Critical Care

Hôpital-Camfrout, France

Critical Care

Hôpital-Camfrout, France
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BETHLEHEM, Pa., May 22, 2017 (GLOBE NEWSWIRE) -- B. Braun Medical Inc. will showcase its portfolio of infusion pump products and integrated technologies, designed to help improve patient safety and outcomes, at the American Association of Critical-Care Nurses (AACN) National Teaching Institute & Critical Care Exposition, May 23-25, at the George R. Brown Convention Center in Houston. At booth #4531, B. Braun Medical will display the AutoProgramming, AutoDocumentation, and AutoNotification benefits of AutoCOMPLETE™ Integrated EMR — the highest level of integration on B. Braun’s Synchronized Intelligence™ Infusion Platform. “AutoCOMPLETE is not only designed to help clinicians to reduce manual data entry errors and save time by increasing documentation accuracy, but also to facilitate improved reporting to help prevent alarm fatigue,” said Mike Golebiowski, Vice President of Automation and Infusion Systems at B. Braun Medical. Alarm fatigue is a concern for healthcare providers as more devices are implemented in the healthcare environment. B. Braun’s Synchronized Intelligence platform is designed to seamlessly integrate real-time data, pumps, and reporting with other platforms for system-wide compatibility to help improve patient outcomes. “When combined with education and institutional leadership, our design can help clinicians achieve up to 100 percent drug library compliance, a reduction in infusion-related medication errors, and a decrease in unnecessary alarms and alerts," Golebiowski said. B. Braun’s integrated IV infusion pump portfolio also includes the Infusomat® Space Infusion System, the Outlook® Infusion Pump, real-time infusion insight through its PharmView application, and real-time wireless reporting with its DoseTrac® Infusion Management Software. Additionally, B. Braun will sponsor three booth presentations and a poster presentation at AACN that will focus on how infusion technology, data and practice improvements are helping clinicians achieve positive outcomes for their patients: To learn more about B. Braun's Synchronized Intelligence Infusion Platform, call 800-227-2862 or visit www.BBraunUSA.com/sync. About B. Braun B. Braun Medical Inc., a leader in infusion therapy and pain management, develops, manufactures, and markets innovative medical products and services to the health care industry. The company is committed to eliminating preventable treatment errors and enhancing patient, clinician and environmental safety. B. Braun Medical is headquartered in Bethlehem, Pa., and is part of the B. Braun Group of Companies in the U.S., which includes B. Braun Interventional Systems, Aesculap® and CAPS®. Globally, the B. Braun Group of Companies employs more than 58,000 employees in 64 countries. Guided by its Sharing Expertise® philosophy, B. Braun continuously exchanges knowledge with customers, partners and clinicians to address the critical issues of improving care and lowering costs. To learn more about B. Braun Medical, visit www.BBraunUSA.com.


This report displays the production, revenue, price, market share & growth rate critical care equipment’s market, which has been analyzed during the period of 2012 to 2017. Albany, NY, April 15, 2017 --( Request Free Sample Report: http://www.marketresearchhub.com/enquiry.php?type=S&repid=1037519 Moreover, with an extensive forecast up to 2022, the report evaluates the global market size and growth prospects. As per the study key highlights, technological advancements in critical care equipment’s, government support and growing private sector investments in the healthcare industry, are key factors fueling the growth of the critical care devices market in the emerging nations. In 2016, the global Critical Care Equipment market has gained a significant growth value and is predictable to reach a high value in (USD million) by the end of 2022, rising at a steady CAGR between 2017 and 2022. At first, the report starts with the overall critical care equipment market along with its segmentation by type and application. Critical care units are special departments of health care facilities that cater to critically ill patients or those with life-threatening severe illnesses. For that, much critical care equipment’s are utilized in applications, such as hospitals and home care. Rising number of hospitals across the world is also a factor contributing towards the growth of this market. On the basis of the type it covers: Infusion Pumps Ventilators Patient Monitors For each type, this report displays the production, revenue, price, market share & growth rate which has been analyzed during the period of 2012 to 2017. On the other hand, for each application, this report focuses on the status and outlook for major applications/end users together with consumption (sales), market share and growth rate. In the next section, on the basis of several key regions, the report also assess the details of production, consumption, revenue (in million USD). Moreover, key players in the global market for critical care equipment highlighted in the report are as follows: Braun Melsungen AG Smiths Medical Akasmedical Medtronic Nihon Kohden General Electric Koninklijke Philips Dragerwerk AG & Co. KGAA Maquet Fresenius KABI BPL Medical Technologies Skanray Browse Full Report With TOC: http://www.marketresearchhub.com/report/global-critical-care-equipment-market-research-report-2017-report.html Further sections of the report cover the following details; manufacturing cost analysis, industrial chain analysis, marketing strategy and marketing effect factors analysis. About Market Research Hub Market Research Hub (MRH) is a next-generation reseller of research reports and analysis. MRH’s expansive collection of market research reports has been carefully curated to help key personnel and decision makers across industry verticals to clearly visualize their operating environment and take strategic steps. MRH functions as an integrated platform for the following products and services: Objective and sound market forecasts, qualitative and quantitative analysis, incisive insight into defining industry trends, and market share estimates. Our reputation lies in delivering value and world-class capabilities to our clients. Contact Us 90 State Street, Albany, NY 12207, United States Toll Free: 866-997-4948 (US-Canada) Tel: +1-518-621-2074 Email: press@marketresearchhub.com Follow us on: Twitter: twitter.com/MktResearchHub LinkedIn: www.linkedin.com/company/market-research-hub Facebook: www.facebook.com/MarketResearchHub/ Albany, NY, April 15, 2017 --( PR.com )-- Advancements in the healthcare industry are constantly increasing to provide extra benefit and advance services for patients. Accordingly, the number of growing diseases and increasing awareness about health has boosted the demand for critical care equipment’s. Increase in number of health care facilities across the globe is expected to fuel the growth of global critical care equipment market, finds a new study added to the wide repository of Market Research Hub (MRH). The study is titled as “Global Critical Care Equipment Market” Research Report 2017 which delivers exhaustive information on the global market covering the vital regions such as Europe, North America, Japan, Southeast Asia, China and India.Request Free Sample Report: http://www.marketresearchhub.com/enquiry.php?type=S&repid=1037519Moreover, with an extensive forecast up to 2022, the report evaluates the global market size and growth prospects. As per the study key highlights, technological advancements in critical care equipment’s, government support and growing private sector investments in the healthcare industry, are key factors fueling the growth of the critical care devices market in the emerging nations. In 2016, the global Critical Care Equipment market has gained a significant growth value and is predictable to reach a high value in (USD million) by the end of 2022, rising at a steady CAGR between 2017 and 2022.At first, the report starts with the overall critical care equipment market along with its segmentation by type and application. Critical care units are special departments of health care facilities that cater to critically ill patients or those with life-threatening severe illnesses. For that, much critical care equipment’s are utilized in applications, such as hospitals and home care. Rising number of hospitals across the world is also a factor contributing towards the growth of this market.On the basis of the type it covers:Infusion PumpsVentilatorsPatient MonitorsFor each type, this report displays the production, revenue, price, market share & growth rate which has been analyzed during the period of 2012 to 2017. On the other hand, for each application, this report focuses on the status and outlook for major applications/end users together with consumption (sales), market share and growth rate.In the next section, on the basis of several key regions, the report also assess the details of production, consumption, revenue (in million USD).Moreover, key players in the global market for critical care equipment highlighted in the report are as follows:Braun Melsungen AGSmiths MedicalAkasmedicalMedtronicNihon KohdenGeneral ElectricKoninklijke PhilipsDragerwerk AG & Co. KGAAMaquetFresenius KABIBPL Medical TechnologiesSkanrayBrowse Full Report With TOC: http://www.marketresearchhub.com/report/global-critical-care-equipment-market-research-report-2017-report.htmlFurther sections of the report cover the following details; manufacturing cost analysis, industrial chain analysis, marketing strategy and marketing effect factors analysis.About Market Research HubMarket Research Hub (MRH) is a next-generation reseller of research reports and analysis. MRH’s expansive collection of market research reports has been carefully curated to help key personnel and decision makers across industry verticals to clearly visualize their operating environment and take strategic steps.MRH functions as an integrated platform for the following products and services: Objective and sound market forecasts, qualitative and quantitative analysis, incisive insight into defining industry trends, and market share estimates. Our reputation lies in delivering value and world-class capabilities to our clients.Contact Us90 State Street,Albany, NY 12207,United StatesToll Free: 866-997-4948 (US-Canada)Tel: +1-518-621-2074Email: press@marketresearchhub.comFollow us on:Twitter: twitter.com/MktResearchHubLinkedIn: www.linkedin.com/company/market-research-hubFacebook: www.facebook.com/MarketResearchHub/ Click here to view the list of recent Press Releases from Market Research Hub


DELRAY BEACH, Fla., May 08, 2017 (GLOBE NEWSWIRE) -- PositiveID Corporation (OTCQB:PSID), a Life Sciences Company focused on detection and diagnostics, announced today that its Thermomedics subsidiary will exhibit the Caregiver® non-contact thermometer at the American Association of Critical-Care Nurses (AACN) National Teaching Institute and Critical Care Exposition from May 23-25 at the George R. Brown Convention Center in Houston, TX. Caregiver, which is FDA cleared for clinical use, is a professional grade, infrared thermometer for measurement of forehead temperature in adults, children, and infants, without contact. It delivers an oral-equivalent temperature directly from the forehead in one to two seconds. Since there is no skin contact and Caregiver does not require probe cover supplies, it reduces the risk of cross-contamination, which is an increasing concern, and saves healthcare facilities the cost of covers, which are as much as $0.05 to $0.10 per temperature, storage space, and waste disposal costs. It is estimated that Caregiver can offer savings of $250 or more per year per device in probe cover supplies alone. PositiveID’s Thermomedics team is exhibiting at the AACN conference to increase exposure and awareness for Caregiver and generate qualified leads for its national network of distributors. The AACN Critical Care Exposition is the largest, most comprehensive trade show for acute and critical care nurses, advanced practice nurses, clinical nurse specialists, nurse practitioners and nurse managers as well as progressive care, transport and emergency department nurses who treat critically ill patients. AACN's audience is estimated at approximately 7,000 influential nurses. About PositiveID Corporation PositiveID Corporation is a life sciences tools and diagnostics Company with an extensive patent portfolio. PositiveID develops biological detection and diagnostics systems, specializing in the development of microfluidic systems for the automated preparation of and performance of biological assays. PositiveID is also a leader in the mobile technology vehicle market, with a focus on the laboratory market and homeland security. For more information on PositiveID, please visit http://www.psidcorp.com, or connect with PositiveID on Twitter, Facebook or LinkedIn. Statements about PositiveID's future expectations, including the likelihood that Caregiver can offer savings of $250 or more per year per device in probe cover supplies alone, constitute "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, Section 21E of the Securities Exchange Act of 1934, and as that term is defined in the Private Litigation Reform Act of 1995. Such forward-looking statements involve risks and uncertainties and are subject to change at any time, and PositiveID's actual results could differ materially from expected results. These risks and uncertainties include, without limitation, the Company’s ability to target the professional healthcare market; the Company’s ability to attract and retain new customers; as well as other risks. Additional information about these and other factors that could affect the Company's business is set forth in the Company's various filings with the Securities and Exchange Commission, including those set forth in the Company's 10-K filed on March 31, 2017, and 10-Qs filed on November 18, 2016, August 12, 2016, and May 16, 2016, under the caption "Risk Factors." The Company undertakes no obligation to update or release any revisions to these forward-looking statements to reflect events or circumstances after the date of this statement or to reflect the occurrence of unanticipated events, except as required by law.


News Article | May 4, 2017
Site: www.businesswire.com

SUFFOLK, Va.--(BUSINESS WIRE)--The Center of Veterinary Expertise (The COVE), recently celebrated its 5-year anniversary providing 24/7 emergency and specialty care for the community’s companion animals. Located at 6550 Hampton Roads Parkway, in Suffolk, team members recently welcomed Suffolk Mayor Linda Johnson to a morning of commemoration, reflection, and recognition. “In 2012, The COVE opened its doors to a very special hospital to provide emergency and advanced care for pets and their families. Since then, we have had over 38,000 patient visits - treating illnesses and/or injuries from kennel cough to major trauma,” said Danielle Russ, Hospital Manager. “It is an honor to serve as a partner to a community filled with incredible pet owners and primary care veterinarians who often refer their patients to us.” As a token of appreciation for the support Suffolk has provided over the years, The COVE owners, surgeon Dr. Jeff T. Stallings, cardiologist Dr. Merrilee T. Small , and hospital manager Danielle Russ, presented Mayor Johnson with a gift of a new bench for Lake Meade Dog Park. The mayor graciously accepted and then presented a Letter of Recognition to the entire team at the practice. “When we lost our pet, my son – who is a grown man – sat in the back for a long time. You were all so kind and compassionate. Now when anyone tells me about their sick pet, I tell them to go to The COVE…it’s right around the corner,” Mayor Johnson shared. “So on behalf of the City of Suffolk, I’d like to thank you for what you do every day for our families and our community – and for being a part of us.” The COVE is Suffolk’s only 24/7 emergency and specialty veterinary hospital. With over 5,000 square feet of custom-built space, world-class care is provided via a staff of expert and compassionate practitioners and board-certified specialists in Cardiology, Surgery, and Emergency/Critical Care. The COVE works as a partner with primary care veterinarians throughout the region to provide advanced care for their patients when needed.


The analysts forecast the global critical care therapeutics market to grow at a CAGR of 3.62% during the period 2017-2021. Critical care or intensive care is the close monitoring and treatment given to individuals with acute, life-threatening illness or injuries such as shock, burns, accidents, complicated surgeries, sepsis, and severe breathing problems. It usually takes place in an ICU or trauma center. Plasma is the fluid portion of the blood, in which all the blood cells are suspended. It makes up about 55% of the total volume of the blood. The other components such as red blood cell (RBC), white blood cell (WBC), and platelets together comprise the remaining 45% of the blood. Plasma is mainly made up of water, which accounts for about 91% of the total volume. For more information or any query mail at sales@wiseguyreports.com The report covers the present scenario and the growth prospects of the global critical care therapeutics market for 2017-2021. To calculate the market size, the report considers the revenue generated from sales of critical care therapeutics was considered. The market is divided into the following segments based on geography: • Americas • APAC • EMEA The report, Global Critical Care Therapeutics Market 2017-2021, has been prepared based on an in-depth market analysis with inputs from industry experts. The report covers the market landscape and its growth prospects over the coming years. The report also includes a discussion of the key vendors operating in this market. Market driver • Growing preference for marketed products over alternative treatment options. • For a full, detailed list, view our report Market challenge • Existence of plasma fractionation supply and demand gap. • For a full, detailed list, view our report Market trend • Increased development of recombinant products for critical care use. • For a full, detailed list, view our report Key questions answered in this report • What will the market size be in 2021 and what will the growth rate be? • What are the key market trends? • What is driving this market? • What are the challenges to market growth? • Who are the key vendors in this market space? • What are the market opportunities and threats faced by the key vendors? • What are the strengths and weaknesses of the key vendors? PART 04: Introduction • Key market highlights • The role of plasma therapeutics in critical care industry • Introduction to plasma therapeutics • Introduction to anticoagulants PART 08: Geographical segmentation • Critical care therapeutics market in Americas • Critical care therapeutics market in EMEA • Critical care therapeutics market in APAC PART 09: Market drivers • High demand for albumin in China • Increasing surgical procedures • Growing preference for marketed products over alternative treatment options • Impact of drivers PART 10: Market challenges • Existence of plasma fractionation supply and demand gap • Spread of pathogenic contaminants • High regulations of plasma products For more information or any query mail at sales@wiseguyreports.com ABOUT US: Wise Guy Reports is part of the Wise Guy Consultants Pvt. Ltd. and offers premium progressive statistical surveying, market research reports, analysis & forecast data for industries and governments around the globe. Wise Guy Reports features an exhaustive list of market research reports from hundreds of publishers worldwide. We boast a database spanning virtually every market category and an even more comprehensive collection of rmaket research reports under these categories and sub-categories. For more information, please visit https://www.wiseguyreports.com


The International Nurses Association is pleased to welcome Connie L. Johnston, RN, CCRN, to their prestigious organization with her upcoming publication in the Worldwide Leaders in Healthcare. Connie L. Johnston is a Registered Nurse currently serving patients within Williamson Medical Center in Franklin, Tennessee. With more than three decades of experience in nursing, she is a specialist critical care nurse. Connie L. Johnston graduated with her Nursing Degree in 1980 from the University of Tennessee at Martin. Since graduating she has completed a number of advanced training courses, earning certification in Basic Life Support, Advanced Cardiac Life Support, and Pediatric Advanced Life Support. Connie is also a Certified Critical Care Registered Nurse. To keep up to date with the latest advances in nursing, Connie maintains a professional membership with the American Association of Critical Care Nurses. A recipient of the Nurse Excellence Award in 2010, Connie attributes her success to her passion for helping others with hands on care and old school nursing values. When she is not working, Connie enjoys gardening, hunting, and traveling. Learn more about Connie L. Johnston here: http://inanurse.org/network/index.php?do=/4136164/info/ and be sure to read her upcoming publication in Worldwide Leaders in Healthcare.


The International Nurses Association is pleased to welcome Connie L. Johnston, RN, CCRN, to their prestigious organization with her upcoming publication in the Worldwide Leaders in Healthcare. Connie L. Johnston is a Registered Nurse currently serving patients within Williamson Medical Center in Westpoint, Tennessee. With more than three decades of experience in nursing, she is a specialist critical care nurse. Connie L. Johnston graduated with her Nursing Degree in 1980 from the University of Tennessee in Knoxville. Since graduating she has completed a number of advanced training courses, earning certification in Basic Life Support, Advanced Cardiac Life Support, and Pediatric Advanced Life Support. Connie is also a Certified Critical Care Registered Nurse. To keep up to date with the latest advances in nursing, Connie maintains a professional membership with the American Association of Critical Care Nurses. A recipient of the Nurse Excellence Award in 2010, Connie attributes her success to her passion for helping others with hands on care and old school nursing values. When she is not working, Connie enjoys gardening, hunting, and traveling. Learn more about Connie L. Johnston here: http://inanurse.org/network/index.php?do=/4136164/info/ and be sure to read her upcoming publication in Worldwide Leaders in Healthcare.


The International Association of HealthCare Professionals is pleased to welcome Debra A. (Zemanek) Cooper, RRT, to their prestigious organization with her upcoming publication in the Worldwide Leaders in Healthcare. Debra is a highly trained and qualified respiratory therapist with extensive expertise in all facets of her work, especially critical care. She has been in practice for more than three decades and has worked at St. Francis Hospital and medical center for 28 years, specializing in Critical Care and Trauma. She is currently serving patients in Vernon, Connecticut. Affiliated with the Eastern Connecticut Health Network. Debra received her degree in Respiratory Therapy in 1978. Since graduating, she has completed a number of advanced training courses, and is also a Certified Asthma Educator. In her role, she is able to assist in the orientation of new personnel and monitor their training programs, providing accurate assessments and recommendations in the area of respiratory care. With her wealth of experience to call upon, Debra provides a comprehensive range of respiratory care and therapy services. These include critical care ventilatory management, and respiratory assessments, as well as coordinating interdisciplinary care. She attributes her success to her passion in the  field and caring for patients. When she is not working, Debra enjoys traveling, walking, arts and crafts, and spending time with her family and friends. She is also involved with pet rescue. Learn more about Debra here: http://www.iahcp.com/8133098.html and be sure to read her upcoming publication in the Worldwide Leaders in Healthcare.


News Article | May 5, 2017
Site: www.eurekalert.org

Results show pregnant women are almost twice as likely to experience a traumatic injury resulting from violent assault, highlighting the need for universal screening in Ob/Gyn clinics SAN DIEGO -- Studies have found that one in six pregnant women have been abused by a partner - beaten, stabbed, shot, or even murdered. New research shows the risks to these women may be especially profound: Pregnant women are twice as likely to be a victim of an assault-related trauma (including suicide) - and die from their injuries - than an accident-related trauma like car accidents or falls, compared to women who are not pregnant, according to a new study from researchers in the Perelman School of Medicine at the University of Pennsylvania. The findings come from a Pennsylvania statewide analysis of hospital trauma cases occurring over a decade, and will be presented Sunday at the American Congress of Obstetricians & Gynecologists' (ACOG) Annual Clinical and Scientific Meeting in San Diego (poster 36G). "Trauma from assaults or accidents complicates 1 in 12 pregnancies and is the leading non-obstetric cause of death among pregnant women. Not only is it associated with complications for the baby, but management of traumatic injuries in pregnant patients has its unique challenges, given the physiologic changes of pregnancy and restrictions doctors may face when treating pregnant patients," said the study's lead author Neha Deshpande, MD, a clinical resident of Obstetrics and Gynecology at the Perelman School of Medicine at the University of Pennsylvania. "Despite the severity of the issue, little is known about how trauma actually impacts pregnant women since accidental and incidental causes of death are excluded in many statewide and national maternal mortality reviews. The striking results of our study suggest that widespread screening for violence and trauma during pregnancy may provide an opportunity to identify women at risk for death during pregnancy." Previous research on the topic has shown that violence is common in pregnancy - even in relationships where previously there were no incidents - but the new study is the first large statewide analysis highlighting the effect of violent trauma on maternal mortality. For their analysis, the researchers used data from the Pennsylvania Trauma Outcomes Study database, a comprehensive and validated registry which includes records of admissions to all accredited trauma centers in the state. The analysis focused on admissions from 2005 through 2015, and included nearly 45,000 cases of trauma among victims who were defined as women of childbearing age (14-49). The researchers found that pregnant trauma victims, on average, suffered less severe injuries than their non-pregnant counterparts. However, despite less severe injuries, pregnant women were nearly twice as likely to be dead when they arrived at the hospital, or die in the hospital. In particular, assault-related trauma was about three times more deadly than accident-related trauma. In addition, after suffering a violent assault, pregnant women were 4.4 times more likely to be transferred to another facility for obstetric services and support. "Since the typical definition of maternal deaths includes only those directly caused or impacted by pregnancy, it does not include accidental or incidental causes of death, making it difficult to accurately gauge the burden of trauma-related deaths on maternal mortality," said senior author Corrina M. Oxford, an assistant professor of Clinical Obstetrics and Gynecology at the Perelman School of Medicine at the University of Pennsylvania. "However, evidence presented in our study suggests this is a pervasive issue that requires further attention to ensure these women, and their babies, are being properly cared for." Results also showed that nearly 1 in 5 pregnant women reported a psychiatric illness or arrived at the hospital following a suicide attempt. Minority and uninsured women were also significantly more likely to experience assault. The authors say the findings point to an opportunity for intervention to safeguard pregnant women, and they recommend universal screening of pregnant women at obstetric clinics for assault and mental illness, similar to screenings for postpartum depression. The research was recently awarded the prestigious 2017 S. Leon Israel Award from the Obstetrical Society of Philadelphia. Co-authors on the study Randi Smith from Traumatology and Critical Care at Penn Medicine, and Lauren Kucirka from Johns Hopkins University School of Medicine. Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $6.7 billion enterprise. The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 20 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $392 million awarded in the 2016 fiscal year. The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania and Penn Presbyterian Medical Center -- which are recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report -- Chester County Hospital; Lancaster General Health; Penn Wissahickon Hospice; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Additional affiliated inpatient care facilities and services throughout the Philadelphia region include Good Shepherd Penn Partners, a partnership between Good Shepherd Rehabilitation Network and Penn Medicine. Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2016, Penn Medicine provided $393 million to benefit our community.


In combination with the standard test of clotting time, new laboratory testing method opens the door to personalized resuscitation for trauma patients CHICAGO (May 15, 2017): By combining a conventional laboratory measurement of blood clotting time (known as the International Normalized Ratio or INR) with a new test of blood clot strength, based upon thrombelastography (TEG®), researchers at the University of Colorado's Department of Surgery, Denver, are able to quickly and efficiently assess the overall ability of blood to clot and identify trauma patients who were most in need of a massive blood transfusion. The investigators believe that in the not too distant future these tests, when used in combination, will be able to personalize trauma care, help surgeons save lives, and make better use of scarce blood bank resources. The ability of the tests to predict the need for massive transfusion was described in an "article in press" published on the Journal of the American College of Surgeons website in advance of print publication. More than 80 percent of deaths in the operating room and 50 percent of deaths in the first 24 hours after injury are due to massive blood loss and impaired coagulation. While only 3 percent of civilian trauma patients receive a massive transfusion in the first day of treatment after trauma, these patients account for 70 percent of all blood transfused in a trauma center.1 "When someone is massively bleeding, you need to give certain blood products early, and the blood bank has to mobilize blood products that are resource scarce, such as platelets, which have only a five-day shelf life. You want to quickly identify patients who will require a large quantity of blood products to save lives and mobilize the blood bank only when you need it," according to lead study author, Hunter B. Moore, MD. However, clinical scoring systems for predicting the need for massive transfusion are problematic. Some rely on vital signs, such as blood pressure and heart rate, which are subjective and highly variable; others require multiple diagnostic imaging and laboratory tests.2 Dr. Moore and his colleagues at the University of Colorado's Department of Surgery developed a new test to predict which patients would require massive transfusion. This test modifies a currently available test of blood clot strength, thrombelastography (TEG®), by adding tissue plasminogen activator (tPA) to a patient's blood sample. Thrombelastography is a point-of-care assay of coagulation that measures the viscoelastic properties of whole blood and determines the ability of blood to clot. Tissue plasminogen activator is a protein involved in the breakdown of blood clots. "When patients go into hemorrhagic shock, they activate the blood's fibrinolysis or clot degradation system at the local or organ level so organs continue to be perfused with blood. At the systemic level, there are backup inhibitors--platelets and proteins--that prevent clot degradation from affecting the whole body. Activators of fibrinolysis include tissue plasminogen activator. As patients progress toward hemorrhagic shock, clot degradation intensifies, and their tPA levels increase. We can unmask this process in the early stages by giving extra tPA to blood samples and forecast if the patient is at high risk of progression to hyperfibrinolysis," Dr. Moore said. Dr. Moore and associates studied more than 300 patients who were treated for trauma between 2014 and 2016. Seventeen percent of the patients required a massive transfusion, and one third of deaths were due to uncontrolled hemorrhage. The investigators assessed how effectively each clinical score could determine the need for massive transfusion, and compared their effectiveness to their new developed test. The analysis showed that this tPA-challenged TEG assay was highly sensitive and specific and took only a few minutes to provide results--up to 30 minutes faster than existing tests. Moreover, when the tPA-challenged TEG assay, was used in combination with the INR, it improved the predictive value of identifying patients who needed transfusion by roughly 40 percent. Additionally, the two-test combination identified 97 percent of patients who did not require blood products, thereby preventing unnecessary transfusions. The researchers therefore propose that trauma teams use the INR as a screening test to determine if someone is at risk for bleeding and then follow up with tPA-challenged TEG to ensure that this result is accurate. The tPA-challenged TEG assays currently require trained technicians to conduct the testing. However, newly available fully automated TEG instruments will streamline this process, according to Dr. Moore. "The fully automated assays will have a standardized methodology for obtaining samples and may be used as a point-of-care test by prehospital providers to screen for the risk of massive transfusion before patients enter the trauma center. These assays will help us move one step closer to the time when the trauma team can tailor or personalize resuscitation to each patient," Dr. Moore said. In addition to Dr. Moore, other study authors include Ernest E. Moore, MD, FACS; Michael P. Chapman, MD; Benjamin R. Huebner, MD; Peter M. Einersen, MD; Solimon Oushy, BA; Christopher C. Silliman, MD, PhD; Anirban Banerjee, PhD; and Angela Sauaia, MD, PhD. Citation: Viscoelastic Tissue Plasminogen Activator Challenge Predicts Massive Transfusion in 15 Minutes. Journal of American College of Surgeons. DOI: http://dx. . This study was supported in part by National Institute of General Medical Sciences grants T32-GM008315 and P50-GM49222; National Heart Lung and Blood Institute grant UM 1HL120877; and Department of Defense Contract Number USAMRAA, W81XWH-12-2-0028. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of General Medical Sciences, National Heart Lung and Blood Institute, National Institutes of Health, or the Department of Defense. Disclaimer: Drs. H. Moore, E. Moore, and Chapman have shared intellectual property with Haemonetics. There is no direct financial relationship. Haemonetics provided reagents and devices to run viscoelastic assays, but has no involvement with data analysis, interpretation, or any contribution to this manuscript. 1 American College of Surgeons Trauma Quality Improvement Program: ACS TQIP Massive Transfusion in Trauma Guidelines. Available at https:/ . Accessed May 11, 2017. 2 Brockamp T et al. Predicting on-goin hemorrhage and transfusion requirement after severe trauma: a validation of six scoring systems and algorithm on the TraumaRegister DGU. Critical Care. 2012; 16(4):R129. About the American College of Surgeons The American College of Surgeons is a scientific and educational organization of surgeons that was founded in 1913 to raise the standards of surgical practice and improve the quality of care for surgical patients. The College is dedicated to the ethical and competent practice of surgery. Its achievements have significantly influenced the course of scientific surgery in America and have established it as an important advocate for all surgical patients. The College has more than 80,000 members and is the largest organization of surgeons in the world. For more information, visit http://www. .

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