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Mayevsky A.,Bar - Ilan University | Mayevsky A.,CritiSense | Walden R.,Sheba Medical Center | Pewzner E.,CritiSense | And 9 more authors.
Journal of Biomedical Optics | Year: 2011

Background: The involvement of mitochondria in pathological states, such as neurodegenerative diseases, sepsis, stroke, and cancer, are well documented. Monitoring of nicotinamide adenine dinucleotide (NADH) fluorescence in vivo as an intracellular oxygen indicator was established in 1950 to 1970 by Britton Chance and collaborators. We use a multiparametric monitoring system enabling assessment of tissue vitality. In order to use this technology in clinical practice, the commercial developed device, the CritiView (CRV), is tested in animal models as well as in patients. Methods and Results: The new CRV enables the optical monitoring of four different parameters, representing the energy balance of various tissues in vivo. Mitochondrial NADH is measured by surface fluorometry/reflectometry. In addition, tissue microcirculatory blood flow, tissue reflectance and oxygenation are measured as well. The device is tested both in vitro and in vivo in a small animal model and in preliminary clinical trials in patients undergoing vascular or open heart surgery. In patients, the monitoring is started immediately after the insertion of a three-way Foley catheter (urine collection) to the patient and is stopped when the patient is discharged from the operating room. The results show that monitoring the urethral wall vitality provides information in correlation to the surgical procedure performed. © 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).


Mayevsky A.,Bar - Ilan University | Mayevsky A.,CritiSense | Barbiro-Michaely E.,Bar - Ilan University
Frontiers of Optoelectronics in China | Year: 2010

Optical monitoring of tissue physiological and biochemical parameters in real-time is a new approach and a powerful tool for better clinical diagnosis and treatment. Most of the devices available for monitoring patients in critical conditions provide information on body respiratory and hemodynamic functions. Currently, monitoring of patients at the cellular and tissue level is very rare. Real-time monitoring of mitochondrial nicotinamide adenine dinucleotide (NADH) as an indicator of intra-cellular oxygen levels started 50 years ago. Mitochondrial dysfunction was recognized as a key element in the pathogenesis of various illnesses. We developed the "CritiView" - a revolutionary patient monitoring system providing real time data on mitochondrial function as well as microcirculatory blood flow, hemoglobin oxygenation as well as tissue reflectance. We hypothesize that under the development of body O2 insufficiency the well known blood flow redistribution mechanism will protect the most vital organs (brain and heart) by increasing blood flow while the less vital organs (gastrointestinal (GI) tract or urogenital system) will become hypoperfused and O2 delivery will diminish. Therefore, the less vital organs will be the initial responders to O2 imbalances and the last to recover after the end of resuscitation. The urethral wall represents a less-vital organ in the body and may be very sensitive to the development of emergency situations in patients. It is assumed that the beginning of deterioration processes (i. e., internal bleeding) as well as resuscitation end-points in critically ill patients will be detected. In this paper, we review the theoretical, technological, experimental and preliminary clinical results accumulated using the "CritiView". Preliminary clinical studies suggest that our monitoring approach is practical in collecting data from the urethral wall in critical care medicine. Using CritiView in critical care medicine may shed new light on body O2 balance and the development of body emergency metabolic state. © 2010 Higher Education Press and Springer Berlin Heidelberg.


CritiSense | Entity website

Clinical Applications CritiView is a adjunctive bedside patient monitoring device to be applied in intensive care, operating suits and emergency care settings, providing: a. Early identification / warning of the bodys critical metabolic imbalances or tissue viability of a patient; b ...


CritiSense | Entity website

Products CritiView (CRV) CritiSense first generation product is a patient monitoring system providing real-time continuous information via four physiological parameters, sensed at the tissue level, reflecting the patients systemic metabolic state. CritiView is a adjunctive bedside patient monitoring device to be applied in intensive care, operating suits and emergency care settings, providing: a ...


CritiSense | Entity website

Publications Recent articles Mayevsky A ., Dekel, N ...


CritiSense | Entity website

".to be a market leader in monitoring the metabolic state of the patient in critical care settings, by continuous, real-time direct assessment of tissue viability using CritiView as a diagnostic tool"


CritiSense | Entity website

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CritiSense | Entity website

About Us Breakthrough technology for real-time monitoring of the metabolic state of the patient and as a novel endpoint of resuscitation Critisense's first generation product - the "CritiView" is an innovative patient monitoring system providing real-time continuous information via four physiological parameters, sensed at the tissue level, reflecting the systemic metabolic state. CritiView is the only device providing continuous, real-time multi-parametric physiological data at the tissue and cellular level, by monitoring the mitochondrial function and the microcirculatory blood flow and oxygen saturation ...


CritiSense | Entity website

Technology CritiView monitors are based on proprietary, patented technology for measuring key parameters of tissue viability continuously, simultaneously and in real-time with a single probe. CritiView simultaneously measures mitochondrial NADH, blood oxygenation, microcirculatory blood flow and tissue reflectance ...

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