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The report "Schizophrenia - Pipeline Review, H1 2017" provides comprehensive information on the therapeutics under development for Schizophrenia (Gastrointestinal), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Schizophrenia (Central Nervous System) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Complete report on Schizophrenia - Pipeline Review, H1 2017 spread across 309 pages is available at http://www.rnrmarketresearch.com/schizophrenia-pipeline-review-h1-2017-market-report.html . Schizophrenia (Central Nervous System) pipeline guide also reviews of key players involved in therapeutic development for Schizophrenia and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Pre-Registration, Phase III, Phase II, Phase I, IND/CTA Filed, Preclinical, Discovery and Unknown stages are 4, 12, 13, 22, 1, 54, 10 and 2 respectively. Similarly, the Universities portfolio in Phase II, Preclinical and Discovery stages comprises 1, 9 and 2 molecules, respectively. Companies discussed in this report include Acadia Pharmaceuticals Inc, Adamed Sp z oo, Aequus Pharmaceuticals Inc, AgeneBio Inc, Alkermes Plc, Angita BV, Astellas Pharma Inc, Athersys Inc, Avanir Pharmaceuticals Inc, Avineuro Pharmaceuticals Inc, BCWorld Pharm Co Ltd, BioCrea GmbH, BioHealthonomics Inc, Boehringer Ingelheim GmbH, Braeburn Pharmaceuticals Inc, Bristol-Myers Squibb Company, Critical Pharmaceuticals Ltd, Curemark LLC, Daewoong Pharmaceutical Co Ltd, Delpor Inc, Denovo Biopharma LLC, Evotec AG, F. Hoffmann-La Roche Ltd, Fabre-Kramer Pharmaceuticals Inc, Galenea Corp, GeNeuro SA, GlaxoSmithKline Plc, Glenmark Pharmaceuticals Ltd, GP Pharm SA, GW Pharmaceuticals Plc, H. Lundbeck A/S, Heptares Therapeutics Ltd, Hisamitsu Pharmaceutical Co Inc, Indivior Plc, Insys Therapeutics Inc, IntelGenx Corp, Intra-Cellular Therapies Inc, Johnson & Johnson, JT Pharmaceuticals Inc, Karuna Pharmaceuticals Inc, KemPharm Inc, Kowa Company Ltd, Laboratorios Farmaceuticos Rovi SA, Lead Discovery Center GmbH, Lohocla Research Corp, Luye Pharma Group Ltd, Mapi Pharma Ltd, Merck & Co Inc, Mitsubishi Tanabe Pharma Corp, Neurocrine Biosciences Inc, NeurOp Inc, Newron Pharmaceuticals SpA, Omeros Corp, Otsuka Holdings Co Ltd, Peptron Inc, Pfizer Inc, Promentis Pharmaceuticals Inc, Ra Pharmaceuticals Inc, Reviva Pharmaceuticals Inc, Richter Gedeon Nyrt, Sage Therapeutics Inc, SK Biopharmaceuticals Co Ltd, Sumitomo Dainippon Pharma Co Ltd, Sunovion Pharmaceuticals Inc, Suven Life Sciences Ltd, Taisho Pharmaceutical Holdings Co Ltd, Tetra Discovery Partners LLC, Teva Pharmaceutical Industries Ltd, Vanda Pharmaceuticals Inc, Vitality Biopharma Inc, VLP Therapeutics LLC, Zogenix Inc, Zysis Ltd Order a copy of this research report at http://www.rnrmarketresearch.com/contacts/purchase?rname=1019645. (This report is available at up to 25% Discount till June 02nd 2017.) "Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline Review, H1 2017", provides comprehensive information on the therapeutics under development for Cognitive Impairment Associated With Schizophrenia (CIAS) (Central Nervous System), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Explore more reports of Therapeutics Market Research at http://www.rnrmarketresearch.com/reports/life-sciences/pharmaceuticals/therapeutics . RnRMarketResearch.com is your one stop market research and industry analysis reports' library providing business data and intelligence information on thousands of micro markets with global as well as regional coverage. Category focused research, country reports, company profiles, regional and global industry profiles and guides to premium reports offering extensive coverage of other 20+ industries are all available in our library of syndicated market research reports.


The report "Schizophrenia - Pipeline Review, H1 2017" provides comprehensive information on the therapeutics under development for Schizophrenia (Gastrointestinal), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Schizophrenia (Central Nervous System) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Complete report on Schizophrenia - Pipeline Review, H1 2017 spread across 309 pages is available at http://www.rnrmarketresearch.com/schizophrenia-pipeline-review-h1-2017-market-report.html . Schizophrenia (Central Nervous System) pipeline guide also reviews of key players involved in therapeutic development for Schizophrenia and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Pre-Registration, Phase III, Phase II, Phase I, IND/CTA Filed, Preclinical, Discovery and Unknown stages are 4, 12, 13, 22, 1, 54, 10 and 2 respectively. Similarly, the Universities portfolio in Phase II, Preclinical and Discovery stages comprises 1, 9 and 2 molecules, respectively. Companies discussed in this report include Acadia Pharmaceuticals Inc, Adamed Sp z oo, Aequus Pharmaceuticals Inc, AgeneBio Inc, Alkermes Plc, Angita BV, Astellas Pharma Inc, Athersys Inc, Avanir Pharmaceuticals Inc, Avineuro Pharmaceuticals Inc, BCWorld Pharm Co Ltd, BioCrea GmbH, BioHealthonomics Inc, Boehringer Ingelheim GmbH, Braeburn Pharmaceuticals Inc, Bristol-Myers Squibb Company, Critical Pharmaceuticals Ltd, Curemark LLC, Daewoong Pharmaceutical Co Ltd, Delpor Inc, Denovo Biopharma LLC, Evotec AG, F. Hoffmann-La Roche Ltd, Fabre-Kramer Pharmaceuticals Inc, Galenea Corp, GeNeuro SA, GlaxoSmithKline Plc, Glenmark Pharmaceuticals Ltd, GP Pharm SA, GW Pharmaceuticals Plc, H. Lundbeck A/S, Heptares Therapeutics Ltd, Hisamitsu Pharmaceutical Co Inc, Indivior Plc, Insys Therapeutics Inc, IntelGenx Corp, Intra-Cellular Therapies Inc, Johnson & Johnson, JT Pharmaceuticals Inc, Karuna Pharmaceuticals Inc, KemPharm Inc, Kowa Company Ltd, Laboratorios Farmaceuticos Rovi SA, Lead Discovery Center GmbH, Lohocla Research Corp, Luye Pharma Group Ltd, Mapi Pharma Ltd, Merck & Co Inc, Mitsubishi Tanabe Pharma Corp, Neurocrine Biosciences Inc, NeurOp Inc, Newron Pharmaceuticals SpA, Omeros Corp, Otsuka Holdings Co Ltd, Peptron Inc, Pfizer Inc, Promentis Pharmaceuticals Inc, Ra Pharmaceuticals Inc, Reviva Pharmaceuticals Inc, Richter Gedeon Nyrt, Sage Therapeutics Inc, SK Biopharmaceuticals Co Ltd, Sumitomo Dainippon Pharma Co Ltd, Sunovion Pharmaceuticals Inc, Suven Life Sciences Ltd, Taisho Pharmaceutical Holdings Co Ltd, Tetra Discovery Partners LLC, Teva Pharmaceutical Industries Ltd, Vanda Pharmaceuticals Inc, Vitality Biopharma Inc, VLP Therapeutics LLC, Zogenix Inc, Zysis Ltd Order a copy of this research report at http://www.rnrmarketresearch.com/contacts/purchase?rname=1019645. (This report is available at up to 25% Discount till June 02nd 2017.) "Cognitive Impairment Associated With Schizophrenia (CIAS) - Pipeline Review, H1 2017", provides comprehensive information on the therapeutics under development for Cognitive Impairment Associated With Schizophrenia (CIAS) (Central Nervous System), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Explore more reports of Therapeutics Market Research at http://www.rnrmarketresearch.com/reports/life-sciences/pharmaceuticals/therapeutics . RnRMarketResearch.com is your one stop market research and industry analysis reports' library providing business data and intelligence information on thousands of micro markets with global as well as regional coverage. Category focused research, country reports, company profiles, regional and global industry profiles and guides to premium reports offering extensive coverage of other 20+ industries are all available in our library of syndicated market research reports.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Feasibility Study | Award Amount: 139.92K | Year: 2015

Age-related macular degeneration (AMD) is the leading cause of blindness in those aged over 50, causing blurring, distortion and loss of central vision and almost always affects quality of life. There are two main types of AMD, wet and dry. Wet AMD is most severe but more treatable and occurs in about 1 in 10 cases. However it causes severe visual loss over a short time, sometimes just months or even hours / days if there is a haemorrhage. Current treatment requires monthly injections into the eye, which are unpleasant for the patient and carry a risk of infection. This project aims to prepare a novel, sustained release treatment to reduce the necessary frequency of injections, improving the patient experience and reducing the risks and costs of treatment.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Collaborative Research & Development | Award Amount: 341.42K | Year: 2011

To address unmet clinical needs, protein-based medicines must be manufactured so as to overcome many limitations including their propensity to degrade and to clear rapidly from blood circulation. Our consortium has developed two proprietary technologies that are based on clinically proven strategies and address the inherent limitations of protein-based medicines. Critical Pharmaceuticals (CP) have developed novel biodegradable microparticles able to encapsulate proteins for prolonged continuous release. PolyTherics (PT) have developed technologies for site-specific PEGylation of proteins that result in the extension of their half-life while in circulation and an increase in their pharmaceutical stability. We propose to combine these technologies to produce high value products with enhanced performance where the combined technology is superior to the technologies used separately.


Patent
Critical Pharmaceuticals | Date: 2016-04-27

A process for preparing microparticles comprising a biologically active material and a polymer and having a mean particle size expressed as the volume mean diameter (VMD) of from 10 to 500 m, wherein the biologically active material is substantially insoluble in the polymer, which process comprises:a. contacting a mixture of the biologically active material or a precursor thereof , the polymer or a precursor thereof and a processing aid with a supercritical fluid which is capable of swelling the polymer under temperature and pressure conditions necessary to maintain the fluid in a supercritical state;b. allowing the supercritical fluid to penetrate and liquefy the polymer, whilst maintaining the temperature and pressure conditions so that the fluid is maintained in a supercritical state;c. releasing the pressure to precipitate microparticles comprising the biologically active agent and the polymer.


There is provided a supercritical fluid-based process for preparing a solid polymer matrix containing a core material, wherein the process includes the step of mixing the polymer, core material and supercritical fluid in a mixing vessel, followed at least one cycle of, without recovering the solid polymer matrix, (i) converting the supercritical fluid in the mixing vessel to a sub-critical state, and then (ii) returning the fluid to the supercritical state, provided that the core material does not comprise any of gonadotropin releasing hormone (GnRH), a GnRH agonist and a GnRH antagonist.


Patent
Critical Pharmaceuticals | Date: 2013-11-14

Absorption of a therapeutic agent across a mucosal membrane or the skin can be enhanced using an absorption enhancer comprising a hydroxy fatty acid ester of polyethylene glycol.


Patent
Critical Pharmaceuticals | Date: 2015-11-20

A process for preparing microparticles comprising a biologically active material and a polymer and having a mean particle size expressed as the volume mean diameter (VMD) of from 10 to 500 m, wherein the biologically active material is substantially insoluble in the polymer, which process comprises: a. contacting a mixture of the biologically active material or a precursor thereof, the polymer or a precursor thereof and a processing aid with a supercritical fluid which is capable of swelling the polymer under temperature and pressure conditions necessary to maintain the fluid in a supercritical state; b. allowing the supercritical fluid to penetrate and liquefy the polymer, whilst maintaining the temperature and pressure conditions so that the fluid is maintained in a supercritical state; c. releasing the pressure to precipitate microparticles comprising the biologically active agent and the polymer.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Collaborative Research & Development | Award Amount: 177.86K | Year: 2012

We plan to develop a nasal spray formulation of PTH1-34 for the treatment of osteoporosis using the CriticalSorb absorption enhancer. Osteoporosis is a prevalent disease (effecting 40% of women by age 80), characterised by reduced bone density and increased risk of fracture, particularly of the hip, wrist and spine, at a cost to the NHS of >£2bn per annum. PTH1-34 is the only drug available that stimulates the formation of new bone, but currently needs to be injected every day. Not only is this invasive method of drug administration not well liked by patients, but it is a complicated multi-step process and as osteoporosis patients are elderly they can find it difficult. The nasal spray we develop is expected to improve ease of use, increase patient compliance with the treatment regimen and increase efficacy with the aim of improving treatments and reducing healthcare costs.


Grant
Agency: European Commission | Branch: H2020 | Program: SME-1 | Phase: NMP-25-2014-1 | Award Amount: 71.43K | Year: 2015

Sustained Release Ocular Bevacizumab for the treatment of wet acute macular degeneration This feasibility study is to verify the technical and economic viability of a sustained release bevacizumab product (SR Bevacizumab) to improve the safety, cost-effectiveness and patient acceptability for the treatment of wet age-related macular degeneration (AMD). AMD is the leading cause of blindness in those aged over 50 and causes blurring, distortion and loss of central vision and almost always affects quality of life. Prototype SR Bevacizumab products will be manufactured using CriticalMix, an advanced manufacturing and processing technology developed by Critical Pharmaceuticals, which will encapsulate bevacizumab in biodegradable polymers suitable for sustained release of the drug in the eye.

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