematic denial, fuelled by the pesticide and agro-industry, of the magnitude of the damage inflicted by these chemicals, and aggressive, unethical marketing tactics.” Elver, who visited the Philippines, Paraguay, Morocco and Poland as part of producing the report, said: “The power of the corporations over governments and over the scientific community is extremely important. If you want to deal with pesticides, you have to deal with the companies – that is why [we use] these harsh words. They will say, of course, it is not true, but also out there is the testimony of the people.” She said some developed countries did have “very strong” regulations for pesticides, such as the EU, which she said based their rules on the “precautionary principle”. The EU banned the use of neonicotinoid pesticides, which harm bees, on flowering crops in 2013, a move strongly opposed by the industry. But she noted that others, such as the US, did not use the precautionary principle. Elver also said that while consumers in developed countries are usually better protected from pesticides, farms workers often are not. In the US, she, said, 90% of farm workers were undocumented and their consequent lack of legal protections and health insurance put them at risk from pesticide use. “The claim that it is a myth that farmers need pesticides to meet the challenge of feeding 7 billion people simply doesn’t stand up to scrutiny,” said a spokesman for the Crop Protection Association, which represents pesticide manufacturers in the UK. “The UN FAO is clear on this – without crop protection tools, farmers could lose as much as 80% of their harvests to damaging insects, weeds and plant disease.” “The plant science industry strongly agrees with the UN special rapporteurs that the right to food must extend to every global citizen, and that all citizens have a right to food that has been produced in a way that is safe for human health and for the environment,” said the spokesman. “Pesticides play a key role in ensuring we have access to a healthy, safe, affordable and reliable food supply.” The report found that just 35% of developing countries had a regulatory regime for pesticides and even then enforcement was problematic. It also found examples of pesticides banned from use in one country still being produced there for export. It recommended a move towards a global treaty to govern the use of pesticides and a move to sustainable practices including natural methods of suppressing pests and crop rotation, as well as incentivising organically produced food. The report said: “Chronic exposure to pesticides has been linked to cancer, Alzheimer’s and Parkinson’s diseases, hormone disruption, developmental disorders and sterility.” It also highlighted the risk to children from pesticide contamination of food, citing 23 deaths in India in 2013 and 39 in China in 2014. Furthermore, the report said, recent Chinese government studies indicated that pesticide contamination meant farming could not continue on about 20% of arable land. “The industry frequently uses the term ‘intentional misuse’ to shift the blame on to the user for the avoidable impacts of hazardous pesticides,” the report said. “Yet clearly, the responsibility for protecting users and others throughout the pesticide life cycle and throughout the retail chain lies with the pesticide manufacturer.”
News Article | February 15, 2017
Tyson Ferraro has accepted the role of Director of Marketing at CSI. In this (re)new(ed) role, Tyson will shape and implement the marketing strategy across all business units at Control Solutions, Inc. Tyson will report directly to Mark Boyd, CEO with day-to-day alignment to Curtis Clark, Executive Vice President. Tyson brings over six years of marketing, sales, and product portfolio management experience. Prior to joining CSI, he worked at Dow AgroSciences where he held leadership roles in both, the Pest Management, and Crop Protection divisions. Before joining Dow, Ty received a Bachelor of Science Degree in Business Marketing and a Master of Business Administration Degree with a concentration on Marketing and Management, both from Indiana University’s Kelley School of Business. His business acumen and professional experience market leading companies serving diverse markets will provide a strong foundation for success as CSI continues to bring innovative and customer-focused solutions to customers across our multiple business lines. Control Solutions began as a family owned business in 1958 and is built on to the commitment of serving the professional pest control and retail markets. CSI has added product lines for the Industrial, Lawn and Garden, Turf, Animal Health and Biocide markets, and is working with over 80 distributors serving those markets. Control Solutions maintains relationships with chemical manufacturers worldwide and provides a ready supply of products in distribution warehouses across the U.S. The partnership with ADAMA multiplies Control Solutions’ agility in continuously adding new products to meet the needs of professionals and homeowners. "The one constant since the beginning in 1958 is our mission focus: to seek out and distribute effective and economical solutions for our customers," stated Mark Boyd, President and founder of CSI. ADAMA Agricultural Solutions Ltd. is a leading global manufacturer and distributor worldwide of crop protection solutions. The Company supplies efficient solutions to farmers across the full farming value-chain, including crop-protection, novel agricultural technologies, and complementary non-crop businesses. In 2013, the Company’s revenues were over $3 billion, and it is ranked seventh in the world in the overall agrochemicals industry. The Company is characterized by its heritage of innovation, farmer-centric approach to product development, and it’s observance of strict standards of environmental protection and quality control. For more information, visit us at http://www.adama.com.
News Article | February 28, 2017
CARY, N.C., Feb. 28, 2017 (GLOBE NEWSWIRE) -- Arysta LifeScience, a Platform Specialty Products company (NYSE:PAH), announced today an increase in the value of its research and development (R&D) pipeline from the addition of seven active substances to its product development portfolio in the last 12 months. Five of them were obtained through in-licensing partnerships with other discovery-based companies. Considering all new products in development for launch from 2017 through 2025, Arysta LifeScience believes that, if successful, its pipeline of products could deliver a combined peak sales potential of up to $1.3 billion. In September, Platform Specialty Products hosted an Investor Day to present its strategy. During this event, Platform’s executive team described its strong focus on niche specialty segments and emphasized its pursuit of differentiation. “Innovation is the lifeblood of our strategy,” said Rakesh Sachdev, CEO of Platform Specialty Products. “Our ideation process starts with the customer, and our teams are focused on solving problems. We are excited with the progress of our R&D efforts in the Agricultural Solutions segment.” Despite challenging near-term market conditions in the agriculture industry, Arysta LifeScience’s leadership remains confident in its ability to continue to deliver sustainable growth. “We have a great innovation engine combined with excellent global market access in high-value niche segments of the industry,” said Diego Lopez Casanello, President of Arysta LifeScience. “This is why our partners entrust us with access to new active substances.” With the addition of these seven new active substances to the Arysta LifeScience product development portfolio, consisting of a herbicide, three insecticides, two fungicides and a novel biostimulant, Arysta LifeScience is nearing the end of the first phase of its pipeline renewal program. Included in this group, as previously announced, are a global collaboration with DuPont Crop Protection on the development of mixtures based on DuPont™ Rynaxypyr® insecticide, as well as an alliance with Beem Biologics to develop a new plant extract as a next generation of biostimulants. In addition, Arysta LifeScience is actively evaluating several earlier-stage compounds that it believes may have the potential to further increase its pipeline value by moving into full development phase during 2017. This press release contains "forward-looking statements" within the meaning of the federal securities laws, which include statements regarding Arysta LifeScience’s future annual sales, pipeline renewal program and further increase of its pipeline value. These statements are based on Arysta LifeScience management's estimates and assumptions with respect to future events and financial performance, and are believed to be reasonable, though are inherently difficult to predict. Actual results could differ materially from those projected as a result of certain factors. A discussion of factors that could cause results to vary is included in Platform's periodic and other reports filed with the Securities and Exchange Commission. Arysta LifeScience or Platform undertakes no obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise. Arysta LifeScience is a global agricultural company specializing in the marketing and distribution of innovative crop protection and life science brands. With more than 200 active ingredients, Arysta LifeScience has a well-integrated biological and chemical portfolio to provide complete solutions to growers. The company’s wide range of offerings includes biosolutions, fungicides, herbicides, insecticides and seed treatments. Arysta LifeScience, which has more than 3,000 employees working in 60 countries to serve customers worldwide, had 2016 revenues of US$1.8 billion. Arysta LifeScience is owned by Platform Specialty Products Corporation (NYSE:PAH), a global innovator of technologically advanced specialty chemical products and provider of technical services (www.platformspecialtyproducts.com). For more information on Arysta LifeScience, visit www.arystalifescience.com.
News Article | March 1, 2017
The report "Ethoxylates Market by Type (Alcohol, Fatty Amine, Fatty Acid, Methyl Ester, Glyceride), Application (Agrochemicals, Household & Personal Care, Pharmaceutical, Oilfield Chemicals), Region - Global Forecast to 2021", published by MarketsandMarkets, the global market was valued at USD 10.16 Billion in 2015 and is projected to reach USD 12.37 Billion by 2021, at a CAGR of 3.33% from 2016 to 2021. Browse 101 market data Tables and 42 Figures spread through 138 Pages and in-depth TOC on "Ethoxylates Market" http://www.marketsandmarkets.com/Market-Reports/ethoxylates-market-124534176.html Early buyers will receive 10% customization on this report. The growing demand for ethoxylates in the household & personal care, and pharmaceutical industries, and shift in consumer lifestyles, is expected to drive the market in the future. Ask for PDF of the Report at http://www.marketsandmarkets.com/pdfdownload.asp?id=124534176 Alcohol ethoxylates accounts for the largest share in the ethoxylates market The global ethoxylates market is segmented based on type, into alcohol, fatty acid, fatty amine, methyl ester, glyceride, and other ethoxylates. In 2015, alcohol ethoxylates captured the maximum share of the overall market; and are also expected to grow at the highest CAGR during the forecast period. Alcohol ethoxylates are considered more environment friendly as compared to other ethoxylates, due to their easy biodegradability. Alcohol ethoxylates are the most widely used type of non-ionic surfactants. Growing demand from the household & personal care industry to boost the ethoxylates market The major end-use industries of ethoxylates are, household & personal care, pharmaceutical, agrochemicals, oilfield, and others. The demand for ethoxylates in the pharmaceutical industry is projected to grow at the highest CAGR during the forecast period. The growth in this industry is driven by the growing healthcare sector in developed and emerging economies. The global ethoxylates market is segmented into five regions, namely, North America, Europe, Asia-Pacific, the Middle East & Africa, and Latin America. The European region is the largest Ethoxylates Market, closely followed by the Asia-Pacific region, in terms of value. The growing end-use industries such as, agrochemicals and household & personal care is driving the demand for ethoxylates in the Asia-Pacific region. Currently, market players such as, BASF SE (Germany), Royal Dutch Shell Plc (Netherlands), Huntsman International LLC (U.S.), Stepan Company (U.S.), Clariant AG (Switzerland), The Dow Chemical Company (U.S.), Sasol Ltd (South Africa), India Glycols Ltd. (India), Ineos Group Ltd. (Switzerland), and Solvay (Belgium) are leading the global ethoxylates market. Surfactants Market by Type (Anionic, Non-Ionic, Cationic, and Amphoteric), Substrate (Synthetic, and Bio-based), Application (Detergents, Personal Care, Textile, Elastomers & Plastics, Crop Protection, Food & Beverage) - Global Forecast to 2021 http://www.marketsandmarkets.com/Market-Reports/biosurfactants-market-493.html MarketsandMarkets is the largest market research firm worldwide in terms of annually published premium market research reports. Serving 1700 global fortune enterprises with more than 1200 premium studies in a year, M&M is catering to a multitude of clients across 8 different industrial verticals. We specialize in consulting assignments and business research across high growth markets, cutting edge technologies and newer applications. Our 850 fulltime analyst and SMEs at MarketsandMarkets are tracking global high growth markets following the "Growth Engagement Model - GEM". The GEM aims at proactive collaboration with the clients to identify new opportunities, identify most important customers, write "Attack, avoid and defend" strategies, identify sources of incremental revenues for both the company and its competitors. M&M's flagship competitive intelligence and market research platform, "RT" connects over 200,000 markets and entire value chains for deeper understanding of the unmet insights along with market sizing and forecasts of niche markets. The new included chapters on Methodology and Benchmarking presented with high quality analytical infographics in our reports gives complete visibility of how the numbers have been arrived and defend the accuracy of the numbers. We at MarketsandMarkets are inspired to help our clients grow by providing apt business insight with our huge market intelligence repository. Visit MarketsandMarkets Blog @ http://www.marketsandmarketsblog.com/market-reports/chemical Connect with us on LinkedIn @ http://www.linkedin.com/company/marketsandmarkets
News Article | February 21, 2017
The report "Herbicides Market by Type (Glyphosate, 2, 4-D, Diquat), Crop Type (Cereals & Grains, Oilseeds & Pulses, Fruits & Vegetables), Mode of Action (Non-selective, Selective), and Region - Global Forecast to 2022", published by Markets and Markets, the global market is estimated at USD 27.21 Billion in 2016 and is projected to reach USD 39.15 Billion by 2022, at a CAGR of 6.25% during the forecast period. Browse 73 market data Tables and 43 Figures spread through 141 Pages and in-depth TOC on "Herbicides Market" Early buyers will receive 10% customization on this report. The market is driven by factors such as adoption of better farming practices and rise in production of cereals & grains, especially in the Asia-Pacific region. The glyphosate segment, by type, is projected to have the highest CAGR during 2016 to 2022. The glyphosate segment is projected to have the highest CAGR during the forecast period. This is due to the fact that glyphosate-based products are being widely adopted in various forms such as gels and powders, which are more convenient to use. Non-selective segment, by mode of action, is projected to grow at the highest CAGR during 2016 to 2022. Non-selective herbicides, based on the mode of action, are projected to have the highest CAGR during the forecast period. Since non-selective herbicides are formulated for both broadleaf and grass weeds, they find wider application on almost all vegetation types and are preferred more than selective herbicides. The cereals & grains segment accounted for largest market share in 2015. Herbicides are applied on a wide scale to most cereal crops to control weeds. Cereals are grown widely across the world, but growth is projected to be higher in the Asia-Pacific region due to increased consumption of rice in the daily diets here. The global demand for herbicides in this segment is high and is projected to grow as producers are focusing on increasing the per unit yield. The South American region dominated the Herbicides Market in 2015. This is due to the emergence of South American countries as agricultural powerhouses, growing above the global growth average. Growth in this region is significantly contributed to by the growth in Brazil and Argentina. Economic growth in South America has been supported by democratization and economic reforms. Availability of arable land and expansion of farmlands, especially in Brazil and Argentina, are driving the growth in this market. Additionally, the regulatory framework in South America is less stringent as compared to North America and Europe. The Pesticide Action Network (South America) handles regulatory control in the region. T Herbicide products can be registered with minimum resistance from other regulatory agencies in the South American region. This report includes a study of development strategies, along with the product portfolios of the leading companies in the Herbicides Market. The key companies profiled are BASF SE (Germany), The Dow Chemical Company (U.S.), E.I. du Pont de Nemours & Company (U.S.), Monsanto Company (U.S.), and Syngenta AG (Switzerland), FMC Corporation (U.S.), Platform Specialty Products Corporation (U.S.), Nufarm Ltd. (Australia), Nissan Chemical Industries Ltd. (Japan), and Drexel Chemical Co. (U.S.). Crop Protection Chemicals Market by Type (Herbicide, Insecticide and Fungicide), Origin (Synthetic and bio-pesticides), Crop Type (Cereals & Oilseeds, Fruits & Vegetables), Mode of Application, Form and by Region - Global Forecast to 2021 Bioherbicides Market by Source (Microbials, Biochemicals & Others), Application Mode (Seed, Soil, Foliar, Post-harvest), Formulation (Granular, Liquid & Others), Application, & by Region - Global Trends & Forecast to 2021 MarketsandMarkets is the largest market research firm worldwide in terms of annually published premium market research reports. Serving 1700 global fortune enterprises with more than 1200 premium studies in a year, M&M is catering to a multitude of clients across 8 different industrial verticals. We specialize in consulting assignments and business research across high growth markets, cutting edge technologies and newer applications. Our 850 fulltime analyst and SMEs at MarketsandMarkets are tracking global high growth markets following the "Growth Engagement Model - GEM". The GEM aims at proactive collaboration with the clients to identify new opportunities, identify most important customers, write "Attack, avoid and defend" strategies, identify sources of incremental revenues for both the company and its competitors. M&M's flagship competitive intelligence and market research platform, "RT" connects over 200,000 markets and entire value chains for deeper understanding of the unmet insights along with market sizing and forecasts of niche markets. The new included chapters on Methodology and Benchmarking presented with high quality analytical infographics in our reports gives complete visibility of how the numbers have been arrived and defend the accuracy of the numbers. We at MarketsandMarkets are inspired to help our clients grow by providing apt business insight with our huge market intelligence repository. Contact: Mr. Rohan MarketsandMarkets 701 Pike Street, Suite 2175, Seattle, WA 98101, United States Tel : 1-888-600-6441 Email: email@example.com Visit MarketsandMarkets Blog @ http://www.marketsandmarketsblog.com/market-reports/agriculture-industry Connect with us on LinkedIn @ http://www.linkedin.com/company/marketsandmarkets
News Article | February 28, 2017
NAPERVILLE, Ill.--(BUSINESS WIRE)--Hubei Xingfa, the world’s second largest producer of glyphosate, will attend the 18th annual China International Agrochemical & Crop Protection Exhibition (CAC) from March 1–3, 2017, at the Shanghai New International Expo Center, marking the company’s continued expansion into the global glyphosate business. The agrochemical industry relies on glyphosate, one of the most widely used herbicides, for a range of weed-control applications in agriculture. Unlike traditional glyphosate manufacturers, Xingfa’s full integration into the glyphosate vertical allows for a reliable and sustainable source of high-quality glyphosate at predictable costs. With 17 phosphate mines, Xingfa has the largest phosphorus reserves in China. Additionally, the company ensures consistent supply of the highest quality glyphosate by maintaining control over its own mining operations, hydropower stations, production of key war ingredients such as glycine and caustic soda, active and formulation manufacturing sites, and shipping wharfs. “We understand that the reliable and affordable supply of high-quality glyphosate is an important need for farmers across the world,” said J. Bryan Kitchen, President at Xingfa USA. “We look forward to opportunities such as CAC to meet face-to-face with the agrochemical community and show them how we are uniquely equipped to help them address these needs.” In order to raise awareness of their unmatched reliability, excellent cost predictability, and localized service, Xingfa will operate booth #2A01–2B01 at CAC 2017. Xingfa has successfully passed the National Environment Production Inspection Verification process and holds numerous international quality control certifications. Additional information on Xingfa’s glyphosate offering can be found at xingfa-glyphosate.com. Interested parties can contact J. Bryan Kitchen, President of Xingfa, to set up a meeting or receive more information about the Xingfa itinerary at CAC 2017. Hubei Chemicals Group Co., LTD. (hereinafter referred to as Xingfa) was established in 1994 with its world headquarters located in Xingshan County, Yichang City, Hubei Province, PRC. With its North American operations based in Naperville, IL, USA, the company focuses on developing, producing and marketing a series of phosphorus chemicals and fine chemicals. Through 20 years of development and innovation, Xingfa is now regarded as the largest manufacturer of fine phosphates in China, as well as the second largest producer of glyphosate in the world. Xingfa has been listed on the Shanghai Stock Exchange (SSE) since 1999 under stock code 600141 and ranks 399th among Fortune 500 companies in China.
News Article | February 16, 2017
There's at least one person in the world for whom smoking has a beneficial effect, and it took an international collaboration of scientists led by a Rice University professor to figure out why. Rice biochemist John Olson and collaborators in Germany and France helped a young woman and her father understand why she has anemia but her father, who is a smoker, does not. The woman, who was in her 20s when diagnosed, and her father share a mutation in the gene that encodes hemoglobin, the protein in red blood cells responsible for taking up and delivering oxygen to cells around the body. The mutation is one of more than 1,000 discovered so far in adult human hemoglobin. Most appear to have no effect on people, but when medical problems occur, the disease is called a hemoglobinopathy and often named after the city or hospital where it was discovered. In this case, the family was living in Mannheim, Germany, but the father was born in the Turkish city of Kirklareli. The Kirklareli mutation did not affect the iron content of her dad's blood, but did appear to be the root cause of the young woman's chronic anemia, according to the researchers. Further investigation revealed that absorbing carbon monoxide from cigarette smoke is therapeutic for those with this rare genetic disorder. A paper on the research appeared this month in the Journal of Biological Chemistry. The mutation is in the alpha subunit of human hemoglobin (H58L) and causes it to rapidly auto-oxidize, or rust, which causes the protein to fall apart, lose heme and precipitate. As a result, the protein loses its ability to carry oxygen. Eventually, Olson said, the red cells themselves become deformed and are destroyed. Remarkably, this same mutation gives the protein an 80,000-fold higher affinity for carbon monoxide than for oxygen. Carbon monoxide from a cigarette will be selectively taken up by the mutant hemoglobin and prevent it from oxidizing and denaturing. This high affinity for carbon monoxide explained why the father showed no signs of anemia, Olson said. "He may never be an athlete because his blood can't carry as much oxygen, but smoking has prevented him from being anemic," he said. "And there's a side benefit. People with this trait are more resistant to carbon monoxide poisoning." Olson said he does not know how or if the doctors treated the young woman. He doesn't even know her name. But he suspected her iron-deficient anemia was more an annoyance than a threat to her life and would not recommend she start smoking to relieve it. "She shouldn't smoke," he said. "But she could take antioxidants, such as a lot of vitamin C, which would help prevent oxidation of her mutant hemoglobin. Her anemia is not that severe. At the same time, she shouldn't worry too much about secondhand smoke, which might have a positive effect." After ruling out common causes like blood loss, gastritis or congenital defects, her doctors were curious enough about her ailment to call upon Emmanuel Bissé, a researcher at the Institute for Clinical Chemistry and Laboratory Medicine at the University of Freiburg, who discovered the mutation after sequencing her DNA. Bissé in turn recruited Olson and his team to help determine why the histidine-to-leucine change caused anemia in the daughter but not the father. Ironically, Ivan Birukou, a graduate student in Olson's lab, had already generated the same mutation in human hemoglobin (one of several hundred made at Rice) to study how the protein rapidly and selectively binds oxygen. "Emmanuel wrote to me and said, 'I know you've been making all these mutants in hemoglobin, and you've probably done the H58L mutation in (alpha) chains. Does this phenotype make sense?'" Olson recalled. "I said, 'We can do a really neat study here, because we've already made the mutant hemoglobin in a recombinant system.' We actually had a crystal structure (matching Kirklareli) that Ivan and (staff scientist) Jayashree Soman never published but had deposited in the Protein Data Bank. We had made this mutation to try to understand what the distal histidine was doing in alpha subunits." They found in their 2010 study that replacing the histidine, which forms a strong hydrogen bond to oxygen, with leucine caused a dramatic decrease in oxygen affinity and an increase in carbon monoxide binding. Olson and Birukou realized back then that histidine played a key role in discriminating between oxygen and carbon monoxide in hemoglobin. "When Emmanuel wrote to me about his discovery, I already 'knew' what was happening with respect to carbon monoxide binding," Olson said. He said that the normal hydrogen bond causes bound oxygen to stick more tightly to hemoglobin in the same way hydrogen bonds cause spilled soda to feel sticky. "When you touch it, the sugar oxygens and hydrogens make hydrogen bonds with the polysaccharides on your finger," Olson said. "That stickiness helps hold onto oxygen. But leucine is more like an oil, like butane or hexane, and oxygen does not stick well inside hemoglobin. In contrast, bound carbon monoxide is more like methane or ethane and can't form hydrogen bonds." Andres Benitez Cardenas, a postdoctoral researcher in Olson's laboratory, did the crucial experiment in which he put carbon monoxide on the mutant alpha subunit of hemoglobin Kirklareli. The bound carbon monoxide slowed down oxidation of the protein and prevented loss of heme and precipitation. "In effect, Andres did the 'smoking experiment' to show why the father's hemoglobin didn't denature and cause anemia," Olson said. He said the effect caused by Kirklareli, though unusual, is not unique. "There is another 'smoking is good for you' mutation," he said, noting discoveries in Zurich in the late 1970s and early '80s. That case mirrored the current collaboration, as the researchers looking for answers then sought help from Nobel Laureate Max Perutz, whose pioneering work on hemoglobin structures won him the prize in 1968. Olson himself served as a reviewer on some of the papers for hemoglobin Zurich in the 1980s. "Emmanuel knew that we had worked on these histidine-to-leucine mutations in myoglobin and hemoglobin, which is why he contacted us," he said. "This type of collaboration is how science and medicine should work together." Bissé is lead author of the paper. Co-authors are Christine Schaeffer-Reiss, Alain Van Dorsselaer and Tchilabalo Dilezitoko Alayi of the University of Strasbourg, France, and the Hubert CURIEN Multidisciplinary Institute, Strasbourg; Thomas Epting and Karl Winkler of the Institute for Clinical Chemistry and Laboratory Medicine at the University of Freiburg; and Birukou, Benitez Cardenas, Soman and graduate student Premila Samuel at Rice. Birukou is now a technical expert at Syngenta Crop Protection, North Carolina. Olson is the Ralph and Dorothy Looney Professor of Biochemistry and Cell Biology at Rice. This news release can be found online at http://news. Located on a 300-acre forested campus in Houston, Rice University is consistently ranked among the nation's top 20 universities by U.S. News & World Report. Rice has highly respected schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and is home to the Baker Institute for Public Policy. With 3,879 undergraduates and 2,861 graduate students, Rice's undergraduate student-to-faculty ratio is 6-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice is ranked No. 1 for happiest students and for lots of race/class interaction by the Princeton Review. Rice is also rated as a best value among private universities by Kiplinger's Personal Finance. To read "What they're saying about Rice," go to http://tinyurl. .
News Article | February 16, 2017
DuPont Crop Protection announced today it has received federal approval from the U.S. Environmental Protection Agency (EPA) for use of DuPont™ FeXapan™ herbicide plus VaporGrip™ Technology on Roundup Ready 2 Xtend® soybeans and cotton. The new herbicide is part of a complete weed-control solution that may be applied in-crop over soybean and cotton varieties carrying traits that provide tolerance to dicamba and glyphosate herbicides. Growers will be able to use FeXapan™ in 2017 to control herbicide-resistant weeds, including kochia, marestail and amaranth species, as part of a complete weed-control program that includes preemergence and postemergence herbicide applications with multiple herbicide modes of action, as well as crop rotation and cultural practices that manage weed growth and weed seed production. “There is a critical need among growers to find effective solutions for controlling herbicide-resistant weeds and protecting soybean yield,” said James Hay, business director, North America, DuPont Crop Protection. “We’re pleased to introduce a complete solution for success that includes FeXapan™ herbicide plus VaporGrip™ Technology and high-yielding genetics with the Roundup Ready 2 Xtend® trait to address those concerns while making best long-term use of crop production technologies. FeXapan™ is a strong addition to the innovative DuPont portfolio of weed-, disease- and insect-control solutions.” When used with Pioneer® brand soybeans with the Roundup Ready 2 Xtend® trait, FeXapan™ will provide a cost-effective option for managing weeds. The integrated seed and herbicide program is designed to work together to increase efficiency and protect yield. FeXapan™ employs a new formulation of dicamba that offers a significant reduction in volatility potential compared with conventional dicamba herbicides, which helps minimize off-target movement when used according to label guidelines. For a list of approved tank-mix partners for FeXapan™ and state registrations, visit FeXapan.dupont.com. As with any crop protection product, growers and applicators should follow best practices to avoid off-target contact when using FeXapan™. DuPont has developed stewardship training to promote best management practices for FeXapan™ use and extended product life. For details, see FeXapan.dupont.com. “Growers know their success depends on technology that improves productivity. Our goal is to collaborate with growers to understand their challenges and to respond with solutions that will help feed the growing world population,” added Hay. FeXapan™ is included in the TruChoice® rewards program, offering local agronomy expertise and individualized crop protection solutions to maximize economic return on every acre. This is the latest addition to the award-winning portfolio by DuPont Crop Protection. DuPont has been recognized with 21 Agrow Awards, including the Best R&D Pipeline Award in 2013 and 2014. DuPont (NYSE: DD) has been bringing world-class science and engineering to the global marketplace in the form of innovative products, materials and services since 1802. The company believes that by collaborating with customers, governments, NGOs and thought leaders we can help find solutions to such global challenges as providing enough healthy food for people everywhere, decreasing dependence on fossil fuels, and protecting life and the environment. For additional information about DuPont and its commitment to inclusive innovation, please visit http://www.dupont.com. DuPont™ FeXapan™ herbicide is not registered for sale or use in all states. Contact your local DuPont retailer or representative for details and availability in your state. Soybeans and cotton with Roundup Ready 2 Xtend® technology contain genes that confer tolerance to glyphosate and dicamba. Glyphosate herbicides will kill crops that are not tolerant to glyphosate. Dicamba will kill crops that are not tolerant to dicamba. Always read and follow all label directions and precautions for use when using any pesticide alone or in tank-mix combinations. Unless indicated, trademarks with ®, TM or SM are trademarks of DuPont or affiliates. Roundup Ready 2 Xtend® is a registered trademark of Monsanto Technology LLC used under license.
News Article | February 15, 2017
The Report "Glufosinate Market by Crop Type (Genetically Modified Crops, Conventional Crops), Form (Liquid Formulation, Dry Formulation), Application (Agricultural, Non Agricultural), and Region - Global Forecast to 2022 ", published by Markets and Markets, is projected to reach USD 2.34 Billion by 2022, the market is estimated to be valued at USD 1.37 Billion in 2016, and is projected to grow at a CAGR of 9.25% from 2016 to 2022. Browse 67 market data Tables and 45 Figures spread through 128 Pages and in-depth TOC on "Glufosinate Market" Early buyers will receive 10% customization on this report. Glufosinate are widely accepted in agricultural and non-agricultural applications and play a vital role in weed controlling. Its usage is growing in recent years because it is considered as a suitable substitute for glyphosate and paraquat. The proportion of glyphosate-resistant weeds has been growing over the past few years because of its extensive usage. Farmers consider glufosinate as a better alternative in the non-selective herbicides market to protect and maintain crop yield. Furthermore, the USFDA considers glufosinate as a safer option compared to other herbicides available in the U.S. market such as paraquat. Hence, glufosinate should be viewed as a business opportunity in the next five years. Genetically modified crops segment, with respect to crop type, is projected to dominate the Glufosinate Market The usage of genetically modified crops is increasing because of its cost-effective characteristic. Genetically modified crops have wide usage applications for glyphosate and glufosinate for weed controlling purposes. Herbicide-tolerant crops consistently occupied the largest planting area of biotech crops. Increase in the area under cultivation of herbicide-tolerant crops will drive growth in Glufosinate Market since glyphosate-resistant weeds are gradually growing across regions. The agricultural applications segment accounted for a larger share in the Glufosinate Market in terms of both, value and volume, in 2015. Glufosinate is used in no-tillage agriculture, which helps farmers in controlling grasses and broad-leaved weeds in a range of agricultural and horticultural crops. It is also used as a desiccant on agricultural crops. Furthermore, the introduction of genetically modified glufosinate-tolerant crops will increase the use of glufosinate on various agricultural applications such as grains, cereals, and oilseeds. Considering the high costs of glufosinate, its usage for non-agricultural applications is limited. In 2015, the North American region accounted for the largest share of the global Glufosinate Market in terms of value and volume. The Glufosinate Market in North America is also projected to grow at a significant CAGR during the forecast period. This region comprises developed economies such as U.S. and Canada, where the U.S. is a key producer of various agricultural applications. There is growing awareness observed in the U.S. with regard to glufosinate products. Glufosinate is registered for use in crops such as almonds, apples, bananas, berries, canola, corn, cotton, grapes, potatoes, rice, soybean, and tree nuts in the U.S. which has resulted in the growth of the market in this region. This report includes a study of marketing and development strategies, along with the product portfolios of leading companies. It includes the profiles of leading companies such as Bayer AG (Germany), The Dow Chemical Company (U.S.), E. I. du Pont de Nemours and Company (U.S.), Syngenta AG (Switzerland), and UPL (India). Crop Protection Chemicals Market by Type (Herbicide, Insecticide and Fungicide), Origin (Synthetic and bio-pesticides), Crop Type (Cereals & Oilseeds, Fruits & Vegetables), Mode of Application, Form and by Region - Global Forecast to 2021 Herbicides Market by Type (Glyphosate, Atrazine, Acetochlor, 2,4-D), by Crop Type (Cereals & Grains, Oilseeds & Pulses, Fruits & Vegetables), by Mode of Action (Selective & Non-Selective) & Geography - Trends and Forecasts to 2019 MarketsandMarkets is the largest market research firm worldwide in terms of annually published premium market research reports. Serving 1700 global fortune enterprises with more than 1200 premium studies in a year, M&M is catering to a multitude of clients across 8 different industrial verticals. We specialize in consulting assignments and business research across high growth markets, cutting edge technologies and newer applications. 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